Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5659-5663

  Hopkins, Corey R ^a   O'Neil, Steven V ^a   Laufersweiler, Michael C ^a   Wang, Yili ^a   Pokross, Matthew ^a   Mekel, Marlene ^a   Evdokimov, Artem ^a   Walter, Richard ^a   Kontoyianni, Maria ^a   Petrey, Maria E ^a   Sabatakos, Georgios ^a   Roesgen, Jeff T ^a   Richardson, Eloise ^a   Demuth Jr , Thomas P ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Alkaline phosphatase assay; N Sulfonyl 2 indole carboxamides; Osteoporosis; PPAR

Indexed keywords

AMIDE; BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ARTICLE; CELL ASSAY; DRUG IDENTIFICATION; IC 50; OSTEOPOROSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TREATMENT INDICATION;

3T3 CELLS; AMIDES; ANIMALS; DRUG DESIGN; INDOLES; MICE; OSTEOPOROSIS; PPAR GAMMA;

EID: 33748873447     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.003     Document Type: Article

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