Unitary cardiac Na+,Ca2+ exchange current magnitudes determined from channel-like noise and charge movements of ion transport

Biophysical Journal

Volumn 71, Issue 2, 1996, Pages 759-768

  Hilgemann, Donald W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CALCIUM CURRENT; CHANNEL GATING; HEART MUSCLE FIBER MEMBRANE; ION EXCHANGE; ION TRANSPORT; OOCYTE; SODIUM CURRENT; SODIUM TRANSPORT; TRANSPORT KINETICS;

EID: 0029737545     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79275-5     Document Type: Article

References (40)

1. Cammack, J. N., S. V. Rakhilin, and E. A. Schwartz. 1994. A GABA transporter operates asymmetrically with variable stoichiometry. Neuron. 13:949-960.
2. Cammack, J. N., and E. A. Schwartz. 1996. Channel behavior in a gamma-aminobutyrate transporter. Proc. Natl. Acad. Sci. USA. 93:723-727.
3. Cheon, J., and J. P. Reeves. 1988. Site density of the sodium-calcium exchange carrier in reconstituted vesicles from bovine cardiac sarcolemma. J. Biol. Chem. 263:2309-2315.
4. 2+ exchange current by MgATP. J. Physiol. (Lond.). 454:37-57.
5. Decoursey, T. E., and V. V. Cherny. 1994. Voltage-activated hydrogen ion currents. J. Membr. Biol. 141:203-215.
6. DeFelice, L. J. 1981. Introduction to Membrane Noise. Plenum Press, New York.
7. DeFelice, L. J., and R. D. Blakely. 1996. Pore models for transporters? Biophys. J. 70:579-580.
8. Dempster, J. 1993. Computer Analysis of Electrophysiological Signals. Academic Press, London.
9. 2+ exchange current in single guinea-pig ventricular cells. J. Physiol. (Lond.). 410:227-249.
10. Fairman, W. A., R. J. Vandenberg, J. L. Arriza, M. P. Kavanaugh, and S. G. Amara. 1995. An excitatory amino acid transporter with properties of a ligand-gated chloride channel. Nature. 375:599-602.
11. Fidler, N., and J. M. Fernandez. 1989. Phase tracking: an improved phase detection technique for cell membrane capacitance measurements. Biophys. J. 56:1153-1162.
12. Galli, A., R. D. Blakely, and L. J. DeFelice. 1996. NETs have channel modes of conduction. Proc. Natl. Acad. Sci. USA. In press.
13. Hilgemann, D. W. 1994. Channel-like function of the Na, K pump probed at microsecond resolution in giant membrane patches. Science. 263: 1429-1432.
14. Hilgemann, D. W. 1995. The giant membrane patch. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 307-327.
15. Hilgemann, D. W. 1996. The cardiac sodium-calcium exchanger in giant membrane patches. Ann. N.Y. Acad. Sci. 779:136-158.
16. Hilgemann, D. W., and A. Collins. 1992. The mechanism of sodium-calcium exchange stimulation by ATP in giant cardiac membrane patches: possible role of aminophospholipid translocase. J. Physiol. (Lond.). 454:59-82.
17. Hilgemann, D. W., A. Collins, and S. Matsuoka. 1992a. Dynamic and steady state properties of cardiac sodium-calcium exchange: calcium-and ATP-dependent activation. J. Gen. Physiol. 100:933-961.
18. Hilgemann, D. W., S. Matsuoka, G. A. Nagel, and A. Collins. 1992b. Dynamic and steady state properties of cardiac sodium-calcium exchange: sodium-dependent inactivation. J. Gen. Physiol. 100: 905-932.
19. 2+ exchanger in giant excised membrane patches. Nature. 352: 715-719.
20. Kaczorowski, G. J., M. L. Barcia, V. F. King, and R. S. Slaughter. 1989. Development and use of inhibitors to study sodium-calcium exchange. In Sodium-Calcium Exchange. T. J. A. Allen, D. Noble, and H. Reuter, editors. Oxford University Press, New York. 66-101.
21. 2+ concentration jump. Ann. N.Y. Acad. Sci. 779:290-292.
22. 2+ exchanger. J. Biol. Chem. 270:16182-16188.
23. Larsson, H. J. P., S. A. Picaud, F. S. Werblin, and H. Lecar. 1996. Noise analysis of the glutamate-activated current in photoreceptors. Biophys. J. 70:733-742.
24. Läuger, P. 1987. Voltage dependence of sodium-calcium exchange: predictions from kinetic models. J. Membr. Biol. 99:1-12.
25. 2+ exchange in single cardiac cells of guinea pig. J. Gen. Physiol. 96: 777-788.
26. Lu, C.-C., A. Kabakov, S. Mager, V. Markin, G. Frazier, and D. W. Hilgemann. 1995. Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp. Proc. Natl. Acad. Sci. USA. 92:11220-11224.
27. Mager, S., C. Min, D. J. Henry, C. Chavkin, B. J. Hoffman, N. Davidson, and H. Lester. 1994. Conducting states of a mammalian serotonin transporter. Neuron. 12:845-859.
28. Matsuoka, S., and D. W. Hilgemann. 1992. Dynamic and steady state properties of cardiac sodium-calcium exchange: ion and voltage dependencies of transport cycle. J. Gen. Physiol. 100:962-1001.
29. Matsuoka, S., and D. W. Hilgemann. 1994. Inactivation of outward Na/Ca exchange current in guinea pig ventricular myocytes. J. Physiol. (Lond.). 476:443-458.
30. Nakao, M., and D. C. Gadsby. 1986. Voltage dependence of Na translocation by the Na/K pump. Nature. 323:628-630.
31. 2+ exchanger. Science. 250:562-565.
32. Niggli, E., and W. J. Lederer. 1991. Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature. 349: 621-623.
33. 2+ exchanger in guinea pig ventricular myocytes. J. Physiol. (Lond.). 472:45-53.
34. Schwartz, E. A., and M. Tachibana. 1990. Electrophysiology of glutamate and sodium cotranpsort in a glial-cell of the salamander retina. J. Physiol. (Lond.). 426:43-80.
35. 2+ exchanger to human chromosome 2p21-p23. Genomics. 12: 616.
36. Stein, W. D. 1986. Transport and Diffusion Across Cell Membranes. Academic Press, San Diego.
37. +/ glucose cotransporter expressed in Xenopus oocytes is electrogenic. Biophys. J. 57:1217-1224.
38. Yang, Y., and F. J. Sigworth. 1994. The conductance of MinK "channels" is very small. Biophys. J. 68:A22.
39. Zhaoping, L., D. A. Nicoll, D. W. Hilgemann, A. Collins, J. T. Penniston, J. Tomich, J. N. Weiss, and K. D. Philipson. 1991. Identification of a peptide inhibitor of the cardiac sarcolemmal Na/Ca Exchanger. J. Biol. Chem. 266:1014-1020.
40. 2- stores. Proc. Natl. Acad. Sci. USA. 90:6295-6300.