Foreignness as a matter of degree: The relative immunogenicity of peptide/MHC ligands

Journal of Theoretical Biology

Volumn 231, Issue 4, 2004, Pages 535-548

  Van Den Berg, Hugo A ^a   Rand, David A ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Autoimmunity; Immunogenicity; Large deviations theory; Negative selection; T cell ignorance; T cell tolerance

Indexed keywords

AUTOANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE;

IMMUNE RESPONSE;

ARTICLE; AUTOIMMUNE DISEASE; FOREIGN BODY; GENE DELETION; GENE INDUCTION; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; THEORY;

ANTIGENS, NEOPLASM; AUTOANTIGENS; AUTOIMMUNITY; HUMANS; IMMUNE TOLERANCE; IMMUNITY, NATURAL; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES;

EID: 5644255710     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtbi.2004.07.008     Document Type: Article

References (58)

1. H.A. van den Berg, N.J. Burroughs, and D.A. Rand Quantifying the strength of ligand antagonism in TCR triggering Bull. Math. Biol. 64 2002 781 808
2. H.A. van den Berg, and C. Molina-París Thymic presentation of autoantigens and the efficiency of negative selection J. Theor. Med. 5 2003 1 22
3. H.A. van den Berg, and D.A. Rand Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy J. Theor. Biol. 224 2003 249 267
4. H.A. van den Berg, and D.A. Rand Dynamics of T cell activation threshold tuning J. Theor. Biol. 228 2004 397 416
5. H.A. van den Berg, D.A. Rand, and N.J. Burroughs A reliable and safe T cell repertoire based on low-affinity T cell receptors J. Theor. Biol. 209 2001 465 486
6. T. Buch, F. Rieux-Laucat, I. Förster, and K. Rajewski Failure of HY-specific thymocytes to escape negative selection by receptor editing Immunity 16 2002 707 718
7. M. Capiński, and E. Kopp Measure, Integral and Probability 1998 Springer Berlin
8. C. Chan, A.J.T. George, and J. Stark T cell sensitivity and specificity - kinetic proofreading revisited Discrete and Continuous Dynamical Systems - Ser. B 3 2003 343 360
9. R.M. Chicz, R.G. Urban, J.C. Gorga, D.A.A. Vignali, W.S. Lane, and J.L. Strominger Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles J. Exp. Med. 178 1993 27 47
10. A. Dembo, and O. Zeitouni Large Deviations Techniques and Applications 1998 Springer New York
11. M.L. Dustin, and A.A. Shaw Costimulation building an immunological synapse Science 283 1999 649 650
12. J.G. Egen, M.S. Kuhns, and J.P. Allison CTLA-4 new insights into its biological function and use in tumor immunotherapy Nat. Immunol. 3 2002 611 618
13. M. Faroudi, C. Utzny, M. Salio, V. Cerundolo, M. Guiraud, S. Müller, and S. Valitutti Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction manifestation of a dual activation threshold Proc. Natl Acad. Sci. USA 100 2003 14145 14150
14. P.J. Fink, and C.J. McMahan Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe Immunol. Today 21 2000 561 566
15. S. Gallucci, and P. Matzinger Danger signals SOS to the immune system Curr. Opin. Immunol. 13 2001 114 119
16. A.W. Goldrath, and M.J. Bevan Selecting and maintaining a diverse T-cell repertoire Nature 402 1999 255 262
17. A. Grakoui, S.K. Bromley, C. Sumen, M.M. Davis, A.S. Shaw, P.M. Allen, and M.L. Dustin The immunological synapse a molecular machine controlling T cell activation Science 285 1999 221 227
18. F. Granucci, I. Zanoni, S. Feau, and P. Ricciardi-Castagnoli Dendritic cell regulation of immune responses a new role for interleukin 2 at the intersection of innate and adaptive immunity EMBO J. 11 2003 2546 2551
19. D.-A. Gross, S. Graff-Dubois, P. Opolon, S. Cornet, P. Alves, A. Bennaceur-Griscelli, O. Faure, P. Guillaume, H. Firat, S. Chouaib, F.A. Lemonnier, J. Davoust, I. Miconnet, R.H. Vonderheide, and K. Kosmatopoulos High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy J. Clin. Invest. 113 2004 425 433
20. Z. Grossman, and W.E. Paul Adaptive cellular interactions in the immune system the tunable activation threshold and the significance of subthreshold responses Proc. Natl Acad. Sci. USA 89 1992 10365 10369
21. P. Guermonprez, J. Valladeau, L. Zitvogel, C. Théry, and S. Amigorena Antigen presentation and T cell stimulation by dendritic cells Annu. Rev. Immunol. 20 2002 621 667
22. S.E. Hamilton, and J.T. Harty Quantitation of CD 8 + T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells J. Immunol. 169 2002 4936 4944
23. D.F. Hunt, R.A. Henderson, J. Shabanowitz, K. Sakaguchi, H. Michel, N. Sevilir, A.L. Cox, E. Appella, and V.H. Engelhard Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry Science 255 1992 1261 1263
24. T.S. Jardetzky, W.S. Lane, R.A. Robinson, and D.C. Wiley Identification of self peptides bound to purified HLA-B27 Nature 353 1991 326 329
25. M.S. Jordan, A. Boesteanu, A.J. Reed, A.L. Petrone, A.E. Holenbeck, M.A. Lerman, A. Naji, and A.J. Caton Thymic selection of CD4 + CD25 + regulatory T cells induced by an agonist self-peptide Nat. Immunol. 2 2001 301 306
26. A.M. Kalergis, N. Boucheron, M.-A. Doucey, E. Palmieri, E.C. Goyarts, Z. Vegh, I.F. Luesher, and S.G. Nathenson Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex Nat. Immunol. 2 2001 229 234
27. J.W. Kappler, N. Roehm, and P. Marrack T cell tolerance by clonal elimination in the thymus Cell 49 1987 273 280
28. P. Kisielow, H. Blüthmann, U.D. Staerz, M. Steinmetz, and H. von Boehmer Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4 + 8 + thymocytes Nature 333 1988 742 746
29. A. Lanzavecchia, G. Iezzi, and A. Viola From TCR engagement to T cell activation a kinetic view of T cell behavior Cell 96 1999 1 4
30. T.M. Laufer, L.H. Glimcher, and D. Lo Using thymus anatomy to dissect T cell repertoire selection Semin. Immunol. 11 1999 65 70
31. A.-M. Lennon-Duménil, A.H. Bakker, P. Wolf-Bryant, H.L. Ploegh, and Lagaudrière-Gesbert A closer look at proteolysis and MHC-class-II-restricted antigen presentation Curr. Opin. Immunol. 14 2002 15 21
32. D.S. Lyons, S.A. Lieberman, J. Hampl, J. Boniface, Y.-H. Chien, L.J. Berg, and M.M. Davis A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists Immunity 5 1996 53 61
33. K. Matsui, J.J. Boniface, P. Steffner, P.A. Reay, and M.M. Davis Kinetics of T-cell receptor binding to peptide/I-E k complexes correlation of the dissociation rate with T-cell responsiveness Proc. Natl Acad. Sci. USA 91 1994 12862 12866
34. P. Matzinger Essay 1 The Danger model in its historical context Scand. J. Immunol. 54 2001 4 9
35. P. Matzinger The Danger model a renewed sense of self Science 296 2002 301 305
36. M. Merkenschlager Tracing interactions of thymocytes with individual stromal cell partners Eur. J. Immunol. 26 1996 892 896
37. M. Merkenschlager, C. Benoist, and D. Mathis Evidence for a single-niche model of positive selection Proc. Natl Acad. Sci. USA 91 1994 11694 11698
38. V. Müller, and S. Bonhoeffer Quantitative constraints on the scope of negative selection TRENDS Immunol. 24 2003 132 135
39. T. Nakayama, C.H. June, T.I. Munitz, M. Sheard, S.A. McCarthy, S.O. Sharrow, L.E. Samelson, and A. Singer Inhibition of T cell receptor expression and function in immature CD4 + CD8 + cells by CD4 Science 249 1990 1558 1561
40. L.B. Nicholson, A.C. Anderson, and V.K. Kuchroo Tuning T cell activation threshold and effector function with cross-reactive peptide ligands Int. Immunol. 12 2000 205 213
41. M. Oelke, M.V. Maus, D. Didiano, C.H. June, A. Mackensen, and J.P. Schneck Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig coated artificial antigen-presenting cells Nat. Med. 9 2003 619 625
42. D. Pardoll Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21 2003 807 839
43. P. Parham The Immune System 2000 Garland Publishing New York
44. J.L. Riley, M. Mao, S. Kobayashi, M. Biery, J. Burchard, G. Cavet, B.G. Gregson, C.H. June, and P.S. Linsey Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors Proc. Natl Acad. Sci. USA 99 2002 11790 11795
45. M.-G. Roncarolo, and M.K. Levings The role of different subsets of T regulatory cells in controlling autoimmunity Curr. Opin. Immunol. 12 2000 676 683
46. A.Y. Rudensky, P. Preston-Hurlburt, S.-C. Hong, A. Barlow, and C.A. Janeway Jr. Sequence analysis of peptides bound to MHC class II molecules Nature 353 1991 622 627
47. Scherer, A., Noest, A., Boer, R.J. de, 2004. Activation-threshold tuning in an affinity model for the T-cell repertoire. Proc. Roy. Soc., online, 03pb0541.2.
48. R. Scollay, and D.I. Godfrey Thymic emigration conveyor belts or lucky dips? Immunol. Today 16 1995 268 273
49. E. Sebza, S. Mariathasan, T. Ohteki, R. Jones, M.F. Bachmann, and P.S. Ohashi Selection of the T cell repertoire Annu. Rev. Immunol. 17 1999 829 874
50. K. Shortman, D. Vremec, and M. Egerton The kinetics of T cell antigen receptor expression by subgroups of CD4 + 8 + thymocytes delineation of CD4 + 8 + 3 2 + thymocytes as post-selection intermediates leading to mature T cells J. Exp. Med. 184 1996 1259 1268
51. P.J. Smith A recursive formulation of the old problem of obtaining moments from cumulants and vice versa Am. Statist. 49 1995 217 218
52. S. Stevanović, and H. Schild Quantitative aspects of T cell activation - peptide generation and editing by MHC class I molecule Semin. Immunol. 11 1999 375 384
53. W. Strober, I.J. Fuss, and R.S. Blumberg The immunology of mucosal models of inflammation Annu. Rev. Immunol. 20 2002 495 549
54. C.D. Surh, and J. Sprent T-cell apoptosis detected in situ during positive and negative selection in the thymus Nature 372 1994 100 103
55. S. Valitutti, and A. Lanzavecchia Serial triggering of TCRs a basis for the sensitivity and specificity of antigen recognition Immunol. Today 18 1997 299 304
56. A. Viola, and A. Lanzavecchia T cell activation determined by T cell receptor number and tunable thresholds Science 273 1996 104 106
57. P. Wong, G.M. Barton, K.A. Forbush, and A.Y. Rudensky Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands J. Exp. Med. 193 2001 1179 1187
58. J.W. Yewdell, and J.R. Bennink Cut and trim generating MHC class I peptide ligands Curr. Opin. Immunol. 13 2001 13 18