-
1
-
-
29144508843
-
Global prevalence of dementia: A Delphi consensus study
-
Ferri C.P., Prince M., Brayne C., et al. 2005. Global prevalence of dementia: A Delphi consensus study. Lancet. 366, 2112-2117.
-
(2005)
Lancet
, vol.366
, pp. 2112-2117
-
-
Ferri, C.P.1
Prince, M.2
Brayne, C.3
-
2
-
-
0034718157
-
Alzheimer's amyloid fibrils: Structure and assembly
-
Serpell L.C. 2000. Alzheimer's amyloid fibrils: Structure and assembly. Biochim. Biophys. Acta. 1502, 16-30.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 16-30
-
-
Serpell, L.C.1
-
3
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner G.G., Wong C.W. 1984. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
-
(1984)
Biochem. Biophys. Res. Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
4
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner G.G., Wong C.W. 1984. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122, 1131-1135.
-
(1984)
Biochem. Biophys. Res. Commun
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
5
-
-
0023132387
-
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
-
Goldgaber D., Lerman M.I., McBride O.W., et al. 1987. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science. 235, 877-880.
-
(1987)
Science
, vol.235
, pp. 877-880
-
-
Goldgaber, D.1
Lerman, M.I.2
McBride, O.W.3
-
6
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J., Lemaire H.G., Unterbeck A., et al. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 325, 733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
-
7
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A., Chartier-Harlin M.C., Mullan M., et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349, 704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
-
8
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy J.A., Higgins G.A. 1992. Alzheimer's disease: The amyloid cascade hypothesis. Science. 256, 184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
9
-
-
34247470620
-
-
Hardy J. 2003. The Genetics of Alzheimer's Disease. In: Alzheimer's Disease and Related Disorders: Research Advances. Eds. Iqbal K., Winblad B. Bucharest: Ana. Aslan. Intl. Acad. of Aging, 29-47.
-
Hardy J. 2003. The Genetics of Alzheimer's Disease. In: Alzheimer's Disease and Related Disorders: Research Advances. Eds. Iqbal K., Winblad B. Bucharest: Ana. Aslan. Intl. Acad. of Aging, 29-47.
-
-
-
-
10
-
-
0027032695
-
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
-
St. George-Hyslop P., Haines J., Rogaev E., et al. 1992. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nature Genet. 2, 330-334.
-
(1992)
Nature Genet
, vol.2
, pp. 330-334
-
-
St. George-Hyslop, P.1
Haines, J.2
Rogaev, E.3
-
11
-
-
0026471656
-
Genetic linkage evidence for a familial Alzhe imer's disease locus on chromosome 14
-
Schellenberg G.D., Bird T.D., Wijsman E.M., et al. 1992. Genetic linkage evidence for a familial Alzhe imer's disease locus on chromosome 14. Science. 258, 668-671.
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
-
12
-
-
0027024651
-
-
Mullan M., Houlden H., Windelspecht M., et al. 1992. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the α1-antichymotrypsin gene. Nature Genet. 2, 340-342.
-
Mullan M., Houlden H., Windelspecht M., et al. 1992. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the α1-antichymotrypsin gene. Nature Genet. 2, 340-342.
-
-
-
-
13
-
-
0027031612
-
Alzheimer's disease to chromosome 14q24.3
-
Mapping of a gene predisposing to early-onset
-
Van Broeckhoven C., Backhovens H., Cruts M., et al. 1992. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nature Genet. 2, 335-339.
-
(1992)
Nature Genet
, vol.2
, pp. 335-339
-
-
Van Broeckhoven, C.1
Backhovens, H.2
Cruts, M.3
-
14
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev E.I., Sherrington R., Rogaeva E.A., et al. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376, 775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
-
15
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R., Rogaev E.I., Liang Y., et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375, 754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
16
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E., Wasco W., Poorkaj P., et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269, 973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
-
19
-
-
0031949628
-
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
-
Crook R., Verkkoniemi A., Perez-Tur J., et al. 1998. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nature Med. 4, 452-455.
-
(1998)
Nature Med
, vol.4
, pp. 452-455
-
-
Crook, R.1
Verkkoniemi, A.2
Perez-Tur, J.3
-
20
-
-
0025735884
-
Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage
-
Pericak-Vance M.A., Bebout J.L., Gaskell P.C. Jr., et al. 1991. Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage. Am. J. Hum. Genet. 48, 1034-1050.
-
(1991)
Am. J. Hum. Genet
, vol.48
, pp. 1034-1050
-
-
Pericak-Vance, M.A.1
Bebout, J.L.2
Gaskell Jr., P.C.3
-
21
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder E.H., Saunders A.M., Strittmatter W.J., et al. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261, 921-923.
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
22
-
-
0028178047
-
Apolipoprotein E, ε4 allele as a major risk factor for sporadic early- and late-onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region
-
Chartier-Harlin M.C., Parfitt M., Legrain S., et al. 1994. Apolipoprotein E, ε4 allele as a major risk factor for sporadic early- and late-onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region. Human Mol. Genet. 3, 569-574.
-
(1994)
Human Mol. Genet
, vol.3
, pp. 569-574
-
-
Chartier-Harlin, M.C.1
Parfitt, M.2
Legrain, S.3
-
23
-
-
0033220122
-
Genetic factors and a polygenic model of Alzheimer's disease
-
Rogaev E.I. Genetic factors and a polygenic model of Alzheimer's disease. Genetika. 35, 1558-1571.
-
Genetika
, vol.35
, pp. 1558-1571
-
-
Rogaev, E.I.1
-
24
-
-
0036385788
-
Regulatory region variability in the human presenilin-2 (PSEN2) gene: Potential contribution to the gene activity and risk for AD
-
Riazanskaia N., Lukiw W.J., Grigorenko A., et al. 2002. Regulatory region variability in the human presenilin-2 (PSEN2) gene: Potential contribution to the gene activity and risk for AD. Mol. Psychiatry. 7, 891-898.
-
(2002)
Mol. Psychiatry
, vol.7
, pp. 891-898
-
-
Riazanskaia, N.1
Lukiw, W.J.2
Grigorenko, A.3
-
25
-
-
0028305380
-
Alzheimer disease
-
Protective effect of apolipoprotein E type 2 allele for late onset
-
Corder E.H., Saunders A.M., Risch N.J., et al. 1994. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nature Genet. 7, 180-184.
-
(1994)
Nature Genet
, vol.7
, pp. 180-184
-
-
Corder, E.H.1
Saunders, A.M.2
Risch, N.J.3
-
26
-
-
33645038471
-
A specific amyloid-β protein assembly in the brain impairs memory
-
Lesne S., Koh M.T., Kotilinek L., et al. 2006. A specific amyloid-β protein assembly in the brain impairs memory. Nature. 440, 352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
-
27
-
-
0038117796
-
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
-
Naslund J., Haroutunian V., Mohs R., et al. 2000. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. J. Am. Med. Ass. 283, 1571-1577.
-
(2000)
J. Am. Med. Ass
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
-
28
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associ ated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I., Iqbal K., Tung Y.C., et al. 1986. Abnormal phosphorylation of the microtubule-associ ated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA. 83, 4913-4917.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
-
29
-
-
0033041179
-
Association of an extended haplotype in the tau gene with progressive supranuclear palsy
-
Baker M., Litvan I., Houlden H., et al. 1999. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Human Mol. Genet. 8, 711-715.
-
(1999)
Human Mol. Genet
, vol.8
, pp. 711-715
-
-
Baker, M.1
Litvan, I.2
Houlden, H.3
-
30
-
-
33646886350
-
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease
-
Theuns J., Brouwers N., Engelborghs S., et al. 2006. Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. Am. J. Hum. Genet. 78, 936-946.
-
(2006)
Am. J. Hum. Genet
, vol.78
, pp. 936-946
-
-
Theuns, J.1
Brouwers, N.2
Engelborghs, S.3
-
31
-
-
0034704198
-
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
-
Bertram L., Blacker D., Mullin K., et al. 2000. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 290, 2302-2303.
-
(2000)
Science
, vol.290
, pp. 2302-2303
-
-
Bertram, L.1
Blacker, D.2
Mullin, K.3
-
32
-
-
0030770726
-
Complete genomic screen in late-onset familial Alzheimer disease: Evidence for a new locus on chromosome 12
-
Pericak-Vance M.A., Bass M.P., Yamaoka L.H., et al. 1997. Complete genomic screen in late-onset familial Alzheimer disease: Evidence for a new locus on chromosome 12. J. Am. Med. Assoc. 278, 1237-1241.
-
(1997)
J. Am. Med. Assoc
, vol.278
, pp. 1237-1241
-
-
Pericak-Vance, M.A.1
Bass, M.P.2
Yamaoka, L.H.3
-
34
-
-
0031939059
-
Molecular mapping of Alzheimer-type dementia in Down's syndrome
-
Prasher V.P., Farrer M.J., Kessling A.M., et al. 1998. Molecular mapping of Alzheimer-type dementia in Down's syndrome. Ann. Neural. 43, 380-383.
-
(1998)
Ann. Neural
, vol.43
, pp. 380-383
-
-
Prasher, V.P.1
Farrer, M.J.2
Kessling, A.M.3
-
35
-
-
29444442794
-
Alzheimer disease with cerebral amyloid angiopathy
-
APP locus duplication causes autosomal dominant early-onset
-
Rovelet-Lecrux A., Hannequin D., Raux G., et al. 2006. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nature Genet. 38, 24-26.
-
(2006)
Nature Genet
, vol.38
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
Hannequin, D.2
Raux, G.3
-
36
-
-
1642573171
-
Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein
-
Moliaka Y.K., Grigorenko A., Madera D., Rogaev E.I. 2004. Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein. FEBS Lett. 557, 185-192.
-
(2004)
FEBS Lett
, vol.557
, pp. 185-192
-
-
Moliaka, Y.K.1
Grigorenko, A.2
Madera, D.3
Rogaev, E.I.4
-
37
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G., Borchelt D.R., Lee M.K., et al. 1996. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17, 181-190.
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
-
38
-
-
4344584730
-
WNT and β-catenin signalling: Diseases and therapies
-
Moon R.T., Kohn A.D., De Ferrari G.V., Kaykas A. 2004. WNT and β-catenin signalling: Diseases and therapies. Nature Rev. Genet. 5, 691-701.
-
(2004)
Nature Rev. Genet
, vol.5
, pp. 691-701
-
-
Moon, R.T.1
Kohn, A.D.2
De Ferrari, G.V.3
Kaykas, A.4
-
39
-
-
0042536471
-
Neuronal and glial calcium signaling in Alzheimer's disease
-
Mattson M.P., Chan S.L. 2003. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium. 34, 385-397.
-
(2003)
Cell Calcium
, vol.34
, pp. 385-397
-
-
Mattson, M.P.1
Chan, S.L.2
-
40
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D., Eckman C., Jensen M., et al. 1996. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-870.
-
(1996)
Nature Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
41
-
-
0035955693
-
-
Kimberly W.T., Zheng J.B., Guenette S.Y., Selkoe D.J. 2001. The intracellular domain of the β-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J. Biol. Chem. 276, 40, 288-40, 292.
-
Kimberly W.T., Zheng J.B., Guenette S.Y., Selkoe D.J. 2001. The intracellular domain of the β-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J. Biol. Chem. 276, 40, 288-40, 292.
-
-
-
-
42
-
-
2642582435
-
Dissection of amyloid-β precursor protein-dependent transcriptional transactivation
-
Cao X., Sudhof T.C. 2004. Dissection of amyloid-β precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279, 24,601-24,611.
-
(2004)
J. Biol. Chem
, vol.279
-
-
Cao, X.1
Sudhof, T.C.2
-
43
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt D.R., Thinakaran G., Eckman C.B., et al. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron. 17, 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
44
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B., Saftig P., Craessaerts K., et al. 1998. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391, 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
-
45
-
-
0033779635
-
Presenilins are required for y-secretase cleavage of β- APP and transmembrane cleavage of Notch-1
-
Zhang Z., Nadeau P., Song W., et al. 2000. Presenilins are required for y-secretase cleavage of β- APP and transmembrane cleavage of Notch-1. Nature Cell Biol. 2, 463-465.
-
(2000)
Nature Cell Biol
, vol.2
, pp. 463-465
-
-
Zhang, Z.1
Nadeau, P.2
Song, W.3
-
46
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and y-secretase activity
-
Wolfe M.S., Xia W., Ostaszewski B.L., et al. 1999. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and y-secretase activity. Nature.398,513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
-
47
-
-
0037173071
-
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms
-
Xia X., Wang P., Sun X., et al. 2002. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms. Proc. Natl. Acad. Sci. USA. 99, 8760-8765.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8760-8765
-
-
Xia, X.1
Wang, P.2
Sun, X.3
-
48
-
-
0033214070
-
A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling
-
Steiner H., Duff K., Capell A., et al. 1999. A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling. J. Biol. Chem. 274, 28,669-28,673.
-
(1999)
J. Biol. Chem
, vol.274
-
-
Steiner, H.1
Duff, K.2
Capell, A.3
-
49
-
-
0035980073
-
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and γ-secretase activities of presenilins
-
Tomita T., Watabiki T., Takikawa R., et al. 2001. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and γ-secretase activities of presenilins. J. Biol. Chem. 276, 33273-33281.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 33273-33281
-
-
Tomita, T.1
Watabiki, T.2
Takikawa, R.3
-
50
-
-
1642555780
-
Mutant presenilins specifically elevate the levels of the 42-residue β-amyloid peptide in vivo: Evidence for augmentation of a 42-specific y-secretase
-
Jankowsky J.L., Fadale D.J., Anderson J., et al. 2004. Mutant presenilins specifically elevate the levels of the 42-residue β-amyloid peptide in vivo: Evidence for augmentation of a 42-specific y-secretase. Human Mol. Genet. 13, 159-170.
-
(2004)
Human Mol. Genet
, vol.13
, pp. 159-170
-
-
Jankowsky, J.L.1
Fadale, D.J.2
Anderson, J.3
-
51
-
-
0030671560
-
-
Li X., Greenwald 1.1997. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. USA. 94, 12204-12209.
-
Li X., Greenwald 1.1997. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. USA. 94, 12204-12209.
-
-
-
-
52
-
-
0031753831
-
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans
-
Levitan D., Greenwald I. 1998. Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Development. 125, 3599-3606.
-
(1998)
Development
, vol.125
, pp. 3599-3606
-
-
Levitan, D.1
Greenwald, I.2
-
53
-
-
0030779784
-
Skeletal and CNS defects in Presenilin-1-deficient mice
-
Shen J., Bronson R.T., Chen D.F., et al. 1997. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89, 629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
-
54
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A., Hartmann D., Annaert W., et al. 1999. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. USA. 96, 11,872-11,877.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
-
55
-
-
0028216808
-
Notch 1 is essential for postimplantation development in mice
-
Swiatek P.J., Lindsell C.E., del Amo F.F., et al. 1994. Notch 1 is essential for postimplantation development in mice. Genes Dev. 8, 707-719.
-
(1994)
Genes Dev
, vol.8
, pp. 707-719
-
-
Swiatek, P.J.1
Lindsell, C.E.2
del Amo, F.F.3
-
56
-
-
0033535504
-
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B., Annaert W., Cupers P., et al. 1999. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature. 398, 518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
-
57
-
-
0037468759
-
The role of presenilin cofactors in the γ-secretase complex
-
Takasugi N., Tomita T., Hayashi I., et al. 2003. The role of presenilin cofactors in the γ-secretase complex. Nature. 422, 438-441.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
-
58
-
-
0037363922
-
HES and HERP families: Multiple effectors of the Notch signaling pathway
-
Iso T., Kedes L., Hamamori Y. 2003. HES and HERP families: Multiple effectors of the Notch signaling pathway. J. Cell Physiol. 194, 237-255.
-
(2003)
J. Cell Physiol
, vol.194
, pp. 237-255
-
-
Iso, T.1
Kedes, L.2
Hamamori, Y.3
-
59
-
-
33846403492
-
Pathological and physiological functions of presenilins
-
Vetrivel K.S., Zhang Y.W., Xu H., Thinakaran G. 2006. Pathological and physiological functions of presenilins. Mol. Neurodegener. 1, 4.
-
(2006)
Mol. Neurodegener
, vol.1
, pp. 4
-
-
Vetrivel, K.S.1
Zhang, Y.W.2
Xu, H.3
Thinakaran, G.4
-
60
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains γ-catenin
-
Yu G., Chen F., Levesque G., et al. 1998. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains γ-catenin. J. Biol. Chem. 273, 16,470-16,475.
-
(1998)
J. Biol. Chem
, vol.273
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
-
61
-
-
0030667426
-
Evidence that levels of presenilins (PS 1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
Thinakaran G., Harris C.L., Ratovitski T., et al. 1997. Evidence that levels of presenilins (PS 1 and PS2) are coordinately regulated by competition for limiting cellular factors. J. Biol. Chem. 272, 28,415-28,422.
-
(1997)
J. Biol. Chem
, vol.272
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
-
62
-
-
0343819757
-
Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state
-
Li Y.M., Lai M.T., Xu M., et al. 2000. Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state. Proc. Natl. Acad. Sci. USA. 97, 6138-6143.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
-
63
-
-
0034621824
-
Photoactivated y-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li Y.M., Xu M., Lai M.T., et al. 2000. Photoactivated y-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 405, 689-694.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
-
64
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
-
Yu G., Nishimura M., Arawaka S., et al. 2000. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing. Nature. 407, 48-54.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
-
65
-
-
0034080403
-
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C., Hepler W., Mickey K.M., Priess J.R. 2000. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development. 127, 2481-2492.
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
66
-
-
23744491374
-
Nicastrin functions as a gamma-secretase-substrate receptor
-
Shah S., Lee S.F., Tabuchi K., et al. 2005. Nicastrin functions as a gamma-secretase-substrate receptor. Cell. 122, 435-447.
-
(2005)
Cell
, vol.122
, pp. 435-447
-
-
Shah, S.1
Lee, S.F.2
Tabuchi, K.3
-
67
-
-
0037173115
-
Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
-
Edbauer D., Winkler E., Haass C., Steiner H. 2002. Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation. Proc. Natl. Acad. Sci. USA. 99, 8666-8671.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8666-8671
-
-
Edbauer, D.1
Winkler, E.2
Haass, C.3
Steiner, H.4
-
68
-
-
0037144422
-
Complex N-linked glycosylated nicastrin associates with active γ-secretase and undergoes tight cellular regulation
-
Kimberly W.T., laVoie M.J., Ostaszewski B.L., et al. 2002. Complex N-linked glycosylated nicastrin associates with active γ-secretase and undergoes tight cellular regulation. J. Biol. Chem. 277, 35,113-35,117.
-
(2002)
J. Biol. Chem
, vol.277
-
-
Kimberly, W.T.1
laVoie, M.J.2
Ostaszewski, B.L.3
-
69
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C., Tsunozaki M., Hale V.A., Priess J.R. 2002. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA. 99, 775-779.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
70
-
-
18444417998
-
aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation
-
Francis R., McGrath G., Zhang J., et al. 2002. aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation. Dev. Cell. 3, 85-97.
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
-
71
-
-
0037160063
-
-
Lee S.F., Shah S., Li H., et al., et al. 2002. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-β precursor protein and Notch. J. Biol. them. 277, 45013-45019.
-
Lee S.F., Shah S., Li H., et al., et al. 2002. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-β precursor protein and Notch. J. Biol. them. 277, 45013-45019.
-
-
-
-
72
-
-
0037424275
-
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1
-
Luo W.J., Wang H., Li H., et al. 2003. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J. Biol. Chem. 278, 7850-7854.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 7850-7854
-
-
Luo, W.J.1
Wang, H.2
Li, H.3
-
73
-
-
0037470037
-
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin-nicastrin complexes
-
Gu Y., Chen F., Sanjo N., et al. 2003. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin-nicastrin complexes. J. Biol. Chem. 278, 7374-7380.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 7374-7380
-
-
Gu, Y.1
Chen, F.2
Sanjo, N.3
-
75
-
-
3342993335
-
Purification and characterization of the human γ-secretase complex
-
Fraering P.C., Ye W., Strub J.M., et al. 2004. Purification and characterization of the human γ-secretase complex. Biochemistry. 43, 9774-9789.
-
(2004)
Biochemistry
, vol.43
, pp. 9774-9789
-
-
Fraering, P.C.1
Ye, W.2
Strub, J.M.3
-
77
-
-
0036410505
-
Identification of a novel class of polytopic proteins with domains associated with probable proteinase activity
-
Grigorenko A.P., Molyaka Yu.K., Korovaitseva G.I., Rogaev E.I. 2002. Identification of a novel class of polytopic proteins with domains associated with probable proteinase activity. Biokhimiya. 67, 995-1005.
-
(2002)
Biokhimiya
, vol.67
, pp. 995-1005
-
-
Grigorenko, A.P.1
Molyaka, Y.K.2
Korovaitseva, G.I.3
Rogaev, E.I.4
-
78
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
Weihofen A., Binns K., Lemberg M.K., et al. 2002. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science. 296, 2215-2218.
-
(2002)
Science
, vol.296
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.K.3
-
79
-
-
6944250394
-
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
-
Grigorenko A.P., Moliaka Y.K., Soto M.C., et al. 2004. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc. Natl. Acad. Sci. USA. 101, 14955-14960.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 14955-14960
-
-
Grigorenko, A.P.1
Moliaka, Y.K.2
Soto, M.C.3
-
80
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report
-
Nicoll J.A., Wilkinson D., Holmes C., et al. 2003. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report. Nature Med. 9, 448-452.
-
(2003)
Nature Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
-
81
-
-
33645013015
-
Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease
-
Siemers E.R., Quinn J.F., Kaye J., et al. 2006. Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease. Neurology. 66, 602-604.
-
(2006)
Neurology
, vol.66
, pp. 602-604
-
-
Siemers, E.R.1
Quinn, J.F.2
Kaye, J.3
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