메뉴 건너뛰기




Volumn 216, Issue 1, 2007, Pages 81-92

Quantitative theories of T-cell responsiveness

Author keywords

Avidity spectrum; Mathematical modeling; T cell receptor; T cell response; Tolerance

Indexed keywords

T LYMPHOCYTE RECEPTOR;

EID: 33947268563     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2006.00491.x     Document Type: Review
Times cited : (23)

References (91)
  • 1
    • 0033581935 scopus 로고    scopus 로고
    • Selecting and maintaining a diverse T-cell repertoire
    • Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature 1999;402:255-262.
    • (1999) Nature , vol.402 , pp. 255-262
    • Goldrath, A.W.1    Bevan, M.J.2
  • 2
  • 5
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987;49:273-280.
    • (1987) Cell , vol.49 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 6
    • 0023900635 scopus 로고
    • Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
    • Kisielow P, Blüthmann H, Staerz UD, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 1988;333:742-746.
    • (1988) Nature , vol.333 , pp. 742-746
    • Kisielow, P.1    Blüthmann, H.2    Staerz, U.D.3    Steinmetz, M.4    von Boehmer, H.5
  • 7
    • 0033136289 scopus 로고    scopus 로고
    • Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo
    • Laufer TM, Fan L, Glimcher LH. Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo. J Immunol 1999;162:5078-5084.
    • (1999) J Immunol , vol.162 , pp. 5078-5084
    • Laufer, T.M.1    Fan, L.2    Glimcher, L.H.3
  • 9
    • 0033738329 scopus 로고    scopus 로고
    • The role of different subsets of T regulatory cells in controlling autoimmunity
    • Roncarolo M-G, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol 2000;12:676-683.
    • (2000) Curr Opin Immunol , vol.12 , pp. 676-683
    • Roncarolo, M.-G.1    Levings, M.K.2
  • 10
    • 1342345915 scopus 로고    scopus 로고
    • CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells
    • Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J Immunol 2004;172:2778-2784.
    • (2004) J Immunol , vol.172 , pp. 2778-2784
    • Zheng, Y.1    Manzotti, C.N.2    Liu, M.3    Burke, F.4    Mead, K.I.5    Sansom, D.M.6
  • 11
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001;19:225-252.
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 12
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity 1997;7:445-450.
    • (1997) Immunity , vol.7 , pp. 445-450
    • Thompson, C.B.1    Allison, J.P.2
  • 13
    • 0043268924 scopus 로고    scopus 로고
    • Dynamics of cell surface molecules during T cell recognition
    • Davis MM, et al. Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem 2003;72:717-742.
    • (2003) Annu Rev Biochem , vol.72 , pp. 717-742
    • Davis, M.M.1
  • 14
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today 1998;19:395-404.
    • (1998) Immunol Today , vol.19 , pp. 395-404
    • Mason, D.1
  • 15
    • 0034659119 scopus 로고    scopus 로고
    • Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: Implications for autoimmunity
    • Abderson AC, et al. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. Cell Immunol 2000;202:88-96.
    • (2000) Cell Immunol , vol.202 , pp. 88-96
    • Abderson, A.C.1
  • 16
    • 0036467394 scopus 로고    scopus 로고
    • The specificity of TCR.pMCH interaction
    • Rudolph MG, Wilson IA. The specificity of TCR.pMCH interaction. Curr Opin Immunol 2002;14:52-65.
    • (2002) Curr Opin Immunol , vol.14 , pp. 52-65
    • Rudolph, M.G.1    Wilson, I.A.2
  • 17
    • 0032549142 scopus 로고    scopus 로고
    • Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
    • Garcia KC, et al. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 1998;279:1166-1172.
    • (1998) Science , vol.279 , pp. 1166-1172
    • Garcia, K.C.1
  • 18
    • 0030925578 scopus 로고    scopus 로고
    • Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
    • Hemmer B, et al. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J Exp Med 1997;185:1651-1659.
    • (1997) J Exp Med , vol.185 , pp. 1651-1659
    • Hemmer, B.1
  • 19
    • 0031966527 scopus 로고    scopus 로고
    • Probing degeneracy in T-cell recognition using peptide combinatorial libraries
    • Hemmer B, Vergelli M, Pinilla C, Houghten R, Martin R. Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol Today 1998;19:163-168.
    • (1998) Immunol Today , vol.19 , pp. 163-168
    • Hemmer, B.1    Vergelli, M.2    Pinilla, C.3    Houghten, R.4    Martin, R.5
  • 20
    • 0030058657 scopus 로고    scopus 로고
    • The repertoire of T cells shaped by a single MHC/peptide ligand
    • Ignatowicz L, Kappler J, Marrack P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 1996;84:521-529.
    • (1996) Cell , vol.84 , pp. 521-529
    • Ignatowicz, L.1    Kappler, J.2    Marrack, P.3
  • 21
    • 0029961893 scopus 로고    scopus 로고
    • Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands
    • Kersh GH, Allen PM. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J Exp Med 1996;184:1259-1268.
    • (1996) J Exp Med , vol.184 , pp. 1259-1268
    • Kersh, G.H.1    Allen, P.M.2
  • 22
    • 0031817312 scopus 로고    scopus 로고
    • Glimpses at the recognition of peptide/MHC complexes by T-cell antigen receptors
    • Mazza G, et al. Glimpses at the recognition of peptide/MHC complexes by T-cell antigen receptors. Immunol Rev 1998;163:187-196.
    • (1998) Immunol Rev , vol.163 , pp. 187-196
    • Mazza, G.1
  • 23
    • 0028017808 scopus 로고
    • A differential-avidity model for T-cell selection
    • Ashton-Rickardt PG, Tonegawa S. A differential-avidity model for T-cell selection. Immunol Today 1994;15:362-366.
    • (1994) Immunol Today , vol.15 , pp. 362-366
    • Ashton-Rickardt, P.G.1    Tonegawa, S.2
  • 24
    • 0034630306 scopus 로고    scopus 로고
    • Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection
    • Alexander-Miller MA. Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection. Cell Immunol 2000;201:58-62.
    • (2000) Cell Immunol , vol.201 , pp. 58-62
    • Alexander-Miller, M.A.1
  • 25
    • 11144356391 scopus 로고    scopus 로고
    • High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy
    • Gross D-A, et al. High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy. J Clin Invest 2004;113:425-433.
    • (2004) J Clin Invest , vol.113 , pp. 425-433
    • Gross, D.-A.1
  • 27
    • 0033399166 scopus 로고    scopus 로고
    • Quantitative aspects of T cell activation - peptide generation and editing by MHC class I molecule
    • Stevanović S, Schild H. Quantitative aspects of T cell activation - peptide generation and editing by MHC class I molecule. Semin Immunol 1999;11:375-384.
    • (1999) Semin Immunol , vol.11 , pp. 375-384
    • Stevanović, S.1    Schild, H.2
  • 28
    • 4544382384 scopus 로고    scopus 로고
    • Discriminating self from nonself with short peptides from large proteomes
    • Burroughs N, Kesxmir C, de Boer R. Discriminating self from nonself with short peptides from large proteomes. Immunogenetics 2004;56:311-320.
    • (2004) Immunogenetics , vol.56 , pp. 311-320
    • Burroughs, N.1    Kesxmir, C.2    de Boer, R.3
  • 29
    • 0036604916 scopus 로고    scopus 로고
    • The TCR signalosome: A dynamic structure with expanding complexity
    • Werlen G, Palmer E. The TCR signalosome: a dynamic structure with expanding complexity. Curr Opin Immunol 2002;14:299-305.
    • (2002) Curr Opin Immunol , vol.14 , pp. 299-305
    • Werlen, G.1    Palmer, E.2
  • 30
    • 33947266978 scopus 로고    scopus 로고
    • New York: Garland Publishing
    • Parham O. The Immue System. New York: Garland Publishing, 2000.
    • (2000) The Immue System
    • Parham, O.1
  • 31
    • 0027399243 scopus 로고
    • Peptides naturally presented by MHC class I molecules
    • Rannessee H-G, Falk K, Rotzshke O. Peptides naturally presented by MHC class I molecules. Annu Rev Immunol 1993;11:213-244.
    • (1993) Annu Rev Immunol , vol.11 , pp. 213-244
    • Rannessee, H.-G.1    Falk, K.2    Rotzshke, O.3
  • 33
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science 2002;296:301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 34
    • 0035286588 scopus 로고    scopus 로고
    • Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
    • Kalergis AM, et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol 2001;2:229-234.
    • (2001) Nat Immunol , vol.2 , pp. 229-234
    • Kalergis, A.M.1
  • 35
    • 0036664812 scopus 로고    scopus 로고
    • Quantifying the strength of ligand antagonism in TCR triggering
    • van den Berg HA, Burroughs N, Rand DA. Quantifying the strength of ligand antagonism in TCR triggering. Bull Math Biol 2002;64:781-808.
    • (2002) Bull Math Biol , vol.64 , pp. 781-808
    • van den Berg, H.A.1    Burroughs, N.2    Rand, D.A.3
  • 36
    • 0034613152 scopus 로고    scopus 로고
    • Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells
    • Lanzavecchia A, Sallusto F. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 2000;290:92-97.
    • (2000) Science , vol.290 , pp. 92-97
    • Lanzavecchia, A.1    Sallusto, F.2
  • 37
    • 0031557886 scopus 로고    scopus 로고
    • Modeling T-cell proliferation: An investigation of the consequences of the Hayflick limit
    • Pilyugin S, Mittler J, Antia R. Modeling T-cell proliferation: an investigation of the consequences of the Hayflick limit. J Theor Biol 1997;186:117-129.
    • (1997) J Theor Biol , vol.186 , pp. 117-129
    • Pilyugin, S.1    Mittler, J.2    Antia, R.3
  • 38
    • 0032827889 scopus 로고    scopus 로고
    • Competition for antigenic sites during T cell proliferation: A mathematical interpretation of in vitro data
    • Borghans JAM, Taams LS, Wauben MHM, de Boer R. Competition for antigenic sites during T cell proliferation: a mathematical interpretation of in vitro data. Proc Natl Acad Sci USA 1999;96:10782-10787.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10782-10787
    • Borghans, J.A.M.1    Taams, L.S.2    Wauben, M.H.M.3    de Boer, R.4
  • 39
    • 0032007065 scopus 로고    scopus 로고
    • Massive expansion of antigen-specific CD8pT cells during an acute virus infection
    • Butz EA, Bevan MJ. Massive expansion of antigen-specific CD8pT cells during an acute virus infection. Immunity 1998;8:167-175.
    • (1998) Immunity , vol.8 , pp. 167-175
    • Butz, E.A.1    Bevan, M.J.2
  • 40
    • 0029552310 scopus 로고
    • Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire
    • Gavin MA, Bevan MJ. Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire. Immunity 1995;3:793-800.
    • (1995) Immunity , vol.3 , pp. 793-800
    • Gavin, M.A.1    Bevan, M.J.2
  • 41
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller MA, Leggatt GR, Berzofsky JA. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc Natl Acad Sci USA 1996;93:4102-4107.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4102-4107
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 43
    • 0032410748 scopus 로고    scopus 로고
    • Models of immune memory: On the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory
    • Antia R, Pilyugin SS, Ahmed R. Models of immune memory: on the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory. Proc Natl Acad Sci USA 1998;95:14926-14931.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14926-14931
    • Antia, R.1    Pilyugin, S.S.2    Ahmed, R.3
  • 44
    • 0034906066 scopus 로고    scopus 로고
    • Stability of a diverse immunological memory is determined by T cell population dynamics
    • Utzny C, Burroughs NJ. Stability of a diverse immunological memory is determined by T cell population dynamics. Bull Math Biol 2001;63:685-713.
    • (2001) Bull Math Biol , vol.63 , pp. 685-713
    • Utzny, C.1    Burroughs, N.J.2
  • 45
    • 33746743790 scopus 로고    scopus 로고
    • Cell death and the maintenance of immunological memory
    • Yates AJ, Callard RE. Cell death and the maintenance of immunological memory. Discr Cont Dynam Sys B 2001;1:43-60.
    • Discr Cont Dynam Sys , vol.B 2001 , Issue.1 , pp. 43-60
    • Yates, A.J.1    Callard, R.E.2
  • 46
    • 0023123622 scopus 로고
    • Immunological discrimination between self and non-self by precursor depletion and memory accumulation
    • de Boer RJ, Hogeweg P. Immunological discrimination between self and non-self by precursor depletion and memory accumulation. J Theor Biol 1987;124:343-369.
    • (1987) J Theor Biol , vol.124 , pp. 343-369
    • de Boer, R.J.1    Hogeweg, P.2
  • 47
    • 0033565717 scopus 로고    scopus 로고
    • How specific should immunological memory be?
    • Borghans JAM, Noest A, de Boer RJ. How specific should immunological memory be? J Immunol 1999;163:569-575.
    • (1999) J Immunol , vol.163 , pp. 569-575
    • Borghans, J.A.M.1    Noest, A.2    de Boer, R.J.3
  • 48
    • 0031870528 scopus 로고    scopus 로고
    • Crossreactivity of the T-cell receptor
    • Borghans J, de Boer RJ. Crossreactivity of the T-cell receptor. Immunol Today 1998;19:428-429.
    • (1998) Immunol Today , vol.19 , pp. 428-429
    • Borghans, J.1    de Boer, R.J.2
  • 49
    • 0035320679 scopus 로고    scopus 로고
    • Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    • Jordan MS, et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-306.
    • (2001) Nat Immunol , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 50
    • 0035181750 scopus 로고    scopus 로고
    • Some quantitative aspects of T cell repertoire se-lection: The requirement for regulatory T cells
    • Mason D. Some quantitative aspects of T cell repertoire se-lection: the requirement for regulatory T cells. Immunol Rev 2001;182:80-88.
    • (2001) Immunol Rev , vol.182 , pp. 80-88
    • Mason, D.1
  • 51
    • 17044454394 scopus 로고    scopus 로고
    • Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance
    • León K, Faro J, Lage A, Carneiro J. Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance. J Autoimmun 2004;22:31-42.
    • (2004) J Autoimmun , vol.22 , pp. 31-42
    • León, K.1    Faro, J.2    Lage, A.3    Carneiro, J.4
  • 52
    • 5644255710 scopus 로고    scopus 로고
    • Foreignness as a matter of degree: The relative immunogenicity of peptide/MHC ligands
    • van den Berg HA, Rand DA. Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands. J Theor Biol 2004;231:535-548.
    • (2004) J Theor Biol , vol.231 , pp. 535-548
    • van den Berg, H.A.1    Rand, D.A.2
  • 53
    • 0037310510 scopus 로고    scopus 로고
    • Preferential escape of subdominant CD8+T cells during negative selection results in an altered antiviral T cell hierarchy
    • Slifka MK, et al. Preferential escape of subdominant CD8+T cells during negative selection results in an altered antiviral T cell hierarchy. J Immunol 2003;170:1231-1239.
    • (2003) J Immunol , vol.170 , pp. 1231-1239
    • Slifka, M.K.1
  • 54
    • 0030475056 scopus 로고    scopus 로고
    • Could endogenous selfpeptides presented by dendritic cells initiate rheumatoid arthritis?
    • Thomas R, Lipsky PE. Could endogenous selfpeptides presented by dendritic cells initiate rheumatoid arthritis? Immunol Today 1996;17:559-564.
    • (1996) Immunol Today , vol.17 , pp. 559-564
    • Thomas, R.1    Lipsky, P.E.2
  • 56
    • 0035925931 scopus 로고    scopus 로고
    • A reliable and safe T cell repertoire based on low-affinity T cell receptors
    • van den Berg HA, Rand DA, Burroughs NJ. A reliable and safe T cell repertoire based on low-affinity T cell receptors. J Theor Biol 2001;209:465-486.
    • (2001) J Theor Biol , vol.209 , pp. 465-486
    • van den Berg, H.A.1    Rand, D.A.2    Burroughs, N.J.3
  • 57
    • 0041620480 scopus 로고    scopus 로고
    • Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
    • van den Berg HA, Rand DA. Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy. J Theor Biol 2003;224:249-267.
    • (2003) J Theor Biol , vol.224 , pp. 249-267
    • van den Berg, H.A.1    Rand, D.A.2
  • 58
    • 0034700306 scopus 로고    scopus 로고
    • Designing lymphocyte functional structure for optimal signal detection: Voilà, T cells
    • Noest AJ. Designing lymphocyte functional structure for optimal signal detection: voilà, T cells. J Theor Biol 2000;207:195-216.
    • (2000) J Theor Biol , vol.207 , pp. 195-216
    • Noest, A.J.1
  • 59
    • 0344739964 scopus 로고    scopus 로고
    • Thymic presentation of autoantigens and the efficiency of negative selection
    • van den Berg HA, Molina-París C. Thymic presentation of autoantigens and the efficiency of negative selection. J Theor Med 2003;5:1-22.
    • (2003) J Theor Med , vol.5 , pp. 1-22
    • van den Berg, H.A.1    Molina-París, C.2
  • 60
    • 0033179679 scopus 로고    scopus 로고
    • On the role of feedback in promoting conflicting goals of the adaptive immune system
    • Segel LA, Lev Bar-Or R. On the role of feedback in promoting conflicting goals of the adaptive immune system. J Immunol 1999;163:1342-1349.
    • (1999) J Immunol , vol.163 , pp. 1342-1349
    • Segel, L.A.1    Lev Bar-Or, R.2
  • 63
    • 0037437760 scopus 로고    scopus 로고
    • Perturbation theory analysis of competition in a heterogeneous population
    • Utzny C, Burroughs NJ. Perturbation theory analysis of competition in a heterogeneous population. Physica D 2003;175:109-126.
    • (2003) Physica D , vol.175 , pp. 109-126
    • Utzny, C.1    Burroughs, N.J.2
  • 64
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks CRF, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.F.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 65
    • 0033614036 scopus 로고    scopus 로고
    • Costimulation: Building an immunological synapse
    • Dustin ML, Shaw AA. Costimulation: building an immunological synapse. Science 1999;283:649-650.
    • (1999) Science , vol.283 , pp. 649-650
    • Dustin, M.L.1    Shaw, A.A.2
  • 66
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: A molecular machine controlling T cell activation
    • Grakoui A, et al. The immunological synapse: a molecular machine controlling T cell activation. Science 1999;285:221-227.
    • (1999) Science , vol.285 , pp. 221-227
    • Grakoui, A.1
  • 67
    • 0036794399 scopus 로고    scopus 로고
    • Staging and resetting T cell activation in SMACs
    • Freiberg BA, et al. Staging and resetting T cell activation in SMACs. Nat Immunol 2002;3:911-917.
    • (2002) Nat Immunol , vol.3 , pp. 911-917
    • Freiberg, B.A.1
  • 68
    • 0036219193 scopus 로고    scopus 로고
    • Negative regulation of immunoreceptor signalling
    • Veillette A, Latour S, Davidson D. Negative regulation of immunoreceptor signalling. Annu Rev Immunol 2002;20:669-707.
    • (2002) Annu Rev Immunol , vol.20 , pp. 669-707
    • Veillette, A.1    Latour, S.2    Davidson, D.3
  • 70
    • 0035826696 scopus 로고    scopus 로고
    • Cooperative enhancement of specificity in a lattice of T cell receptors
    • Chan C, George AJT, Stark J. Cooperative enhancement of specificity in a lattice of T cell receptors. Proc Natl Acad Sci USA 2001;98:5758-5763.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5758-5763
    • Chan, C.1    George, A.J.T.2    Stark, J.3
  • 71
    • 0036739732 scopus 로고    scopus 로고
    • Kinetic proofreading in receptor-mediated transduction of cellular signals: Receptor aggregation, partially activated receptors, and cytosolic messengers
    • Hlavacek WS, Redondo A, Wofsy C, Goldstein B. Kinetic proofreading in receptor-mediated transduction of cellular signals: receptor aggregation, partially activated receptors, and cytosolic messengers. Bull Math Biol 2002;64:887-911.
    • (2002) Bull Math Biol , vol.64 , pp. 887-911
    • Hlavacek, W.S.1    Redondo, A.2    Wofsy, C.3    Goldstein, B.4
  • 72
    • 2942588906 scopus 로고    scopus 로고
    • Mathematical and computational models of immune-receptor signalling
    • Goldstein B, Faeder JR, Hlavacek W. Mathematical and computational models of immune-receptor signalling. Nat Rev Immunol 2004;4:445-456.
    • (2004) Nat Rev Immunol , vol.4 , pp. 445-456
    • Goldstein, B.1    Faeder, J.R.2    Hlavacek, W.3
  • 73
    • 0029928254 scopus 로고    scopus 로고
    • A model for antigen-induced T cell unresponsiveness based on autophosphorylative protein tyrosine kinase activity
    • Kaufman M, Andris F, Leo O. A model for antigen-induced T cell unresponsiveness based on autophosphorylative protein tyrosine kinase activity. Int Immunol 1996;8:613-624.
    • (1996) Int Immunol , vol.8 , pp. 613-624
    • Kaufman, M.1    Andris, F.2    Leo, O.3
  • 75
    • 23044469067 scopus 로고    scopus 로고
    • Interaction between the CD8 coreceptor and MHC class I stabilizes TCR-antigen complexes at the cell surface
    • Wooldridge L, et al. Interaction between the CD8 coreceptor and MHC class I stabilizes TCR-antigen complexes at the cell surface. J Biol Chem 2005;280:27491-27501.
    • (2005) J Biol Chem , vol.280 , pp. 27491-27501
    • Wooldridge, L.1
  • 76
    • 0035914485 scopus 로고    scopus 로고
    • lck complexes
    • lck complexes. J Exp Med 2001;194:1485-1495.
    • (2001) J Exp Med , vol.194 , pp. 1485-1495
    • Arcaro, A.1
  • 77
    • 0036467498 scopus 로고    scopus 로고
    • Interactions between MHC molecules and coreceptors of the TCR
    • König R. Interactions between MHC molecules and coreceptors of the TCR. Curr Opin Immunol 2002;14:75-83.
    • (2002) Curr Opin Immunol , vol.14 , pp. 75-83
    • König, R.1
  • 79
    • 0028797801 scopus 로고
    • CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes
    • Luescher IF, et al. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature 1995;373:353-356.
    • (1995) Nature , vol.373 , pp. 353-356
    • Luescher, I.F.1
  • 80
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan TW. Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci USA 1995;92:5042-5046.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5042-5046
    • McKeithan, T.W.1
  • 82
    • 0030219704 scopus 로고    scopus 로고
    • Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity
    • Schodin BA, Tsomides TJ, Kranz DM. Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity. Immunity 1996;5:137-146.
    • (1996) Immunity , vol.5 , pp. 137-146
    • Schodin, B.A.1    Tsomides, T.J.2    Kranz, D.M.3
  • 83
    • 0033579882 scopus 로고    scopus 로고
    • The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model
    • Girgis L, Davis MM, Fazekas de St. Groth B. The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model. J Exp Med 1999;189:265-277.
    • (1999) J Exp Med , vol.189 , pp. 265-277
    • Girgis, L.1    Davis, M.M.2    Fazekas de, S.3    Groth, B.4
  • 84
    • 0042853581 scopus 로고    scopus 로고
    • T cell sensitivity and specificity - kinetic proofreading revisited
    • Chan C, George AFT, Stark J. T cell sensitivity and specificity - kinetic proofreading revisited. Discr Cont Dynam Sys B 2003;3:343-360.
    • Discr Cont Dynam Sys , vol.B 2003 , Issue.3 , pp. 343-360
    • Chan, C.1    George, A.F.T.2    Stark, J.3
  • 85
    • 0031172162 scopus 로고    scopus 로고
    • Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition
    • Valitutti S, Lanzavecchia A. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol Today 1997;18:299-304.
    • (1997) Immunol Today , vol.18 , pp. 299-304
    • Valitutti, S.1    Lanzavecchia, A.2
  • 86
    • 16344370564 scopus 로고    scopus 로고
    • T-cell receptor binding kinetics required for T-cell activation depend on the density of the cognate ligand of the antigen-presenting cell
    • Gonzales PA, et al. T-cell receptor binding kinetics required for T-cell activation depend on the density of the cognate ligand of the antigen-presenting cell. Proc Natl Acad Sci USA 2005;102:4824-4829.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4824-4829
    • Gonzales, P.A.1
  • 87
    • 0033592574 scopus 로고    scopus 로고
    • A quantitative theory of affinity-driven T cell repertoire selection
    • Detours V, Mehr R, Perelson AS. A quantitative theory of affinity-driven T cell repertoire selection. J Theor Biol 1999;200:389-403.
    • (1999) J Theor Biol , vol.200 , pp. 389-403
    • Detours, V.1    Mehr, R.2    Perelson, A.S.3
  • 88
    • 2342502543 scopus 로고    scopus 로고
    • Dynamics of T cell activation threshold tuning
    • van den Berg HA, Rand DA. Dynamics of T cell activation threshold tuning. J Theor Biol 2004;228:397-416.
    • (2004) J Theor Biol , vol.228 , pp. 397-416
    • van den Berg, H.A.1    Rand, D.A.2
  • 89
    • 0026447431 scopus 로고
    • The optimal number of major histocompatibility molecules in an individual
    • Nowak MA, Tarczy-Hornoch K, Austyn JM. The optimal number of major histocompatibility molecules in an individual. Proc Natl Acad Sci USA 1992;89:10896-10899.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10896-10899
    • Nowak, M.A.1    Tarczy-Hornoch, K.2    Austyn, J.M.3
  • 90
    • 0347405308 scopus 로고    scopus 로고
    • Thymic selection does not limit the individual MHC diversity
    • Borghans J, Noest A, de Boer RJ. Thymic selection does not limit the individual MHC diversity. Eur J Immunol 2003;33:3353-3358.
    • (2003) Eur J Immunol , vol.33 , pp. 3353-3358
    • Borghans, J.1    Noest, A.2    de Boer, R.J.3
  • 91
    • 0037373593 scopus 로고    scopus 로고
    • Quantitative constraints on the scope of negative selection
    • Müller V, Bonhoeffer S. Quantitative constraints on the scope of negative selection. Trends Immunol 2003;24:132-135.
    • (2003) Trends Immunol , vol.24 , pp. 132-135
    • Müller, V.1    Bonhoeffer, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.