메뉴 건너뛰기




Volumn 151, Issue 2, 2007, Pages 163-174

The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2)

Author keywords

ABCG2; ATP binding cassette transporter; Chemosensitizers; Multidrug resistance; Pharmacokinetics; Physiological roles

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; APIGENIN; BENZIMIDAZOLE DERIVATIVE; BIOCHANIN A; BREAST CANCER RESISTANCE PROTEIN; CHRYSIN; DAUNORUBICIN; DIFLOMOTECAN; ELACRIDAR; FLAVOPIRIDOL; FOLIC ACID; FUMITREMORGIN C; GENISTEIN; HESPERETIN; IMATINIB; KAEMPFEROL; KO 132; KO 134; KO 143; METHOTREXATE; MITOXANTRONE; NARINGENIN; NONSTEROID ANTIINFLAMMATORY AGENT; NOVOBIOCIN; OMEPRAZOLE; PANTOPRAZOLE; SILYMARIN; TAG 11; TAG 139; TAMOXIFEN; TOPOTECAN; UNCLASSIFIED DRUG;

EID: 34248594839     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707218     Document Type: Review
Times cited : (58)

References (125)
  • 2
    • 0037089528 scopus 로고    scopus 로고
    • A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for doxorubicin resistance
    • Allen JD, Jackson SC, Schinkel AH (2002a). A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for doxorubicin resistance. Cancer Res 62: 2294-2299.
    • (2002) Cancer Res , vol.62 , pp. 2294-2299
    • Allen, J.D.1    Jackson, S.C.2    Schinkel, A.H.3
  • 3
    • 0000890967 scopus 로고    scopus 로고
    • Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C
    • Allen JD, Van Loevezijn A, Lakhai JM, Van Der Valk M, Van Tellingen O, Reid G et al. (2002b). Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther 1: 417-425.
    • (2002) Mol Cancer Ther , vol.1 , pp. 417-425
    • Allen, J.D.1    Van Loevezijn, A.2    Lakhai, J.M.3    Van Der Valk, M.4    Van Tellingen, O.5    Reid, G.6
  • 4
    • 0029820166 scopus 로고    scopus 로고
    • Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database
    • Allikmets R, Gerrand B, Hutchinson A, Dean M (1996). Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet 5: 1649-1655.
    • (1996) Hum Mol Genet , vol.5 , pp. 1649-1655
    • Allikmets, R.1    Gerrand, B.2    Hutchinson, A.3    Dean, M.4
  • 5
    • 0032404092 scopus 로고    scopus 로고
    • A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
    • Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M (1998). A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 58: 5337-5339.
    • (1998) Cancer Res , vol.58 , pp. 5337-5339
    • Allikmets, R.1    Schriml, L.M.2    Hutchinson, A.3    Romano-Spica, V.4    Dean, M.5
  • 6
    • 23844530574 scopus 로고    scopus 로고
    • Oligomerization of the human ABC transporter ABCG2: Evaluation of the native protein and chimeric dimers
    • Bhatia A, Schafer HJ, Hrycyna CA (2005). Oligomerization of the human ABC transporter ABCG2: evaluation of the native protein and chimeric dimers. Biochemistry 44: 10893-10904.
    • (2005) Biochemistry , vol.44 , pp. 10893-10904
    • Bhatia, A.1    Schafer, H.J.2    Hrycyna, C.A.3
  • 7
    • 16844384057 scopus 로고    scopus 로고
    • The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (gleevec): Implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable brain penetration of imatinib in patients
    • Breedveld P, Pluim D, Cipriani G, Wielinga P, Van Tellingen O, Schinkel AH et al. (2005). The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable brain penetration of imatinib in patients. Cancer Res 65: 2577-2582.
    • (2005) Cancer Res , vol.65 , pp. 2577-2582
    • Breedveld, P.1    Pluim, D.2    Cipriani, G.3    Wielinga, P.4    Van Tellingen, O.5    Schinkel, A.H.6
  • 8
    • 4143142207 scopus 로고    scopus 로고
    • Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: Potential role for breast cancer resistance protein in clinical drug-drug interactions
    • Breedveld P, Zelcer N, Pluim D, Sonmezer O, Tibben MM, Beijnen JH et al. (2004). Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res 64: 5804-5811.
    • (2004) Cancer Res , vol.64 , pp. 5804-5811
    • Breedveld, P.1    Zelcer, N.2    Pluim, D.3    Sonmezer, O.4    Tibben, M.M.5    Beijnen, J.H.6
  • 9
    • 0042354831 scopus 로고    scopus 로고
    • Transport of methotrexate, methotrexate polyglutamines, and 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport
    • Chen ZS, Robey RW, Belinsky MG, Schvaveleva I, Ren XO, Sugimoto Y et al. (2003). Transport of methotrexate, methotrexate polyglutamines, and 17-(β-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res 63: 4048-4054.
    • (2003) Cancer Res , vol.63 , pp. 4048-4054
    • Chen, Z.S.1    Robey, R.W.2    Belinsky, M.G.3    Schvaveleva, I.4    Ren, X.O.5    Sugimoto, Y.6
  • 10
    • 33750478648 scopus 로고    scopus 로고
    • Multiple drug binding sites on the R482G isoform of the ABCG2 transporter
    • Clark R, Kerr I, Callaghan R (2006). Multiple drug binding sites on the R482G isoform of the ABCG2 transporter. Br J Pharmacol 149: 506-515.
    • (2006) Br J Pharmacol , vol.149 , pp. 506-515
    • Clark, R.1    Kerr, I.2    Callaghan, R.3
  • 11
    • 0037113346 scopus 로고    scopus 로고
    • Localisation of breast cancer resistance protein in microvessel endothelium of human brain
    • Cooray HC, Blackmore CG, Maskell L, Barrand MA (2002). Localisation of breast cancer resistance protein in microvessel endothelium of human brain. Neuroreport 13: 2059-2063.
    • (2002) Neuroreport , vol.13 , pp. 2059-2063
    • Cooray, H.C.1    Blackmore, C.G.2    Maskell, L.3    Barrand, M.A.4
  • 13
    • 32044437970 scopus 로고    scopus 로고
    • Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids
    • Cooray HC, Shahi S, Cahn AP, Van Veen HW, Hladky SB, Barrand MA (2006). Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids. Eur J Pharmacol 531: 25-33.
    • (2006) Eur J Pharmacol , vol.531 , pp. 25-33
    • Cooray, H.C.1    Shahi, S.2    Cahn, A.P.3    Van Veen, H.W.4    Hladky, S.B.5    Barrand, M.A.6
  • 14
    • 0023897681 scopus 로고
    • Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone
    • Dalton WS, Cress AE, Alberts DS, Trent JM (1988). Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone. Cancer Res 48: 1882-1888.
    • (1988) Cancer Res , vol.48 , pp. 1882-1888
    • Dalton, W.S.1    Cress, A.E.2    Alberts, D.S.3    Trent, J.M.4
  • 15
    • 0032695270 scopus 로고    scopus 로고
    • Reversal of resistance by GF120918 in cell lines expressing the ABC halftransporter MXR
    • De Bruin M, Miyake K, Litman T, Robey R, Bates SE (1999). Reversal of resistance by GF120918 in cell lines expressing the ABC halftransporter MXR. Cancer Lett 146: 117-126.
    • (1999) Cancer Lett , vol.146 , pp. 117-126
    • De Bruin, M.1    Miyake, K.2    Litman, T.3    Robey, R.4    Bates, S.E.5
  • 17
    • 0036772386 scopus 로고    scopus 로고
    • Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffinembedded material
    • Diestra JE, Scheffer GL, Catala II, Maliepaard M, Schnellens JH, Scheper RJ et al. (2002). Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffinembedded material. J Pathol 198: 213-219.
    • (2002) J Pathol , vol.198 , pp. 213-219
    • Diestra, J.E.1    Scheffer, G.L.2    Catala, I.I.3    Maliepaard, M.4    Schnellens, J.H.5    Scheper, R.J.6
  • 19
    • 0028837002 scopus 로고
    • Expression of a 95 kDa membrane protein is associated with low daunorubicin accumulates in leukaemic blast cells
    • Doyle LA, Ross DD, Sridhara R, Fojo AT, Kaufmann SH, Lee EJ et al. (1995). Expression of a 95 kDa membrane protein is associated with low daunorubicin accumulates in leukaemic blast cells. Br J Cancer 71: 52-58.
    • (1995) Br J Cancer , vol.71 , pp. 52-58
    • Doyle, L.A.1    Ross, D.D.2    Sridhara, R.3    Fojo, A.T.4    Kaufmann, S.H.5    Lee, E.J.6
  • 21
    • 27144483358 scopus 로고    scopus 로고
    • Identification of ABCG2 as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    • Ebert B, Seidel A, Lampen A (2005). Identification of ABCG2 as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis 26: 1754-1763.
    • (2005) Carcinogenesis , vol.26 , pp. 1754-1763
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 22
    • 12344330537 scopus 로고    scopus 로고
    • Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference
    • Ee PL, He X, Ross DD, Beck WT (2004a). Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther 3: 1577-1583.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1577-1583
    • Ee, P.L.1    He, X.2    Ross, D.D.3    Beck, W.T.4
  • 23
    • 1242293680 scopus 로고    scopus 로고
    • Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene
    • Ee PL, Kamalakaran S, Tonetii D, He X, Ross DD, Beck WT (2004b). Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res 64: 1247-1251.
    • (2004) Cancer Res , vol.64 , pp. 1247-1251
    • Ee, P.L.1    Kamalakaran, S.2    Tonetii, D.3    He, X.4    Ross, D.D.5    Beck, W.T.6
  • 24
    • 33745726722 scopus 로고    scopus 로고
    • The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding
    • Ejendal KFK, Diop NK, Schweiger LC, Hrycyna CA (2006). The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding. Protein Sci 15: 1597-1607.
    • (2006) Protein Sci , vol.15 , pp. 1597-1607
    • Ejendal, K.F.K.1    Diop, N.K.2    Schweiger, L.C.3    Hrycyna, C.A.4
  • 26
    • 33645930969 scopus 로고    scopus 로고
    • Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues
    • Fetsch PA, Abati A, Litman T, Morisaki K, Honjo Y, Mittal K et al. (2006). Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues. Cancer Lett 235: 84-92.
    • (2006) Cancer Lett , vol.235 , pp. 84-92
    • Fetsch, P.A.1    Abati, A.2    Litman, T.3    Morisaki, K.4    Honjo, Y.5    Mittal, K.6
  • 27
    • 0344393732 scopus 로고    scopus 로고
    • Strategies for reversing drug resistance
    • Fojo T, Bates S (2003). Strategies for reversing drug resistance. Oncogene 22: 7512-7523.
    • (2003) Oncogene , vol.22 , pp. 7512-7523
    • Fojo, T.1    Bates, S.2
  • 28
    • 0034086522 scopus 로고    scopus 로고
    • Population pharmacokinetic model for topotecan derived from phase I clinical trials
    • Gallo JM, Laub PB, Rowinsky EK, Grochow LB, Baker SD (2000). Population pharmacokinetic model for topotecan derived from phase I clinical trials. J Clin Oncol 18: 2459-2467.
    • (2000) J Clin Oncol , vol.18 , pp. 2459-2467
    • Gallo, J.M.1    Laub, P.B.2    Rowinsky, E.K.3    Grochow, L.B.4    Baker, S.D.5
  • 29
    • 0031435428 scopus 로고    scopus 로고
    • Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
    • Goodell MA, Rosenzweig M, Kim H, Marks DF, Demaria M, Paradis G et al. (1997). Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3: 1337-1345.
    • (1997) Nat Med , vol.3 , pp. 1337-1345
    • Goodell, M.A.1    Rosenzweig, M.2    Kim, H.3    Marks, D.F.4    Demaria, M.5    Paradis, G.6
  • 30
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE (2002). Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 31
    • 0036731990 scopus 로고    scopus 로고
    • Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permit their transport to the apical surface
    • Graf GA, Li WP, Gerard RD, Gelissen I, White A, Cohen JC et al. (2002). Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permit their transport to the apical surface. J Clin Invest 110: 659-669.
    • (2002) J Clin Invest , vol.110 , pp. 659-669
    • Graf, G.A.1    Li, W.P.2    Gerard, R.D.3    Gelissen, I.4    White, A.5    Cohen, J.C.6
  • 32
    • 0042143281 scopus 로고    scopus 로고
    • Targeted prodrug design to optimise drug delivery
    • Han HK, Amidon GL (2000). Targeted prodrug design to optimise drug delivery. AAPS PharmSci 2: E6.
    • (2000) AAPS PharmSci , vol.2
    • Han, H.K.1    Amidon, G.L.2
  • 33
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medical significance of the flavonoids
    • Havsteen BH (2002). The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96: 67-202.
    • (2002) Pharmacol Ther , vol.96 , pp. 67-202
    • Havsteen, B.H.1
  • 34
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins CF (1992). ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113.
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 35
    • 0035884595 scopus 로고    scopus 로고
    • Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells
    • Honjo Y, Hrycyna CA, Yan QW, Medina-Perez WY, Robey RW, Van De Laar A et al. (2001). Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. Cancer Res 61: 6635-6639.
    • (2001) Cancer Res , vol.61 , pp. 6635-6639
    • Honjo, Y.1    Hrycyna, C.A.2    Yan, Q.W.3    Medina-Perez, W.Y.4    Robey, R.W.5    Van De Laar, A.6
  • 36
    • 2942586678 scopus 로고    scopus 로고
    • Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression
    • Ifergan I, Shafran A, Jansen G, Hooijberg JH, Scheffer GL, Assaraf YG (2004). Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. J Biol Chem 279: 25527-25534.
    • (2004) J Biol Chem , vol.279 , pp. 25527-25534
    • Ifergan, I.1    Shafran, A.2    Jansen, G.3    Hooijberg, J.H.4    Scheffer, G.L.5    Assaraf, Y.G.6
  • 37
    • 0042856460 scopus 로고    scopus 로고
    • Breast cancer resistance protein exports sulfated estrogens but not free estrogens
    • Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y (2003). Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol 64: 610-618.
    • (2003) Mol Pharmacol , vol.64 , pp. 610-618
    • Imai, Y.1    Asada, S.2    Tsukahara, S.3    Ishikawa, E.4    Tsuruo, T.5    Sugimoto, Y.6
  • 38
    • 12544251673 scopus 로고    scopus 로고
    • Estrogen-mediated post transcription down-regulation of breast cancer resistance protein/ABCG2
    • Imai Y, Ishikawa E, Asada S, Sugimoto Y (2005). Estrogen-mediated post transcription down-regulation of breast cancer resistance protein/ABCG2. Cancer Res 65: 596-604.
    • (2005) Cancer Res , vol.65 , pp. 596-604
    • Imai, Y.1    Ishikawa, E.2    Asada, S.3    Sugimoto, Y.4
  • 39
    • 0036598543 scopus 로고    scopus 로고
    • C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance
    • Imai Y, Nakane M, Kage K, Tsukahara S, Ishikawa E, Tsuruo T et al. (2002a). C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol Cancer Ther 1: 611-616.
    • (2002) Mol Cancer Ther , vol.1 , pp. 611-616
    • Imai, Y.1    Nakane, M.2    Kage, K.3    Tsukahara, S.4    Ishikawa, E.5    Tsuruo, T.6
  • 40
    • 3042569646 scopus 로고    scopus 로고
    • Phytoestrogens/ flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance
    • Imai Y, Tsukahara S, Asada S, Sugimoto Y (2004). Phytoestrogens/ flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res 64: 4346-4352.
    • (2004) Cancer Res , vol.64 , pp. 4346-4352
    • Imai, Y.1    Tsukahara, S.2    Asada, S.3    Sugimoto, Y.4
  • 41
    • 0036011103 scopus 로고    scopus 로고
    • Estrone and 17-β-estradiol reverse breast cancer resistance protein-mediated multidrug resistance
    • Imai Y, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y (2002b). Estrone and 17-β-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn J Cancer Res 93: 231-235.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 231-235
    • Imai, Y.1    Tsukahara, S.2    Ishikawa, E.3    Tsuruo, T.4    Sugimoto, Y.5
  • 42
    • 12844280511 scopus 로고    scopus 로고
    • Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2)
    • Janvilisri T, Shahi S, Venter H, Balakrishnan L, Van Veen HW (2005). Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J 385: 419-426.
    • (2005) Biochem J , vol.385 , pp. 419-426
    • Janvilisri, T.1    Shahi, S.2    Venter, H.3    Balakrishnan, L.4    Van Veen, H.W.5
  • 43
    • 0038757689 scopus 로고    scopus 로고
    • Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis
    • Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, Van Veen HW (2003). Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem 278: 20645-20651.
    • (2003) J Biol Chem , vol.278 , pp. 20645-20651
    • Janvilisri, T.1    Venter, H.2    Shahi, S.3    Reuter, G.4    Balakrishnan, L.5    Van Veen, H.W.6
  • 45
    • 0037180446 scopus 로고    scopus 로고
    • The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
    • Jonker JW, Buitelaar M, Wagenaar E, Van Der Valk MA, Scheffer GL, Scheper RJ et al. (2002). The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci USA 99: 15649-15654.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15649-15654
    • Jonker, J.W.1    Buitelaar, M.2    Wagenaar, E.3    Van Der Valk, M.A.4    Scheffer, G.L.5    Scheper, R.J.6
  • 46
    • 14644409841 scopus 로고    scopus 로고
    • The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk
    • Jonker JW, Merino G, Musters S, Van Herwaarden AE, Bolscher E, Wagenaar E et al. (2005). The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat Med 11: 127-129.
    • (2005) Nat Med , vol.11 , pp. 127-129
    • Jonker, J.W.1    Merino, G.2    Musters, S.3    Van Herwaarden, A.E.4    Bolscher, E.5    Wagenaar, E.6
  • 48
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V (1976). A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 445: 152-162.
    • (1976) Biochim Biophys Acta , vol.445 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 49
    • 0037050736 scopus 로고    scopus 로고
    • Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization
    • Kage K, Tsukahara S, Sugiyama T, Asada S, Ishikawa E, Tsuruo T et al. (2002). Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. Int J Cancer 97: 626-630.
    • (2002) Int J Cancer , vol.97 , pp. 626-630
    • Kage, K.1    Tsukahara, S.2    Sugiyama, T.3    Asada, S.4    Ishikawa, E.5    Tsuruo, T.6
  • 50
    • 0035012619 scopus 로고    scopus 로고
    • Expression of multidrug resistance-related transporters in human breast carcinoma
    • Kanzaki A, Toi M, Nakayama K, Bando H, Mutoh M, Uchida T et al. (2001). Expression of multidrug resistance-related transporters in human breast carcinoma. Jpn J Cancer Res 92: 452-458.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 452-458
    • Kanzaki, A.1    Toi, M.2    Nakayama, K.3    Bando, H.4    Mutoh, M.5    Uchida, T.6
  • 51
    • 0036154828 scopus 로고    scopus 로고
    • The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells
    • Kim M, Turnquist H, Jackson J, Sgagias M, Yan Y, Gong M et al. (2002). The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res 8: 22-28.
    • (2002) Clin Cancer Res , vol.8 , pp. 22-28
    • Kim, M.1    Turnquist, H.2    Jackson, J.3    Sgagias, M.4    Yan, Y.5    Gong, M.6
  • 52
    • 19944399722 scopus 로고    scopus 로고
    • Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta
    • Kobayashi D, Ieiri I, Hirota T, Takane H, Maegawa S, Kigawa J et al. (2005). Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta. Drug Metab Dispos 33: 94-101.
    • (2005) Drug Metab Dispos , vol.33 , pp. 94-101
    • Kobayashi, D.1    Ieiri, I.2    Hirota, T.3    Takane, H.4    Maegawa, S.5    Kigawa, J.6
  • 54
    • 0036019374 scopus 로고    scopus 로고
    • Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2
    • Kowalski P, Stein U, Scheffer GL, Lage H (2002). Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2. Cancer Gene Ther 9: 579-586.
    • (2002) Cancer Gene Ther , vol.9 , pp. 579-586
    • Kowalski, P.1    Stein, U.2    Scheffer, G.L.3    Lage, H.4
  • 55
    • 0028792273 scopus 로고
    • The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: Impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5mg
    • Kremer JM, Hamilton RA (1995). The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5mg. J Rheumatol 22: 2072-2077.
    • (1995) J Rheumatol , vol.22 , pp. 2072-2077
    • Kremer, J.M.1    Hamilton, R.A.2
  • 56
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • Krishna R, Mayer LD (2000). Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 11: 265-283.
    • (2000) Eur J Pharm Sci , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 57
    • 2642526992 scopus 로고    scopus 로고
    • The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    • Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE et al. (2004). The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279: 24218-24225.
    • (2004) J Biol Chem , vol.279 , pp. 24218-24225
    • Krishnamurthy, P.1    Ross, D.D.2    Nakanishi, T.3    Bailey-Dell, K.4    Zhou, S.5    Mercer, K.E.6
  • 59
    • 0036644903 scopus 로고    scopus 로고
    • Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and p-glycoprotein inhibitor GF120918
    • Kruijtzer CMF, Beijnen JH, Rosing H, Ten Bokkel Huinink WW, Schot M, Jewell RC et al. (2002). Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and p-glycoprotein inhibitor GF120918. J Clin Oncol 20: 2943-2950.
    • (2002) J Clin Oncol , vol.20 , pp. 2943-2950
    • Kruijtzer, C.M.F.1    Beijnen, J.H.2    Rosing, H.3    Ten Bokkel Huinink, W.W.4    Schot, M.5    Jewell, R.C.6
  • 60
    • 33846664466 scopus 로고    scopus 로고
    • ATP-binding cassette, subfamily G (ABCG family)
    • Kusuhara H, Sugiyama Y (2006). ATP-binding cassette, subfamily G (ABCG family). Pflugers Arch Eur J Physiol 453: 735-744.
    • (2006) Pflugers Arch Eur J Physiol , vol.453 , pp. 735-744
    • Kusuhara, H.1    Sugiyama, Y.2
  • 61
    • 0141888537 scopus 로고    scopus 로고
    • The role of ABC transporters in clinical practice
    • Leonard GD, Fojo T, Bates SE (2003). The role of ABC transporters in clinical practice. Oncologist 8: 411-424.
    • (2003) Oncologist , vol.8 , pp. 411-424
    • Leonard, G.D.1    Fojo, T.2    Bates, S.E.3
  • 62
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie EM, Deeley RG, Cole SPC (2005). Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Tox Appl Pharmacol 204: 216-237.
    • (2005) Tox Appl Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.C.3
  • 63
    • 0035033774 scopus 로고    scopus 로고
    • Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids
    • Leslie EM, Mao Q, Oleschuk CJ, Deeley RG, Cole SPC (2001). Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids. Mol Pharmacol 59: 1171-1180.
    • (2001) Mol Pharmacol , vol.59 , pp. 1171-1180
    • Leslie, E.M.1    Mao, Q.2    Oleschuk, C.J.3    Deeley, R.G.4    Cole, S.P.C.5
  • 64
    • 20144362553 scopus 로고    scopus 로고
    • Modulation of BCRP mediated atypical multidrug resistance phenotype by RNA interference
    • Li WT, Zhou GY, Song XR, Chi WL, Ren RM, Wang XW (2005). Modulation of BCRP mediated atypical multidrug resistance phenotype by RNA interference. Neoplasma 52: 219-224.
    • (2005) Neoplasma , vol.52 , pp. 219-224
    • Li, W.T.1    Zhou, G.Y.2    Song, X.R.3    Chi, W.L.4    Ren, R.M.5    Wang, X.W.6
  • 65
    • 0034081847 scopus 로고    scopus 로고
    • The multidrug-resistant phenotype associated with over-expression of the new ABC half-transporter, MXR (ABCG2)
    • Litman T, Brangi M, Hudson E, Fetsch P, Abati A, Ross DD et al. (2000). The multidrug-resistant phenotype associated with over-expression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 113: 2011-2021.
    • (2000) J Cell Sci , vol.113 , pp. 2011-2021
    • Litman, T.1    Brangi, M.2    Hudson, E.3    Fetsch, P.4    Abati, A.5    Ross, D.D.6
  • 66
    • 18644367250 scopus 로고    scopus 로고
    • Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2
    • Litman T, Jensen U, Hansen A, Covitz K, Zhan Z, Fetsch P et al. (2002). Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2. Biochim Biophys Acta 1565: 6-16.
    • (2002) Biochim Biophys Acta , vol.1565 , pp. 6-16
    • Litman, T.1    Jensen, U.2    Hansen, A.3    Covitz, K.4    Zhan, Z.5    Fetsch, P.6
  • 67
    • 0037412250 scopus 로고    scopus 로고
    • ABCG subfamily of human ATP-binding cassette proteins
    • Lorkowski S, Cullen P (2002). ABCG subfamily of human ATP-binding cassette proteins. Pure Appl Chem 74: 2057-2081.
    • (2002) Pure Appl Chem , vol.74 , pp. 2057-2081
    • Lorkowski, S.1    Cullen, P.2
  • 68
  • 70
    • 27644480743 scopus 로고    scopus 로고
    • Role of the breast cancer resistance protein (ABCG2) in drug transport
    • Mao Q, Unadkat JD (2005). Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J 7: E118-E133.
    • (2005) AAPS J , vol.7
    • Mao, Q.1    Unadkat, J.D.2
  • 71
    • 33750446035 scopus 로고    scopus 로고
    • Purification and 3D structural analysis of oligomeric human multidrug transporters ABCG2
    • McDevitt CA, Collins RF, Conway M, Modok S, Storm J, Kerr ID et al. (2006). Purification and 3D structural analysis of oligomeric human multidrug transporters ABCG2. Structure 14: 1623-1632.
    • (2006) Structure , vol.14 , pp. 1623-1632
    • McDevitt, C.A.1    Collins, R.F.2    Conway, M.3    Modok, S.4    Storm, J.5    Kerr, I.D.6
  • 72
    • 17844372454 scopus 로고    scopus 로고
    • Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver
    • Merino G, Van Herwaarden AE, Wagenaar E, Jonker JW, Schinkel AH (2005). Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver. Mol Pharmacol 67: 1765-1771.
    • (2005) Mol Pharmacol , vol.67 , pp. 1765-1771
    • Merino, G.1    Van Herwaarden, A.E.2    Wagenaar, E.3    Jonker, J.W.4    Schinkel, A.H.5
  • 73
    • 0242300543 scopus 로고    scopus 로고
    • Single amino acid substitutions in the transmembrane domain of breast cancer resistance protein (BCRP) alter cross resistance patterns in the transfectants
    • Miwa M, Tsukahara S, Ishikawa E, Asada S, Imai Y, Sugimoto Y (2003). Single amino acid substitutions in the transmembrane domain of breast cancer resistance protein (BCRP) alter cross resistance patterns in the transfectants. Int J Cancer 107: 757-767.
    • (2003) Int J Cancer , vol.107 , pp. 757-767
    • Miwa, M.1    Tsukahara, S.2    Ishikawa, E.3    Asada, S.4    Imai, Y.5    Sugimoto, Y.6
  • 74
    • 0032895533 scopus 로고    scopus 로고
    • Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistance cells: Demonstration of homology to ABC transporter genes
    • Miyake K, Mickley L, Litman T, Zhan Z, Robey R, Christensen B et al. (1999). Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistance cells: demonstration of homology to ABC transporter genes. Cancer Res 59: 8-13.
    • (1999) Cancer Res , vol.59 , pp. 8-13
    • Miyake, K.1    Mickley, L.2    Litman, T.3    Zhan, Z.4    Robey, R.5    Christensen, B.6
  • 75
    • 1242319383 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms result in impaired membrane localization and reduced ATPase activity in multidrug transporter ABCG2
    • Mizuarai S, Aozasa N, Kotani H (2004). Single nucleotide polymorphisms result in impaired membrane localization and reduced ATPase activity in multidrug transporter ABCG2. Int J Cancer 109: 238-246.
    • (2004) Int J Cancer , vol.109 , pp. 238-246
    • Mizuarai, S.1    Aozasa, N.2    Kotani, H.3
  • 76
    • 4143107239 scopus 로고    scopus 로고
    • Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2- methylamino-4-(3-pyridylmethyl) benzothiasole (E3040) sulphate in breast cancer resistance protein (Bcrp1/Abcg2) knockout mice
    • Mizuno N, Suzuki M, Kusuhara H, Suzuki H, Takeuchi K, Niwa T et al. (2004). Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2- methylamino-4-(3-pyridylmethyl) benzothiasole (E3040) sulphate in breast cancer resistance protein (Bcrp1/Abcg2) knockout mice. Drug Metab Dispos 32: 898-901.
    • (2004) Drug Metab Dispos , vol.32 , pp. 898-901
    • Mizuno, N.1    Suzuki, M.2    Kusuhara, H.3    Suzuki, H.4    Takeuchi, K.5    Niwa, T.6
  • 77
    • 33644755350 scopus 로고    scopus 로고
    • Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer
    • Nakagawa H, Saito H, Ikegami Y, Aida-Hyugaji S, Sawada S, Ishikawa T (2005). Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer. Cancer Lett 234: 81-89.
    • (2005) Cancer Lett , vol.234 , pp. 81-89
    • Nakagawa, H.1    Saito, H.2    Ikegami, Y.3    Aida-Hyugaji, S.4    Sawada, S.5    Ishikawa, T.6
  • 78
    • 0026496549 scopus 로고
    • Reduced intracellular drug accumulation in the absence of p-glycoprotein (MDR1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells
    • Nakagawa M, Schneider E, Dixon KH, Horton J, Kelley K, Morrow C et al. (1992). Reduced intracellular drug accumulation in the absence of p-glycoprotein (MDR1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. Cancer Res 52: 6175-6181.
    • (1992) Cancer Res , vol.52 , pp. 6175-6181
    • Nakagawa, M.1    Schneider, E.2    Dixon, K.H.3    Horton, J.4    Kelley, K.5    Morrow, C.6
  • 79
    • 13944269488 scopus 로고    scopus 로고
    • Gefitinib ('iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance
    • Nakamura Y, Oka M, Soda H, Shiozawa K, Yoshikawa M, Itoh A et al. (2005). Gefitinib ('iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance. Cancer Res 65: 1541-1546.
    • (2005) Cancer Res , vol.65 , pp. 1541-1546
    • Nakamura, Y.1    Oka, M.2    Soda, H.3    Shiozawa, K.4    Yoshikawa, M.5    Itoh, A.6
  • 80
    • 0345735768 scopus 로고    scopus 로고
    • Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis
    • Nakanishi T, Doyle LA, Hassel B, Wei Y, Bauer KS, Wu S et al. (2003a). Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Mol Pharmacol 64: 1452-1462.
    • (2003) Mol Pharmacol , vol.64 , pp. 1452-1462
    • Nakanishi, T.1    Doyle, L.A.2    Hassel, B.3    Wei, Y.4    Bauer, K.S.5    Wu, S.6
  • 81
    • 0042835753 scopus 로고    scopus 로고
    • Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients
    • Nakanishi T, Karp JE, Tan M, Doyle LA, Peters T, Yang W et al. (2003b). Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients. Clin Cancer Res 9: 3320-3328.
    • (2003) Clin Cancer Res , vol.9 , pp. 3320-3328
    • Nakanishi, T.1    Karp, J.E.2    Tan, M.3    Doyle, L.A.4    Peters, T.5    Yang, W.6
  • 82
    • 0034789387 scopus 로고    scopus 로고
    • Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
    • Ozvegy C, Litman T, Szakacs G, Nagy Z, Bates SE, Varadi A et al. (2001). Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun 285: 111-117.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 111-117
    • Ozvegy, C.1    Litman, T.2    Szakacs, G.3    Nagy, Z.4    Bates, S.E.5    Varadi, A.6
  • 83
    • 0037073730 scopus 로고    scopus 로고
    • Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter
    • Ozvegy C, Varadi A, Sarkadi B (2002). Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. J Biol Chem 277: 47980-47990.
    • (2002) J Biol Chem , vol.277 , pp. 47980-47990
    • Ozvegy, C.1    Varadi, A.2    Sarkadi, B.3
  • 84
    • 12844255054 scopus 로고    scopus 로고
    • Single amino acid (482) variants of the ABCG2 multidrug transporter: Major differences in transport capacity and substrate recognition
    • Ozvegy-Laczka C, Koblos G, Sarkadi B, Varadi A (2005). Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition. Biochim Biophys Acta 1668: 53-63.
    • (2005) Biochim Biophys Acta , vol.1668 , pp. 53-63
    • Ozvegy-Laczka, C.1    Koblos, G.2    Sarkadi, B.3    Varadi, A.4
  • 85
    • 11844284860 scopus 로고    scopus 로고
    • Human breast cancer resistance protein (BCRP/ABCG2): Interactions with steroid drugs, hormones, the dietary carcinogen PhIP, and transport of cimetidine
    • Pavek P, Merino G, Wagenaar E, Bolscher E, Novotna M, Jonker JW et al. (2005). Human breast cancer resistance protein (BCRP/ABCG2): interactions with steroid drugs, hormones, the dietary carcinogen PhIP, and transport of cimetidine. J Pharmacol Exp Ther 312: 144-152.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 144-152
    • Pavek, P.1    Merino, G.2    Wagenaar, E.3    Bolscher, E.4    Novotna, M.5    Jonker, J.W.6
  • 88
    • 0032535004 scopus 로고    scopus 로고
    • Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C
    • Rabindran SK, He H, Singh M, Brown E, Collins KI, Annable T et al. (1998). Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res 58: 5850-5858.
    • (1998) Cancer Res , vol.58 , pp. 5850-5858
    • Rabindran, S.K.1    He, H.2    Singh, M.3    Brown, E.4    Collins, K.I.5    Annable, T.6
  • 89
    • 0033966957 scopus 로고    scopus 로고
    • Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
    • Rabindran SK, Ross DD, Doyle LA, Yang W, Greenberger LM (2000). Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res 60: 47-50.
    • (2000) Cancer Res , vol.60 , pp. 47-50
    • Rabindran, S.K.1    Ross, D.D.2    Doyle, L.A.3    Yang, W.4    Greenberger, L.M.5
  • 91
    • 0035138482 scopus 로고    scopus 로고
    • Overexpression of the ATP-binding cassette half transporter, ABCG2 (MXR/BCRP/ABCP1), in flavopiridol-resistant human breast cancer cells
    • Robey RW, Medina-Perez WY, Nishiyama K, Lahusen T, Miyake K, Litman T et al. (2001). Overexpression of the ATP-binding cassette half transporter, ABCG2 (MXR/BCRP/ABCP1), in flavopiridol-resistant human breast cancer cells. Clin Cancer Res 7: 145-152.
    • (2001) Clin Cancer Res , vol.7 , pp. 145-152
    • Robey, R.W.1    Medina-Perez, W.Y.2    Nishiyama, K.3    Lahusen, T.4    Miyake, K.5    Litman, T.6
  • 92
    • 0034234653 scopus 로고    scopus 로고
    • Expression of breast cancer resistance protein in blast cells from patients with acute leukemia
    • Ross DD, Karp JE, Chen TT, Doyle LA (2000). Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood 96: 365-368.
    • (2000) Blood , vol.96 , pp. 365-368
    • Ross, D.D.1    Karp, J.E.2    Chen, T.T.3    Doyle, L.A.4
  • 93
    • 0035726216 scopus 로고    scopus 로고
    • Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia
    • Sargent JM, Williamson CJ, Maliepaard M, Elgie AW, Scheper RJ, Taylor CG (2001). Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia. Br J Haematol 115: 257-262.
    • (2001) Br J Haematol , vol.115 , pp. 257-262
    • Sargent, J.M.1    Williamson, C.J.2    Maliepaard, M.3    Elgie, A.W.4    Scheper, R.J.5    Taylor, C.G.6
  • 94
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system
    • Sarkadi B, Homoloya L, Szakacs G, Varadi A (2006). Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol Rev 86: 1179-1236.
    • (2006) Physiol Rev , vol.86 , pp. 1179-1236
    • Sarkadi, B.1    Homoloya, L.2    Szakacs, G.3    Varadi, A.4
  • 95
    • 0036064629 scopus 로고    scopus 로고
    • Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia
    • Sauerbrey A, Sell W, Steinbach D, Voigt A, Zintl F (2002). Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia. Br J Haematol 118: 147-150.
    • (2002) Br J Haematol , vol.118 , pp. 147-150
    • Sauerbrey, A.1    Sell, W.2    Steinbach, D.3    Voigt, A.4    Zintl, F.5
  • 96
    • 0037079708 scopus 로고    scopus 로고
    • The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    • Scharenberg CW, Harkey MA, Torok-Storb B (2002). The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 99: 507-512.
    • (2002) Blood , vol.99 , pp. 507-512
    • Scharenberg, C.W.1    Harkey, M.A.2    Torok-Storb, B.3
  • 99
    • 13444288036 scopus 로고    scopus 로고
    • Staud F, Pavek P (2005). Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 37: 720-725.
    • Staud F, Pavek P (2005). Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 37: 720-725.
  • 100
    • 0036052296 scopus 로고    scopus 로고
    • BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia
    • Steinbach D, Sell W, Voigt A, Hermann J, Zintl F, Sauerbrey A (2002). BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Leukemia 16: 1443-1447.
    • (2002) Leukemia , vol.16 , pp. 1443-1447
    • Steinbach, D.1    Sell, W.2    Voigt, A.3    Hermann, J.4    Zintl, F.5    Sauerbrey, A.6
  • 101
    • 5644264888 scopus 로고    scopus 로고
    • Gefitinib enhances the antitumour activity and oral bioavailability of irinotecan in mice
    • Stewart CF, Leggas M, Schuetz JD, Panetta JC, Cheshire PJ, Peterson J et al. (2004). Gefitinib enhances the antitumour activity and oral bioavailability of irinotecan in mice. Cancer Res 64: 7491-7499.
    • (2004) Cancer Res , vol.64 , pp. 7491-7499
    • Stewart, C.F.1    Leggas, M.2    Schuetz, J.D.3    Panetta, J.C.4    Cheshire, P.J.5    Peterson, J.6
  • 102
    • 0034665902 scopus 로고    scopus 로고
    • Hoechst dye efflux reveals a novel CD7+CD34- lymphoid progenitor in human umbilical cord blood
    • Storms RW, Goodell MA, Fisher A, Mulligan RC, Smith C (2000). Hoechst dye efflux reveals a novel CD7+CD34- lymphoid progenitor in human umbilical cord blood. Blood 96: 2125-2133.
    • (2000) Blood , vol.96 , pp. 2125-2133
    • Storms, R.W.1    Goodell, M.A.2    Fisher, A.3    Mulligan, R.C.4    Smith, C.5
  • 103
    • 0041309866 scopus 로고    scopus 로고
    • Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists
    • Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T (2003). Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther 2: 105-112.
    • (2003) Mol Cancer Ther , vol.2 , pp. 105-112
    • Sugimoto, Y.1    Tsukahara, S.2    Imai, Y.3    Sugimoto, Y.4    Ueda, K.5    Tsuruo, T.6
  • 104
    • 0016840257 scopus 로고
    • Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster
    • Sullivan DT, Sullivan MC (1975). Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster. Biochem Genet 13: 603-613.
    • (1975) Biochem Genet , vol.13 , pp. 603-613
    • Sullivan, D.T.1    Sullivan, M.C.2
  • 105
    • 0038265441 scopus 로고    scopus 로고
    • ABCG2 transports sulfated conjugates of steroids and xenobiotics
    • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y (2003). ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem 278: 22644-22649.
    • (2003) J Biol Chem , vol.278 , pp. 22644-22649
    • Suzuki, M.1    Suzuki, H.2    Sugimoto, Y.3    Sugiyama, Y.4
  • 107
    • 9644282955 scopus 로고    scopus 로고
    • Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice
    • Tanaka Y, Slitt AL, Leazer TM, Maher JM, Klaassen CD (2005). Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 326: 181-187.
    • (2005) Biochem Biophys Res Commun , vol.326 , pp. 181-187
    • Tanaka, Y.1    Slitt, A.L.2    Leazer, T.M.3    Maher, J.M.4    Klaassen, C.D.5
  • 108
    • 0025733402 scopus 로고
    • Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line
    • Taylor CW, Dalton WS, Parrish PR, Gleason MC, Bellamy WT, Thompson FH et al. (1991). Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. Br J Cancer 63: 923-929.
    • (1991) Br J Cancer , vol.63 , pp. 923-929
    • Taylor, C.W.1    Dalton, W.S.2    Parrish, P.R.3    Gleason, M.C.4    Bellamy, W.T.5    Thompson, F.H.6
  • 109
    • 0027548728 scopus 로고
    • The transporters associated with antigen presentation
    • Townsend A, Trowsdale J (1993). The transporters associated with antigen presentation. Semin Cell Biol 4: 53-61.
    • (1993) Semin Cell Biol , vol.4 , pp. 53-61
    • Townsend, A.1    Trowsdale, J.2
  • 110
    • 0033572627 scopus 로고    scopus 로고
    • Tissue-specific expression of functional isoforms of mouse folylpoly-γ-glutamate synthetase: A basis for targeting folate antimetabolites
    • Turner FB, Andreassi JF, Ferguson J, Titus S, Tse A, Taylor SM et al. (1999). Tissue-specific expression of functional isoforms of mouse folylpoly-γ-glutamate synthetase: a basis for targeting folate antimetabolites. Cancer Res 59: 6074-6079.
    • (1999) Cancer Res , vol.59 , pp. 6074-6079
    • Turner, F.B.1    Andreassi, J.F.2    Ferguson, J.3    Titus, S.4    Tse, A.5    Taylor, S.M.6
  • 111
    • 0036100195 scopus 로고    scopus 로고
    • Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)
    • Van Den Heuvel-Eibrink MM, Weimer EA, Prins A, Meijerink JP, Vossebeld PJ, Van Der Holt B et al. (2002). Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML). Leukemia 16: 833-839.
    • (2002) Leukemia , vol.16 , pp. 833-839
    • Van Den Heuvel-Eibrink, M.M.1    Weimer, E.A.2    Prins, A.3    Meijerink, J.P.4    Vossebeld, P.J.5    Van Der Holt, B.6
  • 112
    • 0037093101 scopus 로고    scopus 로고
    • Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia
    • Van Der Kolk DM, Vellenga E, Scheffer GL, Muller M, Bates SE, Scheper RJ et al. (2002). Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia. Blood 99: 3763-3770.
    • (2002) Blood , vol.99 , pp. 3763-3770
    • Van Der Kolk, D.M.1    Vellenga, E.2    Scheffer, G.L.3    Muller, M.4    Bates, S.E.5    Scheper, R.J.6
  • 113
    • 30344444454 scopus 로고    scopus 로고
    • The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins
    • Van Herwaarden AE, Schinkel AH (2006). The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins. Trends Pharmacol Sci 27: 10-16.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 10-16
    • Van Herwaarden, A.E.1    Schinkel, A.H.2
  • 114
    • 0032565840 scopus 로고    scopus 로고
    • Solid phase synthesis of fumitremorgin, verruculogen and tryprostatin analogs based on a cyclization/cleavage strategy
    • Van Loevezijn A, Van Maarseveen JH, Stegman K, Visser GM, Koomen GJ (1998). Solid phase synthesis of fumitremorgin, verruculogen and tryprostatin analogs based on a cyclization/cleavage strategy. Tetrahedron Lett 39: 4737-4740.
    • (1998) Tetrahedron Lett , vol.39 , pp. 4737-4740
    • Van Loevezijn, A.1    Van Maarseveen, J.H.2    Stegman, K.3    Visser, G.M.4    Koomen, G.J.5
  • 115
    • 0034212332 scopus 로고    scopus 로고
    • The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism
    • Van Veen HW, Margolles A, Muller M, Higgins CF, Konings WN (2000). The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism. EMBO J 19: 2503-2514.
    • (2000) EMBO J , vol.19 , pp. 2503-2514
    • Van Veen, H.W.1    Margolles, A.2    Muller, M.3    Higgins, C.F.4    Konings, W.N.5
  • 116
    • 0034234294 scopus 로고    scopus 로고
    • Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux
    • Volk EL, Rohde K, Rhee M, McGuire JJ, Doyle LA, Ross DD et al. (2000). Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux. Cancer Res 60: 3514-3521.
    • (2000) Cancer Res , vol.60 , pp. 3514-3521
    • Volk, E.L.1    Rohde, K.2    Rhee, M.3    McGuire, J.J.4    Doyle, L.A.5    Ross, D.D.6
  • 118
    • 2442520293 scopus 로고    scopus 로고
    • Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2
    • Xu J, Liu Y, Yang Y, Bates SE, Zhang J (2004). Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2. J Biol Chem 279: 19781-19789.
    • (2004) J Biol Chem , vol.279 , pp. 19781-19789
    • Xu, J.1    Liu, Y.2    Yang, Y.3    Bates, S.E.4    Zhang, J.5
  • 120
    • 33644758036 scopus 로고    scopus 로고
    • Functional SNPs of the breast cancer resistance protein; therapeutic effects and inhibitor development
    • Yanese K, Tsukahara S, Mitsuhashi J, Sugimoto Y (2005). Functional SNPs of the breast cancer resistance protein; therapeutic effects and inhibitor development. Cancer Lett 234: 73-80.
    • (2005) Cancer Lett , vol.234 , pp. 73-80
    • Yanese, K.1    Tsukahara, S.2    Mitsuhashi, J.3    Sugimoto, Y.4
  • 121
    • 22144481699 scopus 로고    scopus 로고
    • Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein
    • Zhang S, Yang X, Coburn RA, Morris ME (2005). Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol 70: 627-639.
    • (2005) Biochem Pharmacol , vol.70 , pp. 627-639
    • Zhang, S.1    Yang, X.2    Coburn, R.A.3    Morris, M.E.4
  • 122
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • Zhang S, Yang X, Morris ME (2004). Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 65: 1208-1216.
    • (2004) Mol Pharmacol , vol.65 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 123
    • 0037125973 scopus 로고    scopus 로고
    • Bcrp1 gene expression is required for normal numbers of population stem cells in mice and confers relative protection to mitoxantrone in hematopoietic cells in vivo
    • Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP (2002). Bcrp1 gene expression is required for normal numbers of population stem cells in mice and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci USA 99: 12339-12344.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12339-12344
    • Zhou, S.1    Morris, J.J.2    Barnes, Y.3    Lan, L.4    Schuetz, J.D.5    Sorrentino, B.P.6
  • 124
    • 0034795256 scopus 로고    scopus 로고
    • The ABC transporter Bcrp1/Abcg2 is expressed in a variety of stem cells and is a molecular determinant of the side-population phenotype
    • Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ et al. (2001). The ABC transporter Bcrp1/Abcg2 is expressed in a variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7: 1028-1034.
    • (2001) Nat Med , vol.7 , pp. 1028-1034
    • Zhou, S.1    Schuetz, J.D.2    Bunting, K.D.3    Colapietro, A.M.4    Sampath, J.5    Morris, J.J.6
  • 125
    • 15244352173 scopus 로고    scopus 로고
    • Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
    • Zhou S, Zong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP (2005). Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood 105: 2571-2576.
    • (2005) Blood , vol.105 , pp. 2571-2576
    • Zhou, S.1    Zong, Y.2    Ney, P.A.3    Nair, G.4    Stewart, C.F.5    Sorrentino, B.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.