CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells

Immunology

Volumn 121, Issue 1, 2007, Pages 129-139

  Duggleby, Richard C ^a,b   Shaw, Tovah N F ^a   Jarvis, Lorna B ^a   Kaur, Gurman ^a   Hill Gaston, J S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Anergy suppression tolerance; Arthritis (including rheumatoid arthritis); Human studies; Phenotype cell markers; Regulatory T cells

Indexed keywords

CD27 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ANTIGEN EXPRESSION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; CELL ISOLATION; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTIVE ARTHRITIS; REGULATORY T LYMPHOCYTE;

ANTIGENS, CD27; ARTHRITIS, REACTIVE; BIOLOGICAL MARKERS; CELL LINE; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 34047238442     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02550.x     Document Type: Article

References (47)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22:531-62.
2. + regulatory T cells. Nat Immunol 2003; 4:330-6.
3. + T regulatory cells. Nat Immunol 2003; 4:337-42.
4. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-61.
5. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 2001; 166:3008-18.
6. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12:431-40.
7. Jaeckel E, von Boehmer H, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 2005; 54:306-10.
8. Gregori S, Giarratana N, Smiroldo S, Adorini L. Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol 2003; 171:4040-7.
9. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 2002; 169:4712-6.
10. Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology 2006; 117:289-300.
11. Annacker O, Powrie F. Homeostasis of intestinal immune regulation. Microbes Infect 2002; 4:567-74.
12. + T regulatory cells suppress Helicobacter hepaticus-induced colitis. J Exp Med 2002; 196:505-15.
13. R cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 2003; 197:111-9.
14. + T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur J Immunol 2002; 32:1282-91.
15. + regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 2002; 169:6298-308.
16. + T cells. J Immunol 2002; 169:3232-41.
17. + regulatory T cells control Leishmania major persistence and immunity. Nature 2002; 420:502-7.
18. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737-42.
19. Weiner HL. Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells. Immunol Rev 2001; 182:207-14.
20. high regulatory cells in human peripheral blood. J Immunol 2001; 167:1245-53.
21. + T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 2001; 31:1122-31.
22. + T cells with regulatory properties from human blood. J Exp Med 2001; 193:1303-10.
23. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193:1285-94.
24. + cells: a naturally occurring population of regulatory T cells. Blood 2001; 98:2736-44.
25. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193:1295-302.
26. + regulatory T cells. J Exp Med 2001; 194:847-53.
27. Mantel PY, Ouaked N, Ruckert B, Karagiannidis C, Welz R, Blaser K, Schmidt-Weber CB. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 2006; 176:3593-602.
28. +/ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-86.
29. - cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J Immunol 2004; 172:5213-21.
30. - T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004; 172:5149-53.
31. high regulatory T cells. Blood 2004; 104:895-903.
32. + T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 2004; 104:453-61.
33. + regulatory T cells suppress effector T cell proliferation. Clin Immunol 2005; 115:3-9.
34. + regulatory T cells ex vivo. Blood 2003; 102:2180-6.
35. + regulatory T cells in inflamed synovia. J Exp Med 2005; 201:1793-803.
36. + T cells with a regulatory phenotype and function. Eur J Immunol 2005; 35:2896-908.
37. + regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004; 6:R335-46.
38. + regulatory T cells. J Immunol 2004; 172:5986-93.
39. + T helper cells. J Exp Med 2002; 196:255-60.
40. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J Exp Med 2002; 196:247-53.
41. + T helper cells. Eur J Immunol 2004; 34:1303-11.
42. + T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant 2004; 4:65-78.
43. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999; 99:23-33.
44. Iezzi G, Scheidegger D, Lanzavecchia A. Migration and function of antigen-primed nonpolarized T lymphocytes in vivo. J Exp Med 2001; 193:987-93.
45. Fritsch RD, Shen X, Sims GP, Hathcock KS, Hodes RJ, Lipsky PE. Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J Immunol 2005; 175:6489-97.
46. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-700.
47. + T reg cells. J Exp Med 2006; 203:1701-11.