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Volumn 43, Issue 1-2, 1997, Pages 132-142

Alzheimer’s, ageing and amyloid: An absurd allegory?

Author keywords

Alzheimer s disease; Oxidative stress; Signal transduction; amyloid

Indexed keywords

AMYLOID BETA PROTEIN;

EID: 0031029245     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000213841     Document Type: Article
Times cited : (13)

References (97)
  • 1
    • 0000383864 scopus 로고
    • Ageing and the dementias
    • Adams JH, Corsellis JAN, Duchen LW (eds), 4. New York. Wiley
    • Tomlinson BE, Corsellis JAN: Ageing and the dementias; in Adams JH, Corsellis JAN, Duchen LW (eds): Greenfields Neuropathology, ed 4. New York. Wiley, 1984, pp 951-1025.
    • (1984) Greenfields Neuropathology , pp. 951-1025
    • Tomlinson, B.E.1    Corsellis, J.2
  • 2
    • 0021077610 scopus 로고
    • Senile dementia of the Alzheimer type
    • Terry RD, Katzman R: Senile dementia of the Alzheimer type. Ann Neurol 1983;14:497-506.
    • (1983) Ann Neurol , vol.14 , pp. 497-506
    • Terry, R.D.1    Katzman, R.2
  • 3
    • 0011868823 scopus 로고
    • Neurochemical, genetic and clinical aspects of Alzheimer’s disease
    • Bergener M, Ermini M, Stähelin HB (eds), London, Academic Press
    • Winblad B, Wallace W, Hardy J, Fowler CJ, Bucht G, Alafuzoff I, Adolfsson R: Neurochemical, genetic and clinical aspects of Alzheimer’s disease; in Bergener M, Ermini M, Stähelin HB (eds): Dimensions in Aging. London, Academic Press. 1986, pp 183-205.
    • (1986) Dimensions in Aging , pp. 183-205
    • Winblad, B.1    Wallace, W.2    Hardy, J.3    Fowler, C.J.4    Bucht, G.5    Alafuzoff, I.6    Adolfsson, R.7
  • 5
    • 0000293742 scopus 로고
    • Über eine eigenartige Erkrankung der Hirnrinde
    • Alzheimer A: Über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiatr 1907;64:146-148.
    • (1907) Allg Z Psychiatr , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 7
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA: Alzheimer's disease: The amyloid cascade hypothesis. Science 1992:256:184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 8
    • 0026570528 scopus 로고
    • P-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE: p-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-389.
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 9
    • 0029102993 scopus 로고
    • Neurodegeneration mediated by glutamate and β-amyloid peptide: A comparison and possible interaction
    • Gray CW, Patel AJ: Neurodegeneration mediated by glutamate and β-amyloid peptide: A comparison and possible interaction. Brain Res 1995;691:169-179.
    • (1995) Brain Res , vol.691 , pp. 169-179
    • Gray, C.W.1    Patel, A.J.2
  • 10
    • 0029064572 scopus 로고
    • Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for P-APP751
    • Higgins LS, Rodems JM, Catalano R, Quon D, Cordell B: Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for P-APP751. Proc Natl Acad Sci USA 1995:92:4402-4406.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4402-4406
    • Higgins, L.S.1    Rodems, J.M.2    Catalano, R.3    Quon, D.4    Cordell, B.5
  • 11
    • 0029055738 scopus 로고
    • Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human p-amyloid precursor protein
    • Moran PM, Higgins LS, Cordell B, Moser PC: Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human p-amyloid precursor protein. Proc Natl Acad Sci USA 1995;92: 5341-5345.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5341-5345
    • Moran, P.M.1    Higgins, L.S.2    Cordell, B.3    Moser, P.C.4
  • 12
    • 0028981717 scopus 로고
    • The Alzheimer’s Ap peptide induces ncurodegcneration and apoptotic cell death in transgenic mice
    • LaFcrla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G: The Alzheimer’s Ap peptide induces ncurodegcneration and apoptotic cell death in transgenic mice. Nature Genet 1995;9:21-30.
    • (1995) Nature Genet , vol.9 , pp. 21-30
    • Lafcrla, F.M.1    Tinkle, B.T.2    Bieberich, C.J.3    Haudenschild, C.C.4    Jay, G.5
  • 20
    • 0028197477 scopus 로고
    • Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines
    • Lahiri DK, Lewis S, Farlow MR: Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines. J Neurosci Res 1994:37: 777-787.
    • (1994) J Neurosci Res , vol.37 , pp. 777-787
    • Lahiri, D.K.1    Lewis, S.2    Farlow, M.R.3
  • 21
    • 0026550678 scopus 로고
    • Adcnylyl cyclase activity in postmortem human brain: Evidence of altered G protein mediation in Alzheimer's disease
    • Cowbum RF, O’Neill C, Ravid R, Alafuzoff I, Winblad B, Fowler CJ: Adcnylyl cyclase activity in postmortem human brain: Evidence of altered G protein mediation in Alzheimer's disease. J Neurochcm 1992:58:1409-1419.
    • (1992) J Neurochcm , vol.58 , pp. 1409-1419
    • Cowbum, R.F.1    O’Neill, C.2    Ravid, R.3    Alafuzoff, I.4    Winblad, B.5    Fowler, C.J.6
  • 22
    • 0027280874 scopus 로고
    • Disrupted Pi-adrcnoccptor-G protein coupling in the temporal cortex of patients with Alzheimer’s disease
    • Cowbum RF, Veslling M, Fowler CJ, Ravid R, Winblad B, O'Neill C: Disrupted Pi-adrcnoccptor-G protein coupling in the temporal cortex of patients with Alzheimer’s disease. Neurosci Lett 1993:155:163-166.
    • (1993) Neurosci Lett , vol.155 , pp. 163-166
    • Cowbum, R.F.1    Veslling, M.2    Fowler, C.J.3    Ravid, R.4    Winblad, B.5    O'neill, C.6
  • 23
    • 0028031955 scopus 로고
    • Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain
    • O’Neill C, Wiehagcr B, Fowler CJ, Ravid R, Winblad B, Cowbum RF: Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. Brain Res 1994;636:193-201.
    • (1994) Brain Res , vol.636 , pp. 193-201
    • O’Neill, C.1    Wiehagcr, B.2    Fowler, C.J.3    Ravid, R.4    Winblad, B.5    Cowbum, R.F.6
  • 24
    • 0027132379 scopus 로고
    • Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer’s disease
    • 2 hydrolysis in Alzheimer’s disease. Life Sci 1993:53: PL439-PL444.
    • (1993) Life Sci , vol.53 , pp. PL439-PL444
    • Ferrari-Dileo, G.1    Flynn, D.D.2
  • 25
    • 0028027552 scopus 로고
    • Cholinergic and serotonincrgic stimulation of phosphoinosi:Ide hydrolysis is decreased in Alzheimer’s disease
    • Crews FT, Kurian P, Freund G: Cholinergic and serotonincrgic stimulation of phosphoinosi:ide hydrolysis is decreased in Alzheimer’s disease. Life Sci 1994:55:1993-2002.
    • (1994) Life Sci , vol.55 , pp. 1993-2002
    • Crews, F.T.1    Kurian, P.2    Freund, G.3
  • 26
    • 0028151332 scopus 로고
    • Area specific alterations in muscarinic stimulated low Km GTPasc activity in aging and Alzheimer’s disease: Implications for altered signal transduction
    • Cutler R, Joseph JA, Yamagami K, Villalobos-Molina R, Roth GS: Area specific alterations in muscarinic stimulated low Km GTPasc activity in aging and Alzheimer’s disease: Implications for altered signal transduction. Brain Res 1994:664:54-60.
    • (1994) Brain Res , vol.664 , pp. 54-60
    • Cutler, R.1    Joseph, J.A.2    Yamagami, K.3    Villalobos-Molina, R.4    Roth, G.S.5
  • 29
    • 0023823738 scopus 로고
    • Decreased brain [3H]inositol 1,4,5-trisphosphate binding in Alzheimer’s disease
    • 3H]inositol 1,4,5-trisphosphate binding in Alzheimer’s disease. Neurosci Lett 1988:94:198-202.
    • (1988) Neurosci Lett , vol.94 , pp. 198-202
    • Young, L.T.1    Kish, S.J.2    Li, P.P.3    Warsh, J.J.4
  • 32
    • 0025296284 scopus 로고
    • Aberrant protein kinase C cascades in Alzheimer’s disease: In Lauder JM (ed): Molecular Aspects of Development and Aging of the Nervous System. New York
    • Saitoh T, Cole G, Huynh TV: Aberrant protein kinase C cascades in Alzheimer’s disease: in Lauder JM (ed): Molecular Aspects of Development and Aging of the Nervous System. New York. Plenum Press. 1990, pp 301-310.
    • (1990) Plenum Press , pp. 301-310
    • Saitoh, T.1    Cole, G.2    Huynh, T.V.3
  • 34
    • 0028201847 scopus 로고
    • Role of neurotransmission in the regulation of amyloid ß-protein precursor processing
    • Nitsch RM, Growdon JH: Role of neurotransmission in the regulation of amyloid ß-protein precursor processing. Biochem Pharmacol 1994; 47:1275-1284.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1275-1284
    • Nitsch, R.M.1    Growdon, J.H.2
  • 35
    • 1842367594 scopus 로고
    • Cultured skin fibroblasts, ‘Alzheimer antigens’, and cellular calcium homeostasis in Alzheimer’s disease
    • FowlerCJ, Carlson LA, Gottfries C-G, Winblad B (eds), London, Smith-Gordon
    • Blass JP, Gibson GE, Black RS, Ko L-W, Shcu K-FR: Cultured skin fibroblasts, ‘Alzheimer antigens’, and cellular calcium homeostasis in Alzheimer’s disease: in FowlerCJ, Carlson LA, Gottfries C-G, Winblad B (eds): Biological Markers in Dementia of Alzheimer Type. London, Smith-Gordon, 1990, pp 203-214.
    • (1990) Biological Markers in Dementia of Alzheimer Type , pp. 203-214
    • Blass, J.P.1    Gibson, G.E.2    Black, R.S.3    Ko, L.-W.4    Shcu, K.-F.5
  • 36
    • 0027244664 scopus 로고
    • Altered ß-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors
    • Huang H-M, Gibson GE: Altered ß-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. J Biol Chem 1993:268:14616-14621.
    • (1993) J Biol Chem , vol.268 , pp. 14616-14621
    • Huang, H.-M.1    Gibson, G.E.2
  • 38
    • 0028538219 scopus 로고
    • The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line
    • Kunishata T, Ikeda S, Araki W, Ta-bika T: The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line. Tohoku J Exp Med 1994:174:225-239.
    • (1994) Tohoku J Exp Med , vol.174 , pp. 225-239
    • Kunishata, T.1    Ikeda, S.2    Araki, W.3    Ta-Bika, T.4
  • 39
    • 0027508926 scopus 로고
    • Alzheimer's disease amyloid ß-protein forms calcium channels in bilayer membranes: Blockade by thro-methamine and aluminium
    • Arispe N, Rojas H, Pollard HB: Alzheimer's disease amyloid ß-protein forms calcium channels in bilayer membranes: Blockade by thro-methamine and aluminium. Proc Natl Acad Sei USA 1993:90:567-571.
    • (1993) Proc Natl Acad Sei USA , vol.90 , pp. 567-571
    • Arispe, N.1    Rojas, H.2    Pollard, H.B.3
  • 40
    • 0028176475 scopus 로고
    • Inhibitory effects of ß-amyloid peptides on nicotine-induced Ca2+ influx in PC12h cells in culture
    • 2+ influx in PC12h cells in culture. Neurosci Lett 1994:173:147-150.
    • (1994) Neurosci Lett , vol.173 , pp. 147-150
    • Takcnouchi, T.1    Munckata, H.2
  • 41
    • 0028138349 scopus 로고
    • Alterations of intracellular calcium regulation during aging and Alzheimer’s disease in nonneuronal cells
    • Eckert A, Hartmann H, Förstl H, Müller WE: Alterations of intracellular calcium regulation during aging and Alzheimer’s disease in nonneuronal cells. Life Sci 1994:55: 2019-2029.
    • (1994) Life Sci , vol.55 , pp. 2019-2029
    • Eckert, A.1    Hartmann, H.2    Förstl, H.3    Müller, W.E.4
  • 42
    • 0029652085 scopus 로고
    • ß-Amy-loid-(1-40) increases long-term potentiation in rat hippocampus in vitro
    • Wu J, Anwyl R, Rowan MJ: ß-Amy-loid-(1-40) increases long-term potentiation in rat hippocampus in vitro. Eur J Pharmacol 1995;284:R1-R3.
    • (1995) Eur J Pharmacol , vol.284 , pp. R1-R3
    • Wu, J.1    Anwyl, R.2    Rowan, M.J.3
  • 43
    • 0025992927 scopus 로고
    • Action of amyloid beta-protein on protein kinase C activity
    • Chauhan A, Chauhan VPS, Brock-erhoff H, Wisniewski HM: Action of amyloid beta-protein on protein kinase C activity. Life Sei 1991:49: 1555-1562.
    • (1991) Life Sei , vol.49 , pp. 1555-1562
    • Chauhan, A.1    Chauhan, V.2    Brock-Erhoff, H.3    Wisniewski, H.M.4
  • 44
    • 0028148893 scopus 로고
    • Effects of Alzheimer's disease-related ß amyloid protein fragments on enzymes metabolising phosphoinositides in brain
    • Wallace MA: Effects of Alzheimer's disease-related ß amyloid protein fragments on enzymes metabolising phosphoinositides in brain. Biochim Biophys Acta 1994; 1227:183-187.
    • (1994) Biochim Biophys Acta , vol.1227 , pp. 183-187
    • Wallace, M.A.1
  • 45
    • 0028989045 scopus 로고
    • ß-Amyloid peptides enhance binding of the calcium mobilising second messengers, inositol(1,4,5)trisphosphatc and inositol-(1,3,4,5)tetrakisphosphate to their receptor sites in rat cortical membranes
    • Cowburn RF, Wiehager B, Sundström E: ß-Amyloid peptides enhance binding of the calcium mobilising second messengers, inositol(1,4,5)trisphosphatc and inositol-(1,3,4,5)tetrakisphosphate to their receptor sites in rat cortical membranes. Neurosci Lett 1995; 191:31-34.
    • (1995) Neurosci Lett , vol.191 , pp. 31-34
    • Cowburn, R.F.1    Wiehager, B.2    Sundström, E.3
  • 46
    • 0028345296 scopus 로고
    • Similar age-related changes of free intracellular calcium in lymphocytes and central neurons: Effects of Alzheimer's disease
    • Hartmann H, Eckert A, Förstl H, Müller WE: Similar age-related changes of free intracellular calcium in lymphocytes and central neurons: Effects of Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci 1994;243:218-223.
    • (1994) Eur Arch Psychiatry Clin Neurosci , vol.243 , pp. 218-223
    • Hartmann, H.1    Eckert, A.2    Förstl, H.3    Müller, W.E.4
  • 47
    • 0025332601 scopus 로고
    • Altered post-receptorial signal transduction mechanism under various stimulation in polymorphonuclear granulocytes of Alzheimer’s disease
    • Fulop T, Kckcssy D, Foris G: Altered post-receptorial signal transduction mechanism under various stimulation in polymorphonuclear granulocytes of Alzheimer’s disease. Mech Age Dev 1990:52:277-285.
    • (1990) Mech Age Dev , vol.52 , pp. 277-285
    • Fulop, T.1    Kckcssy, D.2    Foris, G.3
  • 48
    • 0026524906 scopus 로고
    • Decrement of muscarinic receptor-stimulated Iow-Km GTPase in striatum and hippocampus from the aged rat
    • Yamagami K, Joseph JA, Roth GS: Decrement of muscarinic receptor-stimulated Iow-Km GTPase in striatum and hippocampus from the aged rat. Brain Res 1992:576:327-331.
    • (1992) Brain Res , vol.576 , pp. 327-331
    • Yamagami, K.1    Joseph, J.A.2    Roth, G.S.3
  • 50
    • 0022461357 scopus 로고    scopus 로고
    • Co-Adrenoceptor-GTP binding regulatory protein: Adenylate cyclase system in cerebral cortical membranes of adult and senescent rats
    • Nomura Y, Kitamura Y, Kawai M, Segawa T: co-Adrenoceptor-GTP binding regulatory protein: Adenylate cyclase system in cerebral cortical membranes of adult and senescent rats. Brain Res 1986:379:1 18-124.
    • Brain Res 1986:379 , vol.1 , pp. 18-124
    • Nomura, Y.1    Kitamura, Y.2    Kawai, M.3    Segawa, T.4
  • 51
    • 0028989636 scopus 로고
    • Loss of cortical sero-toninia signal transduction in senescent rats: Reversal following inhibition of protein kinase C
    • Rahman S, McLean JH, Darbv-King A, Paterno G, Reynolds JN, Neuman RS: Loss of cortical sero-toninia signal transduction in senescent rats: Reversal following inhibition of protein kinase C. Neuroscience 1995:66:891-901.
    • (1995) Neuroscience , vol.66 , pp. 891-901
    • Rahman, S.1    McLean, J.H.2    Darbv-King, A.3    Paterno, G.4    Reynolds, J.N.5    Neuman, R.S.6
  • 52
    • 0025668422 scopus 로고
    • Selective cross-activation/ inhibition of second-messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata
    • Joseph JA, Kowatch MA, Maki T, Roth GS: Selective cross-activation/ inhibition of second-messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata. Brain Res 1990:537:40-48.
    • (1990) Brain Res , vol.537 , pp. 40-48
    • Joseph, J.A.1    Kowatch, M.A.2    Maki, T.3    Roth, G.S.4
  • 53
    • 0027300335 scopus 로고
    • Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium
    • Hartmann H, Eckert A, Miillcr WE: Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium. Neurosci Lett 1993:152:181-184.
    • (1993) Neurosci Lett , vol.152 , pp. 181-184
    • Hartmann, H.1    Eckert, A.2    Miillcr, W.E.3
  • 54
    • 85053524585 scopus 로고
    • Changes in transmembrane signaling mechanisms during aging: Cellular and molecular aspects
    • Macieira-Coel-ho A (ed), CRC Press
    • Miyamoto A, Roth GS: Changes in transmembrane signaling mechanisms during aging: Cellular and molecular aspects; in Macieira-Coel-ho A (ed): Molecular Basis of AginG, Boca Raton. CRC Press. 1955, pp 293-306.
    • (1955) Molecular Basis of Aging, Boca Raton , pp. 293-306
    • Miyamoto, A.1    Roth, G.S.2
  • 55
    • 0029100939 scopus 로고
    • Fernandez Hl.: Platelets are the primary source of amyloid beta-pep-tide in human blood
    • Chen M, Inestrosa NC, Ross GS, Fernandez Hl.: Platelets are the primary source of amyloid beta-pep-tide in human blood. Biochem Biophys Res Commun 1995:213:96-103.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 96-103
    • Chen, M.1    Inestrosa, N.C.2    Ross, G.S.3
  • 56
    • 0027435535 scopus 로고
    • Protein phosphorylation inhibits production of Alzheimer amyloid ß/ A4 peptide
    • Buxbaum JD, Koo EH, Grecngard P: Protein phosphorylation inhibits production of Alzheimer amyloid ß/ A4 peptide. Proc Natl Acad Sei USA 1993:90:9195-9198.
    • (1993) Proc Natl Acad Sei USA , vol.90 , pp. 9195-9198
    • Buxbaum, J.D.1    Koo, E.H.2    Grecngard, P.3
  • 58
    • 0028207004 scopus 로고
    • Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-indepcndcnt manner
    • Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P: Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-indepcndcnt manner. Proc Natl Acad Sci USA 1994:91:4489-4493.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4489-4493
    • Buxbaum, J.D.1    Ruefli, A.A.2    Parker, C.A.3    Cypess, A.M.4    Greengard, P.5
  • 59
    • 0028204224 scopus 로고
    • Calcium ionophore increases amyloid β peptide production by cultured cells
    • Querforth HW, Selkoe DJ: Calcium ionophore increases amyloid β peptide production by cultured cells. Biochemistry 1994:33:4550-4561.
    • (1994) Biochemistry , vol.33 , pp. 4550-4561
    • Querforth, H.W.1    Selkoe, D.J.2
  • 60
    • 0028965767 scopus 로고
    • Conventional protein kinase C (PKC)-a and novel PKCE, but not -Ô, increase the secretion of an N-terminal fragment of Alzheimer’s disease amyloid precursor protein from PKC cDNA transfected 3YI fibroblasts
    • Kinouchi T, Sorimachi H, Maruya-ma K, Mizuno K, Ohno S, lshiura S, Suzuki K: Conventional protein kinase C (PKC)-a and novel PKCE, but not -Ô, increase the secretion of an N-terminal fragment of Alzheimer’s disease amyloid precursor protein from PKC cDNA transfected 3YI fibroblasts. FEBS Lett 1995:364:203-206.
    • (1995) FEBS Lett , vol.364 , pp. 203-206
    • Kinouchi, T.1    Sorimachi, H.2    Maruya-Ma, K.3    Mizuno, K.4    Ohno, S.5    Lshiura, S.6    Suzuki, K.7
  • 61
    • 0029379605 scopus 로고
    • Processing of the β-amy-loid precursor protein and its regulation in Alzheimer’s disease
    • Checler F: Processing of the β-amy-loid precursor protein and its regulation in Alzheimer’s disease. J Neu-rochem 1995:65:1431-1444.
    • (1995) J Neu-Rochem , vol.65 , pp. 1431-1444
    • Checler, F.1
  • 63
    • 0029087650 scopus 로고
    • Microglial release of nitric oxide by the synergistic action of p-amy-loidand IFN-Y
    • Goodwin JL, Uemura E, Cunnick JE: Microglial release of nitric oxide by the synergistic action of p-amy-loidand IFN-Y. Brain Res 1995:692: 207-214.
    • (1995) Brain Res , vol.692 , pp. 207-214
    • Goodwin, J.L.1    Uemura, E.2    Cunnick, J.E.3
  • 65
    • 0029128511 scopus 로고
    • Interleukin-1 and nerve growth factor induce hypersecretion and hy-pcrsulfation of neuroblastoma proteoglycans which bind P-amyloid
    • Leveuglc B, Ding W, Buée L, Fillit HM: Interleukin-1 and nerve growth factor induce hypersecretion and hy-pcrsulfation of neuroblastoma proteoglycans which bind P-amyloid. J Neuroimmunol 1995:60:151-160.
    • (1995) J Neuroimmunol , vol.60 , pp. 151-160
    • Leveuglc, B.1    Ding, W.2    Buée, L.3    Fillit, H.M.4
  • 66
    • 0028872219 scopus 로고
    • Human neurons that constitutivcly secrete AP do not induce Alzheimer’s disease pathology following transplantation and long-term survival in the rodent brain
    • Mantione JR, KJeppner SR, Miya-zono M, Wertkin AM, Lee VM-Y, Trojanowski JQ: Human neurons that constitutivcly secrete AP do not induce Alzheimer’s disease pathology following transplantation and long-term survival in the rodent brain. Brain Res 1995:671:333-337.
    • (1995) Brain Res , vol.671 , pp. 333-337
    • Mantione, J.R.1    Kjeppner, S.R.2    Miya-Zono, M.3    Wertkin, A.M.4    Lee, V.-Y.5    Trojanowski, J.Q.6
  • 67
    • 0028289083 scopus 로고
    • Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study
    • Breitner JCS, Gau BA, Welsh KAS, Plassman BL, McDonald WM, Helms MJ, Anthony JC: Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study. Neurology 1994;44:227-232.
    • (1994) Neurology , vol.44 , pp. 227-232
    • Breitner, J.1    Gau, B.A.2    Welsh, K.3    Plassman, B.L.4    McDonald, W.M.5    Helms, M.J.6    Anthony, J.C.7
  • 69
    • 0026677832 scopus 로고
    • Descriptive epidemiology and risk factors for Alzheimer’s disease
    • Amaducci L, Falcini M, Lippi A: Descriptive epidemiology and risk factors for Alzheimer’s disease. Acta Neurol Scand 1992;(suppl 139):21 -25.
    • (1992) Acta Neurol Scand
    • Amaducci, L.1    Falcini, M.2    Lippi, A.3
  • 71
    • 0026897342 scopus 로고
    • The putative role of free radicals in the loss of neuronal functioning in senescence
    • Joseph JA: The putative role of free radicals in the loss of neuronal functioning in senescence. Integ Physiol Behav Sci 1992;27:217-227.
    • (1992) Integ Physiol Behav Sci , vol.27 , pp. 217-227
    • Joseph, J.A.1
  • 72
    • 0026775958 scopus 로고
    • Free radical theory of aginG
    • Harman D: Free radical theory of aginG, Mutation Res 1992:275:257-266.
    • (1992) Mutation Res , vol.275 , pp. 257-266
    • Harman, D.1
  • 73
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP: Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;76:139-162.
    • (1994) Physiol Rev , vol.76 , pp. 139-162
    • Yu, B.P.1
  • 74
    • 0026704066 scopus 로고
    • An introduction to the free radical hypothesis in Parkinson's disease
    • Olanow CW: An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol 1992:32: S2-S9.
    • (1992) Ann Neurol , vol.32 , pp. S2-S9
    • Olanow, C.W.1
  • 75
    • 0028902823 scopus 로고
    • Lipid peroxidation contributes to age-related membrane rigidity
    • Choi M, Jackson C, Yu BP: Lipid peroxidation contributes to age-related membrane rigidity. Free Rad Biol Med 1995;18:977-984.
    • (1995) Free Rad Biol Med , vol.18 , pp. 977-984
    • Choi, M.1    Jackson, C.2    Yu, B.P.3
  • 76
    • 0028893636 scopus 로고
    • Brain synaptosomal aging: Free radicals and membrane fluidity
    • Choi M, Yu BP: Brain synaptosomal aging: Free radicals and membrane fluidity. Free Rad Biol Med 1995; 18:133-139.
    • (1995) Free Rad Biol Med , vol.18 , pp. 133-139
    • Choi, M.1    Yu, B.P.2
  • 77
    • 0024360002 scopus 로고
    • Effect of chronic food restriction in aging ratS, I, Liver subcellular membranes
    • Langaniere S, Yu BP: Effect of chronic food restriction in aging ratS, I, Liver subcellular membranes. Mech Age Dev 1989:48: 207-219.
    • (1989) Mech Age Dev , vol.48 , pp. 207-219
    • Langaniere, S.1    Yu, B.P.2
  • 79
    • 0025942074 scopus 로고
    • Age-related elevation of lipid peroxidation products: Diminution of superoxide dismutase activity in the central nervous system of rats
    • Gupta A, Hasan M, Chander R, Kapoor NK: Age-related elevation of lipid peroxidation products: Diminution of superoxide dismutase activity in the central nervous system of rats. Gerontology 1991:37:305-309.
    • (1991) Gerontology , vol.37 , pp. 305-309
    • Gupta, A.1    Hasan, M.2    Chander, R.3    Kapoor, N.K.4
  • 80
    • 0024374653 scopus 로고
    • Decreased per-oxidative potential in rat brain microsomal fractions during ageing
    • Devasagayam TPA: Decreased per-oxidative potential in rat brain microsomal fractions during ageing. Neurosci Lett 1989;103:92-96.
    • (1989) Neurosci Lett , vol.103 , pp. 92-96
    • Devasagayam, T.1
  • 81
    • 0024319235 scopus 로고
    • Cerebral enzyme antioxidant system influence of aging and phosphatidylcholine
    • Benzi G, Pastoris O, Marzatico F, Villa F: Cerebral enzyme antioxidant system influence of aging and phosphatidylcholine. J Cereb Blood Flow Metab 1989;9:373-380.
    • (1989) J Cereb Blood Flow Metab , vol.9 , pp. 373-380
    • Benzi, G.1    Pastoris, O.2    Marzatico, F.3    Villa, F.4
  • 82
    • 0026520111 scopus 로고
    • NGF restores decrease in catalasc activity and increases superoxide dismutase and glutathione peroxide activity in the brain of aged rats
    • Nistico G, Ciriolo MR, Fiskin K, lannone M, De Artino A, Rotilio G: NGF restores decrease in catalasc activity and increases superoxide dismutase and glutathione peroxide activity in the brain of aged rats. Free Rad Biol Med 1992; 12:177-181.
    • (1992) Free Rad Biol Med , vol.12 , pp. 177-181
    • Nistico, G.1    Ciriolo, M.R.2    Fiskin, K.3    Lannone, M.4    De Artino, A.5    Rotilio, G.6
  • 83
    • 0027430183 scopus 로고
    • Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain
    • Benkovic SA, Connor JR: Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain. J Comp Neurol 1993;338:97-113.
    • (1993) J Comp Neurol , vol.338 , pp. 97-113
    • Benkovic, S.A.1    Connor, J.R.2
  • 84
    • 0018935535 scopus 로고
    • The effect of age on the activity and molecular properties of human brain monoamine oxidase
    • Fowler CJ, Wiberg A, Oreland L, Marcusson J, Winblad B: The effect of age on the activity and molecular properties of human brain monoamine oxidase. J Neural Transm 1980;49:1-20.
    • (1980) J Neural Transm , vol.49 , pp. 1-20
    • Fowler, C.J.1    Wiberg, A.2    Oreland, L.3    Marcusson, J.4    Winblad, B.5
  • 85
    • 0025832844 scopus 로고
    • Reversal of age-related increase in brain protein oxidation: Decrease in enzyme activity, and loss in temporal and spatial memory by chronic n-terl-butyl-al-pha-phenylnitrone
    • Carney JM, Starke-Reed PE, Oliver CN, Landum RW, Cheng MS, Wu JF, Floyd RA: Reversal of age-related increase in brain protein oxidation: Decrease in enzyme activity, and loss in temporal and spatial memory by chronic n-terl-butyl-al-pha-phenylnitrone. Proc Natl Acad Sci USA 1991:88:3633-3636.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3633-3636
    • Carney, J.M.1    Starke-Reed, P.E.2    Oliver, C.N.3    Landum, R.W.4    Cheng, M.S.5    Wu, J.F.6    Floyd, R.A.7
  • 86
    • 0027489345 scopus 로고
    • Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain
    • Zhang JRP, Andrus PK, Hall ED: Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain. J Neurochem 1993:61:1640-1647.
    • (1993) J Neurochem , vol.61 , pp. 1640-1647
    • Zhang, J.1    Rus, P.K.2    Hall, E.D.3
  • 87
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP: Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;76:139-162.
    • (1994) Physiol Rev , vol.76 , pp. 139-162
    • Yu, B.P.1
  • 88
    • 0028169004 scopus 로고
    • Bcl-2 protein expression in aged brain and neu-rodegencrative diseases
    • Migheli A, Cavalla P, Piva R, Gior-dana MT, Schifier D: Bcl-2 protein expression in aged brain and neu-rodegencrative diseases. Neuroreport 1994;5:1906-1908.
    • (1994) Neuroreport , vol.5 , pp. 1906-1908
    • Migheli, A.1    Cavalla, P.2    Piva, R.3    Gior-Dana, M.T.4    Schifier, D.5
  • 89
    • 0029145084 scopus 로고
    • Are reactive oxygen species involved in Alzheimer’s disease?
    • Benzi G, Moretti A: Are reactive oxygen species involved in Alzheimer’s disease? Neurobiol Aging 1995:16:661-674.
    • (1995) Neurobiol Aging , vol.16 , pp. 661-674
    • Benzi, G.1    Moretti, A.2
  • 90
    • 0023897554 scopus 로고
    • Age-related decrements in the muscarinic enhancement of K’-evoked release of endogenous striatal dopamine: An indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence
    • Joseph JA, Dalton TK, Hunt WA: Age-related decrements in the muscarinic enhancement of K’-evoked release of endogenous striatal dopamine: An indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence. Brain Res 1988;454:140-148.
    • (1988) Brain Res , vol.454 , pp. 140-148
    • Joseph, J.A.1    Dalton, T.K.2    Hunt, W.A.3
  • 91
    • 0023895221 scopus 로고
    • Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: A deficit at the ligand-muscarinic receptor interface?
    • Joseph JA, Dalton TK, Roth GS, Hunt WA: Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: A deficit at the ligand-muscarinic receptor interface? Brain Res 1988:454:149-155.
    • (1988) Brain Res , vol.454 , pp. 149-155
    • Joseph, J.A.1    Dalton, T.K.2    Roth, G.S.3    Hunt, W.A.4
  • 92
    • 0028926437 scopus 로고
    • In vivo or in vitro administration of the nitronc spin-trapping compound, n-tcrt-butyl-alpha-phenylni-tronc (PBN), reduces age-related deficits in striatal muscarinic receptor sensitivity
    • Joseph JA, Cao G, Cutler RC: In vivo or in vitro administration of the nitronc spin-trapping compound, n-tcrt-butyl-alpha-phenylni-tronc (PBN), reduces age-related deficits in striatal muscarinic receptor sensitivity. Brain Res 1995;671: 73-77.
    • (1995) Brain Res , vol.671 , pp. 73-77
    • Joseph, J.A.1    Cao, G.2    Cutler, R.C.3
  • 93
    • 0026777379 scopus 로고
    • Possible ‘accelerated striatal aging’ induced by S6Fe heavy-particlc irradiation: Implications for manned space flights
    • S6Fe heavy-particlc irradiation: Implications for manned space flights. Ra-diat Res 1992:130:88-93.
    • (1992) Ra-Diat Res , vol.130 , pp. 88-93
    • Joseph, J.A.1    Hunt, W.A.2    Rabin, B.M.3    Dalton, T.K.4
  • 94
    • 0027363295 scopus 로고
    • Deficits in the sensitivity of striatal muscarinic receptors induced by 56Fe heavy-particle irradiation: Further ‘age-ra-diation' parallels
    • 56Fe heavy-particle irradiation: Further ‘age-ra-diation' parallels. Radiat Res 1993; 135:257-261.
    • (1993) Radiat Res , vol.135 , pp. 257-261
    • Joseph, J.A.1    Hunt, W.A.2    Rabin, B.M.3    Dalton, T.K.4    Harris, A.H.5
  • 95
    • 0028167748 scopus 로고
    • Reductions of 56Fe heavy-particle irradiation-induced deficits in striatal muscarinic receptor sensitivity by selective cross-acti-vation/inhibition of second-messenger systems
    • 56Fe heavy-particle irradiation-induced deficits in striatal muscarinic receptor sensitivity by selective cross-acti-vation/inhibition of second-messenger systems. Radiat Res 1994:139: 60-66.
    • (1994) Radiat Res , vol.139 , pp. 60-66
    • Joseph, J.A.1    Villalobos-Molina, R.2    Rabin, B.M.3    Dalton, T.K.4    Harris, A.5    Kandasamy, S.6
  • 96
    • 0028117852 scopus 로고
    • Iron-56 irradiation diminishes muscarinic but not alpha-1 -adrcnergic-stimulatcd low-Km GTPase in rat brain
    • Villalobos-Molina R, Joseph JA, Rabin BM, Kandasamy SB, Dalton TK, Roth GS: Iron-56 irradiation diminishes muscarinic but not alpha-1 -adrcnergic-stimulatcd low-Km GTPase in rat brain. Radiat Res 1994;140:382-386.
    • (1994) Radiat Res , vol.140 , pp. 382-386
    • Villalobos-Molina, R.1    Joseph, J.A.2    Rabin, B.M.3    Kandasamy, S.B.4    Dalton, T.K.5    Roth, G.S.6
  • 97
    • 0029961574 scopus 로고    scopus 로고
    • Age differences in sensitivity to H1O2- or NO-induced reductions in K’-cvokcd dopamine release from superfused striatal slices: Reversals by PBN or Trolox
    • Joseph JA, Villalobos-Molina K, Denisova N, Erat S, Cutler R, Strain JG: Age differences in sensitivity to H1O2- or NO-induced reductions in K’-cvokcd dopamine release from superfused striatal slices: Reversals by PBN or Trolox. Free Rad Biol Med 1996:20:821-830.
    • (1996) Free Rad Biol Med , vol.20 , pp. 821-830
    • Joseph, J.A.1    Villalobos-Molina, K.2    Denisova, N.3    Erat, S.4    Cutler, R.5    Strain, J.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.