Transporters as channels

Annual Review of Physiology

Volumn 69, Issue , 2007, Pages 87-112

  DeFelice, Louis J ^a   Goswami, Tapasree ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Biophysics; Membrane; Neuroscience; Synapse

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMPHETAMINE; COCAINE; DOPAMINE TRANSPORTER; GLUCOSE TRANSPORTER; GLUTAMATE TRANSPORTER; METAL ION; METHAMPHETAMINE; NORADRENALIN TRANSPORTER; PALYTOXIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SODIUM CALCIUM EXCHANGE PROTEIN;

CELL METABOLISM; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; TRANSPORT KINETICS;

ANIMALS; CARRIER PROTEINS; HUMANS; ION CHANNELS; METALS; NEUROTRANSMITTER TRANSPORT PROTEINS; POTASSIUM CHANNELS; SYNAPTIC TRANSMISSION;

EID: 33947305641     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.69.031905.164816     Document Type: Review

References (111)

1. + channel voltage sensor measured with luminescence energy transfer. Nature 436:848-51
2. + channel. Nature 423:33-41
3. DeFelice LJ. 2004. Transporter structure and mechanism. Trends Neurosci. 27:352-59
4. Gu H, Wall SC, Rudnick G. 1994. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J. Biol. Chem. 269:7124-30
5. Gu HH, Wall S, Rudnick G. 1996. Ion coupling stoichiometry for the norepinephrine transporter in membrane vesicles from stably transfected cells. J. Biol. Chem. 271:6911-16
6. Bruns D, Engert F, Lux HD. 1993. A fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo. Neuron 10:559-72
7. Lauger P. 1991. Electronic Ion Pumps. Sunderland, MA: Sinauer
8. DeFelice LJ. 1992. Ion pumps as stochastic machines. Cell 70:9-10
9. Moore RE, Scheuer PJ. 1971. Palytoxin: a new marine toxin from a coelenterate. Science 172:495-98
10. Ikeda M, Mitan K, Ito K. 1988. Palytoxin induces a nonselective cation channel in single ventricular cells of rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 337:591-93
11. +-ATPase. Toxicon 27:1171-87
12. Artigas P, Gadsby DC. 2003. Na/K-pump ligands modulate gating of palytoxin-induced ion channels. Proc. Natl. Acad. Sci. USA 100:501-5
13. Artigas P, Gadsby DC. 2004. Large diameter of palytoxin-inclnced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands. J. Gen. Physiol. 123:357-76
14. Hilgemann DW. 1994. Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches. Science 263:1429-32
15. Lu CC, Kabakov A, Markin VS, Mager S, Frazier GA, Hilgemann DW. 1995. Memhrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp. Proc. Natl. Acad. Sci. USA 92:11220-24
16. 2+ exchange current magnitudes determined from channel-like noise and charge movements of ion transport. Biophys. J. 71:759-68
17. 2+ exchanger. Nature 427:544-48
18. 2+ exchange in giant excised sarcolemmal membrane patches. Nature 344:242-45
19. Hilgemann DW, Lu CC. 1998. Giant membrane patches: improvements and applications. Methods Enzymol. 293:267-80
20. 2+ exchanger. Nature 352:715-18
21. 2+] during the cardiac action potential. Circ. Res. 90:182-89
22. Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. 2004. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys. J. 87:3351-71
23. Brasnjo G, Otis TS. 2001. Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression. Neuron 31:607-16
24. Dzubay JA, Otis TS. 2002. Climbing fiber activation of metabotropic glutamate receptors on cerebellar Purkinje neurons. Neuron 36:1159-67
25. Otis TS, Kavanaugh MP. 2000. Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2. J. Neurosci. 20:2749-57
26. Otis TS, Kavanaugh MP, Jahr CE. 1997. Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse. Science 277:1515-18
27. Larsson HP, Picaud SA, Werblin FS, Lecar H. 1996. Noise analysis of the glutamate-activated current in photoreceptors. Biophys. J. 70:733-42
28. Blakelv RD, Robinson MB, Amara SG. 1988. Expression of neurotransmitter transport from rat brain mRNA in Xenopus laevis oocytes. Proc. Natl. Acad. Sci. USA 85:9846-50
29. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. 1995. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375:599-603
30. Widiche JI, Amara SG, Kavanaugh MP. 1995. Ion fluxes associated with excitatory amino acid transport. Neuron 15:721-28
31. Wacliche JI, Arriza JL, Amara SG, Kavanaugh MP. 1995. Kinetics of a human glutamate transporter. Neuron 14:1019-27
32. Wadiche JI, Kavanaugh MP. 1998. Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J. Neurosci. 18:7650-61
33. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG. 1997. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 94:4155-60
34. Rothstein JD, Kuncl RW. 1995. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J. Neurochem. 65:643-51
35. Bergles DE, Tzingounis AV, Jahr CE. 2002. Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters. J. Neurosci. 22:10153-62
36. Bergles DE, Dzubay JA, Jahr CE. 1997. Glutamate transporter currents in Bergmann glial cells follow the time course of extrasynaptic glutamate. Proc. Natl. Acad. Sci. USA 94:14821-25
37. Wong AY, Fay AM, Bowie D. 2006. External ions are coactivators of kainate receptors. J. Neurosci. 26:5750-55
38. Cunningham P, Afzal-Ahmed I, Naftalin RJ. 2006. Docking studies show that D-glucose and quercetin slide through the transporter GLUT1. J. Biol. Chem. 281:5797-803
39. Hediger MA, Ikeda T, Coady M, Gundersen CB, Wright EM. 1987. Expression of size-selected mRNA encoding the intestinal Na/glucose cotransporter in Xenopus laevis oocytes. Proc. Natl. Acad. Sci. USA 84:2634-37
40. + and glucose transport. Proc. Natl. Acad. Sci. USA 95:7789-94
41. + channel. J. Biol. Chem. 276:1728-34
42. +/glucose transporter (hSGLT1) in bacterial membrane vesicles. Biochemistry 42:9147-52
43. Apparsundaram S, Ferguson SM, George AL Jr, Blakely RD. 2000. Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. Biochem. Biophys. Res. Commun. 276:862-67
44. -, and pH dependence of the human choline transporter in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. J. Neurosci. 26:9851-59
45. Axelrod J, Kopin IJ. 1969. The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves. Prog. Brain Res. 31:21-32
46. Cammack JN, Rakhilin SV, Schwartz EA. 1994. A GABA transporter operates asymmetrically and with variable stoichiometry. Neuron 13:949-60
47. Cammack JN, Schwartz EA. 1996. Channel behavior in a γ- aminobutyrate transporter. Proc. Natl. Acad. Sci. USA 93:723-27
48. Galli A, Blakely RD, DeFelice LJ. 1996. Norepinephrine transporters have channel modes of conduction. Proc. Natl Acad. Sci. USA 93:8671-76
49. Lin F, Lester HA, Mager S. 1996. Single-channel currents produced by the serotonin transporter and analysis of a mutation affecting ion permeation. Biophys. J. 71:3126-35
50. Carvelli L, McDonald PW, Blakely RD, DeFelice LJ. 2004. Dopamine transporters depolarize neurons by a channel mechanism. Proc. Natl. Acad. Sci. USA 101:16046-51
51. Lester HA, Mager S, Quick MW, Corey JL. 1994. Permeation properties of neurotransmitter transporters. Annu. Rev. Pharmacol. Toxicol. 34:219-49
52. Lester HA, Cao Y, Mager S. 1996. Listening to neurotransmitter transporters. Neuron 17:807-10
53. DeFelice LJ, Blakely RD. 1996. Pore models for transporters? Biophys. J. 70:579-80
54. Sonders MS, Amara SG. 1996. Channels in transporters. Curr. Opin. Neurobiol, 6:294-302
55. Su A, Mager S, Mayo SL, Lester HA. 1996. A multi-substrate single-file model for ion-coupled transporters. Biophys. J. 70:762-77
56. DeFelice LJ, Adams SV, Ypey DL. 2001. Single-file diffusion and neurotransmitter transporters: Hodgkin and Keynes model revisited. Biosystems 62:57-66
57. Adams SV, DeFelice LJ. 2002. Flux coupling in the human serotonin transporter. Biophys. J. 83:3268-82
58. Adams SV, DeFelice LJ. 2003. Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis. Biophys. J. 85:1548-59
59. Hodgkin AL, Keynes RD. 1955. The potassium permeability of a giant nerve fibre. J. Physiol. 128:61-88
60. + conduction and selectivity. Science 280:69-77
61. Hodgkin A. 1994. Chance and Design: Reminiscences of Science in Peace and War. Cambridge, UK: Cambridge Univ. Press
62. Blakely RD, Berson HE, Fremeau RT Jr, Caron MG, Peek MM, et al. 1991. Cloning and expression of a functional serotonin transporter from rat brain. Nature 354:66-70
63. Ramamoorthy S, Cool DR, Mahesh VB, Leibach FH, Melikian HE, et al. 1993. Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. J. Biol. Chem. 268:21626-31
64. Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, et al. 1998. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biol. Psychiatry 44:169-78
65. Rudnick G, Wall SC. 1992. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: Serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl. Acad. Sci. USA 89:1817-21
66. Keyes SR, Rudnick G. 1982. Coupling of transmembrane proton gradients to platelet serotonin transport. J. Biol. Chem. 257:1172-76
67. Galli A, Petersen CI, deBlaquiere M, Blakely RD, DeFelice LJ. 1997. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. J. Nenrosci. 17:3401-11
68. Petersen CI, DeFelice LJ. 1999. Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nat. Neurosci. 2:605-10
69. Mager S, Min C, Henry DJ, Chavkin C, Hoffman BJ, et al. 1994. Conducting states of a mammalian serotonin transporter. Neuron 12:845-59
70. Quick MW. 2003. Regulating the conducting states of a mammalian serotonin transporter. Neuron 40:537-49
71. Galli A, Blakely RD, DeFelice LJ. 1998. Patch-clamp and amperometric recordings from norepinephrine transporters: channel activity and voltage-dependent uptake. Proc. Natl. Acad. Sci. USA 95:13260-65
72. Galli A, DeFelice LJ, Duke BJ, Moore KR, Blakely RD. 1995. Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter- transfected HEK-293 cells blocked by cocaine and antidepressants. J. Exp. Biol. 198(Pt. 10):2197-212
73. Kahlig KM, Javitch JA, Galli A. 2003. Amphetamine regulation of dopamine transport: Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier. J. Biol. Chem. 279:8966-75
74. Khoshbouei H, Sen N, Guptaroy B, Johnson L, Lund D, et al. 2004. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS Biol. 2:E78
75. +-dependent mechanism. J. Biol. Chem. 278:12070-77
76. Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, et al. 2005. Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc. Natl. Acad. Sci. USA 102:3495-500
77. Ingram SL, Prasad BM, Amara SG. 2002. Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nat. Neurosci. 5:971-78
78. Gunshin FI, Mackenzie B, Berger UV, Gunshin Y, Romero MF, et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-88
79. +-coupled iron uptake with concomitant uncoupled cation currents. J. Biol. Chem. 274:35089-94
80. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi II, et al. 1999. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J. Biol. Chem. 274:22739-46
81. Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. 2004. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2:E50
82. Kaplan J, Jordan I, Sturrock A. 1991. Regulation of the transferrin-independent iron transport system in cultured cells. J. Biol. Chem. 266:2997-3004
83. +/bivalent cation antiporter. Biochem. J. 354:511-19
84. Wang T, Weinman SA. 2004. Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin. Gastroenterology 126:1157-66
85. Aller SG, Unger VM. 2006. Projection structure of the human copper transporter CTR1 at 6-Å resolution reveals a compact trimer with a novel channel-like architecture. Proc. Natl. Acad. Sci. USA 103:3627-32
86. - channels. J. Gen. Physiol. 123:109-19
87. - channels. Nature 427:803-7
88. Iyer R, Iverson TM, Accardi A, Miller C. 2002. A biological role for prokaryotic ClC chloride channels. Nature 419:715-18
89. Gadsby DC. 2004. Ion transport: Spot the difference. Nature 427:795-97
90. Lindley D. 2001. Boltzmann's Atom: The Great Debate that Launched a Revolution in Physics. New York: Free Press
91. Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. 2002. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415:287-94
92. Dutzler R, Campbell EB, MacKinnon R. 2003. Gating the selectivity filter in ClC chloride channels. Science 300:108-12
93. Widdas WF. 1952. Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer. J. Physiol. 118:23-39
94. Jardetzky O. 1966. Simple allosteric model for membrane pumps. Nature 211:969-70
95. DeFelice LJ. 2004. Going against the flow. Nature 432:279
96. - dependent neurotransmitter transporters. Nature 437:215-23
97. Miller C. 2006. ClC chloride channels viewed through a transporter lens. Nature 440:484-89
98. Hille B. 2001. Ion Channels of Excitable Membranes. Sunderland, MA: Sinauer. 3rd ed.
99. DeFelice LJ. 1981. Introduction to Membrane Noise. New York: Plenum
100. Hodgkin AL, Horowicz P. 1959. The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J. Physiol. 148:127-60
101. Hodgkin AL, Horowicz P. 1959. Movements of Na and K in single muscle fibres. J. Physiol. 145:405-32
102. Starace DM, Bezanilla F. 2004. A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427:548-52
103. Ramsey IS, Moran MM, Chong JA, Clapham DE. 2006. A voltage-gated proton-selective channel lacking the pore domain. Nature 440:1213-16
104. + channel. J. Gen. Physiol. 117:469-90
105. Starace DM, Bezanilla F. 2004. A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427:548-53
106. Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback HR. 2003. The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. FEBS Lett. 555:96-101
107. Yernool D, Boudker O, Jin Y, Gouaux E. 2004. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature 431:811-18
108. Khademi S, O'Connell J 3rd, Remis J, Robles-Colmenares Y, Miereke LJ, Stroud RM. 2004. Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 Å. Science 305:1587-94
109. Ferguson SM, Blakely RD. 2004. The choline transporter resurfaces: new roles for synaptic vesicles? Mol. Interv. 4:22-37
110. Henry LK, DeFelice LJ, Blakely RD. 2006. Getting the message across: A recent transporter structure shows the way. Neuron 49:791-96
111. Nelson N, Sacher A, Nelson H. 2002. The significance of molecular slips in transport systems. Nat. Rev. Mol. Cell Biol. 3:876-81