Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia

Archives of Neurology

Volumn 57, Issue 8, 2000, Pages 1153-1160

  Luterman, James D ^a   Haroutunian, Vahram ^b   Yemul, Shrishailam ^a   Ho, Lap ^a   Purohit, Dushyant ^a   Aisen, Paul S ^c   Mohs, Richard ^a   Pasinetti, Giulio Maria ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; COGNITION; CYTOKINE RELEASE; DISEASE COURSE; ENTORHINAL CORTEX; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NURSING HOME; PRIORITY JOURNAL; SENILE PLAQUE; TEMPORAL CORTEX;

EID: 0033876817     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.57.8.1153     Document Type: Article

References (25)

1. Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer's disease (DAT): Lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT
2. Physiological and pathological roles of interleukin-6 in the central nervous system
3. Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease
4. Studies of neuroimmune markers in Alzheimer's disease
5. Circulating cytokines in Alzheimer's disease
6. Role of the brain in interleukin-6 modulation
7. Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
8. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms
9. Glial-neuronal interactions in Alzheimer's disease: The potential role of a 'cytokine cycle' in disease progression
10. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
11. Transforming growth factor-beta: Neuronal and glial expression in CNS degenerative diseases
12. TGF-beta in the central nervous system: Potential roles in ischemic injury and neurodegenerative diseases
13. Transforming growth factor-betas in neurodegenerative disease
14. Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer's disease: Interleukin-1 beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor receptors I and II, and alpha1 -antichymotrypsin
15. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease
16. Evolution of neuronal changes in the course of Alzheimer's disease
17. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
18. Regional distribution of neuritic plaques in nondemented elderly and cases of very mild Alzheimer disease
19. The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: A commentary
20. A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles
21. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
22. TGF-beta1 is an organizer of responses to neurodegeneration
23. Induction of the alpha(1)-antichymotrypsin gene in the brain associated with TGF-beta1 deficiency or systemic administration of endotoxin
24. A randomized controlled trial of prednisone in Alzheimer's disease