The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through Gαi-protein signalling

AIDS

Volumn 20, Issue 10, 2006, Pages 1369-1377

  Lin, Yea Lih ^a   Mettling, Clément ^a   Portalès, Pierre ^b   Réant, Brigitte ^a,b   Robert Hebmann, Véronique ^c   Reynes, Jacques ^d   Clot, Jacques ^b   Corbeau, Pierre ^a,b  

^a INSTITUTE OF HUMAN GENETICS   (France)

^b HÔPITAL SAINT ELOI   (France)

^c Laboratoire Infections Rétrovirales et Signalisation Cellulaire   (France)

^d GUI DE CHAULIAC HOSPITAL   (France)

Author keywords

Cell activation; Chemokine receptor; Co receptor; G protein coupled receptor; HIV life cycle

Indexed keywords

ANTIGEN P24; CHEMOKINE RECEPTOR CCR5; G PROTEIN COUPLED RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; SMALL INTERFERING RNA;

ANTIGEN DETECTION; ARTICLE; CALCIUM MOBILIZATION; CCR5 GENE; CD4+ T LYMPHOCYTE; CELL DENSITY; CELL SURFACE; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS REPLICATION; WILD TYPE;

CD4-POSITIVE T-LYMPHOCYTES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HIV INFECTIONS; HIV-1; HUMANS; PERTUSSIS TOXIN; RECEPTORS, CCR5; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; VIRULENCE; VIRUS REPLICATION;

EID: 33745460918     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aids.0000233570.51899.e2     Document Type: Article

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