Down-regulation of IL-8 expression in human airway epithelial cells through helper-dependent adenoviral-mediated RNA interference

Cell Research

Volumn 15, Issue 2, 2005, Pages 111-119

  Cao, Huibi ^a,c   Wang, Anan ^a   Martin, Bernard ^a   Koehler, David R ^a,c   Zeitlin, Pamela L ^d   Tanawell, A Keith ^a,b,c   Hu, Jim ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemokine; Cystic fibrosis; Helper dependent adenoviral vector; Inflammation; Interleukin 8; Neutrophil; RNA interference

Indexed keywords

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); BURKHOLDERIA; BURKHOLDERIA CENOCEPACIA;

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8;

ADENOVIRUS; ANIMAL; ARTICLE; BIOSYNTHESIS; BURKHOLDERIA; CELL LINE; CYTOLOGY; DOWN REGULATION; EPITHELIUM CELL; GENETICS; HELPER VIRUS; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; REPORTER GENE; RESPIRATORY TRACT MUCOSA; RNA INTERFERENCE;

ADENOVIRIDAE; ANIMALS; BURKHOLDERIA; CELL LINE; CYTOKINES; DOWN-REGULATION; EPITHELIAL CELLS; GENES, REPORTER; HELPER VIRUSES; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; NF-KAPPA B; RESPIRATORY MUCOSA; RNA INTERFERENCE;

EID: 18944376379     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290275     Document Type: Article

References (66)

1. Olson TS, Singbartl K, Ley K. L-selectin is required for fMLP-but not C5a-induced margination of neutrophils in pulmonary circulation. Am J Physiol 2002; 282:R1245-52.
2. Bonfield TL, Panuska JR, Konstan MW, et al. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 1995; 152:2111-8.
3. Mahida YR, Ceska M, Effenberger F, et al. Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis. Clin Sci (Lond) 1992; 82:273-5.
4. Loetscher P, Dewald B, Baggiolini M, Seitz M. Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs. Cytokine 1994; 6:162-70.
5. Kukielka GL, Smith CW, LaRosa GJ, et al. Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo. J Clin Invest 1995; 95:89-103.
6. Moss RB, Kurup VP, Knutsen AP, et al. Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosis. Clin Infect Dis 2003; 37:S225-64.
7. Ordonez CL, Henig NR, Mayer-Hamblett N, et al. Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosis. Am J Respir Crit Care Med 2003; 168:1471-5.
8. George J. Gene therapy progress and prospects: Adenoviral vectors. Gene Ther 2003; 10:1135-41.
9. Stricter RM. Interleukin-8: a very important chemokine of the human airway epithelium. Am J Physiol 2002; 283:L688-9.
10. Li J, Kartha S, Iasvovskaia S, et al. Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol 2002; 283:L690-9.
11. Reddi K, Phagoo SB, Anderson KD, Warburton D. Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cells Line: signaling through CD14 and mitogen-activated protein kinase. Pediatr Res 2003; 54:297-305.
12. Eidelman O. Control of the Proinflammatory State in Cystic Fibrosis Lung Epithelial cell by Genes from the TNF-αR/NF-κB Pathway. Mol Med 2001; 7:523-34.
13. Li J, Johnson XD, Iazvovskaia S, et al. Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells. Am J Physiol 2003; 284:L307-15.
14. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406:782-7.
15. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999; 274:10689-92.
16. Zhang G, Ghosh S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 2001; 107:13-9.
17. Gewirtz AT. Intestinal epithelial toll-like receptors: to protect. And serve? Curr Pharm Des 2003; 9:1-5.
18. Sekido N, Mukaida N, Harada A, et al. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 1993; 365:654-7.
19. Mian BM, Dinney CPN, Bermejo CE, et al. Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB. Clin Cancer Res 2003; 9:3167-75.
20. Wada T, Tomosugi N, Naito T, et al. Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis. J Exp Med 1994; 180:1135-40.
21. Auten RL, Richardson RM, White JR, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther 2001; 299:90-5.
22. Sharp P, Zamore PD. Molecular biology. RNA interference. Science 2000; 287:2431-3.
23. Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411:494-8.
24. Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002; 26:199-213.
25. Sui G, Soohoo C, Affar el B, et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A 2002; 99:5515-20.
26. Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A 2002; 99:6047-52.
27. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391:806-11.
28. Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature 2002; 418:435-8.
29. Oshiumi H, Begum NA, Masumoto M, Seya T. RNA interference for mammalian cells. Nippon Yakurigaku Zasshi 2002; 120:91-5.
30. Parks R. Improvements of Adenoviral Vector Technology: Overcoming Barriers for Gene Therapy. Clin Genet 2000; 58:1-11.
31. Flotte TR, Afione SA, Solow R, et al. Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter. J Biol Chem 1993; 268:3781-90.
32. Zeitlin PL, Lu L, Rhim J, et al. A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection. Am J Respir Cell Mol Biol 1991; 4:313-9.
33. Ng P, Parks RJ, Graham FL. Preparation of helper-dependent adenoviral vectors. Meth Mol Med 2002; 69:371-88.
34. Kramer A, Keller W. Preparation and fractionation of mammalian extracts active in pre-mRNA splicing. Meth Enzymol 1990; 181:3-19.
35. Black HR, Yankaskas JR, Johnson LG, Noah TL. Interleukin-8 production by cystic fibrosis nasal epithelial cells after tumor necrosis factor-alpha and respiratory syncytial virus stimulation. Am J Respir Cell Mol Biol 1998; 19:210-5.
36. Richmond A. Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol 2002; 2:664-74.
37. Baggiolini M. Chemokines in pathology and medicine. J Intern Med 2001; 250:91-104.
38. Luster AD. Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338:436-45.
39. Mukaida N. Pathophysiological roles of interleukin-8/CXCL8 in pumonary disease. Am J Physiol 2003; 284:L566-77.
40. Payne AS, Cornelius LA. The role of chemokines in melanoma tumor growth and metastasis. J Invest Dermatol 2002; 118:915-22.
41. Tullus K, Noack GW, Burman LG, et al. Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia. Eur J Pediatr 1996; 155:112-6.
42. Boekholdt SM, Peters RJ, Hack CE, et al. IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prespective population study. Arterioscler Thromb Vasc Biol 2004; 24:1503-8.
43. Li A, Dubey S, Varney ML, Dave BJ, Singh RK. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003; 170:3369-76.
44. Simonini A, Moscucci M, Muller DW, et al. IL-8 is an angiogenic factor in human coronary atherectomy tissue. Circulation 2000; 101:1519-26.
45. Ostergaard C, Yieng-Kow RV, Larsen CG, et al. Treatment with a monoclonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally. Clin Exp Immunol 2000; 122:207-11.
46. Yang XD, Corvalan JR, Wang P, Roy CM, Davis CG. Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states. J Leukoc Biol 1999; 66:401-10.
47. Huang S, Mills L, Mian B, et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol 2002; 161:125-34.
48. Koehler DR, Hitt MM, Hu J. Challenges and strategies for cystic fibrosis lung gene therapy. Mol Ther 2001; 4:84-91.
49. Arts GJ, Langemeijer E, Tissingh R, et al. Adenoviral vectors expressing siRNAs for discovery and validation of gene function. Genome Res 2003; 13:2325-32.
50. Shen C, Buck AK, Liu X, Winkler M, Reske SN. Gene silencing by adenovirus-delivered siRNA. FEBS Lett 2003; 539:111-4.
51. Tiscornia G, Singer O, Ikawa M, Verma IM. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A 2003; 100:1844-8.
52. Xia H, Mao Q, Paulson HL, Davidson BL. siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002; 20:1006-10.
53. Hillgenberg M, Tonnies H, Strauss M. Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer. J Virol 2001; 75:9896-908.
54. Palmer D, Ng P. Improved system for helper-dependent adenoviral vector production. Mol Ther 2003; 8:846-52.
55. Kube D, Sontich U, Fletcher D, Davis PB. Proinflammatory cytokine responses to P. aeruginosa infection in human airway epithelial cell lines. Am J Physiol 2001; 280:L493-502.
56. Palfreyman RW, Watson ML, Eden C, Smith AW. Induction of biologically active interleukin-8 from lung epithelial cells by Burkholderia (Pseudomonas) cepacia products. Infect Immun 1997; 65:617-22.
57. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21335-76.
58. Armstrong DS, Grimwood K, Carlin JB, et al. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997; 156:1197-204.
59. Muhlebach MS, Stewart PW, Leigh MW, Noah TL. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 1999; 160:186-91.
60. Aldallal N, McNaughton EE, Manzel LJ, et al. Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. Am J Respir Crit Care Med 2002; 166:1248-56.
61. Venkatakrishnan A, Stecenko AA, King G, et al. Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol 2000; 23:396-403.
62. Davidson DJ, Dorin JR, McLachlan G, et al. Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens. Nat Genet 1995; 9:351-7.
63. Koehler DR, Sajjan U, Chow Y-H, et al. Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia. Proc Natl Acad Sci U S A 2003; 100:15364-9.
64. -/- mice. Infect Immun 2001; 69:5138-50.
65. Chi JT, Chang HY, Wang NN, et al. Genomewide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci USA 2003; 100:6343-6.
66. Higginbotham JN, Seth P, Blaese RM, Ramsey WJ. The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid. Hum Gene Ther 2002; 13:129-41.