A multi-substrate single-file model for ion-coupled transporters

Biophysical Journal

Volumn 70, Issue 2 I, 1996, Pages 762-777

  Su, Alyce ^a   Mager, Sela ^b   Mayo, Stephen L ^b   Lester, Henry A ^b  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CARRIER PROTEIN; GLUCOSE TRANSPORTER; ION CHANNEL; SEROTONIN;

ACTIVE TRANSPORT; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; ION EXCHANGE; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSPORT KINETICS;

HUMULUS; ORYCTOLAGUS CUNICULUS;

EID: 0030051119     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79616-9     Document Type: Article

References (57)

1. Amara, S. G., and J. L. Arriza. 1993. Neurotransmitter ion-coupled transporters: three distinct gene families. Curr. Opin. Neurobiol. 3:337-344.
2. Andersen, O. S., J. E. N Silveira, and P. R. Steinmetz. 1985. Intrinsic characteristics of the proton pump in the luminal membrane of a tight unnary epithelium. The relation between transport rate and △μH. J. Gen. Physiol. 86:215-234.
3. Baldwin, S. A. 1993. Mammalian passive glucose ion-coupled transporters: members of an ubiquitous family of active and passive transport proteins. Biochim. Biophys. Acta. 1165:17-49.
4. Barnett, J. E. G., G. D. Holman, R. A. Chalkley, and K. A. Munday. 1975. Evidence for two asymmetric conformational states in the human erythrocyte sugar-transport system. Biochem. J. 145:417-429.
5. Cammack, J. N., S V. Rakhilin, and E. A. Schwanz. 1994. A GABA ion-coupled transporter operates asymmetrically and with variable stoichiometry. Neuron. 13:1-20.
6. Cammack, J. N., and E. A. Schwartz. 1993. Ions required for the electrogenic transport of GABA by horizontal cells of the catfish retina. J. Physiol. 473:81-102.
7. Cammack, J N., and E. A. Schwartz. 1995. Channel behavior in a GABA transporter. Proc. Natl. Acad. Sci. USA. In press.
8. Chen, D. P., and R. S. Eisenberg. 1993. Flux, coupling, and selectivity in ionic channels of one conformation. Biophys. J. 65:727-746.
9. Dani, J. A., and D. G. Levitt 1990. Diffusion and kinetic approaches to describe permeation in ionic channels. J. Theor. Biol. 146:289-301.
10. DeFelice, L. J., R. Galli, and D. Blakely. 1995. Current fluctuations in norepinephrine transporters. Biophys. J. 68:A232.
11. Dougherty, D. A. 1995. Cation-π interactions in chemistry and biology. Science, In press.
12. Eisenberg, R. S. 1994. Atomic biology, electrostatics, and ionic channels. In New Developments and Theoretical Studies of Proteins. Ron Elbor, editor World Scientific Publishing, Philadelphia. 1-116.
13. Franciolini, F., and W. Nonner. 1994, A multiion permeation mechanism in neuronal background chloride channels. J. Gen. Physiol. 104:725-746
14. Frolhich, O. 1988. The "tunneling" mode of biological carrier-mediated transport. J. Membr. Biol. 101:189-198.
15. Gadsby, D. C., R. F. Rakowski, and P. De Weer. 1993. Extracellular access to the Na. K pump: pathway similar to ion channel. Science 260:100-103.
16. Galli, A., L. DeFelice, B.-J. Duke, K. R. Moore, and R. D. Blakely. 1995. Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antide-pressants. J. Exp. Biol. 198:2197-2212.
17. Guastella, J. H., N. Nelson, H. Nelson, L. Czyzyk, S. Keynan, M. C. Midel, N. Davidson, H. Lester, and B. Kanner. 1990. Cloning and expression of a rat brain GABA ion-coupled transporter. Science. 249:1303-1306.
18. Harvey, W. R., and C. L. Slayman. 1994. Coupling as a way of life. J. Exp. Biol. 196 (Transporters): 1-4.
19. Hasegawa, H., W Skach, O. Baker, M C., Calayag, V. Lingappa, and A. S. Verkman 1992. A multifunctional aqueous channel formed by CFTR. Science. 258:1477-1479.
20. Hernandez, J. A., and J. Fischbarg. 1994. Transport properties of single-file pores with two conformational states. Biophys. J. 67:996-1006.
21. 2+ exchanger. Nature. 352:715-718.
22. Hill, T. L. 1977. Free Energy Transduction m Biology. Academic Press. New York.
23. Hille, B. 1992. Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA.
24. Ingber, L 1993. Simulated annealing: practice versus theory. J. Math Comput. Modelling. 18:29-57.
25. Jardetzky, O. 1966. Simple allosteric model for membrane pumps. Nature 211:969-970.
26. Kanner, B. I. and S. Schuldiner. 1987. Mechanism of transport and storage of neurotransmitters CRC Crit Rev Biochem. 22:1-38.
27. Keynan, S., and B. I. Kanner. 1988. γ-Aminobutyric acid transport in reconstituted preparations from rat brain: coupled sodium and chloride fluxes. Biochemistry. 27:12-17.
28. +. Am. J. Physiol 255:C486-C494.
29. Krupka, R. M 1989. Role of substrate binding forces in exchange-only transport systems. II. Implications for the mechanism of the anion-exchanger of red cells. J. Membr. Biol. 109:159-171.
30. Krupka, R. M., and R. Deves. 1988. The choline carrier of erythrocytes. Location of the NEM-reactive thiol group in the inner gated channel J. Membr. Biol 101:43-47
31. Lagnado, L., K. Cervetto, and P. A. McNaughton. 1988. Ion transport by the Na-Ca exchanger in isolated rod outer segments. Proc. Natl. Acid. Sci. USA 85:4548-4552.
32. Lauger, P. 1979. A channel mechanism for electrogenic ion pumps Biochim. Biophys. Acta. 552:143-61.
33. Lauger, P. 1991. Electrogenic Ion Pumps. Sinauer Associates, Sunderland, MA
34. Lester, H. A., S. Mager, M. W. Quick, and J. L. Corey. 1994. Permeation properties of neurotransmitter ion-coupled transporters. Anna. Rev. Pharmacol. Toxicol. 34:219-249.
35. Lowe, A. G., and A. R. Walmsley. 1986. The kinetics of glucose transport in human red blood cells. Biochim. Biophys. Acta. 857:146-154.
36. Mabjeesh, N. J., and B. I. Kanner. 1989. Low-affinity γ-aminobutyric acid transport in rat brain. Biochemistry. 28:7694-7699.
37. Mager, S., C. Min. D. Henry, N. Davidson, C. Chavkim, B. Hoffman, and H. A. Lester. 1994. Conducting states of a mammalian serotonin transporter. Neuron. 12:845-859.
38. Mager, S., J. Naeve, M. Quick, C Labarca, N. Davidson. and H. A. Lester. 1993. Steady states, charge movements, and rates for a cloned GABA ion-coupled transporter expressed in Xenopus oocytes. Neuron. 10:177-188.
39. McQuarrie, D. A. 1976. Statistical Mechanics. Harper & Row, New York.
40. Nakamoto, R. K., R. Rao, and C. W. Slayman. 1989. Transmembrane segments of the P-type cation-transporting ATPases. A comparative study. Ann. N.Y. Acad. Sci. 574:165-179.
41. +/glucose cotransporter. I. Voltage clamp studies. J. Membr. Biol. 125:49-62.
42. +/glucose cotransporter. II. A transport model under nonrapid equilibrium conditions. J. Membr. Biol. 125:63-79.
43. Picaud, S. A., H. P. Larsson, G. B. Grant. H. Lecar. and F. S. Werblin, 1995 A glutamate gated chloride channel with glutamate transporter-like properties in cone photoreceptors of the tiger salamander. J. Neurophysiol 74:1760-1771.
44. Press, W. H., S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery. 1992. Numerical Recipes in c. 36-41. Cambridge University Press, Cambridge.
45. Rakowski, R. F. 1993. Charge movement by the Na/K pump in Xenopus oocytes. J Gen Physiol. 101:117-114.
46. Risso, S, L. DeFelice, and R. D. Blakely. 1995. Sodium-dependent GABA-induced current in GAT1-transfected HeLa cells J. Physiol. In press.
47. Rudnick, G., and J. Clark. 1993. From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim. Biophvs. Acta. 1144:249-263
48. Schultz, S. G. 1980. Basic Principles of Membrane Transport. Cambridge. University Press, Cambridge. 33-41. 85. 95. 96.
49. Schultz, S. G. 1986. Ion-coupled transport of organic solutes across biological membranes, in Membrane Physiology. T. E. Andreoli, J. F. Hollfman, D. D. Fanestil, and S. G. Schultz, editors. Plenum Press. New York. 283-294.
50. Schwanz, E. A., and M. Tachibana. 1990. Electrophysiology of glutamate and sodium co-transport in a glial cell of the salamander retina. J. Physiol. 426:32-80.
51. Stein, W. D. 1986. Transport and Diffusion across Cell Membranes. Academic Press. Orlando, FL. 337-361, 613-616.
52. +/ glucose cotransporter expressed in Xenopus oocytes is electrogenic. Biophys, J. 57:1217-1224.
53. Wadiche, J. I., S. G. Amara, and M. P. Kavanaugh. 1995b. Ion fluxes associated with excitatory amino acid transport. Neuron. 15: 721-728.
54. Wadiche, J. I. J. L. Arriza, S. G. Amara, and M. P. Kavanaugh. 1995a. Kinetics of a human glutamate transporter. Neuron. 14:1019-1027.
55. Walmsley, A. R. 1988. The dynamics of the glucose ion-coupled transporter. Trends Biochem. Sci. 13:226-231.
56. Wang, J. S., J. M. Tang, and R. S. Eisenberg. 1992. A calcium conducting channel akin to a calcium pump. J. Membr. Biol. 130:163-181.
57. +/glucose ion-coupled cotransporter. Annu. Rev. Physiol. 55:575-89.