Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy

Journal of Immunology

Volumn 170, Issue 3, 2003, Pages 1231-1239

  Slifka, Mark K ^b   Blattman, Joseph N ^d   Sourdive, David J D ^d   Liu, Fei ^c   Huffman, Donald L ^a   Wolfe, Tom ^a   Hughes, Anna ^a   Oldstone, Michael B A ^c   Ahmed, Rafi ^d   Von Herrath, Matthias G ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; COMPLEMENTARITY DETERMINING REGION; GENETIC POLYMORPHISM; IMMUNE RESPONSE; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; VIRUS INFECTION;

EID: 0037310510     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.3.1231     Document Type: Article

References (49)

1. Ashton-Rickardt, P. G., A. Bandeira, J. R. Delaney, L. Van Kaer, H. P. Pircher. R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
2. Hoffmann, M. W., W. R. Heath. D. Ruschmeyer, and J. F. Miller. 1995. Deletion of high-avidity T cells by thymic epithelium. Proc. Natl. Acad. Sci. USA 92:9851.
3. Jameson, S. C., and M. J. Bevan. 1998. T-cell selection. Curr. Opin. Immunol. 10:214.
4. Sebzda, E., S. Mariathasan, T. Ohteki, R. Jones, M. F. Bachmann, and P. S. Ohashi. 1999. Selection of the T cell repertoire. Annu. Rev. Immunol. 17:829.
5. Kishimoto, H., and J. Sprent. 2000. The thymus and negative selection. Immunol. Res. 21:315.
6. Nikolic-Zugic, J., and M. J. Bevan. 1990. Role of self-peptides in positively selecting the T-cell repertoire. Nature 344:65.
7. + T cells. Immunity 7:209.
8. Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
9. von Herrath, M. G., J. Dockter, and M. B. Oldstone. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1:231.
10. von Herrath, M. G., J. Dockter, M. Nerenberg, J. E. Gairin, and M. B. Oldstone. 1994. Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus. J. Exp. Med. 180:1901.
11. von Herrath, M. G., B. Coon, and M. B. Oldstone. 1997. Low-affinity cytotoxic T-lymphocytes require IFN-γ to clear an acute viral infection. Virology 229:349.
12. + T cells without selection of higher affinity TCR. Nat. Immunol. 2:711.
13. Chen, W., J. W. Yewdell, R. L. Levine, and J. R. Bennink. 1999. Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants. J. Exp. Med. 189:1757.
14. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. D. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177.
15. Pannetier, C., M. Cochet, S. Darche, A. Casrouge, M. Zoller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β-chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90:4319.
16. Sourdive, D. J. D., K. Murali-Krishna, J. D. Altman, A. J. Zajac, J. K. Whitmire, C. Pannetier, P. Kourilsky, B. Evavold, A. Sette, and R. Ahmed. 1998. Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188:71.
17. Vijh, S., and E. G. Pamer. 1997. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 158:3366.
18. Cunningham, B. C., and J. A. Wells. 1989. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244:1081.
19. Bachmann, M. F., A. Oxenius, D. E. Speiser, S. Mariathasan, H. Hengartner, R. M. Zinkernagel, and P. S. Ohashi. 1997. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation. Eur. J. Immunol. 27:2195.
20. Bachmann, M. F., D. E. Speiser, and P. S. Ohashi. 1997. Functional management of an antiviral cytotoxic T-cell response. J. Virol. 71:5764.
21. Ahmed, R. 1994. Virus persistence and immune memory. Semin. Virol. 5:319.
22. Bachmann, M. F., K. McKall-Faienza, R. Schmits, D. Bouchard, J. Beach, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1997. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7:549.
23. Bachmann, M. F., M. Barner, and M. Kopf. 1999. CD2 sets quantitative thresholds in T cell activation. J. Exp. Med. 190:1383.
24. Harrington, L. E., M. Galvan, L. G. Baum, J. D. Altman, and R. Ahmed. 2000. Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. J. Exp. Med. 191:1241.
25. Crawford, F., H. Kozono, J. White, P. Marrack, and J. Kappler. 1998. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8:675.
26. Busch, D. H., and E. G. Pamer. 1999. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189:701.
27. Yee, C., P. A. Savage, P. P. Lee, M. M. Davis, and P. D. Greenberg. 1999. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162:2227.
28. de Visser, K. E., T. A. Cordaro, D. Kioussis, J. B. Haanen, T. N. Schumacher, and A. M. Kruisbeek. 2000. Tracing and characterization of the low-avidity self-specific T cell repertoire. Eur. J. Immunol. 30:1458.
29. Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13:829.
30. + T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas. J. Immunol. 164:191.
31. Fahmy, T. M., J. G. Bieler, M. Edidin, and J. P. Schneck. 2001. Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen. Immunity 14:135.
32. + T cells for melanoma immunotherapy in human MHC class I-transgenic mice. J. Immunol. 167:5824.
33. Kalergis, A. M., N. Boucheron, M. A. Doucey, E. Palmieri, E. C. Goyarts, Z. Vegh, I. F. Luescher, and S. G. Nathenson. 2001. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat. Immunol. 2:229.
34. Lin, M. Y., and R. M. Welsh. 1998. Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice. J. Exp. Med. 188:1993.
35. Teh, H. S., H. Kishi, B. Scott, and H. Von Boehmer. 1989. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. 169:795.
36. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
37. Busch, D. H., I. M. Pilip, S. Vijh, and E. G. Pamer. 1998. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity 8:353.
38. + T cells can be distinguished by their cytokine profiles and phenotypic markers. J. Immunol. 164:208.
39. + T cells with a predominant Vβ usage during the primary immune response to HIV. Nature 370:463.
40. McHeyzer-Williams, M. G., and M. M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science 268:106.
41. Maryanski, J. L., C. V. Jongeneel, P. Bucher, J. L. Casanova, and P. R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 4:47.
42. + T cells at the levels of T cell repertoire and presentation of viral antigens. J. Exp. Med. 193:1319.
43. Yewdell, J. W., and J. R. Bennink. 1999. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu. Rev. Immunol. 17:51.
44. + T cell homeostasis by perforin and interferon-γ. Science 290:1354.
45. + T-cell responses is dramatically modified by DNA immunization and is regulated by γ-interferon. J. Virol. 76:4251.
46. Stockinger, B. 1999. T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv. Immunol. 71:229.
47. Cibotti, R., J. M. Kanellopoulos, J. P. Cabaniols, O. Halle-Panenko, K. Kosmatopoulos, E. Sercarz, and P. Kourilsky. 1992. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad. Sci. USA 89:416.
48. Klein, L., T. Klein, U. Ruther, and B. Kyewski. 1998. CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium. J. Exp. Med. 188:5.
49. von Herrath, M. G., C. F. Evans, M. S. Horwitz, and M. B. Oldstone. 1996. Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of Langerhans and the central nervous system. Immunol. Rev. 152:111.