Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

Brain Research

Volumn 844, Issue 1-2, 1999, Pages 126-134

  Mirzoeva, Salida ^a   Koppal, Tanuja ^a   Petrova, Tatiana V ^a   Lukas, Thomas J ^a   Watterson, D Martin ^a   Van Eldik, Linda J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Ca(2+) calmodulin dependent protein kinase; CREB; Lipopolysaccharide; NF kappa B; Nitric oxide synthase; Phosphorylation; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCINEURIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K 252A; LIPOPOLYSACCHARIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; IMMUNOBLOTTING; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STROKE;

AMIDINES; ANIMALS; BENZYLAMINES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM SIGNALING; CARBAZOLES; CELL LINE; CELL NUCLEUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUG DESIGN; ENZYME INHIBITORS; FLAVONOIDS; IMIDAZOLES; ISOQUINOLINES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PYRIDINES; STAUROSPORINE; SULFONAMIDES;

EID: 0032850931     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01911-3     Document Type: Article

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