Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter

Biochemical Journal

Volumn 354, Issue 3, 2001, Pages 511-519

  Goswami, T ^a   Bhattacharjee, A ^a   Babal, P ^a   Searle, S ^a   Moore, E ^a   Li, M ^a   Blackwell, J M ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Infection; Metal ion transporter; Nramp1

Indexed keywords

ACTIVATION ANALYSIS; DISEASES; PH; POSITIVE IONS; RNA;

INFECTIOUS DISEASES; MACROPHAGE PROTEINS; TRANSPORTER ACTIVITY;

PROTEINS;

ANTIPORTER; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CELL PROTEIN; MACROPHAGE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; ENDOSOME; FEMALE; HOST RESISTANCE; INFECTION; ISOTOPE LABELING; LYSOSOME MEMBRANE; MACROPHAGE; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTON TRANSPORT; XENOPUS;

ANIMALS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CATIONS, DIVALENT; ELECTRIC CONDUCTIVITY; FEMALE; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; ION PUMPS; ION TRANSPORT; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTONS; SUBSTRATE SPECIFICITY; XENOPUS;

ANIMALIA; EUKARYOTA; MAMMALIA; MURINAE; PROKARYOTA;

EID: 0035868324     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540511     Document Type: Article

References (54)

1. Genetic regulation of macrophage activation: Understanding the function of Nramp1 (= Ity/Lsh/Bcg)
2. Understanding the multiple functions of Nramp1
3. Variation in the NRAMP1 gene is associated with susceptibility to tuberculosis in West Africans
4. Susceptibility to leprosy is linked to the human NRAMP1 gene
5. Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35
6. The natural resistance-associated macrophage protein gene is associated with Crohn's disease
7. Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis
8. Natural resistance to infections with intracellular pathogens: The Nramp1 protein is recruited to the membrane of the phagosome
9. Localisation of Nramp1 in macrophages: Modulation with activation and infection
10. Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg
11. Resistance to intracellular infections: Comparative genomic analysis of Nramp
12. Protein phylogenies provide evidence of a radical discontinuity between arthropod and vertebrate immune systems
13. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria
14. Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio
15. Malvolio, the Drosophila homologue of mouse Nramp1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour
16. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
17. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
18. The role of iron in Nramp1 mediated inhibition of mycobacterial growth
19. 2+ depletion blocks endosome fusion
20. Implication of phagosome-lysosome fusion in restriction of Mycobacterium avlum growth in bone marrow macrophages from genetically resistant mice
21. Host resistance to intracellular infection: Mutation of natural resistanceassociated macrophage protein 1 (Nramp1) impairs phagosomal acidification
22. Nramp1 transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: Influence on antigen processing and presentation
23. Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: Influence on oxidative burst and nitric oxide pathways
24. Isolation of plasma membrane complexes from Xenopus oocytes
25. Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene
26. Mutational anlaysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters
27. Natural resistance to intracellular infections: Natural resistance-associated macrophage protein 1 (NRAMP1) functions as a pH-dependent manganese transporter at the phagosomal membrane
28. Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family
29. Nramp2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein accessible cytoplasmic pool
30. Cellular and subcellular localization of the nramp2 iron transporter in the intestinal brush border and regulation by dietary iron
31. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
32. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
33. Metal ion transporters and homeostasis
34. Structural features of the uniporter/synporter/antiporter superfamily
35. Energizing porters by proton-motive force
36. Membrane transport proteins: Implications of sequence comparisons
37. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
38. Nucleotide and deduced protein sequences of the class D tetracycline resistance determinant: Relationship to other antimicrobial transport proteins
39. Ectopic expression of Nramp1 in COS-1 cells modulates iron accumulation
40. Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169
41. Evidence for a link between iron metabolism and Nramp1 gene mediated inhibition of mycobacterial growth
42. Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress
43. Effects of iron- and hemoglobin-loaded human monocyte-derived macrophages on oxidation and uptake of LDL
44. Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis
45. The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms
46. Stabilized expression of mRNA is associated with mycobacterial resistance controlled by Nramp1
47. Quantitative photometrical assessment of iron deposits in synovial membranes in different joint diseases
48. The roles of inflammation and iron deficiency as causes of anemia
49. Pathogenesis and treatment of the anemia of chronic disease
50. Nramp1 is expressed in neurones and is associated with behavioural and immune responses to stress
51. Iron and ferritin in substantia nigra in Parkinson's disease
52. Altered brain metabolism of iron as a cause of neurodegenerative diseases?
53. Iron metabolism and Parkinson's disease
54. Amyloid precursor protein, copper and Alzheimer's disease