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Volumn 56, Issue , 2005, Pages 225-248

Therapeutic intervention and targets for sepsis

Author keywords

Drotrecogin alfa (activated); Heparin; HMGB 1; Hydrocortisone; Tissue factor pathway inhibitor

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ACETYLCYSTEINE; ANTISERUM; ANTITHROMBIN III; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; BRADYKININ ANTAGONIST; CORTICOSTEROID; DROTRECOGIN; HYBRID PROTEIN; IBUPROFEN; IMMUNOMODULATING AGENT; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; LIPID A; METHYLENE BLUE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; PENTOXIFYLLINE; PROSTAGLANDIN E1; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; SELENIUM; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR; UNINDEXED DRUG;

EID: 14544299688     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.56.082103.104356     Document Type: Review
Times cited : (147)

References (122)
  • 1
    • 0026710191 scopus 로고
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • Bone RC, Balk RA, Cerra FB, et al. 1992. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644-55
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3
  • 2
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, et al. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29:1303-10
    • (2001) Crit. Care Med. , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3
  • 3
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, et al. 2003. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348:1546-54
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3
  • 4
    • 0042832200 scopus 로고    scopus 로고
    • Long-term mortality and medical care charges in patients with severe sepsis
    • Weycker D, Akhras KS, Edelsberg J, et al. 2003. Long-term mortality and medical care charges in patients with severe sepsis. Crit. Care Med. 31:2316-23
    • (2003) Crit. Care Med. , vol.31 , pp. 2316-2323
    • Weycker, D.1    Akhras, K.S.2    Edelsberg, J.3
  • 5
    • 0031003777 scopus 로고    scopus 로고
    • Magnitude and duration of the effect of sepsis on survival
    • Quartin AA, Schein RM, Kett DH, et al. 1997. Magnitude and duration of the effect of sepsis on survival. JAMA 277:1058-63
    • (1997) JAMA , vol.277 , pp. 1058-1063
    • Quartin, A.A.1    Schein, R.M.2    Kett, D.H.3
  • 6
    • 0030746482 scopus 로고    scopus 로고
    • Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
    • Zeni F, Freeman B, Natanson C. 1997. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment (editorial). Crit. Care Med. 25:1095-100
    • (1997) Crit. Care Med. , vol.25 , pp. 1095-1100
    • Zeni, F.1    Freeman, B.2    Natanson, C.3
  • 7
    • 0028893025 scopus 로고
    • The natural history of the systemic inflammatory response syndrome (SIRS)
    • Rangel-Frausto MS, Pittet D, Costigan M, et al. 1995. The natural history of the systemic inflammatory response syndrome (SIRS). JAMA 273:117-23
    • (1995) JAMA , vol.273 , pp. 117-123
    • Rangel-Frausto, M.S.1    Pittet, D.2    Costigan, M.3
  • 10
    • 0000912790 scopus 로고
    • Time course of cytokine levels in sepsis
    • Abstr.
    • Thijs LG, Hack CE. 1995. Time course of cytokine levels in sepsis. Intensive Care Med. 21(Suppl. 2):S258 (Abstr.)
    • (1995) Intensive Care Med. , vol.21 , Issue.SUPPL. 2
    • Thijs, L.G.1    Hack, C.E.2
  • 11
    • 0025647250 scopus 로고
    • Experimental endotoxemia in humans: Analysis of cytokine release and coagulation, fibrinolytic and complement pathways
    • van Deventer SJH, Buller HR, ten Cate JW, et al. 1990. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic and complement pathways. Blood 76:2520-26
    • (1990) Blood , vol.76 , pp. 2520-2526
    • Van Deventer, S.J.H.1    Buller, H.R.2    Ten Cate, J.W.3
  • 12
    • 0035826080 scopus 로고    scopus 로고
    • Severe sepsis - A new treatment with both anticoagulant and antiinflammatory properties
    • Matthay MA. 2001. Severe sepsis - a new treatment with both anticoagulant and antiinflammatory properties. N. Engl. J. Med. 344:759-62
    • (2001) N. Engl. J. Med. , vol.344 , pp. 759-762
    • Matthay, M.A.1
  • 13
    • 25644453690 scopus 로고    scopus 로고
    • Sepsis
    • ed. RS Irwin, JM Rippe. Philadelphia: Lippincott, Williams & Wilkins. 2367 pp
    • Marik PE, Varon J. 2003. Sepsis. In Irwin and Rippe's Intensive Care Medicine, ed. RS Irwin, JM Rippe, 5:1822-33. Philadelphia: Lippincott, Williams & Wilkins. 2367 pp.
    • (2003) Irwin and Rippe's Intensive Care Medicine , vol.5 , pp. 1822-1833
    • Marik, P.E.1    Varon, J.2
  • 15
    • 0029903114 scopus 로고    scopus 로고
    • Sir Isaac Newton, sepsis, SIRS and CARS
    • Bone RC. 1996. Sir Isaac Newton, sepsis, SIRS and CARS. Crit. Care Med. 24:1125-28
    • (1996) Crit. Care Med. , vol.24 , pp. 1125-1128
    • Bone, R.C.1
  • 16
    • 0032734726 scopus 로고    scopus 로고
    • Clinical aspects: From systemic inflammation to " immunoparalysis"
    • Volk HD, Reinke P, Docke WD. 2000. Clinical aspects: from systemic inflammation to "immunoparalysis." Chem. Immunol. 74:162-77
    • (2000) Chem. Immunol. , vol.74 , pp. 162-177
    • Volk, H.D.1    Reinke, P.2    Docke, W.D.3
  • 17
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. 2003. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348:138-50
    • (2003) N. Engl. J. Med. , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 19
    • 0027312882 scopus 로고
    • Pathogenesis of disseminated intravascular coagulopathy in sepsis
    • Levi M, ten Cate H, van der Poll T, et al. 1993. Pathogenesis of disseminated intravascular coagulopathy in sepsis. JAMA 270:975-79
    • (1993) JAMA , vol.270 , pp. 975-979
    • Levi, M.1    Ten Cate, H.2    Van Der Poll, T.3
  • 20
    • 0034913357 scopus 로고    scopus 로고
    • Vascular bed-specific hemostasis: Role of endothelium in sepsis pathogenesis
    • Aird WC. 2001. Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis. Crit. Care Med. 29(Suppl. 7):28-35
    • (2001) Crit. Care Med. , vol.29 , Issue.SUPPL. 7 , pp. 28-35
    • Aird, W.C.1
  • 21
    • 14544267445 scopus 로고    scopus 로고
    • Immune dysregulation and coagulation
    • ed. MM Levy, JL Vincent. Des Plaines, IL: Soc. Crit. Care Med. 137 pp
    • Opal SM. 2003. Immune dysregulation and coagulation. In Sepsis: Pathophysiologic Insights and Current Management, ed. MM Levy, JL Vincent, 1:17-23. Des Plaines, IL: Soc. Crit. Care Med. 137 pp.
    • (2003) Sepsis: Pathophysiologic Insights and Current Management , vol.1 , pp. 17-23
    • Opal, S.M.1
  • 22
    • 0029039574 scopus 로고
    • Tissue factor pathway inhibitor and the current concept of blood coagulation
    • Broze GJ Jr. 1995. Tissue factor pathway inhibitor and the current concept of blood coagulation. Blood Coagul. Fibrinolysis 6(Suppl. 1):S7-13
    • (1995) Blood Coagul. Fibrinolysis , vol.6 , Issue.SUPPL. 1
    • Broze Jr., G.J.1
  • 23
    • 0033495803 scopus 로고    scopus 로고
    • New potential therapeutic modalities: Tissue factor pathway inhibitor
    • Creasey AA. 2000. New potential therapeutic modalities: tissue factor pathway inhibitor. Sepsis 3:173-82
    • (2000) Sepsis , vol.3 , pp. 173-182
    • Creasey, A.A.1
  • 24
    • 0027363207 scopus 로고
    • Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin
    • Wesselschmidt R, Likert K, Huang Z, et al. 1993. Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin. Blood Coagul. Fibrinolysis 4:713-20
    • (1993) Blood Coagul. Fibrinolysis , vol.4 , pp. 713-720
    • Wesselschmidt, R.1    Likert, K.2    Huang, Z.3
  • 25
    • 0033503086 scopus 로고
    • Relative insufficiency of the fibrinolytic system in disseminated intravascular coagulation
    • Levi M, van der Poll T, de Jonge E, et al. 1993. Relative insufficiency of the fibrinolytic system in disseminated intravascular coagulation. Sepsis 3:119-24
    • (1993) Sepsis , vol.3 , pp. 119-124
    • Levi, M.1    Van Der Poll, T.2    De Jonge, E.3
  • 26
    • 0024334658 scopus 로고
    • Coagulation, fibrinolysis, and kallikrein systems in sepsis: Relation to outcome
    • Hesselvik JF, Blomback M, Brodin B, et al. 1989. Coagulation, fibrinolysis, and kallikrein systems in sepsis: relation to outcome. Crit. Care Med. 17:724-33
    • (1989) Crit. Care Med. , vol.17 , pp. 724-733
    • Hesselvik, J.F.1    Blomback, M.2    Brodin, B.3
  • 27
    • 0023727896 scopus 로고
    • Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo
    • van Hinsbergh VW, Kooistra T, van den Berg EA, et al. 1988. Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo. Blood 72:1467-73
    • (1988) Blood , vol.72 , pp. 1467-1473
    • Van Hinsbergh, V.W.1    Kooistra, T.2    Van Den Berg, E.A.3
  • 28
    • 0023907147 scopus 로고
    • Plasminogen activator inhibitor activity in bacterial infection
    • Paramo JA, Fernandez DF, Rocha E. 1988. Plasminogen activator inhibitor activity in bacterial infection. Thromb. Haemost. 59:451-54
    • (1988) Thromb. Haemost. , vol.59 , pp. 451-454
    • Paramo, J.A.1    Fernandez, D.F.2    Rocha, E.3
  • 29
    • 0027214771 scopus 로고
    • Time course of hemostatic abnormalities in sepsis and its relation to outcome
    • Lorente JA, Garcia-Frade LJ, Landin L, et al. 1993. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 103:1536-42
    • (1993) Chest , vol.103 , pp. 1536-1542
    • Lorente, J.A.1    Garcia-Frade, L.J.2    Landin, L.3
  • 30
    • 0033509816 scopus 로고    scopus 로고
    • New potential therapeutic modalities: Antithrombin III
    • Opal SM, Thijs LG. 1999. New potential therapeutic modalities: antithrombin III. Sepsis 3:153-59
    • (1999) Sepsis , vol.3 , pp. 153-159
    • Opal, S.M.1    Thijs, L.G.2
  • 31
    • 0029593690 scopus 로고
    • Clinical relevance of antithrombin deficiencies
    • Mammen EF. 1995. Clinical relevance of antithrombin deficiencies. Semin. Hematol 4(Suppl. 2):2-6
    • (1995) Semin. Hematol. , vol.4 , Issue.SUPPL. 2 , pp. 2-6
    • Mammen, E.F.1
  • 32
    • 14544296864 scopus 로고    scopus 로고
    • Factor VII and antithrombin III activity during sepsis and septic shock in neutropenic patients
    • Mesters RW, Mannucci PW, Coppola R, et al. 1996. Factor VII and antithrombin III activity during sepsis and septic shock in neutropenic patients. Blood 96:2302-10
    • (1996) Blood , vol.96 , pp. 2302-2310
    • Mesters, R.W.1    Mannucci, P.W.2    Coppola, R.3
  • 33
    • 0031825290 scopus 로고    scopus 로고
    • Anti-thrombin III in patients with severe sepsis: A randomized, placebo-controlled, double-blind, multicenter trial plus a meta-analysis on all randomized-placebo-controlled, double blind trials with antithrombin III in severe sepsis
    • Eisele B, Lamy M, Thijs LG, et al. 1998. Anti-thrombin III in patients with severe sepsis: a randomized, placebo-controlled, double-blind, multicenter trial plus a meta-analysis on all randomized-placebo-controlled, double blind trials with antithrombin III in severe sepsis. Intensive Care Med. 24:663-72
    • (1998) Intensive Care Med. , vol.24 , pp. 663-672
    • Eisele, B.1    Lamy, M.2    Thijs, L.G.3
  • 34
    • 0035904368 scopus 로고    scopus 로고
    • High-dose antithrombin III in severe sepsis: A randomized controlled trial
    • Warren BL, Eid A, Singer P, et al. 2001. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 286:1869-78
    • (2001) JAMA , vol.286 , pp. 1869-1878
    • Warren, B.L.1    Eid, A.2    Singer, P.3
  • 35
    • 0025861039 scopus 로고
    • Inflammation and coagulation: Linked processes potentially regulated through a common pathway mediated by protein C
    • Esmon CT, Taylor FB Jr, Snow TR. 1991. Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C. Thromb. Haemost. 66:160-65
    • (1991) Thromb. Haemost. , vol.66 , pp. 160-165
    • Esmon, C.T.1    Taylor Jr., F.B.2    Snow, T.R.3
  • 36
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al. 2001. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344:699-709
    • (2001) N. Engl. J. Med. , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 37
    • 0034834039 scopus 로고    scopus 로고
    • Low levels of protein C are associated with poor outcomes in severe sepsis
    • Yan SB, Heiterbrand JD, Hartman DL, et al. 2001. Low levels of protein C are associated with poor outcomes in severe sepsis. Chest 120:915-22
    • (2001) Chest , vol.120 , pp. 915-922
    • Yan, S.B.1    Heiterbrand, J.D.2    Hartman, D.L.3
  • 38
    • 0037251585 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    • Ely EW, Laterre PF, Angus DC, et al. for the PROWESS Investigators. 2003. Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit. Care Med. 31:12-19
    • (2003) Crit. Care Med. , vol.31 , pp. 12-19
    • Ely, E.W.1    Laterre, P.F.2    Angus, D.C.3
  • 39
    • 0037248228 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis
    • Bernard GR. 2003. Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis. Crit. Care Med. 31(Suppl.):S85-93
    • (2003) Crit. Care Med. , vol.31 , Issue.SUPPL.
    • Bernard, G.R.1
  • 40
    • 0037389471 scopus 로고    scopus 로고
    • Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
    • Bernard GR, Macias WL, Joyce DE, et al. 2003. Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care. 7:155-63
    • (2003) Crit Care , vol.7 , pp. 155-163
    • Bernard, G.R.1    Macias, W.L.2    Joyce, D.E.3
  • 41
    • 0034707685 scopus 로고    scopus 로고
    • A meta-analysis comparing low-molecular-weight heparins with unfractionated heparin in the treatment of venous thromboembolism
    • Dolovich LR, Ginsberg JS, Douketis JD, et al. 2000. A meta-analysis comparing low-molecular-weight heparins with unfractionated heparin in the treatment of venous thromboembolism. Arch. Intern. Med. 160:181-88
    • (2000) Arch. Intern. Med. , vol.160 , pp. 181-188
    • Dolovich, L.R.1    Ginsberg, J.S.2    Douketis, J.D.3
  • 42
    • 0037179705 scopus 로고    scopus 로고
    • Assessing the use of activated protein C in the treatment of severe sepsis
    • Siegel JP. 2002. Assessing the use of activated protein C in the treatment of severe sepsis. N. Engl. J. Med. 347:1030-34
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1030-1034
    • Siegel, J.P.1
  • 43
    • 0037179685 scopus 로고    scopus 로고
    • Risks and benefits of activated protein C treatment for severe sepsis
    • Warren HS, Suffredini AF, Eichacker PQ, et al. 2002. Risks and benefits of activated protein C treatment for severe sepsis. N. Engl. J. Med. 347:1027-30
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1027-1030
    • Warren, H.S.1    Suffredini, A.F.2    Eichacker, P.Q.3
  • 45
    • 0022256529 scopus 로고
    • APACHE II: A severity of disease classification system
    • Knaus WA, Draper EA, Wagner DP, et al. 1985. APACHE II: a severity of disease classification system. Crit. Care Med. 13:818-29
    • (1985) Crit. Care Med. , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3
  • 46
    • 5644284525 scopus 로고    scopus 로고
    • Change in first day vasopressor use is predictive of outcome in severe sepsis, regardless of steroid use
    • Abstr.
    • Vincent JL, Sundin DP, Trzaskoma BL, et al. 2003. Change in first day vasopressor use is predictive of outcome in severe sepsis, regardless of steroid use. Crit. Care Med. 12(Suppl.):A116 (Abstr.)
    • (2003) Crit. Care Med. , vol.12 , Issue.SUPPL.
    • Vincent, J.L.1    Sundin, D.P.2    Trzaskoma, B.L.3
  • 47
    • 1642449358 scopus 로고    scopus 로고
    • Failure to improve during first day of therapy is predictive of 28-day mortality in severe sepsis
    • Abstr.
    • Levy MM, Macias WL, Russell JA, et al. 2003. Failure to improve during first day of therapy is predictive of 28-day mortality in severe sepsis. Chest 124(Suppl.):120S (Abstr.)
    • (2003) Chest , vol.124 , Issue.SUPPL.
    • Levy, M.M.1    Macias, W.L.2    Russell, J.A.3
  • 48
    • 2942609124 scopus 로고    scopus 로고
    • Prompt administration of drotrecogin alfa (activated) is associated with improved survival
    • Abstr.
    • Wheeler AP, Steingrub J, Linde-Zwirble W, et al. 2003. Prompt administration of drotrecogin alfa (activated) is associated with improved survival. Crit. Care Med. 12(Suppl.):A120 (Abstr.)
    • (2003) Crit. Care Med. , vol.12 , Issue.SUPPL.
    • Wheeler, A.P.1    Steingrub, J.2    Linde-Zwirble, W.3
  • 49
    • 2942552352 scopus 로고    scopus 로고
    • Clinical use of drotrecogin alfa (activated): Patients treated in MERCURY differ from those in PROWES S
    • Abstr.
    • Schmidt G, Bates B, McCollam JS, et al. 2003. Clinical use of drotrecogin alfa (activated): patients treated in MERCURY differ from those in PROWES S. Crit. Care Med. 12(Suppl.):A116 (Abstr.)
    • (2003) Crit. Care Med. , vol.12 , Issue.SUPPL.
    • Schmidt, G.1    Bates, B.2    McCollam, J.S.3
  • 51
    • 2942571307 scopus 로고    scopus 로고
    • Early intervention with drotrecogin alfa (activated) improves survival benefit
    • Abstr.
    • Vincent JL, Levy MM, Macias WL, et al. 2003. Early intervention with drotrecogin alfa (activated) improves survival benefit. Crit. Care Med. 12(Suppl.):A123 (Abstr.)
    • (2003) Crit. Care Med. , vol.12 , Issue.SUPPL.
    • Vincent, J.L.1    Levy, M.M.2    Macias, W.L.3
  • 52
    • 0001563188 scopus 로고
    • The effectiveness of hydrocortisone in the management of severe infection
    • Bennett EL, Finland M, Hamborger M, et al. 1963. The effectiveness of hydrocortisone in the management of severe infection. JAMA 183:462-65
    • (1963) JAMA , vol.183 , pp. 462-465
    • Bennett, E.L.1    Finland, M.2    Hamborger, M.3
  • 53
    • 0023252009 scopus 로고
    • A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
    • Bone RC, Fisher CJJ, Clemmer TP, et al. 1987. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N. Engl. J. Med. 317:653-58
    • (1987) N. Engl. J. Med. , vol.317 , pp. 653-658
    • Bone, R.C.1    Fisher, C.J.J.2    Clemmer, T.P.3
  • 54
    • 0023239471 scopus 로고
    • Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis
    • Veterans Administration Systemic Sepsis Cooperative Study Group. 1987. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N. Engl. J. Med. 659-65
    • (1987) N. Engl. J. Med. , pp. 659-665
  • 55
    • 0023713254 scopus 로고
    • Ineffectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock
    • Luce JM, Montgomery AB, Marks JD, et al. 1988. Ineffectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Am. Rev. Resp. Dis. 138:62-68
    • (1988) Am. Rev. Resp. Dis. , vol.138 , pp. 62-68
    • Luce, J.M.1    Montgomery, A.B.2    Marks, J.D.3
  • 56
    • 0029036182 scopus 로고
    • Steroid controversy in sepsis and septic shock: A meta-analysis
    • Lefering R, Neugebauer EA. 1995. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit. Care Med. 23:1294-303
    • (1995) Crit. Care Med. , vol.23 , pp. 1294-1303
    • Lefering, R.1    Neugebauer, E.A.2
  • 57
    • 0029090390 scopus 로고
    • Corticosteroid treatment for sepsis: A critical appraisal and meta-analysis of the literature
    • Cronin L, Cook DJ, Carlet J, et al. 1995. Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit. Care Med. 23:1430-39
    • (1995) Crit. Care Med. , vol.23 , pp. 1430-1439
    • Cronin, L.1    Cook, D.J.2    Carlet, J.3
  • 58
    • 0342980285 scopus 로고    scopus 로고
    • A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin
    • Annane D, Sebille V, Troche G, et al. 2000. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283:1038-45
    • (2000) JAMA , vol.283 , pp. 1038-1045
    • Annane, D.1    Sebille, V.2    Troche, G.3
  • 59
    • 0038468344 scopus 로고    scopus 로고
    • Circulating vasopressin levels in septic shock
    • Sharshar T, Blanchard A, Paillard M, et al. 2003. Circulating vasopressin levels in septic shock. Crit. Care Med. 31:1752-58
    • (2003) Crit. Care Med. , vol.31 , pp. 1752-1758
    • Sharshar, T.1    Blanchard, A.2    Paillard, M.3
  • 60
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    • Annane D, Sebille V, Charpentier C, et al. 2002. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-71
    • (2002) JAMA , vol.288 , pp. 862-871
    • Annane, D.1    Sebille, V.2    Charpentier, C.3
  • 61
    • 0031942028 scopus 로고    scopus 로고
    • Reversal of late septic shock with supraphysiologic doses of hydrocortisone
    • Bollaert PE, Charpentier C, Levy B, et al. 1998. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit. Care Med. 26:645-50
    • (1998) Crit. Care Med. , vol.26 , pp. 645-650
    • Bollaert, P.E.1    Charpentier, C.2    Levy, B.3
  • 62
    • 0032946372 scopus 로고    scopus 로고
    • Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study
    • Briegel J, Forst H, Haller M, et al. 1999. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit. Care Med. 27:723-32
    • (1999) Crit. Care Med. , vol.27 , pp. 723-732
    • Briegel, J.1    Forst, H.2    Haller, M.3
  • 63
    • 0031894232 scopus 로고    scopus 로고
    • Corticosteroids in septic shock: Resurrection of the last rites
    • Matot I, Sprung CL. 1998. Corticosteroids in septic shock: resurrection of the last rites. Crit. Care Med. 26:627-30
    • (1998) Crit. Care Med. , vol.26 , pp. 627-630
    • Matot, I.1    Sprung, C.L.2
  • 64
    • 0037250881 scopus 로고    scopus 로고
    • Adrenal insufficiency during septic shock
    • Marik PE, Zaloga GP. 2003. Adrenal insufficiency during septic shock. Crit. Care Med. 31:141-15
    • (2003) Crit. Care Med. , vol.31 , pp. 141-115
    • Marik, P.E.1    Zaloga, G.P.2
  • 65
    • 0041942666 scopus 로고    scopus 로고
    • Clinical equipoise remains for issues of adrenocorticotropic hormone adminstration, cortisol testing, and therapeutic use of hydrocortisone
    • Annane D, Briegel J, Keh D, et al. 2003. Clinical equipoise remains for issues of adrenocorticotropic hormone adminstration, cortisol testing, and therapeutic use of hydrocortisone. Crit. Care Med. 31:2250-51
    • (2003) Crit. Care Med. , vol.31 , pp. 2250-2251
    • Annane, D.1    Briegel, J.2    Keh, D.3
  • 66
    • 0037456430 scopus 로고    scopus 로고
    • Corticosteroid insufficiency in acutely ill patients
    • Cooper MS, Stewart PM. 2003. Corticosteroid insufficiency in acutely ill patients. N. Engl. J. Med. 348:727-34
    • (2003) N. Engl. J. Med. , vol.348 , pp. 727-734
    • Cooper, M.S.1    Stewart, P.M.2
  • 67
  • 68
    • 0017585669 scopus 로고
    • Mechanism of inappropriate polyuria in septic patients
    • Cortez A, Zito J, Lucas C. 1977. Mechanism of inappropriate polyuria in septic patients. Arch. Surg. 172:471-76
    • (1977) Arch. Surg. , vol.172 , pp. 471-476
    • Cortez, A.1    Zito, J.2    Lucas, C.3
  • 69
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • Rivers E, Nguyen B, Havstad S, et al. 2001. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N. Engl. J. Med. 345:1368-77
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3
  • 70
    • 0028872009 scopus 로고
    • A trial of goal-oriented hemodynamic therapy in critically ill patients
    • Gattinoni L, Brazzi L, Pelosi P, et al. 1995. A trial of goal-oriented hemodynamic therapy in critically ill patients. N. Engl. J. Med. 333:1025-32
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1025-1032
    • Gattinoni, L.1    Brazzi, L.2    Pelosi, P.3
  • 71
    • 0028275095 scopus 로고
    • Elevation of systemic oxygen delivery in the treatment of critically ill patients
    • Hayes MA, Timmins AC, Yau EHS, et al. 1994. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N. Engl. J. Med. 330:1717-22
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1717-1722
    • Hayes, M.A.1    Timmins, A.C.2    Yau, E.H.S.3
  • 72
    • 0036308072 scopus 로고    scopus 로고
    • Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
    • Want L, Brown J, Varki A, et al. 2002. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J. Clin. Invest. 110:127-36
    • (2002) J. Clin. Invest. , vol.110 , pp. 127-136
    • Want, L.1    Brown, J.2    Varki, A.3
  • 73
    • 0032610504 scopus 로고    scopus 로고
    • Heparin in inflammation: Potential therapeutic applications beyond anticoagulation
    • Tyrell DJ, Home AP, Holme KR, et al. 1999. Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv. Pharm. 46:151-208
    • (1999) Adv. Pharm. , vol.46 , pp. 151-208
    • Tyrell, D.J.1    Home, A.P.2    Holme, K.R.3
  • 75
    • 0037160548 scopus 로고    scopus 로고
    • Use of anticoagulants in patients with sepsis
    • Langer M, Riccardi F, Piovella F, et al. 2002. Use of anticoagulants in patients with sepsis. JAMA 287:448-19
    • (2002) JAMA , vol.287 , pp. 448-419
    • Langer, M.1    Riccardi, F.2    Piovella, F.3
  • 76
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
    • Abraham E, Reinhart K, Opal S, et al. 2003. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 290:238-47
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3
  • 77
    • 1542316768 scopus 로고    scopus 로고
    • Extracellular role of HMGB1 in inflammation and sepsis
    • Wang H, Yang H, Tracey KJ. 2004. Extracellular role of HMGB1 in inflammation and sepsis. J. Intern. Med. 255:320-31
    • (2004) J. Intern. Med. , vol.255 , pp. 320-331
    • Wang, H.1    Yang, H.2    Tracey, K.J.3
  • 78
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M, et al. 1999. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248-51
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 79
    • 0141830087 scopus 로고    scopus 로고
    • IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    • Rendon-Mitchell B, Ochani M, Li J, et al. 2003. IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism. J. Immunol. 170:3890-97
    • (2003) J. Immunol. , vol.170 , pp. 3890-3897
    • Rendon-Mitchell, B.1    Ochani, M.2    Li, J.3
  • 80
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. 2002. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418:191-95
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 81
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous HMGB1
    • Yang H, Ochani M, Li J, et al. 2004. Reversing established sepsis with antagonists of endogenous HMGB1. Proc. Natl. Acad. Sci. USA. 101:296-301
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 296-301
    • Yang, H.1    Ochani, M.2    Li, J.3
  • 82
    • 0035891570 scopus 로고    scopus 로고
    • HMGB1 as a late mediator of lethal systemic inflammation
    • Wang H, Yang H, Czura CJ, et al. 2001. HMGB1 as a late mediator of lethal systemic inflammation. Am. J. Resp. Crit. Care Med. 164:1768-73
    • (2001) Am. J. Resp. Crit. Care Med. , vol.164 , pp. 1768-1773
    • Wang, H.1    Yang, H.2    Czura, C.J.3
  • 83
    • 0034664791 scopus 로고    scopus 로고
    • HMG-1 as a mediator of acute lung inflammation
    • Abraham E, Arcaroli J, Carmody A, et al. 2000. HMG-1 as a mediator of acute lung inflammation. J. Immunol. 165:2950-54
    • (2000) J. Immunol. , vol.165 , pp. 2950-2954
    • Abraham, E.1    Arcaroli, J.2    Carmody, A.3
  • 84
    • 0038578608 scopus 로고    scopus 로고
    • Novel strategies for the treatment of sepsis
    • Riedemann NC, Guo RF, Ward PA. 2003. Novel strategies for the treatment of sepsis. Nat. Med. 9:517-24
    • (2003) Nat. Med. , vol.9 , pp. 517-524
    • Riedemann, N.C.1    Guo, R.F.2    Ward, P.A.3
  • 85
    • 0037125985 scopus 로고    scopus 로고
    • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    • Ulloa L, Ochani M, Yang H, et al. 2002. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc. Natl. Acad. Sci. USA 99:1235156
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1235156
    • Ulloa, L.1    Ochani, M.2    Yang, H.3
  • 86
    • 0019906260 scopus 로고
    • Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli
    • Ziegler EJ, McCutchan JA, Fierer J, et al. 1982. Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N. Engl. J. Med. 307:1225-30
    • (1982) N. Engl. J. Med. , vol.307 , pp. 1225-1230
    • Ziegler, E.J.1    McCutchan, J.A.2    Fierer, J.3
  • 87
    • 0025917510 scopus 로고
    • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis
    • Greenman RL, Schein RMH, Martin MA, et al. 1991. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. JAMA 266:1097-102
    • (1991) JAMA , vol.266 , pp. 1097-1102
    • Greenman, R.L.1    Schein, R.M.H.2    Martin, M.A.3
  • 88
    • 0029043636 scopus 로고
    • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial
    • Bone RC, Balk RA, Fein AM, et al. 1995. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. Crit. Care Med. 23:994-1006
    • (1995) Crit. Care Med. , vol.23 , pp. 994-1006
    • Bone, R.C.1    Balk, R.A.2    Fein, A.M.3
  • 89
    • 0034607323 scopus 로고    scopus 로고
    • E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: A randomized controlled trial
    • Angus DC, Birmingham MC, Balk RA, et al., for the E5 Study Investigators. 2000. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. JAMA 283:1723-30
    • (2000) JAMA , vol.283 , pp. 1723-1730
    • Angus, D.C.1    Birmingham, M.C.2    Balk, R.A.3
  • 90
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial
    • The HA-1A Sepsis Study Group
    • Zeigler EJ, Fisher CJ Jr, Sprung CL, et al. 1991. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N. Engl. J. Med. 324:429-36
    • (1991) N. Engl. J. Med. , vol.324 , pp. 429-436
    • Zeigler, E.J.1    Fisher Jr., C.J.2    Sprung, C.L.3
  • 91
    • 0028557981 scopus 로고
    • Treatment of septic shock with human monoclonal antibody HA-1A: A randomized, double-blind, placebo-controlled trial
    • McCloskey RV, Straube RC, Sanders C, et al., for the CHESS Trial Study Group. 1994. Treatment of septic shock with human monoclonal antibody HA-1A: a randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 121:1-5
    • (1994) Ann. Intern. Med. , vol.121 , pp. 1-5
    • McCloskey, R.V.1    Straube, R.C.2    Sanders, C.3
  • 92
    • 0034675328 scopus 로고    scopus 로고
    • 21) as adjunctive treatment for children with severe meningococcal sepsis: A randomised trial
    • 21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. Lancet 356:961-67
    • (2000) Lancet , vol.356 , pp. 961-967
    • Levin, M.1    Quint, P.A.2    Goldstein, B.3
  • 93
    • 0026052634 scopus 로고
    • Treatment of gram-negative septic shock with an immunoglobulin preparation: A prospective, randomized clinical trial
    • Schedel I, Dreikhausen U, Nentwig B, et al. 1991. Treatment of gram-negative septic shock with an immunoglobulin preparation: a prospective, randomized clinical trial. Crit. Care Med. 19:1104-13
    • (1991) Crit. Care Med. , vol.19 , pp. 1104-1113
    • Schedel, I.1    Dreikhausen, U.2    Nentwig, B.3
  • 94
    • 8044246571 scopus 로고    scopus 로고
    • The effects of ibuprofen on the physiology and survival of patients with sepsis
    • Bernard GR, Wheeler AP, Russell JA, et al., for the Ibuprofen in Sepsis Study Group. 1997. The effects of ibuprofen on the physiology and survival of patients with sepsis. N. Engl. J. Med. 336:912-18
    • (1997) N. Engl. J. Med. , vol.336 , pp. 912-918
    • Bernard, G.R.1    Wheeler, A.P.2    Russell, J.A.3
  • 95
    • 0034764687 scopus 로고    scopus 로고
    • A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome
    • Vincent JL, Brase R, Santman F, et al. 2001. A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome. Intensive Care Med. 27:1578-83
    • (2001) Intensive Care Med. , vol.27 , pp. 1578-1583
    • Vincent, J.L.1    Brase, R.2    Santman, F.3
  • 96
    • 0027494843 scopus 로고
    • A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome
    • Yu M, Tomasa G. 1993. A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. Crit. Care Med. 21:1635-12
    • (1993) Crit. Care Med. , vol.21 , pp. 1635-1612
    • Yu, M.1    Tomasa, G.2
  • 97
    • 0027945044 scopus 로고
    • Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: A randomized, double-blind, placebo-controlled, multicenter clinical trial
    • BN 52021 Sepsis Study Group
    • Dhainaut JF, Tenaillon A, Le Tulzo Y, et al. 1994. Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: a randomized, double-blind, placebo-controlled, multicenter clinical trial. BN 52021 Sepsis Study Group. Crit. Care Med. 22:1720-28
    • (1994) Crit. Care Med. , vol.22 , pp. 1720-1728
    • Dhainaut, J.F.1    Tenaillon, A.2    Le Tulzo, Y.3
  • 98
    • 0032433468 scopus 로고    scopus 로고
    • Confirmatory platelet-activating factor receptor antagonist trial in patients with severe Gram-negative bacterial sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial
    • Dhainaut JF, Tenaillon A, Hemmer M, et al., for the BN 52021 Sepsis Investigator Group. 1998. Confirmatory platelet-activating factor receptor antagonist trial in patients with severe Gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. Crit. Care Med. 26:1963-71
    • (1998) Crit. Care Med. , vol.26 , pp. 1963-1971
    • Dhainaut, J.F.1    Tenaillon, A.2    Hemmer, M.3
  • 99
    • 0000918029 scopus 로고    scopus 로고
    • Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis
    • Vincent JL, Spapen H, Bakker J, et al. 2000. Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. Crit. Care Med. 28:638-12
    • (2000) Crit. Care Med. , vol.28 , pp. 638-612
    • Vincent, J.L.1    Spapen, H.2    Bakker, J.3
  • 100
    • 10744219506 scopus 로고    scopus 로고
    • Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial
    • Opal S, Laterre PF, Abraham E, et al. and the Controlled Mortality Trial of Platelet-Activating Factor Acetylhydrolase in Severe Sepsis (COMPASS) Investigators. 2004. Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial. Crit. Care Med. 32:332-11
    • (2004) Crit. Care Med. , vol.32 , pp. 332-311
    • Opal, S.1    Laterre, P.F.2    Abraham, E.3
  • 101
    • 0032495658 scopus 로고    scopus 로고
    • Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
    • Abraham E, Anzueto A, Gutierrez G, et al., for the NORASEPT II Study Group. 1998. Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. Lancet 351:929-33
    • (1998) Lancet , vol.351 , pp. 929-933
    • Abraham, E.1    Anzueto, A.2    Gutierrez, G.3
  • 102
    • 0002057472 scopus 로고    scopus 로고
    • Neutralization of TNF by a monoclonal antibody improves survival and reduces organ dysfunction in human sepsis: Results of the MONARCS trial
    • Panacek EA, Marshall J, Fischkoff S, et al. 2000. Neutralization of TNF by a monoclonal antibody improves survival and reduces organ dysfunction in human sepsis: results of the MONARCS trial. Chest 118:888
    • (2000) Chest , vol.118 , pp. 888
    • Panacek, E.A.1    Marshall, J.2    Fischkoff, S.3
  • 103
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein
    • Fisher CJ Jr, Agosti JM, Opal SM, et al., for the Soluble TNF Receptor Sepsis Study Group. 1996. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. N. Engl. J. Med. 334:1697-702
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1697-1702
    • Fisher Jr., C.J.1    Agosti, J.M.2    Opal, S.M.3
  • 104
    • 8244235133 scopus 로고    scopus 로고
    • p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial
    • Ro 45-2081 Study Group
    • Abraham E, Glauser MP, Butler T, et al. 1997. p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. JAMA 277:1531-38
    • (1997) JAMA , vol.277 , pp. 1531-1538
    • Abraham, E.1    Glauser, M.P.2    Butler, T.3
  • 105
    • 0028239555 scopus 로고
    • Recombinant human interleukin l receptor antagonist in the treatment of patients with sepsis syndrome: Results from a randomized, double-blind, placebo-controlled trial
    • Fisher CJ Jr, Dhainaut JF, Opal SM, et al. 1994. Recombinant human interleukin l receptor antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled trial. JAMA 271:1836-43
    • (1994) JAMA , vol.271 , pp. 1836-1843
    • Fisher Jr., C.J.1    Dhainaut, J.F.2    Opal, S.M.3
  • 106
    • 0030877935 scopus 로고    scopus 로고
    • Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial
    • Opal SM, Fisher CJ Jr, Dhainaut JF, et al. 1997. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. Crit. Care Med. 25:1115-24
    • (1997) Crit. Care Med. , vol.25 , pp. 1115-1124
    • Opal, S.M.1    Fisher Jr., C.J.2    Dhainaut, J.F.3
  • 107
    • 0031962714 scopus 로고    scopus 로고
    • Effect of pentoxifylline in severe sepsis. Results of a randomized, double-blind, placebo-controlled study
    • Staubach KH, Schroder J, Stuber F, et al. 1998. Effect of pentoxifylline in severe sepsis. Results of a randomized, double-blind, placebo-controlled study. Arch. Surg. 133:94-100
    • (1998) Arch. Surg. , vol.133 , pp. 94-100
    • Staubach, K.H.1    Schroder, J.2    Stuber, F.3
  • 108
    • 0027970408 scopus 로고
    • Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: Results from a prospective, randomized, double-blind study
    • Spies CD, Reinhart K, Witt I, et al. 1994. Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study. Crit. Care Med. 22:1738-46
    • (1994) Crit. Care Med. , vol.22 , pp. 1738-1746
    • Spies, C.D.1    Reinhart, K.2    Witt, I.3
  • 109
    • 0029807263 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock
    • Peake SL, Moran JL, Leppard PI. 1996. N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. Crit. Care Med. 24:1302-10
    • (1996) Crit. Care Med. , vol.24 , pp. 1302-1310
    • Peake, S.L.1    Moran, J.L.2    Leppard, P.I.3
  • 110
    • 0032830201 scopus 로고    scopus 로고
    • Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome
    • Angstwurm MW, Schottdorf J, Schopohl J, Gaertner R. 1999. Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Crit. Care Med. 27:1807-13
    • (1999) Crit. Care Med. , vol.27 , pp. 1807-1813
    • Angstwurm, M.W.1    Schottdorf, J.2    Schopohl, J.3    Gaertner, R.4
  • 111
    • 0008021312 scopus 로고    scopus 로고
    • Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127): Results of a randomized, double-blind, placebo-controlled trial
    • Fein A, Bernard GR, Criner GJ, et al. 1997. Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127): results of a randomized, double-blind, placebo-controlled trial. JAMA 277:482-87
    • (1997) JAMA , vol.277 , pp. 482-487
    • Fein, A.1    Bernard, G.R.2    Criner, G.J.3
  • 112
    • 9144220131 scopus 로고    scopus 로고
    • G-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: Results of a randomized, double-blind, placebo-controlled multicenter study (Study No. 144-002)
    • G-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (Study No. 144-002). Crit. Care Med. 32:1-12
    • (2004) Crit. Care Med. , vol.32 , pp. 1-12
    • Bakker, J.1    Grover, R.2    McLuckie, A.3
  • 113
    • 4444273012 scopus 로고    scopus 로고
    • Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock
    • Lopez A, Lorente JA, Steingrub J, et al. 2004. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit. Care Med. 32:21-30
    • (2004) Crit. Care Med. , vol.32 , pp. 21-30
    • Lopez, A.1    Lorente, J.A.2    Steingrub, J.3
  • 114
    • 0026346162 scopus 로고
    • Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
    • Petros A, Bennett D, Vallance P. 1991. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338:1557-58
    • (1991) Lancet , vol.338 , pp. 1557-1558
    • Petros, A.1    Bennett, D.2    Vallance, P.3
  • 115
    • 0028872983 scopus 로고
    • Methylene blue administration in septic shock: A clinical trial
    • Preiser JC, Lejeune P, Roman A, et al. 1995. Methylene blue administration in septic shock: a clinical trial. Crit. Care Med. 23:259-64
    • (1995) Crit. Care Med. , vol.23 , pp. 259-264
    • Preiser, J.C.1    Lejeune, P.2    Roman, A.3
  • 116
    • 0036906749 scopus 로고    scopus 로고
    • The influence of methylene blue infusion on cytokine levels during severe sepsis
    • Memis D, Karamanlioglu B, Yuksel M, et al. 2002. The influence of methylene blue infusion on cytokine levels during severe sepsis. Anaesthesia Intensive Care 30:755-62
    • (2002) Anaesthesia Intensive Care , vol.30 , pp. 755-762
    • Memis, D.1    Karamanlioglu, B.2    Yuksel, M.3
  • 117
    • 0033823702 scopus 로고    scopus 로고
    • A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia
    • Nelson S, Heyder AM, Stone J, et al., for the Multilobar Pneumonia Study Group. 2000. A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. J. Infect. Dis. 182:970-73
    • (2000) J. Infect. Dis. , vol.182 , pp. 970-973
    • Nelson, S.1    Heyder, A.M.2    Stone, J.3
  • 118
    • 0037099153 scopus 로고    scopus 로고
    • A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction
    • Presneill JJ, Harris T, Stewart AG, et al. 2002. A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction. Am. J. Resp. Crit. Care Med. 166:138-13
    • (2002) Am. J. Resp. Crit. Care Med. , vol.166 , pp. 138-113
    • Presneill, J.J.1    Harris, T.2    Stewart, A.G.3
  • 119
    • 0030444623 scopus 로고    scopus 로고
    • Effect of hemofiltration on hemodynamics and systemic concentrations of anaphylotoxins and cytokines in human sepsis
    • Hoffman JN, Hartl WH, Deppisch, et al. 1996. Effect of hemofiltration on hemodynamics and systemic concentrations of anaphylotoxins and cytokines in human sepsis. Intensive Care Med. 22:1360-67
    • (1996) Intensive Care Med. , vol.22 , pp. 1360-1367
    • Hoffman, J.N.1    Hartl, W.H.2    Deppisch3
  • 120
    • 0030995223 scopus 로고    scopus 로고
    • Cytokine removal and cardiovascular hemodynamics in septic patients with continuous veno-venous hemofiltration
    • Heering P, Morgera S, Schmitz FJ, et al. 1997. Cytokine removal and cardiovascular hemodynamics in septic patients with continuous veno-venous hemofiltration. Intensive Care Med. 23:288-96
    • (1997) Intensive Care Med. , vol.23 , pp. 288-296
    • Heering, P.1    Morgera, S.2    Schmitz, F.J.3
  • 121
    • 0028935349 scopus 로고
    • Early enteral administration of a formula (Impact®) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: Results of a multicenter, prospective, randomized, clinical trial
    • Bower RH, Cerra FB, Bershadsky B, et al. 1995. Early enteral administration of a formula (Impact®) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit. Care Med. 23:436-49
    • (1995) Crit. Care Med. , vol.23 , pp. 436-449
    • Bower, R.H.1    Cerra, F.B.2    Bershadsky, B.3
  • 122
    • 0034068769 scopus 로고    scopus 로고
    • An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients
    • Galban C, Montejo JC, Mesejo A, et al. 2000. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit. Care Med. 28:643-48
    • (2000) Crit. Care Med. , vol.28 , pp. 643-648
    • Galban, C.1    Montejo, J.C.2    Mesejo, A.3


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