p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

EMBO Journal

Volumn 19, Issue 23, 2000, Pages 6517-6526

  Takekawa, Mutsuhiro ^a   Adachi, Masaaki ^a   Nakahata, Atsuko ^a   Nakayama, Ichiro ^a   Itoh, Fumio ^a   Tsukuda, Hiroyuki ^a   Taya, Yoichi ^b   Imai, Kohzoh ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Dephosphorylation; DNA damage; p38; p53; Wip1

Indexed keywords

ANISOMYCIN; HYDROGEN PEROXIDE; MESYLIC ACID METHYL ESTER; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PROTEIN P53; PROTEIN WIP1; SYNAPTOPHYSIN; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; GAMMA RADIATION; GENOTOXICITY; MONKEY; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; STRESS; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

ANIMALIA;

EID: 0034383398     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.23.6517     Document Type: Article

References (45)

1. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100 in various cell lines
2. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
3. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
4. How to activate p53
5. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation: Duration of JNK activation may determine cell death and proliferation
6. Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB203580
7. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
8. Kinetic analysis of human serine/threonine protein phosphatase 2Cα
9. Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast
10. The complexity of p53 modulation: Emerging patterns from divergent signals
11. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
12. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
13. p53 in growth control and neoplasia
14. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
15. Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells
16. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient
17. p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
18. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
19. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase
20. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases
21. The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53
22. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
23. p53: Puzzle and paradigm
24. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
25. p53, the cellular gatekeeper for growth and division
26. Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
27. A two-component system that regulates an osmosensing MAP kinase cascade in yeast
28. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
29. New developments in the multi-site phosphorylation and integration of stress signalling at p53
30. MP2C, a plant protein phosphatase 2C, functions as a negative regulator of mitogen-activated protein kinase pathways in yeast and plants
31. Heat shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases
32. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
33. The p53 pathway
34. A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents
35. Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in osmoregulation of fission yeast
36. Mitogen-activated protein kinase cascades and regulation of gene expression
37. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
38. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
39. Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways
40. p53 tagged sites from human genomic DNA
41. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
42. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
43. Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases
44. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gent
45. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat