-
1
-
-
33750456519
-
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
-
Olsen, J. V. et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127, 635-648 (2006).
-
(2006)
Cell
, vol.127
, pp. 635-648
-
-
Olsen, J.V.1
-
2
-
-
0036527429
-
Protein kinases - the major drug targets of the twenty-first century?
-
Cohen, P. Protein kinases - the major drug targets of the twenty-first century? Nature Rev. Drug Discov. 1, 309-315 (2002).
-
(2002)
Nature Rev. Drug Discov
, vol.1
, pp. 309-315
-
-
Cohen, P.1
-
3
-
-
33750299450
-
-
Tonks, N. K. Protein tyrosine phosphatases: from genes, to function, to disease. Nature Rev. Mol. Cell Biol. 7, 833-846 (2006). An up-to-date review with a regulatory, structural and genomics perspective on the PTPs.
-
Tonks, N. K. Protein tyrosine phosphatases: from genes, to function, to disease. Nature Rev. Mol. Cell Biol. 7, 833-846 (2006). An up-to-date review with a regulatory, structural and genomics perspective on the PTPs.
-
-
-
-
4
-
-
33750374137
-
The twentieth century struggle to decipher insulin signalling
-
Cohen, P. The twentieth century struggle to decipher insulin signalling. Nature Rev. Mol. Cell Biol. 7, 867-873 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol
, vol.7
, pp. 867-873
-
-
Cohen, P.1
-
5
-
-
33751538328
-
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1
-
Zhang, Y. et al. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol. Cell 24, 759-770 (2006).
-
(2006)
Mol. Cell
, vol.24
, pp. 759-770
-
-
Zhang, Y.1
-
6
-
-
0028089860
-
Inhibitors of protein kinases and phosphatases
-
MacKintosh, C. & MacKintosh, R. W. Inhibitors of protein kinases and phosphatases. Trends Biochem. Sci. 19, 444-448 (1994).
-
(1994)
Trends Biochem. Sci
, vol.19
, pp. 444-448
-
-
MacKintosh, C.1
MacKintosh, R.W.2
-
7
-
-
0035252894
-
Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
Janssens, V. & Goris, J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439 (2001).
-
(2001)
Biochem. J
, vol.353
, pp. 417-439
-
-
Janssens, V.1
Goris, J.2
-
8
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
MacKeigan, J. P., Murphy, L. O. & Blenis, J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biol. 7, 591-600 (2005).
-
(2005)
Nature Cell Biol
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
9
-
-
33749537857
-
Genome-wide functional analysis of human cell-cycle regulators
-
Mukherji, M. et al. Genome-wide functional analysis of human cell-cycle regulators. Proc. Natl Acad. Sci. USA 103, 14819-14824 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 14819-14824
-
-
Mukherji, M.1
-
10
-
-
2942581416
-
Protein tyrosine phosphatases in the human genome
-
Alonso, A. et al. Protein tyrosine phosphatases in the human genome. Cell 117, 699-711 (2004).
-
(2004)
Cell
, vol.117
, pp. 699-711
-
-
Alonso, A.1
-
11
-
-
27944470541
-
-
Begley, M. J. & Dixon, J. E. The structure and regulation of myotubularin phosphatases. Curr. Opin. Struct. Biol. 15, 614-620 (2005). An examination of the myotubularin subfamily of the PTPs, which discusses the molecular basis of their unique substrate specificity as revealed by structural studies.
-
Begley, M. J. & Dixon, J. E. The structure and regulation of myotubularin phosphatases. Curr. Opin. Struct. Biol. 15, 614-620 (2005). An examination of the myotubularin subfamily of the PTPs, which discusses the molecular basis of their unique substrate specificity as revealed by structural studies.
-
-
-
-
12
-
-
34447280860
-
-
ed. Moorhead, G, Humana Press, Totawa
-
Mustelin, T. in Methods in Molecular Biology. (ed. Moorhead, G.) 9-22 (Humana Press, Totawa, 2007).
-
(2007)
Methods in Molecular Biology
, pp. 9-22
-
-
Mustelin, T.1
-
13
-
-
0344875035
-
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
-
Li, X. et al. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 426, 247-254 (2003).
-
(2003)
Nature
, vol.426
, pp. 247-254
-
-
Li, X.1
-
14
-
-
0344443181
-
The transcription factor Eyes absent is a protein tyrosine phosphatase
-
Tootle, T. L. et al. The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature 426, 299-302 (2003).
-
(2003)
Nature
, vol.426
, pp. 299-302
-
-
Tootle, T.L.1
-
15
-
-
22344456265
-
-
Meinhart, A., Kamenski, T., Hoeppner, S., Baumli, S. & Cramer, P. A structural perspective of CTD function. Genes Dev. 19, 1401-1415 (2005). A comprehensive look at the regulation of RNA Pol II CTD by protein kinases and phosphatases with a structural emphasis.
-
Meinhart, A., Kamenski, T., Hoeppner, S., Baumli, S. & Cramer, P. A structural perspective of CTD function. Genes Dev. 19, 1401-1415 (2005). A comprehensive look at the regulation of RNA Pol II CTD by protein kinases and phosphatases with a structural emphasis.
-
-
-
-
16
-
-
12844250536
-
Small CTD phosphatases function in silencing neuronal gene expression
-
Yeo, M. et al. Small CTD phosphatases function in silencing neuronal gene expression. Science 307, 596-600 (2005).
-
(2005)
Science
, vol.307
, pp. 596-600
-
-
Yeo, M.1
-
17
-
-
0038168110
-
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5
-
Yeo, M., Lin, P. S., Dahmus, M. E. & Gill, G. N. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278, 26078-26085 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 26078-26085
-
-
Yeo, M.1
Lin, P.S.2
Dahmus, M.E.3
Gill, G.N.4
-
19
-
-
0022482857
-
Isolation and characterization of an inhibitor-sensitive and a polycation-stimulated protein phosphatase from rat liver nuclei
-
Jakes, S., Mellgren, R. L. & Schlender, K. K. Isolation and characterization of an inhibitor-sensitive and a polycation-stimulated protein phosphatase from rat liver nuclei. Biochim. Biophys. Acta 888, 135-142 (1986).
-
(1986)
Biochim. Biophys. Acta
, vol.888
, pp. 135-142
-
-
Jakes, S.1
Mellgren, R.L.2
Schlender, K.K.3
-
20
-
-
0022450582
-
Identification of high levels of protein phosphatase-1 in rat liver nuclei
-
Kuret, J., Bell, H. & Cohen, P. Identification of high levels of protein phosphatase-1 in rat liver nuclei. FEBS Lett. 203, 197-202 (1986).
-
(1986)
FEBS Lett
, vol.203
, pp. 197-202
-
-
Kuret, J.1
Bell, H.2
Cohen, P.3
-
21
-
-
0032101295
-
Differential subcellular localization of protein phosphatase-1 α, γ1, and δ isoforms during both interphase and mitosis in mammalian cells
-
Andreassen, P. R., Lacroix, F. B., Villa-Moruzzi, E. & Margolis, R. L. Differential subcellular localization of protein phosphatase-1 α, γ1, and δ isoforms during both interphase and mitosis in mammalian cells. J. Cell Biol. 141, 1207-1215 (1998).
-
(1998)
J. Cell Biol
, vol.141
, pp. 1207-1215
-
-
Andreassen, P.R.1
Lacroix, F.B.2
Villa-Moruzzi, E.3
Margolis, R.L.4
-
22
-
-
0035207924
-
Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells
-
Trinkle-Mulcahy, L., Sleeman, J. E. & Lamond, A. I. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J. Cell Sci. 114, 4219-4228 (2001).
-
(2001)
J. Cell Sci
, vol.114
, pp. 4219-4228
-
-
Trinkle-Mulcahy, L.1
Sleeman, J.E.2
Lamond, A.I.3
-
23
-
-
26844576400
-
Determinants of the nucleolar targeting of protein phosphatase-1
-
Lesage, B., Beullens, M., Ceulemans, H., Himpens, B. & Bollen, M. Determinants of the nucleolar targeting of protein phosphatase-1. FEBS Lett. 579, 5626-5630 (2005).
-
(2005)
FEBS Lett
, vol.579
, pp. 5626-5630
-
-
Lesage, B.1
Beullens, M.2
Ceulemans, H.3
Himpens, B.4
Bollen, M.5
-
24
-
-
0037317592
-
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1α to the endoplasmic reticulum and promotes dephosphorylation of the α subunit of eukaryotic translation initiation factor 2
-
Brush, M. H., Weiser, D. C. & Shenolikar, S. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1α to the endoplasmic reticulum and promotes dephosphorylation of the α subunit of eukaryotic translation initiation factor 2. Mol. Cell. Biol. 23, 1292-1303 (2003).
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 1292-1303
-
-
Brush, M.H.1
Weiser, D.C.2
Shenolikar, S.3
-
25
-
-
0030977268
-
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1
-
Egloff, M. P. et al. Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J. 16, 1876-1887 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 1876-1887
-
-
Egloff, M.P.1
-
26
-
-
3042547846
-
Structural basis of protein phosphatase 1 regulation
-
Terrak, M., Kerff, F., Langsetmo, K., Tao, T. & Dominguez, R. Structural basis of protein phosphatase 1 regulation. Nature 429, 780-784 (2004).
-
(2004)
Nature
, vol.429
, pp. 780-784
-
-
Terrak, M.1
Kerff, F.2
Langsetmo, K.3
Tao, T.4
Dominguez, R.5
-
27
-
-
0030036564
-
Identification of proteinphosphatase-1- binding domains on the glycogen and myofibrillar targetting subunits
-
Johnson, D. F. et al. Identification of proteinphosphatase-1- binding domains on the glycogen and myofibrillar targetting subunits. Eur. J. Biochem. 239, 317-325 (1996).
-
(1996)
Eur. J. Biochem
, vol.239
, pp. 317-325
-
-
Johnson, D.F.1
-
28
-
-
0030680153
-
A protein phosphatase-1-binding motif identified by the panning of a random peptide display library
-
Zhao, S. & Lee, E. Y. A protein phosphatase-1-binding motif identified by the panning of a random peptide display library. J. Biol. Chem. 272, 28368-28372 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 28368-28372
-
-
Zhao, S.1
Lee, E.Y.2
-
29
-
-
34447259360
-
-
ed. Moorhead, G, Humana Press, Totawa
-
Roadcap, D., Matthew, H. & Shenolikar, S. in Methods in Molecular Biology. (ed. Moorhead, G.) 181-196 (Humana Press, Totawa, 2007).
-
(2007)
Methods in Molecular Biology
, pp. 181-196
-
-
Roadcap, D.1
Matthew, H.2
Shenolikar, S.3
-
30
-
-
0038819929
-
Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1
-
Wakula, P., Beullens, M., Ceulemans, H., Stalmans, W. & Bollen, M. Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1. J. Biol. Chem. 278, 18817-18823 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 18817-18823
-
-
Wakula, P.1
Beullens, M.2
Ceulemans, H.3
Stalmans, W.4
Bollen, M.5
-
31
-
-
30744432348
-
Structural analysis of the protein phosphatase 1 docking motif: Molecular description of binding specificities identifies interacting proteins
-
Meiselbach, H., Sticht, H. & Enz, R. Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem. Biol. 13, 49-59 (2006).
-
(2006)
Chem. Biol
, vol.13
, pp. 49-59
-
-
Meiselbach, H.1
Sticht, H.2
Enz, R.3
-
32
-
-
0029083171
-
Subunit structure and regulation of protein phosphatase-1 in rat liver nuclei
-
Jagiello, I., Beullens, M., Stalmans, W. & Bollen, M. Subunit structure and regulation of protein phosphatase-1 in rat liver nuclei. J. Biol. Chem. 270, 17257-17263 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 17257-17263
-
-
Jagiello, I.1
Beullens, M.2
Stalmans, W.3
Bollen, M.4
-
33
-
-
2642511406
-
Proteomic characterization of protein phosphatase complexes of the mammalian nucleus
-
Tran, H. T., Ulke, A., Morrice, N., Johannes, C. J. & Moorhead, G. B. Proteomic characterization of protein phosphatase complexes of the mammalian nucleus. Mol. Cell. Proteomics 3, 257-265 (2004).
-
(2004)
Mol. Cell. Proteomics
, vol.3
, pp. 257-265
-
-
Tran, H.T.1
Ulke, A.2
Morrice, N.3
Johannes, C.J.4
Moorhead, G.B.5
-
34
-
-
33644524404
-
Repo-Man recruits PP1γ to chromatin and is essential for cell viability
-
Trinkle-Mulcahy, L. et al. Repo-Man recruits PP1γ to chromatin and is essential for cell viability. J. Cell Biol. 172, 679-692 (2006).
-
(2006)
J. Cell Biol
, vol.172
, pp. 679-692
-
-
Trinkle-Mulcahy, L.1
-
35
-
-
33747072663
-
PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K
-
Kwiek, N. C., Thacker, D. F., Datto, M. B., Megosh, H. B. & Haystead, T. A. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. Cell Signal 18, 1769-1778 (2006).
-
(2006)
Cell Signal
, vol.18
, pp. 1769-1778
-
-
Kwiek, N.C.1
Thacker, D.F.2
Datto, M.B.3
Megosh, H.B.4
Haystead, T.A.5
-
36
-
-
1542314816
-
SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1
-
Llorian, M., Beullens, M., Andres, I., Ortiz, J. M. & Bollen, M. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Biochem. J. 378, 229-238 (2004).
-
(2004)
Biochem. J
, vol.378
, pp. 229-238
-
-
Llorian, M.1
Beullens, M.2
Andres, I.3
Ortiz, J.M.4
Bollen, M.5
-
37
-
-
0242664782
-
Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure
-
Sagara, J. et al. Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. J. Biol. Chem. 278, 45611-45619 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 45611-45619
-
-
Sagara, J.1
-
38
-
-
33845329203
-
Functional and quantitative proteomics using SILAC
-
Mann, M. Functional and quantitative proteomics using SILAC. Nature Rev. Mol. Cell Biol. 7, 952-958 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol
, vol.7
, pp. 952-958
-
-
Mann, M.1
-
39
-
-
33749186913
-
Condensin and Repo-Man/PP1 co-operate in the regulation of chromosome architecture during mitosis
-
Vagnarelli, P. et al. Condensin and Repo-Man/PP1 co-operate in the regulation of chromosome architecture during mitosis. Nature Cell Biol. 8, 1133-1142 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1133-1142
-
-
Vagnarelli, P.1
-
40
-
-
33750006297
-
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
-
Xing, Y. et al. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell 127, 341-353 (2006).
-
(2006)
Cell
, vol.127
, pp. 341-353
-
-
Xing, Y.1
-
41
-
-
33846118688
-
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
-
Cho, U. S. & Xu, W. Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature 445, 53-57 (2006).
-
(2006)
Nature
, vol.445
, pp. 53-57
-
-
Cho, U.S.1
Xu, W.2
-
42
-
-
33845404441
-
-
Xu, Y. et al. Structure of the protein phosphatase 2A holoenzyme. Cell 127, 1239-1251 (2006). References 41 and 42 are landmark studies reporting the characterization of the first structure of a trimeric PP2A. The interaction of each subunit with the others and how the B′ subunits probably define substrate specificity are revealed.
-
Xu, Y. et al. Structure of the protein phosphatase 2A holoenzyme. Cell 127, 1239-1251 (2006). References 41 and 42 are landmark studies reporting the characterization of the first structure of a trimeric PP2A. The interaction of each subunit with the others and how the B′ subunits probably define substrate specificity are revealed.
-
-
-
-
43
-
-
0035930339
-
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway
-
Jacinto, E., Guo, B., Arndt, K. T., Schmelzle, T. & Hall, M. N. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol. Cell 8, 1017-1026 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 1017-1026
-
-
Jacinto, E.1
Guo, B.2
Arndt, K.T.3
Schmelzle, T.4
Hall, M.N.5
-
44
-
-
28644433887
-
-
Gingras, A. C. et al. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol. Cell. Proteomics 4, 1725-1740 (2005). Excellent study in which TAP-tagged stable cell lines were used to define the binding partners and complexes of human PP4.
-
Gingras, A. C. et al. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol. Cell. Proteomics 4, 1725-1740 (2005). Excellent study in which TAP-tagged stable cell lines were used to define the binding partners and complexes of human PP4.
-
-
-
-
45
-
-
0030874269
-
Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65α
-
Turowski, P., Favre, B., Campbell, K. S., Lamb, N. J. & Hemmings, B. A. Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65α. Eur. J. Biochem. 248, 200-208 (1997).
-
(1997)
Eur. J. Biochem
, vol.248
, pp. 200-208
-
-
Turowski, P.1
Favre, B.2
Campbell, K.S.3
Lamb, N.J.4
Hemmings, B.A.5
-
46
-
-
0029834655
-
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm
-
McCright, B., Rivers, A. M., Audlin, S. & Virshup, D. M. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J. Biol. Chem. 271, 22081-22089 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 22081-22089
-
-
McCright, B.1
Rivers, A.M.2
Audlin, S.3
Virshup, D.M.4
-
47
-
-
0032703317
-
Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A
-
Strack, S., Chang, D., Zaucha, J. A., Colbran, R. J. & Wadzinski, B. E. Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A. FEBS Lett. 460, 462-466 (1999).
-
(1999)
FEBS Lett
, vol.460
, pp. 462-466
-
-
Strack, S.1
Chang, D.2
Zaucha, J.A.3
Colbran, R.J.4
Wadzinski, B.E.5
-
48
-
-
0033972224
-
-
Yan, Z., Fedorov, S. A., Mumby, M. C. & Williams, R. S. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol. Cell. Biol. 20, 1021-1029 (2000).
-
Yan, Z., Fedorov, S. A., Mumby, M. C. & Williams, R. S. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol. Cell. Biol. 20, 1021-1029 (2000).
-
-
-
-
49
-
-
0034601367
-
Adenovirus E4orf4 protein interacts with both Bα and B′ subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα
-
Shtrichman, R., Sharf, R. & Kleinberger, T. Adenovirus E4orf4 protein interacts with both Bα and B′ subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα. Oncogene 19, 3757-3765 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3757-3765
-
-
Shtrichman, R.1
Sharf, R.2
Kleinberger, T.3
-
50
-
-
0036796741
-
Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle
-
Gentry, M. S. & Hallberg, R. L. Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol. Biol. Cell 13, 3477-3492 (2002).
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 3477-3492
-
-
Gentry, M.S.1
Hallberg, R.L.2
-
51
-
-
33750076984
-
The α-4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A
-
Prickett, T. D. & Brautigan, D. L. The α-4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. J. Biol. Chem. 281, 30503-30511 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 30503-30511
-
-
Prickett, T.D.1
Brautigan, D.L.2
-
52
-
-
33747334635
-
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IκBε
-
Stefansson, B. & Brautigan, D. L. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IκBε. J. Biol. Chem. 281, 22624-22634 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 22624-22634
-
-
Stefansson, B.1
Brautigan, D.L.2
-
53
-
-
13244253758
-
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
-
Yang, J. et al. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J. 24, 1-10 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 1-10
-
-
Yang, J.1
-
54
-
-
0035793943
-
Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region
-
Borthwick, E. B., Zeke, T., Prescott, A. R. & Cohen, P. T. Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region. FEBS Lett. 491, 279-284 (2001).
-
(2001)
FEBS Lett
, vol.491
, pp. 279-284
-
-
Borthwick, E.B.1
Zeke, T.2
Prescott, A.R.3
Cohen, P.T.4
-
55
-
-
2342667394
-
Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5
-
Jeong, J. Y., Johns, J., Sinclair, C., Park, J. M. & Rossie, S. Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5. BMC Cell Biol. 4, 3 (2003).
-
(2003)
BMC Cell Biol
, vol.4
, pp. 3
-
-
Jeong, J.Y.1
Johns, J.2
Sinclair, C.3
Park, J.M.4
Rossie, S.5
-
56
-
-
0031915128
-
Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)
-
Huang, X. & Honkanen, R. E. Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC). J. Biol. Chem. 273, 1462-1468 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 1462-1468
-
-
Huang, X.1
Honkanen, R.E.2
-
57
-
-
85115039960
-
-
Moller, S. G., Kim, Y. S., Kunkel, T. & Chua, N. H. PP7 is a positive regulator of blue light signaling in Arabidopsis. Plant Cell 15, 1111-1119 (2003).
-
Moller, S. G., Kim, Y. S., Kunkel, T. & Chua, N. H. PP7 is a positive regulator of blue light signaling in Arabidopsis. Plant Cell 15, 1111-1119 (2003).
-
-
-
-
58
-
-
0030465532
-
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 Å resolution
-
Das, A. K., Helps, N. R., Cohen, P. T. & Barford, D. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 Å resolution. EMBO J. 15, 6798-6809 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 6798-6809
-
-
Das, A.K.1
Helps, N.R.2
Cohen, P.T.3
Barford, D.4
-
59
-
-
2442602365
-
Plant PP2C phosphatases: Emerging functions in stress signaling
-
Schweighofer, A., Hirt, H. & Meskiene, I. Plant PP2C phosphatases: emerging functions in stress signaling. Trends Plant Sci. 9, 236-243 (2004).
-
(2004)
Trends Plant Sci
, vol.9
, pp. 236-243
-
-
Schweighofer, A.1
Hirt, H.2
Meskiene, I.3
-
60
-
-
33745713599
-
Characterization of a novel human protein phosphatase 2C family member, PP2Cκ
-
Dai, J. et al. Characterization of a novel human protein phosphatase 2C family member, PP2Cκ. Int. J. Mol. Med. 17, 1117-1123 (2006).
-
(2006)
Int. J. Mol. Med
, vol.17
, pp. 1117-1123
-
-
Dai, J.1
-
61
-
-
0029586401
-
Cytosolic and nuclear localization of protein phosphatase 2C β 1 in COS and BHK cells
-
Wenk, J. & Mieskes, G. Cytosolic and nuclear localization of protein phosphatase 2C β 1 in COS and BHK cells. Eur. J. Cell. Biol. 68, 377-386 (1995).
-
(1995)
Eur. J. Cell. Biol
, vol.68
, pp. 377-386
-
-
Wenk, J.1
Mieskes, G.2
-
62
-
-
0345118287
-
Molecular cloning of PP2Cε, a novel member of the protein phosphatase 2C family
-
Komaki, K. et al. Molecular cloning of PP2Cε, a novel member of the protein phosphatase 2C family. Biochim. Biophys. Acta 1630, 130-137 (2003).
-
(2003)
Biochim. Biophys. Acta
, vol.1630
, pp. 130-137
-
-
Komaki, K.1
-
63
-
-
0032901297
-
The type 2C Ser/Thr phosphatase PP2Cγ is a pre-mRNA splicing factor
-
Murray, M. V., Kobayashi, R. & Krainer, A. R. The type 2C Ser/Thr phosphatase PP2Cγ is a pre-mRNA splicing factor. Genes Dev. 13, 87-97 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 87-97
-
-
Murray, M.V.1
Kobayashi, R.2
Krainer, A.R.3
-
64
-
-
0037068447
-
Comprehensive proteomic analysis of the human spliceosome
-
Zhou, Z., Licklider, L. J., Gygi, S. P. & Reed, R. Comprehensive proteomic analysis of the human spliceosome. Nature 419, 182-185 (2002).
-
(2002)
Nature
, vol.419
, pp. 182-185
-
-
Zhou, Z.1
Licklider, L.J.2
Gygi, S.P.3
Reed, R.4
-
65
-
-
0033523023
-
Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5′-triphosphatase and diphosphatase activities
-
Deshpande, T., Takagi, T., Hao, L., Buratowski, S. & Charbonneau, H. Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5′-triphosphatase and diphosphatase activities. J. Biol. Chem. 274, 16590-16594 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 16590-16594
-
-
Deshpande, T.1
Takagi, T.2
Hao, L.3
Buratowski, S.4
Charbonneau, H.5
-
66
-
-
0028274296
-
Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase
-
Tillmann, U., Wagner, J., Boerboom, D., Westphal, H. & Tremblay, M. L. Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase. Mol. Cell. Biol. 14, 3030-3040 (1994).
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 3030-3040
-
-
Tillmann, U.1
Wagner, J.2
Boerboom, D.3
Westphal, H.4
Tremblay, M.L.5
-
67
-
-
0032831897
-
Identification and molecular characterization of BP75, a novel bromodomain-ontaining protein
-
Cuppen, E., van Ham, M., Pepers, B., Wieringa, B. & Hendriks, W. Identification and molecular characterization of BP75, a novel bromodomain-ontaining protein. FEBS Lett. 459, 291-298 (1999).
-
(1999)
FEBS Lett
, vol.459
, pp. 291-298
-
-
Cuppen, E.1
van Ham, M.2
Pepers, B.3
Wieringa, B.4
Hendriks, W.5
-
68
-
-
0037002187
-
Nuclear localization of non-receptor protein tyrosine phosphatase ε is regulated by its unique N-terminal domain
-
Kraut, J., Volohonsky, G., Toledano-Katchalski, H. & Elson, A. Nuclear localization of non-receptor protein tyrosine phosphatase ε is regulated by its unique N-terminal domain. Exp. Cell Res. 281, 182-199 (2002).
-
(2002)
Exp. Cell Res
, vol.281
, pp. 182-199
-
-
Kraut, J.1
Volohonsky, G.2
Toledano-Katchalski, H.3
Elson, A.4
-
69
-
-
24944513021
-
EGF-stimulation activates the nuclear localization signal of SHP-1
-
He, D., Song, X., Liu, L., Burk, D. H. & Zhou, G. W. EGF-stimulation activates the nuclear localization signal of SHP-1. J. Cell Biochem. 94, 944-953 (2005).
-
(2005)
J. Cell Biochem
, vol.94
, pp. 944-953
-
-
He, D.1
Song, X.2
Liu, L.3
Burk, D.H.4
Zhou, G.W.5
-
70
-
-
0031935043
-
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase
-
Tiganis, T., Bennett, A. M., Ravichandran, K. S. & Tonks, N. K. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 18, 1622-1634 (1998).
-
(1998)
Mol. Cell. Biol
, vol.18
, pp. 1622-1634
-
-
Tiganis, T.1
Bennett, A.M.2
Ravichandran, K.S.3
Tonks, N.K.4
-
71
-
-
0030006084
-
The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1
-
Kharbanda, S. et al. The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1. Proc. Natl Acad. Sci. USA 93, 6898-6901 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 6898-6901
-
-
Kharbanda, S.1
-
72
-
-
0033828668
-
Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation
-
Wadham, C., Gamble, J. R., Vadas, M. A. & Khew-Goodall, Y. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. J. Cell Sci. 113, 3117-3123 (2000).
-
(2000)
J. Cell Sci
, vol.113
, pp. 3117-3123
-
-
Wadham, C.1
Gamble, J.R.2
Vadas, M.A.3
Khew-Goodall, Y.4
-
73
-
-
0028277983
-
Nuclear localization of the PEP protein tyrosine phosphatase
-
Flores, E., Roy, G., Patel, D., Shaw, A. & Thomas, M. L. Nuclear localization of the PEP protein tyrosine phosphatase. Mol. Cell. Biol. 14, 4938-4946 (1994).
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 4938-4946
-
-
Flores, E.1
Roy, G.2
Patel, D.3
Shaw, A.4
Thomas, M.L.5
-
74
-
-
0032538444
-
FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO
-
Archambault, J. et al. FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO. J. Biol. Chem. 273, 27593-27601 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 27593-27601
-
-
Archambault, J.1
-
75
-
-
12344250639
-
-
Gohla, A., Birkenfeld, J. & Bokoch, G. M. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nature Cell Biol. 7, 21-29 (2005). Reports the identification of chronophin, a HAD-type phosphatase as a cofilin protein phosphatase.
-
Gohla, A., Birkenfeld, J. & Bokoch, G. M. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nature Cell Biol. 7, 21-29 (2005). Reports the identification of chronophin, a HAD-type phosphatase as a cofilin protein phosphatase.
-
-
-
-
76
-
-
33748415171
-
-
Shi, Y., Reddy, B. & Manley, J. L. PP1/PP2A phosphatases are required for the second step of pre-mRNA splicing and target specific snRNP proteins. Mol. Cell 23, 819-829 (2006). Re-addresses the role of PP1 and PP2A in spliceosome catalysis.
-
Shi, Y., Reddy, B. & Manley, J. L. PP1/PP2A phosphatases are required for the second step of pre-mRNA splicing and target specific snRNP proteins. Mol. Cell 23, 819-829 (2006). Re-addresses the role of PP1 and PP2A in spliceosome catalysis.
-
-
-
-
77
-
-
0036498531
-
Signaling by protein phosphatases in the nucleus
-
Bollen, M. & Beullens, M. Signaling by protein phosphatases in the nucleus. Trends Cell Biol. 12, 138-145 (2002).
-
(2002)
Trends Cell Biol
, vol.12
, pp. 138-145
-
-
Bollen, M.1
Beullens, M.2
-
78
-
-
33646795889
-
Shugoshin collaborates with protein phosphatase 2A to protect cohesin
-
Kitajima, T. S. et al. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 441, 46-52 (2006).
-
(2006)
Nature
, vol.441
, pp. 46-52
-
-
Kitajima, T.S.1
-
79
-
-
33646819227
-
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
-
Riedel, C. G. et al. Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature 441, 53-61 (2006).
-
(2006)
Nature
, vol.441
, pp. 53-61
-
-
Riedel, C.G.1
-
80
-
-
33646098667
-
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
-
Tang, Z. et al. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev. Cell 10, 575-585 (2006).
-
(2006)
Dev. Cell
, vol.10
, pp. 575-585
-
-
Tang, Z.1
-
81
-
-
33749186913
-
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis
-
Vagnarelli, P. et al. Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nature Cell Biol. 8, 1133-1142 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1133-1142
-
-
Vagnarelli, P.1
-
82
-
-
33750618926
-
Mitotic phosphatases: No longer silent partners
-
Trinkle-Mulcahy, L. & Lamond, A. I. Mitotic phosphatases: no longer silent partners. Curr. Opin. Cell Biol. 18, 623-631 (2006).
-
(2006)
Curr. Opin. Cell Biol
, vol.18
, pp. 623-631
-
-
Trinkle-Mulcahy, L.1
Lamond, A.I.2
-
83
-
-
0030925222
-
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
-
Fiscella, M. et al. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Natl Acad. Sci. USA 94, 6048-6053 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6048-6053
-
-
Fiscella, M.1
-
84
-
-
0034383398
-
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
-
Takekawa, M. et al. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 19, 6517-6526 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 6517-6526
-
-
Takekawa, M.1
-
85
-
-
0032541227
-
Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways
-
Takekawa, M., Maeda, T. & Saito, H. Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J. 17, 4744-4752 (1998).
-
(1998)
EMBO J
, vol.17
, pp. 4744-4752
-
-
Takekawa, M.1
Maeda, T.2
Saito, H.3
-
86
-
-
4344560876
-
The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair
-
Lu, X. et al. The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol. Cell 15, 621-634 (2004).
-
(2004)
Mol. Cell
, vol.15
, pp. 621-634
-
-
Lu, X.1
-
87
-
-
16844383386
-
Substrate specificity of the human protein phosphatase 2Cδ, Wip1
-
Yamaguchi, H. et al. Substrate specificity of the human protein phosphatase 2Cδ, Wip1. Biochemistry 44, 5285-5294 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 5285-5294
-
-
Yamaguchi, H.1
-
88
-
-
18844405191
-
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
-
Lu, X., Nannenga, B. & Donehower, L. A. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev. 19, 1162-1174 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 1162-1174
-
-
Lu, X.1
Nannenga, B.2
Donehower, L.A.3
-
89
-
-
0141593530
-
A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2
-
Ohta, M., Guo, Y., Halfter, U. & Zhu, J. K. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Proc. Natl Acad. Sci. USA 100, 11771-11776 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 11771-11776
-
-
Ohta, M.1
Guo, Y.2
Halfter, U.3
Zhu, J.K.4
-
90
-
-
33747676873
-
Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1
-
Yoda, A. et al. Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. J. Biol. Chem. 281, 24847-24862 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 24847-24862
-
-
Yoda, A.1
-
91
-
-
0344643062
-
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break
-
Leroy, C. et al. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol. Cell 11, 827-835 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 827-835
-
-
Leroy, C.1
-
92
-
-
33748150967
-
Wip1 phosphatase modulates ATM-dependent signaling pathways
-
Shreeram, S. et al. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol. Cell 23, 757-764 (2006).
-
(2006)
Mol. Cell
, vol.23
, pp. 757-764
-
-
Shreeram, S.1
-
93
-
-
10044225999
-
Autophosphorylation of ataxia- telangiectasia mutated is regulated by protein phosphatase 2A
-
Goodarzi, A. A. et al. Autophosphorylation of ataxia- telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J. 23, 4451-4461 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 4451-4461
-
-
Goodarzi, A.A.1
-
94
-
-
31444445458
-
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
-
Keogh, M. C. et al. A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery. Nature 439, 497-501 (2006).
-
(2006)
Nature
, vol.439
, pp. 497-501
-
-
Keogh, M.C.1
-
95
-
-
28444483130
-
γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
-
Chowdhury, D. et al. γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 20, 801-809 (2005).
-
(2005)
Mol. Cell
, vol.20
, pp. 801-809
-
-
Chowdhury, D.1
-
96
-
-
0035374588
-
Protein phosphatases regulate DNA-dependent protein kinase activity
-
Douglas, P., Moorhead, G. B., Ye, R. & Lees-Miller, S. P. Protein phosphatases regulate DNA-dependent protein kinase activity. J. Biol. Chem. 276, 18992-18998 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 18992-18998
-
-
Douglas, P.1
Moorhead, G.B.2
Ye, R.3
Lees-Miller, S.P.4
-
97
-
-
28844444559
-
Transcriptional control by chromosome-associated protein phosphatase-1
-
Bennett, D. Transcriptional control by chromosome-associated protein phosphatase-1. Biochem. Soc. Trans. 33, 1444-1446 (2005).
-
(2005)
Biochem. Soc. Trans
, vol.33
, pp. 1444-1446
-
-
Bennett, D.1
-
98
-
-
0026731973
-
Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing
-
Mermoud, J. E., Cohen, P. & Lamond, A. I. Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing. Nucleic Acids Res. 20, 5263-5269 (1992).
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 5263-5269
-
-
Mermoud, J.E.1
Cohen, P.2
Lamond, A.I.3
-
99
-
-
0037205485
-
The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly
-
Beullens, M. & Bollen, M. The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. J. Biol. Chem. 277, 19855-19860 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 19855-19860
-
-
Beullens, M.1
Bollen, M.2
-
100
-
-
0030199521
-
Interaction of protein phosphatase type 1 with a splicing factor
-
Hirano, K., Erdodi, F., Patton, J. G. & Hartshorne, D. J. Interaction of protein phosphatase type 1 with a splicing factor. FEBS Lett. 389, 191-194 (1996).
-
(1996)
FEBS Lett
, vol.389
, pp. 191-194
-
-
Hirano, K.1
Erdodi, F.2
Patton, J.G.3
Hartshorne, D.J.4
-
101
-
-
0034405427
-
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
-
Ajuh, P. et al. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. EMBO J. 19, 6569-6581 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 6569-6581
-
-
Ajuh, P.1
-
102
-
-
0035893314
-
Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain
-
Cho, E. J., Kobor, M. S., Kim, M., Greenblatt, J. & Buratowski, S. Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain. Genes Dev. 15, 3319-3329 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 3319-3329
-
-
Cho, E.J.1
Kobor, M.S.2
Kim, M.3
Greenblatt, J.4
Buratowski, S.5
-
103
-
-
14244267814
-
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator
-
Kong, S. E. et al. Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator. J. Biol. Chem. 280, 4299-4306 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 4299-4306
-
-
Kong, S.E.1
-
104
-
-
27644494876
-
Smad transcription factors
-
Massague, J., Seoane, J. & Wotton, D. Smad transcription factors. Genes Dev. 19, 2783-2810 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2783-2810
-
-
Massague, J.1
Seoane, J.2
Wotton, D.3
-
105
-
-
33646950265
-
-
Lin, X. et al. PPM1A functions as a Smad phosphatase to terminate TGFβ signaling. Cell 125, 915-928 (2006). Using a functional genomics approach, PP2Cα was identified as the SMAD2 and SMAD3 C-terminal phosphatase in the nucleus.
-
Lin, X. et al. PPM1A functions as a Smad phosphatase to terminate TGFβ signaling. Cell 125, 915-928 (2006). Using a functional genomics approach, PP2Cα was identified as the SMAD2 and SMAD3 C-terminal phosphatase in the nucleus.
-
-
-
-
106
-
-
33846028557
-
Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-α signaling
-
Wrighton, K. H. et al. Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-α signaling. J. Biol. Chem. 281, 38365-38375 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 38365-38375
-
-
Wrighton, K.H.1
-
107
-
-
0036699073
-
-
Bennett, D. & Alphey, L. PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Nature Genet. 31, 419-423 (2002).
-
Bennett, D. & Alphey, L. PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Nature Genet. 31, 419-423 (2002).
-
-
-
-
108
-
-
33845970267
-
Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small CTD phosphatases (SCPs) has distinct outcomes for BMP and TGFβ pathways
-
Sapkota, G. et al. Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small CTD phosphatases (SCPs) has distinct outcomes for BMP and TGFβ pathways. J. Biol. Chem. 281, 40412-40419 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 40412-40419
-
-
Sapkota, G.1
-
109
-
-
33846028557
-
Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-β signaling
-
Wrighton, K. H. et al. Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-β signaling. J. Biol. Chem. 281, 38365-38375 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 38365-38375
-
-
Wrighton, K.H.1
-
110
-
-
33644996932
-
Identification of phosphatases for Smad in the BMP/DPP pathway
-
Chen, H. B., Shen, J., Ip, Y. T. & Xu, L. Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev. 20, 648-653 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 648-653
-
-
Chen, H.B.1
Shen, J.2
Ip, Y.T.3
Xu, L.4
-
111
-
-
33747044916
-
Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling
-
Knockaert, M., Sapkota, G., Alarcon, C., Massague, J. & Brivanlou, A. H. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc. Natl Acad. Sci. USA 103, 11940-11945 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 11940-11945
-
-
Knockaert, M.1
Sapkota, G.2
Alarcon, C.3
Massague, J.4
Brivanlou, A.H.5
-
112
-
-
33846002754
-
Dephosphorylation of Smad1 in the BMP signaling pathway by PPM1A
-
Duan, X., Liang, Y. Y., Feng, X. H. & Lin, X. Dephosphorylation of Smad1 in the BMP signaling pathway by PPM1A. J. Biol. Chem. 281, 36526-36532 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 36526-36532
-
-
Duan, X.1
Liang, Y.Y.2
Feng, X.H.3
Lin, X.4
-
113
-
-
0036583926
-
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
-
Ong, S. E. et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteomics 1, 376-386 (2002).
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 376-386
-
-
Ong, S.E.1
-
114
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning, G., Whyte, D. B., Martinez, R., Hunter, T. & Sudarsanam, S. The protein kinase complement of the human genome. Science 298, 1912-1934 (2002).
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
115
-
-
0037081563
-
Protein phosphatase 1 - targeted in many directions
-
Cohen, P. T. Protein phosphatase 1 - targeted in many directions. J. Cell Sci. 115, 241-256 (2002).
-
(2002)
J. Cell Sci
, vol.115
, pp. 241-256
-
-
Cohen, P.T.1
-
116
-
-
0347285350
-
A genomic perspective on protein tyrosine phosphatases: Gene structure, pseudogenes, and genetic disease linkage
-
Andersen, J. N. et al. A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J. 18, 8-30 (2004).
-
(2004)
FASEB J
, vol.18
, pp. 8-30
-
-
Andersen, J.N.1
-
117
-
-
15844416253
-
Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
-
Loh, C. et al. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271, 10884-10891 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 10884-10891
-
-
Loh, C.1
-
118
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly, M. et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544-1548 (1999).
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
-
119
-
-
30844443048
-
Cofilin phosphatases and regulation of actin dynamics
-
Huang, T. Y., DerMardirossian, C. & Bokoch, G. M. Cofilin phosphatases and regulation of actin dynamics. Curr. Opin. Cell Biol. 18, 26-31 (2006).
-
(2006)
Curr. Opin. Cell Biol
, vol.18
, pp. 26-31
-
-
Huang, T.Y.1
DerMardirossian, C.2
Bokoch, G.M.3
-
120
-
-
33746729798
-
Myotubularin phosphatases: Policing 3-phosphoinositides
-
Robinson, F. L. & Dixon, J. E. Myotubularin phosphatases: policing 3-phosphoinositides. Trends Cell Biol. 16, 403-412 (2006).
-
(2006)
Trends Cell Biol
, vol.16
, pp. 403-412
-
-
Robinson, F.L.1
Dixon, J.E.2
|