Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation

Journal of Biological Chemistry

Volumn 277, Issue 50, 2002, Pages 47980-47990

  Özvegy, Csilla ^a   Varadi, András ^a   Sarkadi, Balázs ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; CELLS; DIMERIZATION; HYDROLYSIS; TUMORS;

MUTATIONS;

BIOCHEMISTRY;

ADENINE NUCLEOTIDE; BREAST CANCER RESISTANCE PROTEIN; FUMITREMORGIN C; GLYCOPROTEIN P; HOE 33342; MITOXANTRONE; MITOXANTRONE RESISTANCE ASSOCIATED PROTEIN; NUCLEOTIDE; PROTEIN INHIBITOR; RHODAMINE 123; UNCLASSIFIED DRUG; VANADIC ACID;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DIMERIZATION; DRUG RESISTANCE; DRUG TRANSPORT; GENE EXPRESSION SYSTEM; GENE OVEREXPRESSION; HUMAN; INSECT CELL; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; TUMOR CELL;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BENZIMIDAZOLES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DNA PRIMERS; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; HYDROLYSIS; KINETICS; MITOXANTRONE; NEOPLASM PROTEINS; POINT MUTATION; RECOMBINANT PROTEINS; RHODAMINE 123; SPODOPTERA; SUBSTRATE SPECIFICITY;

ANIMALIA; INSECTA;

EID: 0037073730     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207857200     Document Type: Article

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