Functional analysis of SNPs variants of BCRP/ABCG2

Pharmaceutical Research

Volumn 21, Issue 10, 2004, Pages 1895-1903

  Kondo, Chihiro ^a   Suzuki, Hiroshi ^b   Itoda, Masaya ^c   Ozawa, Shogo ^c   Sawada, Jun Ichi ^c   Kobayashi, Daisuke ^d   Ieiri, Ichiro ^e   Mine, Kazunori ^d   Ohtsubo, Kenji ^e   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e TOTTORI UNIVERSITY   (Japan)

Author keywords

adenovirus; BCRP ABCG2; interindividual difference; SNPs

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; COMPLEMENTARY DNA; ISOPROTEIN; PLASMID VECTOR; PROTEIN A149P; PROTEIN P269S; PROTEIN Q141K; PROTEIN Q166E; PROTEIN R163K; PROTEIN S441N; PROTEIN V12M; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; PROTEIN VARIANT; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS RECOMBINANT; WILD TYPE;

ADENOVIRIDAE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; DNA PRIMERS; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; LLC-PK1 CELLS; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; TRANSPORT VESICLES;

EID: 6344284092     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000045245.21637.d4     Document Type: Article

References (28)

1. L. A. Doyle, W. Yang, L. V. Abruzzo, T. Krogmann, Y. Gao, A. K. Rishi, and D. D. Ross. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl. Acad. Sci. USA 95:15665-15670 (1998).
2. K. Miyake, T. Litman, R. Robey, and S. E. Bates. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett. 146:117-126 (1999).
3. R. Allikmets, L. M. Schriml, A. Hutchinson, V. Romano-Spica, and M. Dean. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 58:5337-5339 (1998).
4. J. D. Allen, R. F. Brinkhuis, J. Wijnholds, and A. H. Schinkel. The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res. 59:4237-4241 (1999).
5. K. J. Bailey-Dell, B. Hassel, L. A. Doyle, and D. D. Ross. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim. Biophys. Acta 1520:234-241 (2001).
6. K. Kage, S. Tsukahara, T. Sugiyama, S. Asada, E. Ishikawa, T. Tsuruo, and Y. Sugimoto. Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. Int. J. Cancer 97:626-630 (2002).
7. T. Litman, T. E. Druley, W. D. Stein, and S. E. Bates. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell. Mol. Life Sci. 58: 931-959 (2001).
8. M. Maliepaard, G. L. Scheffer, I. F. Faneyte, M. A. van Gastelen, A. C. Pijnenborg, A. H. Schinkel, M. J. van De Vijver, R. J. Scheper, and J. H. Schellens. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 61:3458-3464 (2001).
9. J. W. Jonker, J. W. Smit, R. F. Brinkhuis, M. Maliepaard, J. H. Beijnen, J. H. Schellens, and A. H. Schinkel. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J. Natl. Cancer Inst. 92:1651-1656 (2000).
10. J. W. Jonker, M. Buitelaar, E. Wagenaar, M. A. van der Valk, G. L. Scheffer, R. J. Scheper, T. Plosch, F. Kuipers, R. P. Oude Elferink, H. Rosing, J. H. Beijnen, and A. H. Schinkel. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc. Natl. Acad. Sci. USA 99:15649-15654 (2002).
11. M. Suzuki, H. Suzuki, Y. Sugimoto, and Y. Sugiyama. ABCG2 transports sulfated conjugates of steroids and xenobiotics. J. Biol. Chem. 278:22644-22649 (2003).
12. Y. Honjo, C. A. Hrycyna, Q. W. Yan, W. Y. Medina-Perez, R. W. Robey, A. van de Laar, T. Litman, M. Dean, and S. E. Bates. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. Cancer Res. 61:6635-6639 (2001).
13. H. Mitomo, R. Kato, A. Ito, S. Kasamatsu, Y. Ikegami, I. Kii, A. Kudo, E. Kobatake, Y. Sumino, and T. Ishikawa. A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport. Biochem. J. 373:767-774 (2003).
14. M. Itoda, Y. Saito, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, H. Suzuki, Y. Sugiyama, S. Ozawa, and J.-I. Sawada. Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotecan. Drug Metab. Pharmacokinet. 18:212-217 (2003).
15. H. Mizuguchi and M. A. Kay. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method. Hum. Gene Ther. 9:2577-2583 (1998).
16. H. Mizuguchi and M. A. Kay. A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors. Hum. Gene Ther. 10:2013-2017 (1999).
17. M. Muller, C. Meijer, G. J. Zaman, P. Borst, R. J. Scheper, N. H. Mulder, E. G. de Vries, and P. L. Jansen. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA 91:13033-13037 (1994).
18. T. Hirohashi, H. Suzuki, X. Y. Chu, I. Tamai, A. Tsuji, and Y. Sugiyama. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). J. Pharmacol. Exp. Ther. 292:265-270 (2000).
19. Y. Imai, M. Nakane, K. Kage, S. Tsukahara, E. Ishikawa, T. Tsuruo, Y. Miki, and Y. Sugimoto. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol. Cancer Ther. 1:611-616 (2002).
20. C. P. Zamber, J. K. Lamba, K. Yasuda, J. Farnum, K. Thummel, J. D. Schuetz, and E. G. Schuetz. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics 13:19-28 (2003).
21. G. Backstrom, J. Taipalensuu, H. Melhus, H. Brandstrom, A. C. Svensson, P. Artursson, and A. Kindmark. Genetic variation in the ATP-binding Cassette Transporter gene ABCG2 (BCRP) in a Swedish population. Eur. J. Pharm. Sci. 18:359-364 (2003).
22. K. Hashimoto, T. Uchiumi, T. Konno, T. Ebihara, T. Nakamura, M. Wada, S. Sakisaka, F. Maniwa, T. Amachi, K. Ueda, and M. Kuwano. Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. Hepatology 36:1236-1245 (2002).
23. S. Mizuarai, N. Aozasa, and H. Kotani. Single nucleotide polymorphisms result in impaired membrane localization and reduced ATPase activity in multidrug transporter ABCG2. Int. J. Cancer 109:238-246 (2004).
24. E. L. Volk and E. Schneider. Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methorexate polyglutamate transporter. Cancer Res. 63:5538-5543 (2003).
25. Z. S. Chen, R. W. Robey, M. G. Belinsky, I. Shchaveleva, X. Q. Ren, Y. Sugimoto, D. D. Ross, S. E. Bates, and G. D. Kruh. Transport of methotrexate, methotrexate polyglutamates, and 17β estraciol 17β-D-glucuronide by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 64: 4048-4054 (2003).
26. S. Zhou, J. J. Morris, Y. Barnes, L. Lan, J. D. Schuetz, and B. P. Sorrentino. Bcrpl gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc. Natl. Acad. Sci. USA 99:12339-12344 (2002).
27. J. Taipalensuu, H. Tornblom, G. Lindberg, C. Einarsson, F. Sjoqvist, H. Melhus, P. Garberg, B. Sjostrom, B. Lundgren, and P. Artursson. Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J. Pharmacol. Exp. Ther. 299:164-170 (2001).
28. K. Nakatomi, M. Yoshikawa, M. Oka, Y. Ikegami, S. Hayasaka, K. Sano, K. Shiozawa, S. Kawabata, H. Soda, T. Ishikawa, S. Tanabe, and S. Kohno. Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells. Biochem. Biophys. Res. Commun. 288:827-832 (2001).