A brief introduction to the protein phosphatase families

Methods in Molecular Biology

Volumn 365, Issue , 2007, Pages 9-22

  Mustelin, Tomas ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

drug targets; HAD family; Protein phosphatases; PTPs, DSPs

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE;

CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GENOME; HUMAN; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; REVIEW; RNA INTERFERENCE;

GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOME, HUMAN; HUMANS; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE;

EID: 34447280860     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1385/1-59745-267-X:9     Document Type: Article

References (92)

1. Hunter, T. (1998) The role of tyrosine phosphorylation in cell growth and disease. Harvey Lect. 94, 81-119.
2. Andersen, J. N., Jansen, P. G., Echwald, S. M., et al. (2004) A genomic perspective on PTPs: gene structure, pseudogenes, and genetic disease linkage. FASEB J. 18, 8-13.
3. Alonso, A., Sasin, J., Osterman, A., et al. (2004) The PTPs in the human genome. Cell 117, 699-711.
4. Bottini, N., Bottini, E., Gloria-Bottini, F., and Mustelin, T. (2002) LMPTP and human disease: in search of biochemical mechanisms. Arch. Immunol. Ther. Exp. (AITE) 50, 95-104.
5. Hunter, T. and Sefton, B. M. (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 77, 1311-1315. (Pubitemid 10072278)
6. Chow, K., Ng, D., Stokes, R., and Johnson, P. (1994) Protein tyrosine phosphorylation in Mycobacterium tuberculosis. FEMS Microbiol. Lett. 124, 203-207. (Pubitemid 124012917)
7. Kennelly, P. J. (2003) Archaeal protein kinases and protein phosphatases: Insights from genomics and biochemistry. Biochem. J. 370, 373-389. (Pubitemid 36315125)
8. Cozzone, A. J., Grangeasse, C., Doublet, P., and Duclos, B. (2004) Protein phosphorylation on tyrosine in bacteria. Arch. Microbiol. 181, 171-181. (Pubitemid 38316642)
9. Walton, K. M. and Dixon, J. E. (1993) Protein tyrosine phosphatases. Annu. Rev. Biochem. 62, 101-120. (Pubitemid 23237866)
10. Tonks, N. K. and Neel, B. G. (1996) From form to function: signaling by PTPs. Cell 87, 365-368.
11. Mustelin, T., Vang, T., and Bottini, N. (2005) Protein tyrosine phosphatases and the immune response. Nat. Rev. Immunol. 5, 43-57. (Pubitemid 40070330)
12. Stoker, A. W. (2005) Protein tyrosine phosphatases and signaling. J. Endocrinol. 185, 19-33.
13. Kappert, K., Peters, K. G., Bohmer, F. D., and Ostman, A. (2005) Tyrosine phosphatases in vessel wall signaling. Cardiovasc. Res. 65, 587-598. (Pubitemid 40138979)
14. Rebay, I., Silver, S. J., and Tootle, T. L. (2005) New vision from Eyes absent: transcription factors as enzymes. Trends Genet. 21, 163-171. (Pubitemid 40269855)
15. Wong, W. and Scott, J. D. (2004) AKAP signalling complexes: focal points in space and time. Nat. Rev. Mol. Cell. Biol. 5, 959-970. (Pubitemid 39611533)
16. Cohen, P. T. (2002) Protein phosphatase 1: targeted in many directions. J. Cell. Sci. 115, 241-256. (Pubitemid 34145174)
17. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol. Rev. 84, 1-39. (Pubitemid 38049874)
18. Feng, G. S. (1999) Shp-2 tyrosine phosphatase: Signaling one cell or many. Exp. Cell Res. 253, 47-54
19. Mustelin, T., Coggeshall, K. M., and Altman, A. (1989) Rapid activation of the T cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc. Natl. Acad. Sci. USA. 86, 6302-6306. (Pubitemid 19210640)
20. Bottini, N., Stefanini, L., Williams, S., et al. (2002) Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J. Biol. Chem. 277, 24,220-24,224. (Pubitemid 34951938)
21. Cote, J. F., Charest, A., Wagner, J., and Tremblay, M. L. (1998) Combination of gene targeting and substrate trapping to identify substrates of PTPs using PTPPEST as a model. Biochemistry 37, 13,128-13,137 . (Pubitemid 28449556)
22. Saxton, T. M., Henkemeyer, M., Gasca, S., et al. (1997) Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16, 2352-2364. (Pubitemid 27258636)
23. Gronda, M., Arab, S., Iafrate, B., Suzuki, H., and Zanke, B. (2001) Hematopoietic PTP suppresses extracellular stimulus-regulated kinase activation. Mol. Cell. Biol. 21, 6851-6858. (Pubitemid 32911246)
24. Elchebly, M., Payette, P., Michaliszyn, E., et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the PTP-1B gene. Science 283, 1544-1548.
25. You-Ten, K. E., Muise, E. S., Itie, A., et al. (1997) Impaired bone marrow microenvironment and immune function in T cell PTP-deficient mice. J. Exp. Med. 186, 683-693 . (Pubitemid 27381533)
26. + thymocytes and B-cell maturation. J. Exp. Med. 183, 1707-1718. (Pubitemid 26134312)
27. Wharram, B. L., Goyal, M., Gillespie, P. J., et al. (2000) Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. Clin. Invest. 106, 1281-1290.
28. Uetani, N., Kato, K., Ogura, H., et al. (2000) Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J. 19, 2775-2785. (Pubitemid 30386750)
29. Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. (1998) Pten is essential for embryonic development and tumour suppression. Nat. Genet. 19, 348-355. (Pubitemid 28357906)
30. Koop, E. A., Gebbink, M. F. B. G., Sweeney, T. E., et al. (2005) Impaired flowinduced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-μ-deficient mice. Am. J. Physiol. (Heart Circ. Physiol.) 288, H1218-H1223. (Pubitemid 40270027)
31. Manning, G., Whyte, D. B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science 298, 1912-1934. (Pubitemid 35425239)
32. Schonthal, A. H. (1998) Role of PP2A in intracellular signal transduction pathways. Front. Biosci. 3, D1262-1273.
33. Lee, J. O. Yang, H., Georgescu, M. M., et al. (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99, 323-334. (Pubitemid 29519911)
34. Begley, M. J. Taylor, G. S., Kim, S. A., Veine, D. M., Dixon, J. E., and Stuckey, J. A. (2003) Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth Syndrome. Mol. Cell 12, 1391-1402. (Pubitemid 38037009)
35. Rayapureddi, J. P., Kattamuri, C., Chan, F. H., and Hegde, R. S. (2005) Characterization of a plant, tyrosine-specific phosphatase of the aspartyl class. Biochemistry 44, 751-8. (Pubitemid 40105506)
36. Roberts, A., Lee, S. Y., McCullagh, E., Silversmith, R. E., and Wemmer, D. E. (2005) Ybiv from Escherichia coli K12 is a HAD phosphatase. Proteins 58, 790-801. (Pubitemid 40271244)
37. Roberts, S. J., Stewart, A. J., Sadler, P. J., and Farquharson, C. (2004) Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem. J. 382, 59-65. (Pubitemid 39141566)
38. Allegrini, S., Scaloni, A., Careddu, M. G., et al. (2004) Mechanistic studies on bovine cytosolic 5'-nucleotidase II, an enzyme belonging to the HAD superfamily. Eur. J. Biochem. 271, 4881-4891. (Pubitemid 40065591)
39. Lunn, J. E., Ashton, A. R., Hatch, M. D., and Heldt, H. W. (2000) Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants. Proc. Natl. Acad. Sci. USA 97, 12,914-12,919.
40. Cronin, A., Mowbray, S., Durk, H., et al. (2003) The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. Proc. Natl. Acad. Sci. USA 100, 1552-1557. (Pubitemid 36254485)
41. Gohla, A., Birkenfeld, J., and Bokoch, G. M. (2005) Chronophin, a novel HADtype serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat. Cell Biol. 7, 21-29. (Pubitemid 40123379)
42. Yeo, M., Lin, P. S., Dahmus, M. E., and Gill, G. N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278, 26,078-26,085. (Pubitemid 36835376)
43. Peisach, E., Selengut, J. D., Dunaway-Mariano, D., and Allen, K. N. (2004) X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry 43, 12,770-12,779. (Pubitemid 39331796)
44. Stewart, A. J., Schmid, R., Blindauer, C. A., Paisey, S. J., and Farquharson, C. (2003) Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein Eng. 16, 889-895. (Pubitemid 38281738)
45. Allen, K. N. and Dunaway-Mariano, D. (2004) Phosphoryl group transfer: evolution of a catalytic scaffold. Trends Biochem. Sci. 29, 495-503. (Pubitemid 39158873)
46. Lahiri, S. D., Zhang, G., Dai, J., Dunaway-Mariano, D., and Allen, K. N. (2004) Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry 43, 2812-2820. (Pubitemid 38327812)
47. Charbonneau, H., Tonks, N. K., Kumar, S., et al. (1989) Human placenta proteintyrosine phosphatase: amino-acid sequence and relationship to a family of receptor-like proteins. Proc. Natl. Acad. Sci. USA 86, 5252-5256. (Pubitemid 19185533)
48. Maehama, T. and Dixon, J. E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 13,375-13,378. (Pubitemid 28268370)
49. Wishart, M. J. and Dixon, J. E. (2002) PTEN and myotubularins phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol. 12, 579-585. (Pubitemid 35461856)
50. Alonso, A., Sasin, J., Burkhalter, S., et al. (2004) The minimal essential core of a cysteine-based PTP revealed by a novel 16-kDa VH1-like phosphatase, VHZ. J. Biol. Chem. 279, 35,768-35,774. (Pubitemid 39100582)
51. Bordo, D. and Bork, P. (2002) The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relations. EMBO Rep. 3, 741-746. (Pubitemid 34966012)
52. Alonso, A., Rojas, A., Godzik, A., and Mustelin, T. (2003) The dual-specific PTP family. Top. Curr. Genet. 5, 333-358.
53. Vincent, C., Duclos, B., Grangeasse, C., et al. (2000) Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gramnegative bacteria. J. Mol. Biol. 304, 311-321.
54. Musumeci, L., Tautz, L., Perego, M., Mustelin, T., and Bottini, N. (2005) Characterization of the YfkJ protein tyrosine phosphatase of Bacillus subtilis and Bacillus anthracis. J. Bacteriol., in press.
55. Kashio, N., Matsumoto, W., Parker, S., and Rothstein, D.M. (1998). The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCRζ in vivo. J. Biol. Chem. 273, 33856-33863.
56. Bolino, A., Muglia, M., Conforti, F. L., et al. (2000) Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2. Nat. Genet. 25, 17-19. (Pubitemid 30257029)
57. Azzedine, H., Bolino, A., Taieb, T., et al. (2003) Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma. Am. J. Hum. Genet. 72, 1141-1153. (Pubitemid 36530002)
58. Mustelin, T. and Hunter, T. (2002) Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPα Science's STKE. http://stke.sciencemag.org/cgi/content/full/OC-sigtrans;2002/115/pe3.
59. Tailor, P., Williams, S., Gilman, J., Couture, C., and Mustelin, T. (1997) Regulation of the low molecular weight phosphotyrosine phosphatase (LMPTP) by phosphorylation at tyrosines 131 and 132. J. Biol. Chem. 272, 5371-5376.
60. Alonso, A., Rahmouni, S., Williams, S., et al. (2003) Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat. Immunol. 4, 44-48. (Pubitemid 36104707)
61. Dorfman, K., Carrasco, D., Gruda, M., Ryan, C., Lira, S. A., and Bravo, R. (1996) Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene 13, 925-931. (Pubitemid 26329078)
62. Hasegawa, K., Martin, F., Huang, G., Tumas, D., Diehl, L., and Chan, A. C. (2004) PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 303, 685-689. (Pubitemid 38141637)
63. Saha, S., Bardelli, A., Buckhaults, P., et al. (2001) A phosphatase associated with metastasis of colorectal cancer. Science 294, 1343-1346. (Pubitemid 33063101)
64. Tartaglia, M., Mehler, E. L., Goldberg, R., et al. (2001) Mutations in PTPN11, encoding the PTP SHP-2, cause Noonan syndrome. Nat. Genet. 29, 465-468. (Pubitemid 34326699)
65. Minassian, B. A., Lee, J. R., Herbrick, J. A., et al. (1998) Mutations in a gene encoding a novel PTP cause progressive myoclonus epilepsy. Nat. Genet. 20, 171-174. (Pubitemid 28455450)
66. Laporte, J., Hu, L. J., Kretz, C., et al. (1996) A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast. Nat. Genet. 13, 175-182. (Pubitemid 26000437)
67. Tchilian, E. Z., Wallace, D. L., Wells, R. S., Flower, D. R., Morgan, G., and Beverley, P. C. L. (2001) A deletion in the gene encoding the CD45 antigen in a patient with SCID. J. Immunol. 166, 1308-1313. (Pubitemid 32060292)
68. Kung, C., Pingel, J. T., Heikinheimo, M., et al. (2000) Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat. Med. 6, 343-345. (Pubitemid 30148629)
69. Bottini, N., Musumeci, L., Alonso, A., et al. (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type 1 diabetes. Nat. Genet. 36, 337-338. (Pubitemid 38437254)
70. Smyth, D., Cooper, J. D., Collins, J. E., et al. (2004) Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53, 3020-3023. (Pubitemid 39425931)
71. Ladner, M. B., Bottini, N., Valdes, A. M., and Noble, J. A. (2005) Association of the single-nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum. Immunol. 66, 60-64. (Pubitemid 40037712)
72. Kawasaki, E., Hutton, J. C., and Eisenbarth, G. S (1996) Molecular cloning and characterization of the human transmembrane PTP homologue, phogrin, an autoantigen of type I diabetes. Biochem. Biophys. Res. Commun. 227, 440-447. (Pubitemid 26362823)
73. Begovich, A. B., Carlton, V. E., Honigberg, L. A., et al. (2004) A missense singlenucleotide polymorphism in a gene encoding a PTP (PTPN22) is associated with rheumatoid arthritis. Am. J. Hum. Genet. 75, 330-337. (Pubitemid 38943877)
74. Kyogoku, C., Langefeld, C. D., Ortmann, W. A., et al. (2004) Genetic association of the R620W polymorphism of PTP PTPN22 with human SLE. Am. J. Hum. Genet. 75, 504-507. (Pubitemid 39095825)
75. Velaga, M. R., Wilson, V., Jennings, C. E., et al. (2004) The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. J. Clin. Endocrinol. Metab. 89, 5862-5865. (Pubitemid 39518482)
76. Mena-Duran, A. V., Togo, S. H., Bazhenova, L., et al. (2005) SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic marker. Br. J. Haematol., 129, 791-794. (Pubitemid 40904530)
77. Fonatsch, C., Haase, D., Freund, M., Bartels, H., and Tesch, H. (1991) Partial trisomy 1q. A nonrandom primary chromosomal abnormality in myelodysplastic syndromes? Cancer Genet. Cytogenet. 56, 243-253.
78. Zanke, B., Squire, J. Griesser, H. et al. (1994) A hematopoietic PTP (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1. Leukemia 8, 236-244. (Pubitemid 24057536)
79. Schweiger, S. and Schneider, R. (2003) The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome. Bioessays 25, 356-366. (Pubitemid 36433182)
80. Ito, A., Koma, Y.-I., and Watabe, K. (2003) A mutation in protein phosphatase type 2A as a cause of melanoma progression. Histol. Histopathol. 18, 1313-1319. (Pubitemid 37265031)
81. Chen, W., Possemato, R., Campbell, K. T., Plattner, C. A., Pallas, D. C., and Hahn, W. C. (2004) Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 5, 127-136. (Pubitemid 38283799)
82. Tautz, L., Bruckner, S., Sareth, S., et al. (2005) Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J. Biol. Chem. 280, 9400-9408. (Pubitemid 40409633)
83. Liang, F., Huang, Z., Lee, S.-Y., et al. (2003) Aurintricarboxylic acid blocks both in vitro and in vivo activity of YopH, an essential virulent factor from Yersinia that cause the plague. J. Biol. Chem. 278, 41,734-41,741. (Pubitemid 37310432)
84. Lazo, J. S. and Wipf, P. (2003) Small molecule regulation of phosphatasedependent cell signaling pathways. Oncol. Res. 13, 347-352.
85. Ducruet, A. P., Vogt, A., Wipf, P., and Lazo, J. (2005) Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease. Annu. Rev. Pharmacol. Toxicol. 45, 725-750. (Pubitemid 40261823)
86. Pellecchia, M., Becattini, B., Crowell, K. J., Fattorusso, R., Forino, M., Fragai, M., Jung, D., Mustelin, T., and Tautz, L. (2004) NMR-based techniques in the hit identification and optimization process. Expert Opin. Ther. Targets 8, 597-611. (Pubitemid 40028369)
87. Umezawa, K., Kawakami, M., and Watanabe, T. (2003) Molecular design and biological activities of protein-tyrosine phosphatase inhibitors. Pharmacol. Ther. 99, 15-24. (Pubitemid 36694747)
88. Li, X., Bhandari, A., Holmes, C. P., and Szardenings, A. K. (2004) Alpha,alphadifluoro-beta-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B. Bioorg. Med. Chem. Lett. 14, 4301-4306. (Pubitemid 38916954)
89. Bialy, L. and Waldmann, H. (2005) Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angew. Chem. Int. Ed. Engl., 44, 3814-3839. (Pubitemid 40885689)
90. Pei, Z., Liu, G., Lubben, T. H., and Szczepankiewicz, B. G. (2004) Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity. Curr. Pharm. Des. 10, 3481-3504. (Pubitemid 39378329)
91. Black, E., Breed, J., Breeze, A.L., et al. (2005) Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg. Med. Chem. Lett. 15, 2503-2507. (Pubitemid 40614978)
92. Kumar, S., Zhou, B., Liang, F., Wang, W. Q., Huang, Z., and Zhang, Z.-Y. (2004) Activity-based probes for protein tyrosine phosphatases. Proc. Natl. Acad. Sci. USA 101, 7943-7948. (Pubitemid 38698033)