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Volumn 18, Issue 11, 2004, Pages 1185-1191

Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis

Author keywords

CLP; Cytokine; Lymphocyte; Protease inhibitor; SIRS

Indexed keywords

ALCOHOL; ANTIRETROVIRUS AGENT; APOPTOSIS INHIBITOR; INTERLEUKIN 10; INTERLEUKIN 6; NELFINAVIR; PROTEINASE INHIBITOR; RAG1 PROTEIN; RITONAVIR;

EID: 3442885900     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-1230com     Document Type: Article
Times cited : (71)

References (74)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., and Pinsky, M. R. (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29, 1303-1310
    • (2001) Crit. Care Med. , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 2
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin, G. S., Mannino, D. M., Eaton, S., and Moss, M. (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348, 1546-1554
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 4
    • 0034015682 scopus 로고    scopus 로고
    • Cytokine signaling-regulation of the immune response in normal and critically ill states
    • Oberholzer, A., Oberholzer, C., and Moldawer, L. L. (2000) Cytokine signaling-regulation of the immune response in normal and critically ill states. Crit. Care Med. 28, N3-12
    • (2000) Crit. Care Med. , vol.28
    • Oberholzer, A.1    Oberholzer, C.2    Moldawer, L.L.3
  • 6
  • 7
    • 0017737597 scopus 로고
    • Delayed hypersensitivity: Indicator of acquired failure of host defenses in sepsis and trauma
    • Meakins, J. L., Pietsch, J. B., Bubenick, O., Kelly, R., Rode, H., Gordon, J., and MacLean, L. D. (1977) Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann. Surg. 186, 241-250
    • (1977) Ann. Surg. , vol.186 , pp. 241-250
    • Meakins, J.L.1    Pietsch, J.B.2    Bubenick, O.3    Kelly, R.4    Rode, H.5    Gordon, J.6    MacLean, L.D.7
  • 8
    • 0033090250 scopus 로고    scopus 로고
    • The effects of injury on the adaptive immune response
    • Lederer, J. A., Rodrick, M. L., and Mannick, J. A. (1999) The effects of injury on the adaptive immune response. Shock 11, 153-159
    • (1999) Shock , vol.11 , pp. 153-159
    • Lederer, J.A.1    Rodrick, M.L.2    Mannick, J.A.3
  • 9
    • 0035434019 scopus 로고    scopus 로고
    • Sepsis syndromes: Understanding the role of innate and acquired immunity
    • Oberholzer, A., Oberholzer, C., and Moldawer, L. L. (2001) Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16, 83-96
    • (2001) Shock , vol.16 , pp. 83-96
    • Oberholzer, A.1    Oberholzer, C.2    Moldawer, L.L.3
  • 10
    • 0028223194 scopus 로고
    • Sepsis-induced apoptosis of the thymocytes in mice
    • Wang, S. D., Huang, K. J., Lin, Y. S., and Lei, H. Y. (1994) Sepsis-induced apoptosis of the thymocytes in mice. J. Immunol. 152, 5014-5021
    • (1994) J. Immunol. , vol.152 , pp. 5014-5021
    • Wang, S.D.1    Huang, K.J.2    Lin, Y.S.3    Lei, H.Y.4
  • 11
    • 0029880871 scopus 로고    scopus 로고
    • Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediators
    • Ayala, A., Herdon, C. D., Lehman, D. L., Ayala, C. A., and Chaudry, I. H. (1996) Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. Blood 87, 4261-4275
    • (1996) Blood , vol.87 , pp. 4261-4275
    • Ayala, A.1    Herdon, C.D.2    Lehman, D.L.3    Ayala, C.A.4    Chaudry, I.H.5
  • 12
    • 0030739250 scopus 로고    scopus 로고
    • Apoptosis in lymphoid and parenchymal cells during sepsis: Findings in normal and T- and B-cell-deficient mice
    • Hotchkiss, R. S., Swanson, P. E., Cobb, J. P., Jacobson, A., Buchman, T. G., and Karl, I. E. (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit. Care Med. 25, 1298-1307
    • (1997) Crit. Care Med. , vol.25 , pp. 1298-1307
    • Hotchkiss, R.S.1    Swanson, P.E.2    Cobb, J.P.3    Jacobson, A.4    Buchman, T.G.5    Karl, I.E.6
  • 14
    • 0035026505 scopus 로고    scopus 로고
    • Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated
    • Chung, C. S., Wang, W., Chaudry, I. H., and Ayala, A. (2001) Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated. Am. J. Physiol. 280, G812-G818
    • (2001) Am. J. Physiol. , vol.280
    • Chung, C.S.1    Wang, W.2    Chaudry, I.H.3    Ayala, A.4
  • 18
    • 2642599034 scopus 로고    scopus 로고
    • Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process
    • Ayala, A., Xin Xu, Y., Ayala, C. A., Sonefeld, D. E., Karr, S. M., Evans, T. A., and Chaudry, I. H. (1998) Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process. Blood 91, 1362-1372
    • (1998) Blood , vol.91 , pp. 1362-1372
    • Ayala, A.1    Xin Xu, Y.2    Ayala, C.A.3    Sonefeld, D.E.4    Karr, S.M.5    Evans, T.A.6    Chaudry, I.H.7
  • 19
    • 0037384023 scopus 로고    scopus 로고
    • Role of intestinal epithelial apoptosis in survival
    • Husain, K. D., and Coopersmith, C. M. (2003) Role of intestinal epithelial apoptosis in survival. Curr. Opin. Crit. Care 9, 159-163
    • (2003) Curr. Opin. Crit. Care , vol.9 , pp. 159-163
    • Husain, K.D.1    Coopersmith, C.M.2
  • 28
    • 0038578608 scopus 로고    scopus 로고
    • Novel strategies for the treatment of sepsis
    • Riedemann, N. C., Guo, R. F., and Ward, P. A. (2003) Novel strategies for the treatment of sepsis. Nat. Med. 9, 517-524
    • (2003) Nat. Med. , vol.9 , pp. 517-524
    • Riedemann, N.C.1    Guo, R.F.2    Ward, P.A.3
  • 30
    • 0142093069 scopus 로고    scopus 로고
    • Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity
    • Chung, C. S., Song, G. Y., Lomas, J., Simms, H. H., Chaudry, I. H., and Ayala, A. (2003) Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J. Leukoc. Biol. 74, 344-351
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 344-351
    • Chung, C.S.1    Song, G.Y.2    Lomas, J.3    Simms, H.H.4    Chaudry, I.H.5    Ayala, A.6
  • 31
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss, R. S., and Karl, I. E. (2003) The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348, 138-150
    • (2003) N. Engl. J. Med. , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 32
  • 35
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran, B., Carcelain, G., Li, T. S., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debre, P., and Leibowitch, J. (1997) Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 277, 112-116
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3    Blanc, C.4    Mathez, D.5    Tubiana, R.6    Katlama, C.7    Debre, P.8    Leibowitch, J.9
  • 36
    • 0035883068 scopus 로고    scopus 로고
    • Antiapoptotic mechanism of HIV protease inhibitors: Preventing mitochondrial transmembrane potential loss
    • Phenix, B. N., Lum, J. J., Nie, Z., Sanchez-Dardon, J., and Badley, A. D. (2001) Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss. Blood 98, 1078-1085
    • (2001) Blood , vol.98 , pp. 1078-1085
    • Phenix, B.N.1    Lum, J.J.2    Nie, Z.3    Sanchez-Dardon, J.4    Badley, A.D.5
  • 37
    • 0018349233 scopus 로고
    • Effect of sepsis on tissue adenine nucleotide levels
    • Chaudry, I. H., Wichterman, K. A., and Baue, A. E. (1979) Effect of sepsis on tissue adenine nucleotide levels. Surgery 85, 205-211
    • (1979) Surgery , vol.85 , pp. 205-211
    • Chaudry, I.H.1    Wichterman, K.A.2    Baue, A.E.3
  • 38
    • 0034132796 scopus 로고    scopus 로고
    • Comparison of the mortality and inflammatory response of two models of sepsis: Lipopolysaccharide vs. cecal ligation and puncture
    • Remick, D. G., Newcomb, D. E., Bolgos, G. L., and Call, D. R. (2000) Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock 13, 110-116
    • (2000) Shock , vol.13 , pp. 110-116
    • Remick, D.G.1    Newcomb, D.E.2    Bolgos, G.L.3    Call, D.R.4
  • 39
    • 0020520054 scopus 로고
    • Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model
    • Baker, C. C., Chaudry, I. H., Gaines, H. O., and Baue, A. E. (1983) Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94, 331-335
    • (1983) Surgery , vol.94 , pp. 331-335
    • Baker, C.C.1    Chaudry, I.H.2    Gaines, H.O.3    Baue, A.E.4
  • 40
    • 84869233580 scopus 로고    scopus 로고
    • Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard-sixth edition
    • (M7-A6, N. d., ed) Wayne, Pennsylvania
    • National and Standards, C. L. (2003) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard-sixth edition. In Approved Standards, 6th edition (M7-A6, N. d., ed) Wayne, Pennsylvania
    • (2003) Approved Standards, 6th Edition
  • 42
    • 0033257553 scopus 로고    scopus 로고
    • Endotoxin, sepsis, and the primrose path
    • O'Reilly, M., Newcomb, D. E., and Remick, D. (1999) Endotoxin, sepsis, and the primrose path. Shock 12, 411-420
    • (1999) Shock , vol.12 , pp. 411-420
    • O'Reilly, M.1    Newcomb, D.E.2    Remick, D.3
  • 43
    • 0025354406 scopus 로고
    • Laboratory models of sepsis and septic shock
    • Fink, M. P., and Heard, S. O. (1990) Laboratory models of sepsis and septic shock. J. Surg. Res. 49, 186-196
    • (1990) J. Surg. Res. , vol.49 , pp. 186-196
    • Fink, M.P.1    Heard, S.O.2
  • 44
    • 0031606321 scopus 로고    scopus 로고
    • Animal models of sepsis and shock: A review and lessons learned
    • Deitch, E. A. (1998) Animal models of sepsis and shock: a review and lessons learned. Shock 9, 1-11
    • (1998) Shock , vol.9 , pp. 1-11
    • Deitch, E.A.1
  • 45
    • 0035019731 scopus 로고    scopus 로고
    • Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice
    • Echtenacher, B., Weigl, K., Lehn, N., and Mannel, D. N. (2001) Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect. Immun. 69, 3550-3555
    • (2001) Infect. Immun. , vol.69 , pp. 3550-3555
    • Echtenacher, B.1    Weigl, K.2    Lehn, N.3    Mannel, D.N.4
  • 46
    • 0026585007 scopus 로고
    • Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia
    • Eskandari, M. K., Bolgos, G., Miller, C., Nguyen, D. T., DeForge, L. E., and Remick, D. G. (1992) Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J. Immunol. 148, 2724-2730
    • (1992) J. Immunol. , vol.148 , pp. 2724-2730
    • Eskandari, M.K.1    Bolgos, G.2    Miller, C.3    Nguyen, D.T.4    DeForge, L.E.5    Remick, D.G.6
  • 47
  • 48
    • 0033969341 scopus 로고    scopus 로고
    • Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
    • Gogos, C. A., Drosou, E., Bassaris, H. P., and Skoutelis, A. (2000) Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J. Infect. Dis. 181, 176-180
    • (2000) J. Infect. Dis. , vol.181 , pp. 176-180
    • Gogos, C.A.1    Drosou, E.2    Bassaris, H.P.3    Skoutelis, A.4
  • 51
    • 0030077878 scopus 로고    scopus 로고
    • Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes
    • Ayala, A., Ertel, W., and Chaudry, I. H. (1996) Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock 5, 79-90
    • (1996) Shock , vol.5 , pp. 79-90
    • Ayala, A.1    Ertel, W.2    Chaudry, I.H.3
  • 52
    • 0034604169 scopus 로고    scopus 로고
    • Apoptosis. Gone but not forgotten
    • Green, D. R., and Beere, H. M. (2000) Apoptosis. Gone but not forgotten. Nature (London) 405, 28-29
    • (2000) Nature (London) , vol.405 , pp. 28-29
    • Green, D.R.1    Beere, H.M.2
  • 57
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., and Henson, P. M. (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101, 890-898
    • (1998) J. Clin. Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 58
    • 0033485401 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells
    • McDonald, P. P., Fadok, V. A., Bratton, D., and Henson, P. M. (1999) Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J. Immunol. 163, 6164-6172
    • (1999) J. Immunol. , vol.163 , pp. 6164-6172
    • McDonald, P.P.1    Fadok, V.A.2    Bratton, D.3    Henson, P.M.4
  • 59
    • 0034960320 scopus 로고    scopus 로고
    • TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    • Chen, W., Frank, M. E., Jin, W., and Wahl, S. M. (2001) TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 14, 715-725
    • (2001) Immunity , vol.14 , pp. 715-725
    • Chen, W.1    Frank, M.E.2    Jin, W.3    Wahl, S.M.4
  • 60
    • 0342751267 scopus 로고    scopus 로고
    • Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages
    • Barker, R. N., Erwig, L., Pearce, W. P., Devine, A., and Rees, A. J. (1999) Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages. Pathobiology 67, 302-305
    • (1999) Pathobiology , vol.67 , pp. 302-305
    • Barker, R.N.1    Erwig, L.2    Pearce, W.P.3    Devine, A.4    Rees, A.J.5
  • 61
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • Sauter, B., Albert, M. L., Francisco, L., Larsson, M., Somersan, S., and Bhardwaj, N. (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423-434
    • (2000) J. Exp. Med. , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 62
    • 0038312126 scopus 로고    scopus 로고
    • Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis
    • Hotchkiss, R. S., Chang, K. C., Grayson, M. H., Tinsley, K. W., Dunne, B. S., Davis, C. G., Osborne, D. F., and Karl, I. E. (2003) Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc. Natl. Acad. Sci. USA 100, 6724-6729
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6724-6729
    • Hotchkiss, R.S.1    Chang, K.C.2    Grayson, M.H.3    Tinsley, K.W.4    Dunne, B.S.5    Davis, C.G.6    Osborne, D.F.7    Karl, I.E.8
  • 63
    • 0031110570 scopus 로고    scopus 로고
    • Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway
    • Hiramatsu, M., Hotchkiss, R. S., Karl, I. E., and Buchman, T. G. (1997) Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7, 247-253
    • (1997) Shock , vol.7 , pp. 247-253
    • Hiramatsu, M.1    Hotchkiss, R.S.2    Karl, I.E.3    Buchman, T.G.4
  • 65
    • 0036417213 scopus 로고    scopus 로고
    • The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis
    • Cinel, I., Buyukafsar, K., Cinel, L., Polat, A., Atici, S., Tamer, L., and Oral, U. (2002) The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. Pharmacol Res. 46, 119-127
    • (2002) Pharmacol Res , vol.46 , pp. 119-127
    • Cinel, I.1    Buyukafsar, K.2    Cinel, L.3    Polat, A.4    Atici, S.5    Tamer, L.6    Oral, U.7
  • 66
    • 0038805609 scopus 로고    scopus 로고
    • Intestinal epithelial regenerative capacity: An "Achilles' heel" in trauma/burn/sepsis injuries?
    • Sayeed, M. M. (2003) Intestinal epithelial regenerative capacity: an "Achilles' heel" in trauma/burn/sepsis injuries? Crit. Care Med. 31, 1864-1866
    • (2003) Crit. Care Med. , vol.31 , pp. 1864-1866
    • Sayeed, M.M.1
  • 67
    • 0037834561 scopus 로고    scopus 로고
    • Progress in clinical neurosciences: Sepsis-associated encephalopathy: Evolving concepts
    • Wilson, J. X., and Young, G. B. (2003) Progress in clinical neurosciences: sepsis-associated encephalopathy: evolving concepts. Can. J. Neurol. Sci. 30, 98-105
    • (2003) Can. J. Neurol. Sci. , vol.30 , pp. 98-105
    • Wilson, J.X.1    Young, G.B.2
  • 68
    • 0036065101 scopus 로고    scopus 로고
    • The natural history of venous thromboembolism: Impact on ventilation/perfusion scan reporting
    • Gray, H. W. (2002) The natural history of venous thromboembolism: impact on ventilation/perfusion scan reporting. Semin. Nucl. Med. 32, 159-172
    • (2002) Semin. Nucl. Med. , vol.32 , pp. 159-172
    • Gray, H.W.1
  • 69
    • 0036583312 scopus 로고    scopus 로고
    • The cardiovascular response in sepsis: Proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein
    • Fowler, D. E., and Wang, P. (2002) The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). Int. J. Mol. Med. 9, 443-449
    • (2002) Int. J. Mol. Med. , vol.9 , pp. 443-449
    • Fowler, D.E.1    Wang, P.2
  • 70
    • 0037611384 scopus 로고    scopus 로고
    • Cellular apoptosis and organ injury in sepsis: A review
    • Power, C., Fanning, N., and Redmond, H. P. (2002) Cellular apoptosis and organ injury in sepsis: a review. Shock 18, 197-211
    • (2002) Shock , vol.18 , pp. 197-211
    • Power, C.1    Fanning, N.2    Redmond, H.P.3
  • 73
    • 0024555884 scopus 로고
    • Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2
    • Goronzy, J., Weyand, C., Quan, J., Fathman, C. G., and O'Hanley, P. (1989) Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2. J. Immunol. 142, 1134-1138
    • (1989) J. Immunol. , vol.142 , pp. 1134-1138
    • Goronzy, J.1    Weyand, C.2    Quan, J.3    Fathman, C.G.4    O'Hanley, P.5


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