The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells

Clinical Cancer Research

Volumn 8, Issue 1, 2002, Pages 22-28

  Kim, Min ^a   Turnquist, Heth ^a   Sgagias, Magda ^a   Yan, Ying ^a   Cowan, Kenneth ^a   Jackson, John ^b   Sharp, John G ^a   Gong, Maokai ^c   Dean, Michael ^c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN 1; CELL MARKER; COMPLEMENTARY DNA; FLUORESCENT DYE; HOE 33342; MESSENGER RNA; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; RETROVIRUS VECTOR; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL POPULATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG UPTAKE; FLUORESCENCE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE HOMOLOGY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZIMIDAZOLES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE; DNA PRIMERS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MICE; MICROSCOPY, FLUORESCENCE; MITOXANTRONE; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0036154828     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database
2. Biochemistry of multidrug resistance mediated by the multidrug transporter
3. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
4. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
5. A multidrug resistance transporter from human MCF-7 breast cancer cells
6. Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines
7. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
8. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
9. Modification of rhodamine staining allows identification of hematopoietic stem cells with preferential short-term or long-term bone marrow-repopulating ability
10. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
11. Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice
12. Factors affecting retroviral vector function and structural integrity
13. Characterization of the cellular reduction of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction
14. Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-π
15. Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein
16. Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells
17. Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo
18. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
19. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
20. Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells
21. Evolution of ATP-binding cassette transporter genes
22. Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression
23. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype