Highly efficient synthesis of ampicillin in an "aqueous solution-precipitate" system: Repetitive addition of substrates in a semicontinuous process

Biotechnology and Bioengineering

Volumn 73, Issue 5, 2001, Pages 426-430

  Youshko, Maxim I ^a   Van Langen, Luuk M ^b   De Vroom, Erik ^c   Van Rantwijk, Fred ^b   Sheldon, Roger A ^b   Švedas, Vytas K ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c DSM RESOLVE   (Netherlands)

Author keywords

Ampicillin synthesis; Aqueous biocatalytic process; Aqueous solution precipitate system; Penicillin acylase

Indexed keywords

ESCHERICHIA COLI; MATHEMATICAL MODELS; PRECIPITATION (CHEMICAL); SOLUTIONS; SYNTHESIS (CHEMICAL);

AMPICILLIN;

BIOTECHNOLOGY;

AMIDASE; AMPICILLIN;

AQUEOUS SOLUTION; ARTICLE; BIOCATALYST; COMPUTER MODEL; DRUG HYDROLYSIS; DRUG SYNTHESIS; MATHEMATICAL MODEL; REACTION ANALYSIS;

AMPICILLIN; ESCHERICHIA COLI; MODELS, THEORETICAL; PENICILLANIC ACID; PENICILLIN AMIDASE; PRECIPITATION; SOLUTIONS; WATER;

EID: 0035811256     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.1076     Document Type: Article

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