Composition variability in soy-derived dietary supplements designated for menopausal symptom prevention

OCL - Oleagineux Corps Gras Lipides

Volumn 13, Issue 5, 2006, Pages 352-362

  Hubert, Jane ^a,b   Paul, François ^a   Dayde, Jean ^b   Berger, Monique ^b  

^a Genibio Recherche   (France)

^b CNRS   (France)

Author keywords

Dietary supplement; Isoflavones; Soy germ; Soyasaponins

Indexed keywords

EID: 34047226946     PISSN: 12588210     EISSN: None     Source Type: Journal    
DOI: 10.1684/ocl.2006.0007     Document Type: Article

References (78)

1. BRYANT M, CASSIDY A, HILL C, POWELL J, TALBOT D, DYE L. Effect of consumption of soy isoflavones on behavioural, somatic and affective symptoms in women with premenstrual syndrome. Br J Nutr 2005; 93: 731-9.
2. ZHANG Y, WANG G-J, SONG T, MURPHY PA, HENDRICH S. Differences in disposition of the soybean isoflavones, glycitein, daidzeine and genistein in human with moderate fecal isoflavone degradation activity. J Nutr 1999; 129:957-62.
3. ALEKEL DL, ST GERMAIN A, PETERSON CT, HANSON KB, STEWART JW, TODA T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am j Clin Nutr 2000; 72: 844-52.
4. MASKARINEC G, FRANKE AA, WILLIAMS AE, et al. Effects of a 2-year randomized soy intervention on sex hormone levels in premenopausal women. Cone Epidemiol Biomark Prev 2004; 13:1736-44.
5. VALACHOVICOVAT, SLIVOVAV, BERGMAN H, SHUHERK J, SLIVAD. Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappa B/AP-1 -dependent and -independent pathways. Int J Oncol 2004; 25:1389-95.
6. ZHENG W, DAI Q, CUSTER LJ, et al. Urinary Excretion of Isoflavonoids and the Risk of Breast Cancer. Canc Epidemiol Biomark Prev 1999; 8: 35-40.
7. ROWLAND I. Soy and colorectal cancer. In: Descheemaeker K, Debruyne I, eds. Soy and Health 2000. Tiensesteenweg 91/3010 Leuven/Belgium: Garant Publishers, 2001: 55-60.
8. LI YW, AHMED F, ALI S, PHILIP PA, KUCUK O, SARKAR FH. Inactivation of nuclear factor kappa B by soy isoflavone genistein contributes to increased apoptosis mduced by chemotherapeutic agents in human cancer cells. Concer Res 2005; 65: 6934-42.
9. WISEMAN H, O'REILLY JD, ADLERCREUTZ H, et al. Isoflavone phytoestrogens consumed in soy decrease F-2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 2000; 72: 395-400.
10. SIMONS AL, RENOUF M, HENDRICH S, MURPHY PA. Human gut microbial degradation of flavonoids: Structure-function relationships. J Agric Food Chem 2005; 53:4258-63.
11. SUETSUGI M, SU LL, KARLSBERG K, YUAN YC, CHEN S. Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res 2003; 1:981-91.
12. LACOMBE S, THÉODOROU-BAYLE V, LA DROITTE P, DAYDÉ J. Les isoflavones du soja dans la filière aliment santé. OCL 2000; 7: 287-94.
13. UZZAN M, LABUZA TP. Critical Issues in R&D of Soy Isoflavone - enriched Foods and Dietary Supplements. J food Sci 2004; 49: 77-86.
14. JACKSON CJC, DINI JP, LAVANDIER C, et al. Effects of processing on the content and composition of isoflavones during manufacturing of soy beverage and tofu. Proc Biochem 2002; 37:1117-23.
15. FRANKE AA, HANKIN JH, YU MC, MASKARINEC G, LOW SH, CUSTER LJ. Isoflavone levels in soy foods consumed by multiethnic populations in Singapore and Hawaii. J Agric Food Chem 1999; 47:977-86.
16. UMPHRESS ST, MURPHY SP, FRANKE AA, CUSTER LJ, BLITZ CL. Isoflavone content of foods with soy additives. J Food Comp Anal 2005; 18: 533-50.
17. SETCHELL KDR, COLE SJ. Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling. J Agric Food Chem 2003; 51:4146-55.
18. WILLIAMSON-HUGHES P, FLICKINER B, MESSINA M, EMPIE M. Isoflavone supplements predominantly containing genistin/genistein reduce hot flushes: A critical analysis of published studies. Proceedings of the 6th Int. symp. on the role of soy in preventing and treating chronic disease. Chicago, IL USA, Oct. 30-Nov 2, 2005.
19. ERDMAN JW, BADGER TM, LAMPE JW, SETCHELL KDR, MESSINA M. Not all soy products are created equal: Caution needed in interpretation of research results. J Nutr 2004; 134:1229S-1233S.
20. CASSIDY A, BROWN JE, HAWDON A, et al. Factors affecting the bioavallability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 2006; 136:45-51.
21. SETCHELL KDR, BROWN NM, DESAI P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 2001 ; 131:1362S-1375S.
22. OAKENFULL D. Soy protein, saponins and plasma cholesterol. J Nutr 2001; 131:2971.
23. POTTER S, BAUM J, TENG H, STILLMAN R, SHAY N, ERDMAN J. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998; 68:1375S-1379S.
24. DECROOS K, VINCKEN JP, HENG L, BAKKER R, GRUPPEN H, VERSTRAETE W. Simultaneous quantification of differently glycosylated, acetylated, and 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one-conjugated soyasaponins using reversed-phase high-performance liquid chromatography with evaporative light scattering detection. J Chromatogr A 2005; 1072:185-93.
25. OKUBO K, IJIMA M, KOBAYASHI K, YOSHIKOSHI M, UCHIDAT, KUDOU S. Components responsible for the undesirable taste of soybean seeds. Biosci Biotechnol Biochem 1992; 56: 99-103.
26. LASZTITY R, HIDEVEGI M, BATA A. Saponins in food, food Rev Int 1998; 14: 371-90.
27. SHIRAIWA M, HARADA K, OKUBO K. Composition and structure of "Group B Saponin" in soybean seed. Agric Biol Chem 1991 ; 55: 911-7.
28. KUDOU S, TONOMURA M, TSUKAMOTO C, et al. Isolation and structural elucidation of DDMP-Conjugated soyasaponins as genuine saponins from soybean seeds. Biosci Biotechnol Biochem 1993; 57:546-50.
29. TSUKAMOTO C, SHIMADAS, IGITAK, et al. Factors affecting isoflavone content in soybean seeds: changes in isoflavones, saponins, and composition of fatty acids at different temperatures during seed development, J Agric Food Chem 1995; 43:1184-92.
30. RUPASINGHE HPV, JACKSON CJC, POYSAV, BERARDO C. DI, Bewley JD, Jenkinson J. Soyasapogenol A and B distribution in soybean (Glycine max L. Merr.) in relation to seed physiology, genetic variability, and growing location. J Agric Food Chem 2003; 51: 5888-94.
31. LEE SO, SIMONS AL, MURPHY PA, HENDRICH S. Soyasaponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters. Exp Biol Med 2005; 230: 472-8.
32. KINJO J, IMAGIRE M, UDAYAMA M, ARAO T, NOHARA T. Studies on the hepatoprotective drugs part 3 - Studies on the constituents of the leguminous plants part 56 - Structure-hepatoprotective relationships study of soyasaponins I-IV having soyasapogenol B as aglycone. Planta Med 1998; 64: 233-6.
33. CURFINKEL DM, RAO AV. Soyasaponins: The relationship between chemical structure and colon anticarcinogenic activity. Nutr Cancer 2003; 47: 24-33.
34. BENATTI P, PELUSO G, NICOLAI R, CALVANI M. Polyunsaturated fatty acids: Biochemical, nutritional and epigenetic properties. J Am Coll Nutr 2004; 23: 281-302.
35. CAMPAGNOLI C, ABBA C, AMBROGGIO S, PERIS C, PERONA M, SANSEVERINO P. Polyunsaturated fatty acids (PUFAs) might reduce hot flushes: an indication from two controlled trials on soy isoflavones alone and with a PUFA supplement. Maturitas 2005; 51:127-34.
36. HUI YH. Soybean oil, in Bailey's Industrial Oil and Fat Products. In: Hui YH, ed. Edible Oil and Fat Products: Oils and Oil Seeds. New York: John Wiley & Sons, 1996:497-601.
37. SCHRYVER T. Increasing health benefits using soy germ. Cereal Foods World 2002; 47:185-8.
38. LOVATI MR, MANZONI C, CIANAZZA E, et al. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells. J Nutr 2000; 130: 2543-9.
39. SIRTORICR, LOVATI MR. Soy proteins and cardiovascular disease. Curr Ather Rep 2001; 3:47-53.
40. DE LUMEN BO. Lunasin: A cancer-preventive soy peptide. Nutr Rev 2005; 63:16-21.
41. OHTA A, UEHARA M, SAKAI K, et al. Combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice. J Nutr 2002; 132: 2048-54.
42. SMIRICKYMR, GRIESHOPCM, ALBIN DM, WUBBEN JE, GABERTVM, FAHEY GC. The influence of soy oligosaccharides on apparent and true ileal amino acid digestibilities and fecal consistency in growing pigs. J Anim Sci 2002; 80: 2433-41.
43. MURPHY PA, SONG T, BUSEMAN G, et al. Isoflavones in retail and institutional soy foods. J Agric Food Chem 1999; 47: 2697-704.
44. HUBERT J, BERGER M, DAYDE J. Use of a simplified HPLC-UV analysis for soyasaponin B determination: Study of saponin and isoflavone variability in soybean cultivars and soy-based health food products. J Agric Food Chem 2005; 53: 3923-30.
45. HUBERT J, BERGER M, DAYDE J. Validation of a high-performance liquid chromatography-ultraviolet method to quantify soy sapogenols A and B in soy germs from different cultivars and in soy isoflavone-enriched supplements. J food So 2005; 70: C471-C477.
46. BUCKEE GK. Determination of total nitrogen in Barley, Malt and Beer by Kjeldahl procedures and the DUMAS combustion method. Collaborative trial. J Inst Brew 1994; 100:57-64.
47. DAYDÉ J, BERGER M, THEODOROU V. Screening and breeding soybeans for isoflavone content and composition. Proceedings of the IV International Soybean Processing and Utilization Conference (ISPUCIV). Feb 29-Mar 5, Foz do Iguassu, PR, Brasil, Embrapa. 2004.
48. RICKERT DA, JOHNSON LA, MURPHY PA. Improved fractionation of glycinin and beta-conglycinin and partitioning of phytochemicals. J Agric Food Chem 2004; 52:1726-34.
49. KING RA, BURSILL DB. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 1998; 67: 867-72.
50. WATANABES, YAMAGUCHI M, SOBUET, et al. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (Kinako). J Nutr 1998; 128:1710-5.
51. IZUMI T, PISKULA MK, OSAWA S, et al. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. Journal of Nutrition 2000; 130:1695-9.
52. DE PASCUAL-TERESA S, HALLUND J, TALBOT D, et al. Absorption of isoflavones in humans: effects of food matrix and processing. J Nutr Biochem 2005; OnlineFirst. doi: 10.1016/j.jnutbio.2005.04.008.
53. BENNETAU-PELISSERO C, ARNAL-SCHNEBELEN B, LAMOTHE V, et al. ELISA as a new method to measure genistein and daidzein in food and human fluids. Food Chem 2003; 82: 645-58.
54. HU J, LEE SO, HENDRICH S, MURPHY PA. Quantification of the group B soyasaponins by high-performance liquid chromatography. J Agrk Food Chem 2002; 50: 2587-94.
55. SHIMOYAMADA M, HARADA K, OKUBO K. Saponin composition in developing soybean seeds (Glycine max (L.) Merrill, cv. Mikuriyaao). Agric Biol Chem 1991; 55:1403-5.
56. SHI J, ARUNASALAM K, YEUNC D, KAKUDA Y, MITTAL G, JIANG Y. Saponins from edible legumes: Chemistry, processing, and health benefits. J Med Food 2004; 7: 67-78.
57. WALKER M. In: Soybean isoflavones lower risk of degenerative diseases. Townsend Lett. Doct. Patients, 1994: 374-8.
58. KILARA A. Harwaler VR Denaturation. In: Nakai S, Modler H, eds. Food Proteins-Properties and characterization. New York: VCH, 1996: 71 -165.
59. DURANTI M, LOVATI MR, DANIV, et al. The {alpha}' Subunit from Soybean 7S Globulin Lowers Plasma Lipids and Upregulates Liver (beta)-VLDL Receptors in Rats Fed a Hypercholesterolemic Diet. J Nutr 2004; 134:1334-9.
60. HOIE LH, CRAUBAUM HJ, HARDE A, GRUENWALD J, WERNECKE KD. Lipidlowering effect of 2 dosages of a soy protein supplement in hypercholesterolemia. Adv Ther 2005; 22:175-86.
61. NAGATA C, TAKATSUKA N, KURISU Y, SHIMIZU H. Decreased serum total cholesterol concentration associated with high intake of soy products in Japanese men and women. J Nutr 1998; 128: 209-13.
62. HE J, GU DF, WU XG, et al. Effect of soybean protein on blood pressure: A randomized, controlled trial. Ann Intern Med 2005; 143:1-9.
63. MERZ-DEMLOW BE, DUNCANAM, WANGEN KE, et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 2000; 71:1462-9.
64. TIKKANEN MJ, WÄHÄLÄ K, OJALA S, VIHMA V, ADLERCREUTZ H. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA 1998; 95: 3106-10.
65. CROUSE JR, MORGAN T, TERRY JG, ELLIS J, VITOLINS M, BURKE GL. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 1999; 159: 2070-6.
66. SHIMOYAMADA M, IKEDO S, OOTSUBO R, WATANABE K. Effects of soybean saponins on chymotryptic hydrolyses of soybean proteins. J Agric Food Chem 1998; 46: 4793-7.
67. DEMAISON L, MOREAU D. Dietary n-3 polyunsaturated fatty acids and coronary heart disease-related mortality: a possible mechanism of action. Cell Mol Life Sci 2002; 59:463-77.
68. HYMOWITZ T, COLLINS FI, PANCZER J, WALCKERWM. Relationship between the content of oil, protein, and sugar in soybean seed. Agnon J 1972; 64: 613-6.
69. TOMOMATSU H. Health effects of oligosaccharides. Food Technol 1994; 48: 61-5.
70. ALI AA, VELASQUEZ MT, HANSEN CT, MOHAMED AI, BHATHENA SJ. Modulation of carbohydrate metabolism and peptide hormones by soybean isoflavones and probiotics in obesity and diabetes. J Nutr Biochem 2005; 16:693-9.
71. ARORA A, NAIR MG, STRASBURG GM. Antioxidant activities of isoflavones and their biological metabolites in a liposomal system. Arch Biochem Biophys 1998; 356:133-41.
72. MITCHELL JH, GARDNER PT, MCPHAIL DB, MORRICE PC, COLLINS AR, DUTHIE GG. Antioxidant efficacy of phytoestrogens in chemical and biological model systems. Arch Biochem Biophys 1998; 360:142-8.
73. LAMPE JW, KARR SC, HUTCHINS AM, SLAVIN JL. Urinary equol excretion with a soy challenge: Influence of habitual diet. Proc Soc Exp Biol Med 1998; 217:335-9.
74. ROWLAND I, WISEMAN H, SANDERS T, ADLERCREUTZ H, BOWEY E. Metabolism of oestrogens and phytoestrogens: role of the gut microflora. Biochem Soc Trans 1999; 27: 304-8.
75. SLAVIN JL. Health benefits of oligosaccharides. J Nutrac Fund Med Foods 1999; 1:43-55.
76. TAMURA M, HIRAYAMA K, ITOH K. Effects of soy oligosaccharides on plasma and cecal isoflavones, and cecal enzyme activities in mice. J Nutr Sci Vitaminol (Tokyo) 2003; 49:168-71.
77. YAMKA RM, HARMON DL, SCHOENHERR WD, et al. In vivo measurement of flatulence and nutrient digestibility in dogs fed poultry by-product meal, conventional soybean meal, and low-oligosaccharide low-phytate soybean meal. Am J Vet Res 2006; 67: 88-94.
78. KOBAYASHI M, MATSUSHITA H, TSUKIYAMA R, SAITO M, SUCITA T. Shoyu polysaccharides from soy sauce improve quality of life for patients with seasonal allergic rhinitis: a double-blind placebo-controlled clinical study. Int J Mol Med 2005; 15:463-7.