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Volumn 8, Issue 4, 1996, Pages 613-624

A model for antigen-induced T cell unresponsiveness based on autophosphorylative protein tyrosine kinase activity

Author keywords

Anergy; Bistability; Long term memory; Receptor desensitization; Signal transduction; T cell activation

Indexed keywords

ANTIGEN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

EID: 0029928254     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.4.613     Document Type: Article
Times cited : (8)

References (66)
  • 1
    • 0026338871 scopus 로고
    • Molecular and genetic insights into T cell antigen receptor structure and function
    • Weiss, A 1991. Molecular and genetic insights into T cell antigen receptor structure and function. Annu. Rev. Genet 25 487.
    • (1991) Annu. Rev. Genet , vol.25 , pp. 487
    • Weiss, A.1
  • 2
    • 0024980981 scopus 로고
    • Antigen receptor tail clue
    • Reth, M. 1989 Antigen receptor tail clue. Nature 338:383
    • (1989) Nature , vol.338 , pp. 383
    • Reth, M.1
  • 3
    • 0026547056 scopus 로고
    • Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon
    • Letourneur, F and Klausner, R D 1992. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon Science 255.79
    • (1992) Science , vol.255 , pp. 79
    • Letourneur, F.1    Klausner, R.D.2
  • 4
    • 0027399703 scopus 로고
    • Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain
    • Irving, B A, Chan, A C. and Weiss, A. 1993. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain J. Exp Med 177:1093.
    • (1993) J. Exp Med , vol.177 , pp. 1093
    • Irving, B.A.1    Chan, A.C.2    Weiss, A.3
  • 5
    • 0027305114 scopus 로고
    • The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif
    • Sancho, J., Franco, R , Chatila, T., Hail, C. and Terhorst, C 1993 The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif Eur J Immunol, 23.1636.
    • (1993) Eur J Immunol , vol.23 , pp. 1636
    • Sancho, J.1    Franco, R.2    Chatila, T.3    Hail, C.4    Terhorst, C.5
  • 6
    • 0026018057 scopus 로고
    • CDS stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T cell line
    • Park, D J , Rho, H W and Rhee, S G 1991 CDS stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T cell line Proc Natl Acad. Sci. USA 88:5453
    • (1991) Proc Natl Acad. Sci. USA , vol.88 , pp. 5453
    • Park, D.J.1    Rho, H.W.2    Rhee, S.G.3
  • 7
    • 0026095639 scopus 로고
    • Functional activation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1
    • Weiss, A., Koretzky, G , Schatzman, R C and Kadlecek, T 1991 Functional activation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc. Natl Acad. Sci. USA 88 5484
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 5484
    • Weiss, A.1    Koretzky, G.2    Schatzman, R.C.3    Kadlecek, T.4
  • 8
    • 0025835006 scopus 로고
    • T cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1
    • Secrist, J P, Karnitz, L and Abraham, R T 1991 T cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1 J. Biol Chem 266:12135
    • (1991) J. Biol Chem , vol.266 , pp. 12135
    • Secrist, J.P.1    Karnitz, L.2    Abraham, R.T.3
  • 9
    • 0021917674 scopus 로고
    • Transmembrane signalling by the T cell antigen receptor Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores
    • Imboden, J. B. and Stobo, J D. 1985 Transmembrane signalling by the T cell antigen receptor Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J. Exp Med 161 446
    • (1985) J. Exp Med , vol.161 , pp. 446
    • Imboden, J.B.1    Stobo, J.D.2
  • 10
    • 0028288927 scopus 로고
    • The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction
    • Chan, A. C., Desai, D M and Weiss, A 1994 The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction Annu Rev Immunol. 12:555
    • (1994) Annu Rev Immunol. , vol.12 , pp. 555
    • Chan, A.C.1    Desai, D.M.2    Weiss, A.3
  • 11
  • 12
    • 0023737931 scopus 로고
    • The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56/ck
    • Veillette, A., Bookman, M A Horak, E. M. and Bolen, J. B 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56/ck Cell 55.301.
    • (1988) Cell , vol.55 , pp. 301
    • Veillette, A.1    Bookman, M.A.2    Horak, E.M.3    Bolen, J.B.4
  • 13
    • 0025016458 scopus 로고
    • The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation
    • Veillette, A and Fournel. M. 1990 The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation. Oncogene 5 1455
    • (1990) Oncogene , vol.5 , pp. 1455
    • Veillette, A.1    Fournel, M.2
  • 14
    • 0027300619 scopus 로고
    • The when and how of Src regulation
    • Cooper, J A. and Howell, B. 1993. The when and how of Src regulation. Cell 73 1051
    • (1993) Cell , vol.73 , pp. 1051
    • Cooper, J.A.1    Howell, B.2
  • 15
    • 0027337981 scopus 로고
    • Signal transduction through a biomolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck
    • Adam, D , Klages, S. Bishop, P., Mahajan, S., Escobedo, J. A and Bolen, J B. 1993. Signal transduction through a biomolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck. J Biol. Chem 268:19882.
    • (1993) J Biol. Chem , vol.268 , pp. 19882
    • Adam, D.1    Klages, S.2    Bishop, P.3    Mahajan, S.4    Escobedo, J.A.5    Bolen, J.B.6
  • 16
    • 0028177398 scopus 로고
    • p56lck-independent activation and tyrosine phosphorylation of p72syk by T cell antigen receptor/CD3 stimulation
    • Couture C , Baier, G , Altman, A. and Mustelin, T. 1994. p56lck-independent activation and tyrosine phosphorylation of p72syk by T cell antigen receptor/CD3 stimulation Proc. Natl Acad. Sci. USA 91 5301
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 5301
    • Couture, C.1    Baier, G.2    Altman, A.3    Mustelin, T.4
  • 17
    • 0025942245 scopus 로고
    • The zeta chain is associated with a tyrosine kinase and upon T cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein
    • Chan, A. C., Irving, B A., Fraser, J D. and Wsiss, A. 1991 The zeta chain is associated with a tyrosine kinase and upon T cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl Acad. Sci USA 88.9166.
    • (1991) Proc. Natl Acad. Sci USA , vol.88 , pp. 9166
    • Chan, A.C.1    Irving, B.A.2    Fraser, J.D.3    Wsiss, A.4
  • 18
    • 0027328526 scopus 로고
    • Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells
    • Wange, R L , Malek, S. N , Desiderio, S and Samelson, L. E. 1993 Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J. Biol Chem 268:19797.
    • (1993) J. Biol Chem , vol.268 , pp. 19797
    • Wange, R.L.1    Malek, S.N.2    Desiderio, S.3    Samelson, L.E.4
  • 19
    • 0027477557 scopus 로고
    • Role of the CD45 tyrosine phosphatase in signal transduction in the immune system
    • Koretzky, G A 1993. Role of the CD45 tyrosine phosphatase in signal transduction in the immune system. FASEB J. 7 420.
    • (1993) FASEB J. , vol.7 , pp. 420
    • Koretzky, G.A.1
  • 20
    • 0027240587 scopus 로고
    • Negative regulation of T cell receptor signalling by tyrosine protein kinase p50csk
    • Chow, L M., Fournel, M , Davidson, D. and Veillette, A. 1993. Negative regulation of T cell receptor signalling by tyrosine protein kinase p50csk. Nature 365.156.
    • (1993) Nature , vol.365 , pp. 156
    • Chow, L.M.1    Fournel, M.2    Davidson, D.3    Veillette, A.4
  • 21
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz, R. H 1990. A cell culture model for T lymphocyte clonal anergy Science 248:1349.
    • (1990) Science , vol.248 , pp. 1349
    • Schwartz, R.H.1
  • 22
    • 0026047598 scopus 로고
    • Altered antigen receptor signaling in anergic T cells from self-tolerant T cell receptor beta-chain transgenic mice
    • Blackman, M. A, Finkel, T H , Kappler, J., Cambier, J. and Marrack, P 1991 Altered antigen receptor signaling in anergic T cells from self-tolerant T cell receptor beta-chain transgenic mice Proc Natl Acad Sci. USA 88.6682.
    • (1991) Proc Natl Acad Sci. USA , vol.88 , pp. 6682
    • Blackman, M.A.1    Finkel, T.H.2    Kappler, J.3    Cambier, J.4    Marrack, P.5
  • 23
    • 0025737076 scopus 로고
    • Induction of long-term but reversible unresponsiveness after activation of murine T cell hybridomas
    • Andris, F., Van Mechelen, M , Legrand, N , Dubois, P M , Kaufman, M, Urbain, J and Leo. O 1991. Induction of long-term but reversible unresponsiveness after activation of murine T cell hybridomas Int Immunol. 3.609.
    • (1991) Int Immunol. , vol.3 , pp. 609
    • Andris, F.1    Van Mechelen, M.2    Legrand, N.3    Dubois, P.M.4    Kaufman, M.5    Urbain, J.6    Leo, O.7
  • 25
    • 0027370384 scopus 로고
    • Superantigens and their potential role in human disease
    • Kotzin, B. L, Leung, D Y, Kappler, J. and Marrack, P. 1993. Superantigens and their potential role in human disease Adv. Immunol 54:99.
    • (1993) Adv. Immunol , vol.54 , pp. 99
    • Kotzin, B.L.1    Leung, D.Y.2    Kappler, J.3    Marrack, P.4
  • 26
    • 7944226596 scopus 로고
    • Theoretical insight into antigen-induced T cell unresponsiveness
    • Perelson, A. S. and Weisbuch, G., eds. Nato ASI Series H 66. Springer Verlag, Berlin
    • Kaufman, M , Andris, F and Leo, O 1992 Theoretical insight into antigen-induced T cell unresponsiveness In Perelson, A. S. and Weisbuch, G., eds. Theoretical and Experimental Insights into Immunology, Nato ASI Series H 66. p. 93. Springer Verlag, Berlin.
    • (1992) Theoretical and Experimental Insights into Immunology , pp. 93
    • Kaufman, M.1    Andris, F.2    Leo, O.3
  • 27
    • 0010424768 scopus 로고
    • A mechanism for memory storage insensitive to molecular turnover: A bistable autophosphorylating kinase
    • Lisman, J. E 1985. A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase. Proc. Natl Acad. Sci. USA 82.3055
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3055
    • Lisman, J.E.1
  • 28
    • 0029267491 scopus 로고
    • Dynamical behaviour of biological regulatory networks I Biological role of feedback loops and practical use of the concept of loop-characteristic state
    • Thomas, R., Thieffry, D and Kaufman, M 1995, Dynamical behaviour of biological regulatory networks I Biological role of feedback loops and practical use of the concept of loop-characteristic state Bull Math Biol 57:247.
    • (1995) Bull Math Biol , vol.57 , pp. 247
    • Thomas, R.1    Thieffry, D.2    Kaufman, M.3
  • 29
    • 0025809282 scopus 로고
    • Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number
    • Graber, M , Bockenstedt, L K and Weiss, A 1991 Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number. J. Immunol. 146:2935
    • (1991) J. Immunol. , vol.146 , pp. 2935
    • Graber, M.1    Bockenstedt, L.K.2    Weiss, A.3
  • 30
    • 0026598574 scopus 로고
    • Intercellular communication and cell-cell adhesion
    • Singer, S J. 1992 Intercellular communication and cell-cell adhesion Science 255:1671.
    • (1992) Science , vol.255 , pp. 1671
    • Singer, S.J.1
  • 31
    • 0026675654 scopus 로고
    • Transmembrane signaling: The joy of aggregation
    • Metzger, H. 1992. Transmembrane signaling: the joy of aggregation J Immunol 149 1477.
    • (1992) J Immunol , vol.149 , pp. 1477
    • Metzger, H.1
  • 32
    • 0141544141 scopus 로고
    • Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation
    • Cooper, and J. A , MacAuley, A 1988. Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation Proc. Natl Acad. Sci. USA 85:4232
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 4232
    • Cooper, J.A.1    MacAuley, A.2
  • 33
    • 0020567474 scopus 로고
    • The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells
    • Erneux, C , Cohen, S. and Garbers, D. 1983. The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells J. Biol. Chem 258:4137.
    • (1983) J. Biol. Chem , vol.258 , pp. 4137
    • Erneux, C.1    Cohen, S.2    Garbers, D.3
  • 34
    • 0023002071 scopus 로고
    • Abnormal tyrosine phosphorylation on T cell receptor in lymphoproliferative disorders
    • Samelson, L. E , Davidson, W F., Morse, H C and Klausner, R. D. 1986 Abnormal tyrosine phosphorylation on T cell receptor in lymphoproliferative disorders. Nature 324:674.
    • (1986) Nature , vol.324 , pp. 674
    • Samelson, L.E.1    Davidson, W.F.2    Morse, H.C.3    Klausner, R.D.4
  • 36
    • 0025947383 scopus 로고
    • - double-negative lymph node cells of MRL lpr/lpr mice
    • - double-negative lymph node cells of MRL lpr/lpr mice Eur J. Immunol. 21:2987.
    • (1991) Eur J. Immunol. , vol.21 , pp. 2987
    • Yokoyama, K.1    Gachelin, G.2
  • 38
    • 0027716926 scopus 로고
    • T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model
    • Homer, R. J , Mamalaki, C Kioussis, D and Flavell, R. A. 1993 T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model Int. Immunol. 5.1495.
    • (1993) Int. Immunol. , vol.5 , pp. 1495
    • Homer, R.J.1    Mamalaki, C.2    Kioussis, D.3    Flavell, R.A.4
  • 39
    • 0025978984 scopus 로고
    • Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells
    • Kupfer, A., Mosmann, T. R and Kupfer, H 1991 Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc Natl Acad Sci. USA 88.775
    • (1991) Proc Natl Acad Sci. USA , vol.88 , pp. 775
    • Kupfer, A.1    Mosmann, T.R.2    Kupfer, H.3
  • 40
    • 0023881127 scopus 로고
    • Receptor-directed focusing of lymphokine release by helper T cells
    • Poo, W J., Conrad, L and Janeway, C A, Jr 1988. Receptor-directed focusing of lymphokine release by helper T cells. Nature 332:378.
    • (1988) Nature , vol.332 , pp. 378
    • Poo, W.J.1    Conrad, L.2    Janeway Jr., C.A.3
  • 41
    • 21344495067 scopus 로고
    • A dilute bootstrap percolation: Lattice model for unresponsiveness in T cell immunology
    • Kaufman, M. and Stauffer, D 1993 A dilute bootstrap percolation: lattice model for unresponsiveness in T cell immunology J Stat Phys 73.843
    • (1993) J Stat Phys , vol.73 , pp. 843
    • Kaufman, M.1    Stauffer, D.2
  • 42
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva, D. R., Urdahl, K B. and Jenkins, M. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation J Immunol 147 3261.
    • (1991) J Immunol , vol.147 , pp. 3261
    • DeSilva, D.R.1    Urdahl, K.B.2    Jenkins, M.3
  • 43
    • 0027298445 scopus 로고
    • Induction of T cell anergy by altered T cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster, J , Evavold, B. D and Allen, P. M. 1993. Induction of T cell anergy by altered T cell-receptor ligand on live antigen-presenting cells. Nature 363 156.
    • (1993) Nature , vol.363 , pp. 156
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 44
    • 0025921599 scopus 로고
    • A characteristic Mls-1a response precedes Mls-1a anergy in vivo
    • Dannecker, G., Macheri, S , Staiano-Coico, L. and Hoffmann, M K. 1991 A characteristic Mls-1a response precedes Mls-1a anergy in vivo. J Immunol 146:2083.
    • (1991) J Immunol , vol.146 , pp. 2083
    • Dannecker, G.1    Macheri, S.2    Staiano-Coico, L.3    Hoffmann, M.K.4
  • 45
    • 0028229166 scopus 로고
    • Specific T cell tolerance may be preceded by a primary response
    • Vidard, L., Colarusso, L. J. and Benacerraf, B. 1994. Specific T cell tolerance may be preceded by a primary response Proc Natl Acad Sci. USA 91:5627
    • (1994) Proc Natl Acad Sci. USA , vol.91 , pp. 5627
    • Vidard, L.1    Colarusso, L.J.2    Benacerraf, B.3
  • 46
    • 0026645704 scopus 로고
    • Early signaling defects in human T cells anergized by T cell presentation of autoantigen
    • LaSalle, J M , Tolentino, P J , Freeman, G J , Nadler, L M and Hafler, D A. 1992. Early signaling defects in human T cells anergized by T cell presentation of autoantigen J Exp Med 176:177
    • (1992) J Exp Med , vol.176 , pp. 177
    • LaSalle, J.M.1    Tolentino, P.J.2    Freeman, G.J.3    Nadler, L.M.4    Hafler, D.A.5
  • 47
    • 0027958565 scopus 로고
    • Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways
    • Gajewski, T. F., Qian, D., Fields, P. and Fitch, F W. 1994. Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways Proc. Natl Acad. Sci. USA 91:38.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 38
    • Gajewski, T.F.1    Qian, D.2    Fields, P.3    Fitch, F.W.4
  • 48
    • 0027301903 scopus 로고
    • Altered protein tyrosine phosphorylation in anergic Th1 cells
    • Cho, E A , Riley, M. P., Sillman, A. L. and Quill. H. 1993 Altered protein tyrosine phosphorylation in anergic Th1 cells J. Immunol. 151 20
    • (1993) J. Immunol. , vol.151 , pp. 20
    • Cho, E.A.1    Riley, M.P.2    Sillman, A.L.3    Quill, H.4
  • 49
    • 0028299694 scopus 로고
    • - T cells is achieved by induction of cell cycling and normalization of CD2 and p59fyn expression
    • - T cells is achieved by induction of cell cycling and normalization of CD2 and p59fyn expression Eur. J. Immunol. 24.558.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 558
    • Clements, J.L.1    Wolfe, J.2    Cooper, S.M.3    Budd, R.C.4
  • 50
  • 51
    • 0027967385 scopus 로고
    • Partial T cell signaling, altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster, J., Shaw, A S , Rothbard, J B and Allen, P M. 1994 Partial T cell signaling, altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79.913
    • (1994) Cell , vol.79 , pp. 913
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 52
    • 0027433501 scopus 로고
    • Difference in signal transduction pathway for IL-2 and IL-4 production in T helper 1 and T helper 2 cell clones in response to anti-CD3
    • Tamura, T, Yanagida, T and Nariuchi. H. 1993. Difference in signal transduction pathway for IL-2 and IL-4 production in T helper 1 and T helper 2 cell clones in response to anti-CD3 J Immunol 151 6051
    • (1993) J Immunol , vol.151 , pp. 6051
    • Tamura, T.1    Yanagida, T.2    Nariuchi, H.3
  • 53
    • 0025248038 scopus 로고
    • Th1 and Th2 clones differ in their response to a tolerogenic signal
    • Gilbert, K. M , Hoang, K. D. and Weigle, W O. 1990 Th1 and Th2 clones differ in their response to a tolerogenic signal J. Immunol. 144:2063
    • (1990) J. Immunol. , vol.144 , pp. 2063
    • Gilbert, K.M.1    Hoang, K.D.2    Weigle, W.O.3
  • 54
    • 0026660731 scopus 로고
    • Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns
    • Williams, M E , Shea, C M , Lichtman, A H and Abbas, A. K 1992. Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns. J Immunol. 149:1921
    • (1992) J Immunol. , vol.149 , pp. 1921
    • Williams, M.E.1    Shea, C.M.2    Lichtman, A.H.3    Abbas, A.K.4
  • 55
    • 0026551832 scopus 로고
    • The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes
    • De Wit, D , Van Mechelen, M , Ryelandt, M , Figueiredo, A. C., Abramowicz, D., Goldman, M , Bazin, H , Urbain, J and Leo, O. 1992 The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes J Exp. Med. 175.9
    • (1992) J Exp. Med. , vol.175 , pp. 9
    • De Wit, D.1    Van Mechelen, M.2    Ryelandt, M.3    Figueiredo, A.C.4    Abramowicz, D.5    Goldman, M.6    Bazin, H.7    Urbain, J.8    Leo, O.9
  • 56
    • 0028040873 scopus 로고
    • In vivo tolenzation of Th1 lymphocytes following a single feeding with ovalbumin: Anergy in the absence of suppression
    • Melamed, D and Friedman, A 1994. In vivo tolenzation of Th1 lymphocytes following a single feeding with ovalbumin: anergy in the absence of suppression. Eur J. Immunol 24 1974.
    • (1994) Eur J. Immunol , vol.24 , pp. 1974
    • Melamed, D.1    Friedman, A.2
  • 57
    • 0025762153 scopus 로고
    • + T cell: Receptor-dependent cytolysis in the absence of interleukin-2 production
    • + T cell: receptor-dependent cytolysis in the absence of interleukin-2 production Science 251 1228
    • (1991) Science , vol.251 , pp. 1228
    • Otten, G.R.1    Germain, R.N.2
  • 58
    • 0027166721 scopus 로고
    • Anergized T cell clones retain their cytolytic ability
    • Go, C , Lancki, D W., Fitch, F W and Miller, J 1993. Anergized T cell clones retain their cytolytic ability J Immunol 150.367
    • (1993) J Immunol , vol.150 , pp. 367
    • Go, C.1    Lancki, D.W.2    Fitch, F.W.3    Miller, J.4
  • 62
    • 0025352299 scopus 로고
    • Beta-arrestin a protein that regulates beta-adrenergic receptor function
    • Lohse, M J , Benovic, J L. Codina, J , Caron, M G and Lefkowitz, R J. 1990 beta-arrestin a protein that regulates beta-adrenergic receptor function Science 248:1547
    • (1990) Science , vol.248 , pp. 1547
    • Lohse, M.J.1    Benovic, J.L.2    Codina, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 63
    • 0022552054 scopus 로고
    • A molecular mechanism for sensory adaptation based on ligand-induced receptor modification
    • Knox, B E., Devreotes, P N , Goldbeter, A. and Segel, L A. 1986 A molecular mechanism for sensory adaptation based on ligand-induced receptor modification. Proc. Natl Acad. Sci. USA 83.2345
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 2345
    • Knox, B.E.1    Devreotes, P.N.2    Goldbeter, A.3    Segel, L.A.4
  • 64
    • 0020171028 scopus 로고
    • Sensitivity amplification in biochemical systems
    • Goldbeter, A. and Koshland, D. E. 1982. Sensitivity amplification in biochemical systems Q Rev Biophys 15.555.
    • (1982) Q Rev Biophys , vol.15 , pp. 555
    • Goldbeter, A.1    Koshland, D.E.2
  • 65
    • 0023661773 scopus 로고
    • Bistability and Irreversible Transitions in a simple substrate cycle
    • Hervagault, J.-F and Canu, S. 1987 Bistability and Irreversible Transitions in a simple substrate cycle J Theor. Biol 127 439
    • (1987) J Theor. Biol , vol.127 , pp. 439
    • Hervagault, J.-F.1    Canu, S.2
  • 66
    • 0028500924 scopus 로고
    • A molecular switch for memory
    • Anwyl, R 1994 A molecular switch for memory. Curr Biol. 4:854.
    • (1994) Curr Biol. , vol.4 , pp. 854
    • Anwyl, R.1


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