ClC chloride channels viewed through a transporter lens

Nature

Volumn 440, Issue 7083, 2006, Pages 484-489

  Miller, Christopher ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; IONS; PROTONS;

CHLORIDE CHANNELS; CHLORIDE/PROTON EXCHANGE-TRANSPORT; VOLTAGE-DEPENDENT GATING;

CHLORIDE MINERALS;

CHLORIDE CHANNEL; CHLORIDE ION; ISOPROTEIN;

CHLORIDE;

CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HUMAN; ION CONDUCTANCE; ION EXCHANGE; ION TRANSPORT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW;

EID: 33645296826     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04713     Document Type: Review

References (60)

1. Jentsch, T. J., Steinmeyer, K. & Schwarz, G. Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348, 510-514 (1990).
2. Pusch, M. Structural insights into chloride and proton-mediated gating of CLC chloride channels. Biochemistry 43, 1135-1144 (2004).
3. Chen, T.-Y. Structure and function of CLC channels. Annu. Rev. Physiol. 67, 809-839 (2005).
4. Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T. & MacKinnon, R. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415, 287-294 (2002).
5. Dutzler, R., Campbell, E. B. & MacKinnon, R. Gating the selectivity filter in ClC chloride channels. Science 300, 108-112 (2003).
6. + exchanger. J. Gen. Physiol. 126, 563-570 (2005).
7. Lobet, S. & Dutzler, R. Ion binding properties of the CLC chloride selectivity filter. EMBO J. (in the press).
8. - channels. Nature 427, 803-807 (2004).
9. Picollo, A. & Pusch, M. Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature 436, 420-423 (2005).
10. Scheel, O., Zdebik, A. A., Lourdel, S. & Jentsch, T. J. Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436, 424-427 (2005).
11. - channels gleaned from human genetic disease and mouse models. Annu. Rev. Physiol. 67, 779-807 (2005).
12. Middleton, R. E., Pheasant, D. J. & Miller, C. Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. Biochemistry 33, 13189-13198 (1994).
13. Middleton, R. E., Pheasant, D. J. & Miller, C. Homodimeric architecture of a ClC-type chloride ion channel. Nature 383, 337-340 (1996).
14. Ludewig, U., Pusch, M. & Jentsch, T. J. Two physically distinct pores in the dimeric ClC-0 chloride channel. Nature 383, 340-343 (1996).
15. Mindell, J. A., Maduke, M., Miller, C. & Grigorieff, N. Projection structure of a ClC-type chloride channel at 6.5 Å resolution. Nature 409, 219-223 (2001).
16. Yin, J., Kuang, Z., Mahankali, U. & Beck, T. L. Ion transit pathways and gating in ClC chloride channels. Proteins 57, 414-421 (2003).
17. Faraldo-Gomez, J. D. & Roux, B. Electrostatics of ion stabilization in a ClC chloride channel homologue from Escherichia coli. J. Mol. Biol. 339, 981-1000 (2004).
18. - pores: electrostatic effects of charged residues. Biophys J. 86, 825-835 (2004).
19. Corry, B., O'Mara, M. & Chung, S. H. Conduction mechanisms of chloride ions in ClC-type channels. Biophys. J. 86, 846-860 (2004).
20. Cohen, J. & Schulten, K. Mechanism of anionic conduction across ClC. Biophys. J. 86, 836-845 (2004).
21. Adelroth, P. & Brzezinski, P. Surface-mediated proton-transfer reactions in membrane-bound proteins. Biochim. Biophys. Acta 1655, 102-115 (2004).
22. Saviane, C., Conti, F. & Pusch, M. The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia. J. Gen. Physiol. 113, 457-468 (1999).
23. Weinreich, F. & Jentsch, T. J. Pores formed by single subunits in mixed dimers of different CLC chloride channels. J. Biol. Chem. 276, 2347-2353 (2001).
24. Estevez, R., Pusch, M., Ferrer-Costa, C., Orozco, M. & Jentsch, T. J. Functional and structural conservation of CBS domains from CLC channels. J. Physiol. (Lond.) 557, 363-378 (2004).
25. Hebeisen, S. & Fahlke, C. Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels. Biophys. J. 89, 1710-1720 (2005).
26. Bennetts, B. et al. Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J. Biol. Chem. 280, 32452-32458 (2005).
27. Meyer, S. & Dutzler, R. Crystal structure of the cytoplasmic domain of the chloride channel ClC-0. Structure 14, 299-307 (2006).
28. Fahlke, C. Ion permeation and selectivity in ClC-type chloride channels. Am. J. Physiol. Renal Physiol. 280, F748-F757 (2001).
29. Geelen, D. et al. Disruption of putative anion channel gene AtCLC-a in Arabidopsis suggests a role in the regulation of nitrate content. Plant J. 21, 259-267 (2000).
30. White, M. M. & Miller, C. Probes of the conduction process of a voltage-gated chloride channel from Torpedo electroplax. J. Gen. Physiol. 78, 1-19 (1981).
31. Miller, C. Open-state substructure of single chloride channels from Torpedo electroplax. Phil. Trans. R. Soc. Lond. B 299, 401-411 (1982).
32. Fahlke, C., Durr, C. & George, A. L. Jr. Mechanism of ion permeation in skeletal muscle chloride channels. J. Gen. Physiol. 110, 551-564 (1997).
33. Rychkov, G. Y., Pusch, M., Roberts, M. L., Jentsch, T. J. & Bretag, A. H. Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. J. Gen. Physiol. 111, 653-665 (1998).
34. Pusch, M., Ludewig, U., Rehfeldt, A. & Jentsch, T. J. Gating of the voltage-dependent chloride channel ClC-0 by the permeant anion. Nature 373, 527-531 (1995).
35. - channel. J. Gen. Physiol. 108, 237-250 (1996).
36. Chen, M. F. & Chen, T. Y. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J. Gen. Physiol. 122, 133-145 (2003).
37. Miller, C. Ionic hopping defended. J. Gen. Physiol. 113, 783-787 (1999).
38. Jentsch, T. J., Stein, V., Weinreich, F. & Zdebik, A. A. Molecular structure and physiological function of chloride channels. Physiol. Rev. 82, 503-568 (2002).
39. Engh, A. M. & Maduke, M. Cysteine accessibility in ClC-0 supports conservation of the ClC intracellularvestibule. J. Gen. Physiol. 125, 601-617 (2005).
40. Accardi, A. & Pusch, M. Conformational changes in the pore of CLC-0. J. Gen. Physiol. 122, 277-294 (2003).
41. Estevez, R., Schroeder, B. C., Accardi, A., Jentsch, T. J. & Pusch, M. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron 38, 47-59 (2003).
42. Rychkov, G. Y., Pusch, M., Roberts, M. L. & Bretag, A. H. Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating. J. Physiol. (Lond.) 530, 379-393 (2001).
43. Hanke, W. & Miller, C. Single chloride channels from Torpedo electroplax: activation by protons. J. Gen. Physiol. 82, 25-45 (1983).
44. Ludewig, U., Pusch, M. & Jentsch, T. J. Independent gating of single pores in CLC-0 chloride channels. Biophys. J. 73, 789-797 (1997).
45. Duffield, M., Rychkov, G., Bretag, A. & Roberts, M. Involvement of helices at the dimer interface in ClC-1 common gating. J. Gen. Physiol. 121, 149-161 (2003).
46. + of the muscle-type ClC chloride channels. J. Gen. Physiol. 118, 23-32 (2001).
47. Rychkov, G. Y. et al. Concentration and pH dependence of skeletal muscle chloride channel ClC-1. J. Physiol. (Lond.) 497, 423-435 (1996).
48. Waldegger, S. & Jentsch, T. J. Functional and structural analysis of ClC-K chloride channels involved in renal disease. J. Biol. Chem. 275, 24527-24533 (2000).
49. Lin, C. W. & Chen, T. Y. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J. Gen. Physiol. 122, 147-159 (2003).
50. Richard, E. A. & Miller, C. Steady-state coupling of ion-channel conformations to a transmembrane ion gradient. Science 247, 1208-1210 (1990).
51. Accardi, A. & Pusch, M. Fast and slow gating relaxations in the muscle chloride channel CLC-1. J. Gen. Physiol. 116, 433-444 (2000).
52. Ludewig, U., Jentsch, T. J. & Pusch, M. Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0. J. Physiol. (Lond.) 498, 691-702 (1997).
53. Jordt, S.-V. & Jentsch, T. J. Molecular dissection of gating in the ClC-2 chloride channel. EMBO J. 16, 1582-1592 (1997).
54. Zuniga, L. et al. The voltage-dependent ClC-2 chloride channel has a dual gating mechanism. J. Physiol. (Lond.) 555, 671-682 (2004).
55. de Santiago, J. A., Nehrke, K. & Arreola, J. Quantitative analysis of the voltage-dependent gating of mouse parotid ClC-2 chloride channel. J. Gen. Physiol. 126, 591-693 (2005).
56. Steinmeyer, K. et al. Inactivation of muscle chloride channel by transposon insertion in mytotonic mice. Nature 354, 304-308 (1991).
57. Haug, K. et al. Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nature Genet. 33, 527-532 (2003).
58. Simon, D. B. et al. Mutations in the chloride channel gene CLCNKB cause Bartter's syndrome type III. Nature Genet. 17, 171-178 (1997).
59. Steinmeyer, K., Schwappach, B., Bens, M., Vandewalle, A. & Jentsch, T. J. Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease. J. Biol. Chem. 270, 31172-31177 (1995).
60. Kornak, U. et al. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104, 205-215 (2001).