Kinetic proofreading in receptor-mediated transduction of cellular signals: Receptor aggregation, partially activated receptors, and cytosolic messengers

Bulletin of Mathematical Biology

Volumn 64, Issue 5, 2002, Pages 887-911

  Hlavacek, William S ^a   Redondo, Antonio ^a   Wofsy, Carla ^b   Goldstein, Byron ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; LIGAND; RECEPTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; BINDING KINETICS; CAPPING PHENOMENON; CELL KINETICS; CYTOSOL; LIGAND BINDING; MATHEMATICAL MODEL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR SENSITIVITY; SECOND MESSENGER; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0036739732     PISSN: 00928240     EISSN: None     Source Type: Journal    
DOI: 10.1006/bulm.2002.0306     Document Type: Article

References (41)

1. Brivanlou, A. H. and J. E. Darnell, Jr (2002). Signal transduction and the control of gene expression. Science 295, 813-818.
2. Chan, C., A. J. T. George and J. Stark (2001). Cooperative enhancement of specificity in a lattice of T cell receptors. Proc. Natl. Acad. Sci. USA 98, 5758-5763.
3. Cochran, J. R., T. O. Cameron and L. J. Stern (2000). The relationship of MHC-peptide binding and T cell activation probed using chemically defined class II oligomers. Immunity 12, 241-250.
4. Cochran, J. R., D. Aivazian, T. O. Cameron and L. J. Stern (2001). Receptor clustering and transmembrane signaling in T cells. Trends Biochem. Sci. 26, 304-310.
5. Ehrenberg, M. and C. Blomberg (1980). Thermodynamic constraints on kinetic proofreading in biosynthetic pathways. Biophys. J. 31, 333-358.
6. Erickson, J., B. Goldstein, D. Holowka and B. Baird (1987). The effect of receptor density on the forward rate constant for binding of ligands to cell surface receptors. Biophys. J. 52, 657-662.
7. Germain, R. N. (2001). The T cell receptor for antigen: signaling and ligand discrimination. J. Biol. Chem. 276, 35223-35226.
8. Germain, R. N. and I. Štefanová (1999). The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol. 17, 467-522.
9. Goldstein, B. and C. Wofsy (1994). Aggregation of cell surface receptors, in Cell Biology, B. Goldstein and C. Wofsy (Eds), Providence, RI: American Mathematical Society, pp. 109-135.
10. Hlavacek, W. S. and M. A. Savageau (1998). Method for determining natural design principles of biological control circuits. J. Intell. Fuzzy Syst. 6, 147-160.
11. Hlavacek, W. S., A. S. Perelson, B. Sulzer, J. Bold, J. Paar, W. Gorman and R. G. Posner (1999). Quantifying aggregation of IgE-FcεRI by multivalent antigen. Biophys. J. 76, 2421-2431.
12. Hlavacek, W. S., A. Redondo, H. Metzger, C. Wofsy and B. Goldstein (2001). Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc. Natl. Acad. Sci. USA 98, 7295-7300.
13. Hopfield, J. J. (1974). Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl. Acad. Sci. USA 71, 4135-4139.
14. Kalergis, A. M., N. Boucheron, M.-A. Doucey, E. Palmieri, E. C. Goyarts, Z. Vegh, I. F. Luescher and S. G. Nathenson (2001). Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat. Immun. 2, 229-234.
15. Keegan, A. D. and W. E. Paul (1992). Multichain immune recognition receptors: similarities in structure and signaling pathways. Immunol. Today 13, 63-68.
16. Kersh, E. N., A. S. Shaw and P. M. Allen (1998). Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281, 572-575.
17. Kim, S., S. M. Patrick, N. S. Braunstein, J. L. Thomas and E. F. Leonard (2001). Modeling of early events in T cell signal transduction after controlled T cell activation by peptide major histocompatibility complex. Ann. Biomed. Eng. 29, 373-383.
18. Lanzavecchia, A., G. Iezzi and A. Viola (1999). From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96, 1-4.
19. Leonard, W. J. and J. J. O'Shea (1998). JAKs and STATs: biological implications. Annu. Rev. Immunol. 16, 293-322.
20. Liu, Z.-J., H. Haleem-Smith, H. Chen and H. Metzger (2001). Unexpected signals in a system subject to kinetic proofreading. Proc. Natl. Acad. Sci. USA 98, 7289-7294.
21. Lord, G. M., R. I. Lechler and A. J. T. George (1999). A kinetic differentiation model for the action of altered TCR ligands. Immunol. Today 20, 33-39.
22. McKeithan, T. W. (1995). Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92, 5042-5046.
23. Metzger, H. (1992). Transmembrane signaling: the joy of aggregation. J. Immunol. 149, 1477-1487.
24. Ninio, J. (1975). Kinetic amplification of enzyme discrimination. Biochimie 57, 587-595.
25. Perelson, A. S. and C. DeLisi (1980). Receptor clustering on a cell surface. I. Theory of receptor cross-linking by ligands bearing two chemically identical functional groups. Math. Biosci. 48, 71-110.
26. Perelson, A. S. (1984). Some mathematical models of receptor clustering by multivalent ligands, in Cell Surface Dynamics: Concepts and Models, A. S. Perelson, C. DeLisi and F. W. Wiegel (Eds), New York: Marcel Dekker, pp. 223-276.
27. Rabinowitz, J. D., C. Beeson, D. S. Lyons, M. M. Davis and H. M. McConnell (1996). Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA 93, 1401-1405.
28. Rosette, C., G. Werlen, M. A. Daniels, P. O. Holman, S. M. Alam, P. J. Travers, N. R. J. Gascoigne, E. Palmer and S. C. Jameson (2001). The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity 15, 59-70.
29. Savageau, M. A. (1985). A theory of alternative designs for biochemical control systems. Biomed. Biochim. Acta 44, 875-880.
30. Segel, L. A. (1988). On the validity of the steady-state assumption of enzyme kinetics. Bull. Math. Biol. 50, 579-593.
31. Segel, L. A. and M. Slemrod (1989). The quasi-steady-state assumption: a case study in perturbation. SIAM Rev. 31, 446-477.
32. Segal, D. M., J. D. Taurog and H. Metzger (1977). Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc. Natl. Acad. Sci. USA 74, 2993-2997.
33. Sloan-Lancaster, J. and P. M. Allen (1996). Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14, 1-27.
34. Sontag, E. D. (2001). Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction. IEEE Trans. Automat. Control 46, 1028-1047.
35. Subramanian, K. (1995). Binding and functional effects of defined ligands with monovalent, bivalent, and bispecific IgE in solution and on the cell surface, PhD thesis, Cornell University, Ithaca, NY.
36. Subramanian, K., D. Holowka, B. Baird and B. Goldstein (1996). The Fc segment of IgE influences the kinetics of dissociation of a symmetrical bivalent ligand from cyclic dimeric complexes. Biochemistry 35, 5518-5527.
37. Torigoe, C., J. K. Inman and H. Metzger (1998). An unusual mechanism for ligand antagonism. Science 281, 568-572.
38. Turner, H. and J.-P. Kinet (1999). Signalling through the high-affinity IgE receptor FcεRI. Nature 402, B24-B30.
39. Voit, E. O. (2000). Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists, Ch. 7, Cambridge, UK: Cambridge University Press.
40. Wofsy, C., D. Coombs and B. Goldstein (2001). Calculations show substantial serial engagement of T cell receptors. Biophys. J. 80, 606-612.
41. Xu, K., B. Goldstein, D. Holowka and B. Baird (1998). Kinetics of multivalent antigen DNP-BSA binding to IgE-FcεRI in relationship to the stimulated tyrosine phosphorylation of FcεRI. J. Immunol. 160, 3225-3235.