An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells

PLoS Medicine

Volumn 3, Issue 1, 2006, Pages 76-93

  Song, Xiao Tong ^a,b   Evel Kabler, Kevin ^a,b   Rollins, Lisa ^a,b   Aldrich, Melissa ^a,b   Gao, Feng ^c   Huang, Xue F ^a,b   Chen, Si Yi ^a,b  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; DENDRITIC CELL VACCINE; GLYCOPROTEIN GP 120; GREEN FLUORESCENT PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMIQUIMOD; INTERLEUKIN 12; JANUS KINASE; LENTIVIRUS VECTOR; POLYINOSINIC POLYCYTIDYLIC ACID; RECOMBINANT ALPHA INTERFERON; SMALL INTERFERING RNA; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12 RECEPTOR; SOCS1 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG POTENCY; DRUG POTENTIATION; ENZYME REGULATION; GENETIC TRANSDUCTION; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREGULATION; INHIBITION KINETICS; LYMPHOCYTE ACTIVATION; MEMORY CELL; MOUSE; NONHUMAN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VACCINATION; VIRUS ENVELOPE; ADOPTIVE TRANSFER; ANIMAL; ANTIBODY PRODUCTION; B LYMPHOCYTE; C57BL MOUSE; CELL CULTURE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; METHODOLOGY; MOUSE MUTANT; T LYMPHOCYTE; TRANSPLANTATION;

ADJUVANTS, IMMUNOLOGIC; ADOPTIVE TRANSFER; AIDS VACCINES; ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; B-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-12; RNA INTERFERENCE; RNA, SMALL INTERFERING; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES; VACCINATION;

EID: 32044433541     PISSN: 15491277     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pmed.0030011     Document Type: Article

References (74)

1. Pantaleo G, Koup RA (2004) Correlates of immune protection in HIV-1 infection: What we know, what we don't know, what we should know. Nat Med 10: 806-810.
2. Desrosiers RC (2004) Prospects for an AIDS vaccine. Nat Med 10: 221-223.
3. + lymphocytes. Science 283: 857-860.
4. + T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 189: 991-998.
5. Burton DR, Desrosiers RC, Doms RW, Koff WC, Kwong PD, et al. (2004) HIV vaccine design and the neutralizing antibody problem. Nat Immunol 5: 233-236.
6. Mascola JR, Stiegler G, VanCott TC, Katinger H, Carpenter CB, et al. (2000) Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat Med 6: 207-210.
7. Gauduin MC, Parren PW, Weir R, Barbas CF, Burton DR, et al. (1997) Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1. Nat Med 3: 1389-1393.
8. McMichael AJ, Hanke T (2003) HIV vaccines 1983-2003. Nat Med 9: 874-880.
9. Nabel GJ (2001) Challenges and opportunities for development of an AIDS vaccine. Nature 410: 1002-1007.
10. Letvin NL, Barouch DH, Montefiori DC (2002) Prospects for vaccine protection against HIV-1 infection and AIDS. Annu Rev Immunol 20: 73-99.
11. Zolla-Pazner S (2004) Identifying epitopes of HIV-1 that induce protective antibodies. Nat Rev Immunol 4: 199-210.
12. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245-252.
13. Beutler B, Rietschel ET (2003) Innate immune sensing and its roots: The story of endotoxin. Nat Rev Immunol 3: 169-176.
14. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
15. Kubo M, Hanada T, Yoshimura A (2003) Suppressors of cytokine signaling and immunity. Nat Immunol 4: 1169-1176.
16. Alexander WS, Hilton DJ (2004) The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 22: 503-529.
17. Marine JC, Topham DJ, McKay C, Wang D, Parganas E, et al. (1999) SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98: 609-616.
18. Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, et al. (1999) SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98: 597-608.
19. Naka T, Tsutsui H, Fujimoto M, Kawazoe Y, Kohzaki H, et al. (2001) SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14: 535-545.
20. Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, et al. (2003) Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19: 437-450.
21. Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, et al. (2002) SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17: 583-591.
22. Baetz A, Frey M, Heeg K, Dalpke AH (2004) Suppressor of cytokine signaling (SOCS) proteins indirectly regulate Toll-like receptor signaling in innate immune cells. J Biol Chem 279: 54708-54715.
23. Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ (2004) Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the Regulation of Toll-like receptor signaling. J Biol Chem 279: 54702-54707.
24. Shen L, Evel-Kabler K, Strube R, Chen SY (2004) Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific antitumor immunity. Nat Biotechnol 22: 1546-1553.
25. Hanada T, Tanaka K, Matsumura Y, Yamauchi M, Nishinakamura H, et al. (2005) Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene. J Immunol 174: 4325-4332.
26. Le Bon A, Schiavoni G, D'Agostino G, Gresser I, Belardelli F, et al. (2001) Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14: 461-470.
27. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408.
28. Hauser H, Shen L, Gu QL, Krueger S, Chen SY (2004) Secretory heat-shock protein as a dendritic cell-targeting molecule: A new strategy to enhance the potency of genetic vaccines. Gene Ther 11: 924-932.
29. You Z, Huang X, Hester J, Toh HC, Chen SY (2001) Targeting dendritic cells to enhance DNA vaccine potency. Cancer Research 61: 3704-3711.
30. Allen JE, Maizels RM (1997) Th1-Th2: Reliable paradigm or dangerous dogma? Immunol Today 18: 387-392.
31. MacDonald AS, Pearce EJ (2002) Cutting edge: Polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol 168: 3127-3130.
32. Gor DO, Rose NR, Greenspan NS (2003) TH1-TH2: A procrustean paradigm. Nat Immunol 4: 503-505.
33. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G (1995) Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 181: 537-546.
34. Balazs M, Martin F, Zhou T, Kearney J (2002) Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17: 341-352.
35. Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, et al. (2002) DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 3: 822-829.
36. MacLennan I, Vinuesa C (2002) Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses. Immunity 17: 235-238.
37. Fantuzzi L, Purificato C, Donato K, Belardelli F, Gessani S (2004) Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: A novel mechanism for AIDS pathogenesis. J Virol 78: 9763-9772.
38. Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, et al. (2001) Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98: 906-912.
39. Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC (2003) Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis 187: 26-37.
40. + (myeloid) dendritic cell numbers in primary HIV-1 infection. Blood 98: 3016-3021.
41. Dubois B, Massacrier C, Vanbervliet B, Fayette J, Briere F, et al. (1998) Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. J Immunol 161: 2223-2231.
42. Dubois B, Vanbervliet B, Fayette J, Massacrier C, Van Kooten C, et al. (1997) Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J Exp Med 185: 941-951.
43. Skok J, Poudrier J, Gray D (1999) Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: A feedback regulation of Th1 development. J Immunol 163: 4284-4291.
44. Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3: 133-146.
45. Eyles JL, Metcalf D, Grusby MJ, Hilton DJ, Starr R (2002) Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem 277: 43735-43740.
46. Feltquate DM, Heaney S, Webster RG, Robinson HL (1997) Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol 158: 2278-2284.
47. Inaba K, Steinman RM, Van Voorhis WC, Muramatsu S (1983) Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc Natl Acad Sci U S A 80: 6041-6045.
48. Flamand V, Sornasse T, Thielemans K, Demanet C, Bakkus M, et al. (1994) Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur J Immunol 24: 605-610.
49. Imami N, Pires A, Hardy G, Wilson J, Gazzard B, et al. (2002) A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J Virol 76: 9011-9023.
50. Letvin NL, Walker BD (2003) Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med 9: 861-866.
51. Colonna M (2001) Can we apply the TH1-TH2 paradigm to all lymphocytes? Nat Immunol 2: 899-900.
52. Catlett IM, Hedrick SM (2005) Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nat Immunol 6: 715-721.
53. Chong MM, Metcalf D, Jamieson E, Alexander WS, Kay TW (2005) Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106: 1668-1675.
54. Judge AD, Sood V, Shaw JR, Fang D, McClintock K, et al. (2005) Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462.
55. Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11: 263-270.
56. Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR (2003) Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5: 834-839.
57. Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, et al. (2000) Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290: 486-492.
58. Oh S, Berzofsky JA, Burke DS, Waldmann TA, Perera LP (2003) Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity. Proc Natl Acad Sci U S A 100: 3392-3397.
59. Dale CJ, De Rose R, Wilson KM, Croom HA, Thomson S, et al. (2004) Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFNgamma or IL-12. Vaccine 23: 188-197.
60. Grohmann U, Belladonna ML, Bianchi R, Orabona C, Ayroldi E, et al. (1998) IL-12 acts directly on DC to promote nuclear localization of NFkappaB and primes DC for IL-12 production. Immunity 9: 315-323.
61. Qu C, Moran TM, Randolph GJ (2003) Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APC. J Immunol 170: 1010-1018.
62. Gett AV, Sallusto F, Lanzavecchia A, Geginat J (2003) T cell fitness determined by signal strength. Nat Immunol 4: 355-360.
63. Iezzi G, Karjalainen K, Lanzavecchia A (1998) The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8: 89-95.
64. Iezzi G, Scotet E, Scheidegger D, Lanzavecchia A (1999) The interplay between the duration of TCR and cytokine signaling determines T cell polarization. Eur J Immunol 29: 4092-4101.
65. Langenkamp A, Casorati G, Garavaglia C, Dellabona P, Lanzavecchia A, et al. (2002) T cell priming by dendritic cells: Thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur J Immunol 32: 2046-2054.
66. Lanzavecchia A, Sallusto F (2000) Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells. Science 290: 92-97.
67. Schluns KS, Lefrancois L (2003) Cytokine control of memory T-cell development and survival. Nat Rev Immunol 3: 269-279.
68. Becker TC, Wherry EJ, Boone D, Murali-Krishna K, Antia R, et al. (2002) Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med 195: 1541-1548.
69. Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, et al. (2004) CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science 304: 590-593.
70. Ma X, Montaner LJ (2000) Proinflammatory response and IL-12 expression in HIV-1 infection. J Leukoc Biol 68: 383-390.
71. + T cell responses induced by dendritic cells generated in the presence of IFN-alpha. J Immunol 172: 7832-7840.
72. Lu W, Arraes LC, Ferreira WT, Andrieu JM (2004) Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nat Med 10: 1359-1365.
73. Yang X, Lee J, Mahony EM, Kwong PD, Wyatt R, et al. (2002) Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin. J Virol 76: 4634-4642.
74. Gao F, Weaver EA, Lu Z, Li Y, Liao H-X, et al. (2005) Antigenicity and immunogenicity of an HIV-1 group M consensus envelope. J Virol 79: 1154-1163.