The apoptotic pathway as a therapeutic target in sepsis

Current Drug Targets

Volumn 8, Issue 4, 2007, Pages 493-500

  Wesche Soldato, Doreen E ^a   Swan, Ryan Z ^a   Chung, Chun Shiang ^a   Ayala, Alfred ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Apoptosis; Death receptor pathway; Human; Mice; Mitochondrial pathway; Organ dysfunction; Sepsis

Indexed keywords

CASPASE INHIBITOR; CORTICOSTEROID; CYCLOOXYGENASE 2; DEATH RECEPTOR; DROTRECOGIN; ENDOTOXIN; ENDOTOXIN ANTIBODY; FAS ANTIGEN; FAS LIGAND; FLUDROCORTISONE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HYBRID PROTEIN; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1 ANTIBODY; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; PROTEINASE; PROTEINASE INHIBITOR; RECOMBINANT ANTITHROMBIN III; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; SMALL INTERFERING RNA; STEROID; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; BLEEDING; CLINICAL TRIAL; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFICACY; DRUG MEGADOSE; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG TARGETING; DRUG TREATMENT FAILURE; ENZYME INHIBITION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPOTHESIS; IMMUNE SYSTEM; LOW DRUG DOSE; LYMPHOCYTE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REVIEW; SEPSIS;

ADRENAL CORTEX HORMONES; APACHE; APOPTOSIS; BLOOD GLUCOSE; HUMANS; INSULIN; PROTEIN C; RECOMBINANT PROTEINS; SEPSIS;

EID: 34247632571     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780362764     Document Type: Review

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