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Volumn 27, Issue 5, 1998, Pages 738-743

Emerging therapies for sepsis and septic shock

Author keywords

Endotoxin; Interleukin; Monoclonal antibody; Tumour necrosis factor

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ANTITHROMBIN III; APROTININ; BN 502021; CENTOXIN; CORTICOSTEROID; ELASTASE INHIBITOR; HIRUDIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; NITRIC OXIDE; OKT 4; PHOSPHORYL LIPID A; SUPEROXIDE DISMUTASE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

EID: 0032413541     PISSN: 03044602     EISSN: 29724066     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (40)
  • 1
    • 0027920980 scopus 로고
    • Pathogenetic mechanisms of septic shock
    • Parillo J E. Pathogenetic mechanisms of septic shock. N Engl J Med 1993; 328:1471-7.
    • (1993) N Engl J Med , vol.328 , pp. 1471-1477
    • Parillo, J.E.1
  • 2
    • 0026874127 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • American College of Chest Physicians / Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-74.
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 4
    • 0023607880 scopus 로고
    • Serial cardiovascular patterns in survivors and non-survivors of human septic shock. Heart rate as an early prediction of prognosis
    • Parker M M, Shelhamer J H, Natanson C, Ailing D W, Parrillo J E. Serial cardiovascular patterns in survivors and non-survivors of human septic shock. Heart rate as an early prediction of prognosis. Crit Care Med 1987; 15:923-9.
    • (1987) Crit Care Med , vol.15 , pp. 923-929
    • Parker, M.M.1    Shelhamer, J.H.2    Natanson, C.3    Ailing, D.W.4    Parrillo, J.E.5
  • 5
    • 0026633301 scopus 로고
    • Tumour necrosis factor - Alpha causes myocardial depression in guinea pigs
    • Heard S O, Perkins M W, Fink M P. Tumour necrosis factor - alpha causes myocardial depression in guinea pigs. Crit Care Med 1992; 20:523-7.
    • (1992) Crit Care Med , vol.20 , pp. 523-527
    • Heard, S.O.1    Perkins, M.W.2    Fink, M.P.3
  • 6
    • 0344149645 scopus 로고
    • Cardiomyocy te depression induced by human septic serum is mediated by nitric oxide and cyclic GMP generation
    • Kumar A, Kosuri R, Kandula P, Olson J, Dee L, Olson J, et al. Cardiomyocy te depression induced by human septic serum is mediated by nitric oxide and cyclic GMP generation. Crit Care Med 1994; 22:A119.
    • (1994) Crit Care Med , vol.22
    • Kumar, A.1    Kosuri, R.2    Kandula, P.3    Olson, J.4    Dee, L.5    Olson, J.6
  • 7
    • 0020627887 scopus 로고
    • Cause-specific management of shock
    • Pinsky M R. Cause-specific management of shock. Postgrad Med 1983; 73:127-35, 138-40, 145.
    • (1983) Postgrad Med , vol.73 , pp. 127-135
    • Pinsky, M.R.1
  • 10
    • 0029041499 scopus 로고
    • Management of septic shock
    • Lynn W A, Cohen J. Management of septic shock. J Infect Dis 1995; 30:207-12.
    • (1995) J Infect Dis , vol.30 , pp. 207-212
    • Lynn, W.A.1    Cohen, J.2
  • 11
    • 0028205777 scopus 로고
    • Lipopolysaccharide-binding protein and CD14 in the lipopolysaccharide-dependent activation of cells
    • Tobias P S, Ulevitch R J. Lipopolysaccharide-binding protein and CD14 in the lipopolysaccharide-dependent activation of cells. Chest 1994; 105(suppl 3):485-505.
    • (1994) Chest , vol.105 , Issue.3 SUPPL. , pp. 485-505
    • Tobias, P.S.1    Ulevitch, R.J.2
  • 12
    • 0028040319 scopus 로고
    • Gram-positive bacteria and sepsis
    • Bone R C. Gram-positive bacteria and sepsis. Arch Intern Med 1994; 154:26-34.
    • (1994) Arch Intern Med , vol.154 , pp. 26-34
    • Bone, R.C.1
  • 13
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin: A randomized, double-blind placebo-controlled trial
    • Ziegler E J, Fischer C J Jr, Sprung C L, Straube R C, Sadoff J C, Foulke G E, et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin: a randomized, double-blind placebo-controlled trial. N Engl J Med 1991; 324:429-36.
    • (1991) N Engl J Med , vol.324 , pp. 429-436
    • Ziegler, E.J.1    Fischer C.J., Jr.2    Sprung, C.L.3    Straube, R.C.4    Sadoff, J.C.5    Foulke, G.E.6
  • 14
    • 0028557981 scopus 로고
    • Treatment of septic shock with human monoclonal antibody HA-1A: A randomized double-blind placebo-controlled trial
    • McCloskey R V, Straube R L, Sanders C, Smith S M, Smith C R. Treatment of septic shock with human monoclonal antibody HA-1A: a randomized double-blind placebo-controlled trial. Ann Intern Med 1994; 121:1-5.
    • (1994) Ann Intern Med , vol.121 , pp. 1-5
    • McCloskey, R.V.1    Straube, R.L.2    Sanders, C.3    Smith, S.M.4    Smith, C.R.5
  • 15
    • 0025917510 scopus 로고
    • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis
    • Greenman R L, Schein R M, Martin M A, Wenzol R P, MacIntyre N R, Emmanual G F, et al. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. JAMA 1991; 166:1097-102.
    • (1991) JAMA , vol.166 , pp. 1097-1102
    • Greenman, R.L.1    Schein, R.M.2    Martin, M.A.3    Wenzol, R.P.4    MacIntyre, N.R.5    Emmanual, G.F.6
  • 16
    • 0029043636 scopus 로고
    • A second large controlled clinical trial of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicentre, randomized, controlled trial
    • Bone R C, Balk R A, Fein A M, Perl T M, Wenzel R P, Reines H D, et al. A second large controlled clinical trial of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicentre, randomized, controlled trial. Crit Care Med 1995; 23:994-1005.
    • (1995) Crit Care Med , vol.23 , pp. 994-1005
    • Bone, R.C.1    Balk, R.A.2    Fein, A.M.3    Perl, T.M.4    Wenzel, R.P.5    Reines, H.D.6
  • 17
    • 0025755711 scopus 로고
    • Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: Dependence on lipopolysaccharide binding protein and CD14
    • Wought S D, Ramos R A, Hermanowski-Vosatka A, Rodwell P, Detruers P A. Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: dependence on lipopolysaccharide binding protein and CD14. J Exp Med 1991; 173:1281-6.
    • (1991) J Exp Med , vol.173 , pp. 1281-1286
    • Wought, S.D.1    Ramos, R.A.2    Hermanowski-Vosatka, A.3    Rodwell, P.4    Detruers, P.A.5
  • 18
    • 0027368661 scopus 로고
    • Protective effect of a recombinant amino-terminal fragment of bactericidal permeability-increasing protein in experimental endotoxemia
    • Kohn F R, Ammons W S, Horwitz A, Grinna L, Theofan G, Weickmann J, et al. Protective effect of a recombinant amino-terminal fragment of bactericidal permeability-increasing protein in experimental endotoxemia. J Infect Dis 1993; 168:1307-10.
    • (1993) J Infect Dis , vol.168 , pp. 1307-1310
    • Kohn, F.R.1    Ammons, W.S.2    Horwitz, A.3    Grinna, L.4    Theofan, G.5    Weickmann, J.6
  • 19
    • 0028289032 scopus 로고
    • Characterisation of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity
    • Hirata M, Shimomura Y, Yoshida M, Morgan J G, Palings I, Wilson D, et al. Characterisation of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity. Infect Immun 1994; 62:1421-6.
    • (1994) Infect Immun , vol.62 , pp. 1421-1426
    • Hirata, M.1    Shimomura, Y.2    Yoshida, M.3    Morgan, J.G.4    Palings, I.5    Wilson, D.6
  • 20
    • 0025160579 scopus 로고
    • Isolation of two isoforms of a novel 15-kDa protein from rabbit polymorphonuclear leukocytes that modulate the antibacterial actions of other leukocyte proteins
    • Ooi C E, Weiss J, Levy O, Elsbach P. Isolation of two isoforms of a novel 15-kDa protein from rabbit polymorphonuclear leukocytes that modulate the antibacterial actions of other leukocyte proteins. J Biol Chem 1990; 265:15956-62.
    • (1990) J Biol Chem , vol.265 , pp. 15956-15962
    • Ooi, C.E.1    Weiss, J.2    Levy, O.3    Elsbach, P.4
  • 21
    • 0017119987 scopus 로고    scopus 로고
    • Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccherides
    • Morrison D C, Jacobs D M. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccherides. Immunochemistry 1996; 13:813-8.
    • (1996) Immunochemistry , vol.13 , pp. 813-818
    • Morrison, D.C.1    Jacobs, D.M.2
  • 23
    • 0028957549 scopus 로고
    • Efficacy and safety of monoclonal antibody to human tumour necrosis factor in patients with sepsis syndrome
    • Abraham E, Wunderink R, Silverman H, Perl T M, Nasraway S, Levy H, et al. Efficacy and safety of monoclonal antibody to human tumour necrosis factor in patients with sepsis syndrome. JAMA 1995; 273:934-41.
    • (1995) JAMA , vol.273 , pp. 934-941
    • Abraham, E.1    Wunderink, R.2    Silverman, H.3    Perl, T.M.4    Nasraway, S.5    Levy, H.6
  • 24
    • 0029835023 scopus 로고    scopus 로고
    • INTERSEPT: An international multicenter, placebo-controlled trial of monoclonal antibody (Mab) to human tumour necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group
    • Cohen J, Carlet J. INTERSEPT: an international multicenter, placebo-controlled trial of monoclonal antibody (MAb) to human tumour necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996; 24:1431-40.
    • (1996) Crit Care Med , vol.24 , pp. 1431-1440
    • Cohen, J.1    Carlet, J.2
  • 25
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumour necrosis factor receptor : Fc fusion protein. The Soluble TNF receptor Sepsis Study Group
    • Fischer C J Jr, Agnosti J M, Opal S M, Lowry S F, Balk R A, Sadoff J C, et al. Treatment of septic shock with the tumour necrosis factor receptor : Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996; 334:1697-702.
    • (1996) N Engl J Med , vol.334 , pp. 1697-1702
    • Fischer C.J., Jr.1    Agnosti, J.M.2    Opal, S.M.3    Lowry, S.F.4    Balk, R.A.5    Sadoff, J.C.6
  • 26
    • 0025225333 scopus 로고
    • Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
    • Ohlsoon K, Bjork P, Bergenfeldt M, Hageman R, Thompson R C. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 1990; 348:550-2.
    • (1990) Nature , vol.348 , pp. 550-552
    • Ohlsoon, K.1    Bjork, P.2    Bergenfeldt, M.3    Hageman, R.4    Thompson, R.C.5
  • 27
    • 0028018567 scopus 로고
    • Initial evaluation of recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized open label, placebo controlled multicenter trial
    • Fischer C J, Slotman G J, Opal S M, Pribble J P, Bone R C, Emmanuel G, et al. Initial evaluation of recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized open label, placebo controlled multicenter trial. Crit Care Med 1994; 22:12-21.
    • (1994) Crit Care Med , vol.22 , pp. 12-21
    • Fischer, C.J.1    Slotman, G.J.2    Opal, S.M.3    Pribble, J.P.4    Bone, R.C.5    Emmanuel, G.6
  • 28
    • 0028239555 scopus 로고
    • Recombinant human interleukin-1 receptor-antagonist in the treatment of patients with sepsis syndrome: Results from a randomized, double-blind, placebo-controlled trial
    • Fischer C J, Dhainaut J F, Opal S M, Balk R A, Slotman G J, Iberti T J, et al. Recombinant human interleukin-1 receptor-antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled trial. JAMA 1994; 271:1836-43.
    • (1994) JAMA , vol.271 , pp. 1836-1843
    • Fischer, C.J.1    Dhainaut, J.F.2    Opal, S.M.3    Balk, R.A.4    Slotman, G.J.5    Iberti, T.J.6
  • 29
    • 0023252009 scopus 로고
    • A controlled clinical trial of high-dose methyl prednisolone in the treatment of severe sepsis and septic shock
    • Bone R C, Fischer C J Jr, Clemmer T P, Slotman G J, Metz C A, Balk R A. A controlled clinical trial of high-dose methyl prednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987; 317:653-8.
    • (1987) N Engl J Med , vol.317 , pp. 653-658
    • Bone, R.C.1    Fischer C.J., Jr.2    Clemmer, T.P.3    Slotman, G.J.4    Metz, C.A.5    Balk, R.A.6
  • 30
    • 0023239471 scopus 로고
    • Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis
    • Veterans Administration Systemic Sepsis Cooperative Study Group. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987; 317:659-65.
    • (1987) N Engl J Med , vol.317 , pp. 659-665
  • 31
    • 0027945044 scopus 로고
    • Platelet activation factor receptor antagonist BN52021 in the treatment of severe sepsis: A randomized double placebo controlled, multicentre clinical trial
    • Dhainaut J F, Tenaillon A, Le Tulzo Y, Schlemmer B, Solet J P, Wolff M, et al. Platelet activation factor receptor antagonist BN52021 in the treatment of severe sepsis: a randomized double placebo controlled, multicentre clinical trial. Crit Care Med 1994; 22:1720-8.
    • (1994) Crit Care Med , vol.22 , pp. 1720-1728
    • Dhainaut, J.F.1    Tenaillon, A.2    Le Tulzo, Y.3    Schlemmer, B.4    Solet, J.P.5    Wolff, M.6
  • 33
    • 0027494843 scopus 로고
    • A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome
    • Yu M, Tomasa G. A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. Crit Care Med 1993; 21:1635-42.
    • (1993) Crit Care Med , vol.21 , pp. 1635-1642
    • Yu, M.1    Tomasa, G.2
  • 35
    • 0029864356 scopus 로고    scopus 로고
    • Nitric oxide and septic shock
    • Cobb J P, Danner R L. Nitric oxide and septic shock. JAMA 1996; 275:1192-6.
    • (1996) JAMA , vol.275 , pp. 1192-1196
    • Cobb, J.P.1    Danner, R.L.2
  • 37
    • 0026346162 scopus 로고
    • Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
    • Petros A, Bennett D, Vallence P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991; 338:1557-8.
    • (1991) Lancet , vol.338 , pp. 1557-1558
    • Petros, A.1    Bennett, D.2    Vallence, P.3
  • 39
    • 0030052232 scopus 로고    scopus 로고
    • Plasmapheresis in severe sepsis or septic shock
    • Stegmayr B G. Plasmapheresis in severe sepsis or septic shock. Blood Purification 1996; 14:94-101.
    • (1996) Blood Purification , vol.14 , pp. 94-101
    • Stegmayr, B.G.1
  • 40
    • 0027724119 scopus 로고
    • Plasmapheresis in the treatment of primary septic shock in humans
    • Gardlund B. Plasmapheresis in the treatment of primary septic shock in humans. Scand J Infect Dis 1993; 25:757-61.
    • (1993) Scand J Infect Dis , vol.25 , pp. 757-761
    • Gardlund, B.1


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