A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 31, 2004, Pages 11233-11238

  Hazuda, Daria J ^a   Anthony, Neville J ^a   Gomez, Robert P ^a   Jolly, Samson M ^a   Wai, John S ^a   Zhuang, Linghang ^a   Fisher, Thorsten E ^a   Embrey, Mark ^a   Guare Jr , James P ^a   Egbertson, Melissa S ^a   Vacca, Joseph P ^a   Huff, Joel R ^a   Felock, Peter J ^a   Witmer, Marc V ^a   Stillmock, Kara A ^a   Danovich, Robert ^a   Grobler, Jay ^a   Miller, Michael D ^a   Espeseth, Amy S ^a   Jin, Lixia ^a   Chen, I Wu ^a   Lin, Jiunn H ^a   Kassahun, Kelem ^a   Ellis, Joan D ^a   Wong, Bradley K ^a   Xu, Wei ^a   Pearson, Paul G ^a   Schleif, William A ^a   Cortese, Riccardo ^b   Emini, Emilio ^a   Summa, Vincenzo ^b   Holloway, M Katharine ^a   Young, Steven D ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYNAPHTHYRIDINE 7 CARBOXAMIDE; ACID; ANTIRETROVIRUS AGENT; DIKETO ACID; INTEGRASE; INTEGRASE INHIBITOR; L 810; L 870; NAPHTHYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MALE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; VIRUS MUTATION;

ANIMALS; CELLS, CULTURED; DOGS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, VIRAL; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HIV-2; HUMANS; MACACA MULATTA; MALE; MUTAGENESIS, SITE-DIRECTED; NAPHTHYRIDINES; RATS; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES; VIRUS INTEGRATION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 3843108916     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0402357101     Document Type: Article

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