Antioxidant to treat osteoarthritis: Dream or reality?

Current Drug Targets

Volumn 8, Issue 2, 2007, Pages 347-357

  Henrotin, Y ^a   Kurz, B ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Antioxidants; Cartilage; Free radicals; Osteoarthritis; Oxgygen

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CATALASE; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; FERRITIN; FLAVONOID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MANGANESE SUPEROXIDE DISMUTASE; METAL ION; METALLOPROTEINASE; METALLOTHIONEIN; PEROXIREDOXIN; PLACEBO; QUERCETIN; REACTIVE OXYGEN METABOLITE; RUTOSIDE; SCAVENGER; SELENIUM; SUPEROXIDE DISMUTASE; THIOREDOXIN; TRANSFERRIN; UNINDEXED DRUG; URATE; ZINC;

ANTIOXIDANT ACTIVITY; BIOCHEMISTRY; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL FUNCTION; CHELATION; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; HUMAN; MECHANICAL STRESS; NONHUMAN; NUTRITIONAL REQUIREMENT; OSTEOARTHRITIS; PAIN; PHYSICAL DISABILITY; REVIEW;

ANTIOXIDANTS; CARTILAGE; HUMANS; OSTEOARTHRITIS; REACTIVE OXYGEN SPECIES;

EID: 33847191703     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007779940151     Document Type: Review

References (192)

1. Nuki, G. (1999) in Pathophysiology of osteoarthritis. Osteoarthritis: clinical and experimental aspects, ed. Reginster, J.Y.; Pelletier, J.P.; Martel-Pelletier, J.; and Henrotin, Y. 1999, Berlin: Springer. 101-114.
2. Henrotin, Y.; Sanchez, C. and Reginster, J.Y. (2002) Exper. Opin. Ther. patents, 12(1), 29-43.
3. Henrotin, Y.E.; Bruckner, P. and Pujol, J.P. (2003) Osteoarthr. Cartil., 11(10), 747-55.
4. Fermor, B.; Weinberg, J.B.; Pisetsky, D.S.; Misukonis, M.A.; Banes, A.J. and Guilak, F. (2001) J. Orthop. Res., 19(4), 729-37.
5. Henrotin, Y.; Deby-Dupont, G.; Deby, C.; De Bruyn, M.; Lamy, M. and Franchimont, P. (1993) Br. J. Rheumatol., 32(7), 562-7.
6. Hiran, T.S.; Moulton, P.J. and Hancock, J.T. (1997) Free Radic. Biol. Med., 23(5), 736-43.
7. Moulton, P.J.; Goldring, M.B. and Hancock, J.T. (1998) Biochem. J., 329(Pt 3), 449-51.
8. Tiku, M.L.; Shah, R. and Allison, G.T. (2000) J. Biol. Chem., 275(26), 20069-76.
9. Loeser, R.F.; Carlson, C.S.; Del Carlo, M. and Cole, A. (2002) Arthritis Rheum., 46(9), 2349-57.
10. Deberg, M.; Labasse, A.; Christgau, S.; Cloos, P.; Bang Henriksen, D.; Chapelle, J.P.; Zegels, B.; Reginster, J.Y. and Henrotin, Y. (2005) Osteoarthr. Cartil., 13(3), 258-65.
11. Burkhardt, H.; Swingel, M.; Menninger, H.; Macartney H.W. and H., T. (1986) Arthritis Rheum., 29(379-387.
12. Pelletier, J.P.; Jovanovic, D.; Fernandes, J.C.; Manning, P.; Connor, J.R.; Currie, M.G.; Di Battista, J.A. and Martel-Pelletier, J. (1998) Arthritis Rheum., 41(7), 1275-86.
13. Pelletier, J.P.; Jovanovic, D.V.; Lascau-Coman, V.; Fernandes, J.C.; Manning, P.T.; Connor, J.R.; Currie, M.G. and Martel-Pelletier, J. (2000) Arthritis Rheum., 43(6), 1290-9.
14. Del Carlo, M., Jr. and Loeser, R.F. (2002) Arthritis Rheum., 46(2), 394-403.
15. Blanco, F.J.; Ochs, R.L.; Schwarz, H. and Lotz, M. (1995) Am. J. Pathol., 146(1), 75-85.
16. Gutteridge, J.M. and Halliwell, B. (2000) Ann. N. Y. Acad. Sci., 899, 136-47.
17. Halliwell, B. (1999) Free Radic. Res., 31(4), 261-72.
18. Grazioli, V.; Schiavo, R.; Casari, E.; Marzatico, F.; Rodriguez y Baena, R. and Gaetani, P. (1998) FEBS Lett., 431(2), 149-53.
19. Borsiczky, B.; Szabo, Z.; Jaberansari, M.T.; Mack, P.P. and Roth, E. (2003) Acta Orthop. Scand., 74(2), 190-5.
20. Yamazaki, K.; Fukuda, K.; Matsukawa, M.; Hara, F.; Matsushita, T.; Yamamoto, N.; Yoshida, K.; Munakata, H. and Hamanishi, C. (2003) Arthritis Rheum., 48(11), 3151-8.
21. Carlo, M.D. Jr. and Loeser, R.F. (2003) Arthritis Rheum., 48(12), 3419-30.
22. Deahl, S.T.; 2nd, Oberley, L.W.; Oberley, T.D. and Elwell, J.H. (1992) J. Bone Miner. Res., 7(2), 187-98.
23. Tsuchida, S. and Sato, K. (1992) Crit. Rev. Biochem. Mol. Biol., 27(4-5), 337-84.
24. Chae, H.Z.; Kang, S.W. and Rhee, S.G. (1999) Methods Enzymol., 300, 219-26.
25. Knoops, B.; Clippe, A.; Bogard, C.; Arsalane, K.; Wattiez, R.; Hermans, C.; Duconseille, E.; Falmagne, P. and Bernard, A. (1999) J. Biol. Chem., 274(43), 30451-8.
26. Wang, M.X.; Wei, A.; Yuan, J.; Trickett, A.; Knoops, B. and Murrell, G.A. (2002) FEBS Lett., 531(2), 359-62.
27. Niki, E. (1987) Ann. N. Y. Acad. Sci., 498, 186-99.
28. Diplock, A.T. (1998) Free Radic. Res., 29(6), 463-7.
29. Rock, C.L.; Jacob, R.A. and Bowen, P.E. (1996) J. Am. Diet Assoc., 96(7), 693-702; quiz 703-4.
30. Machlin, L.J. and Bendich, A. (1987) FASEB J., 1(6), 441-5.
31. Anderson, D. and Phillips, B.J. (1990) Prog. Clin. Biol. Res., 340E, 361-70.
32. Thurnham, D.I. (1994) Proc. Nutr. Soc., 53(1), 77-87.
33. Hertog, M.G.; Feskens, E.J.; Hollman, P.C.; Katan, M.B. and Kromhout, D. (1993) Lancet, 342(8878), 1007-11.
34. Soares, D.G.; Andreazza, A.C. and Salvador, M. (2003), J. Agric. Food Chem., 51(4), 1077-1080.
35. Wenzel, U.; Nickel, A.; Kuntz, S. and Daniel, H. (2004) Carcinogenesis, 25(5):703-712.
36. Tannenbaum, S.R.; Wishnok, J.S. and Leaf, C.D. (1991) Am. J. Clin. Nutr., 53(1 Suppl), 247S-250S.
37. Clark, A.G.; Rohrbaugh, A.L.; Otterness, I. and Kraus, V.B. (2002) Matrix Biol., 21(2), 175-84.
38. Hering, T.M.; Kollar, J.; Huynh, T.D.; Varelas, J.B. and Sandell, L.J. (1994) Arch. Biochem. Biophys., 314(1), 90-8.
39. Ronziere, M.C.; Roche, S.; Gouttenoire, J.; Demarteau, O.; Herbage, D. and Freyria, A.M. (2003) Biomaterials, 24(5), 851-61.
40. Shapiro, I.M.; Leboy, P.S.; Tokuoka, T.; Forbes, E.; DeBolt, K.; Adams, S.L. and Pacifici, M. (1991) Am. J. Clin. Nutr., 54(6 Suppl), 1209S-1213S.
41. Sullivan, T.A.; Uschmann, B.; Hough, R. and Leboy, P.S. (1994) J. Biol. Chem., 269(36), 22500-6.
42. Schwartz, E.R. and Adamy, L. (1977) J. Clin. Invest., 60(1), 96-106.
43. Malicev, E.; Woyniak, G.; Knezevic, M.; Radosavljevic, D. and Jeras, M. (2000) Pflugers Arch., 440(5 Suppl), R46-8.
44. Kurz, B.; Jost, B. and Schunke, M. (2002) Osteoarthr. Cartil., 10(2), 119-26.
45. Scott, G.; (1997). In Antioxidants in science, technology, medicine and nutrition. Chichester, Albion Publishing.
46. Kurz, B. and Schunke, M. (1997) Anat. Anz., 179(5), 439-46.
47. Kurz, B.; Lemke, A.; Kehn, M.; Domm, C.; Patwari, P.; Frank, E.H.; Grodzinsky, A.J. and Schunke, M. (2004) Arthritis Rheum., 50(1), 123-30.
48. Prior, R.L. (2003) Am. J. Clin. Nutr., 78(3 Suppl), 570S-578S.
49. Zhu, Q.Y.; Huang, Y. and Chen, Z.Y. (2000) J. Nutr. Biochem., 11(1), 14-21.
50. Lopez-Lopez, G.; Moreno, L.; Cogolludo, A.; Galisteo, M.; Ibarra, M.; Duarte, J.; Lodi, F.; Tamargo, J. and Perez-Vizcaino, F. (2004) Mol. Pharmacol., 65(4), 851-9.
51. Huk, I.; Brovkovych, V.; Nanobash Vili, J.; Weigel, G.; Neumayer, C.; Partyka, L.; Patton, S. and Malinski, T. (1998) Br. J. Surg., 85(8), 1080-5.
52. Rock, C.L.; Saxe, G.A.; Ruffin, M.T.T.; August, D.A. and Schottenfeld, D. (1996) Nutr. Cancer, 25(3), 281-96.
53. Chug-Ahuja, J.K.; Holden, J.M.; Forman, M.R.; Mangels, A.R.; Beecher, G.R. and Lanza, E. (1993) J. Am. Diet Assoc., 93(3), 318-23.
54. Burton, G.W. and Ingold, K.U. (1984) Science, 224(4649), 569-73.
55. Palozza, P. (1998) Nutr. Rev., 56(9), 257-65.
56. Deneke, S.M. (2000) Curr. Top. Cell Regul., 36(151-80.
57. Teixeira, C.C.; Shapiro, I.M.; Hatori, M.; Rajpurohit, R. and Koch, C. (1996) Biochem. J., 314(Pt 1), 21-6.
58. Teixeira, C.C.; Rajpurohit, R.; Mansfield, K.; Nemelivsky, Y.V. and Shapiro, I.M. (2003) J. Bone Miner Res., 18(4), 662-8.
59. Tschan, T.; Hoerler, I.; Houze, Y.; Winterhalter, K.H.; Richter, C. and Bruckner, P. (1990) J. Cell Biol., 111(1), 257-60.
60. Habuchi, O.; Miyachi, T.; Kaigawa, S.; Nakashima, S.; Fujiwara, C. and Hisada, M. (1991) Biochim. Biophys. Acta, 1093(2-3), 153-61.
61. Li, W.Q.; Dehnade, F. and Zafarullah, M. (2000) Biochem. Biophys. Res. Commun., 275(3), 789-94.
62. Watson, W.H.; Yang, X.; Choi, Y.E.; Jones, D.P. and Kehrer, J.P. (2004) Toxicol. Sci., 78(1), 3-14.
63. Holmgren, A. (1979) J. Biol. Chem., 254(9), 3664-71.
64. Halliwell, B.; Gutteridge, J.M. and Cross, C.E. (1992) J. Lab. Clin. Med., 119(6), 598-620.
65. Zafarullah, M.; Martel-Pelletier, J.; Cloutier, J.M.; Gedamu, L. and Pelletier, J.P. (1992) FEBS Lett., 306(2-3), 169-72.
66. Sauer, G.R.; Nie, D.; Wu, L.N. and Wuthier, R.E. (1998) J. Cell Biochem., 68(1), 110-20.
67. Zafarullah, M.; Su, S. and Gedamu, L. (1993) Exp. Cell Res., 208(2), 371-7.
68. Sauer, G.R.; Smith, D.M.; Cahalane, M.; Wu, L.N. and Wuthier, R.E. (2003) J. Cell Biochem., 88(5), 954-69.
69. Kang, Y.J.; Li, G. and Saari, J.T. (1999) Am. J. Physiol., 276(3 Pt 2), H993-7.
70. Abel, J. and de Ruiter, N. (1989) Toxicol. Lett., 47(2), 191-6.
71. Thornalley, P.J. and Vasak, M. (1985) Biochim. Biophys. Acta, 827(1), 36-44.
72. Hennekens, C.H. (1986) N. Engl. J. Med., 315(20), 1288-9.
73. van Poppel, G.; Kardinaal, A.; Princen, H. and Kok, F.J. (1994) Ann. Med., 26(6), 429-34.
74. Kowsari, B.; Finnie, S.K.; Carter, R.L.; Love, J.; Katz, P.; Longley, S. and Panush, R.S. (1983) J. Am. Diet Assoc., 82(6), 657-9.
75. Karatas, F.; Ozates, I.; Canatan, H.; Halifeoglu, I.; Karatepe, M. and Colakt, R. (2003) Indian J. Med. Res., 118(178-81.
76. Kamanli, A.; Naziroglu, M.; Aydilek, N. and Hacievliyagil, C. (2004) Cell Biochem. Funct., 22(1), 53-7.
77. Heliovaara, M.; Knekt, P.; Aho, K.; Aaran, R.K.; Alfthan, G. and Aromaa, A. (1994) Ann. Rheum. Dis., 53(1), 51-3.
78. Hagfors, L.; Leanderson, P.; Skoldstam, L.; Andersson, J. and Johansson, G. (2003) Nutr. J., 2(1), 5.
79. Kaiki, G.; Tsuji, H.; Yonezawa, T.; Sekido, H.; Takano, T.; Yamashita, S.; Hirano, N. and Sano, A. (1990) J. Orthop. Res., 8(5), 731-40.
80. Yoshikawa, T.; Tanaka, H. and Kondo, M. (1983) Biochem. Med., 29(2), 227-34.
81. Jordan, J.M.; De Roos, A.J.; Renner, J.B.; Luta, G.; Cohen, A.; Craft, N.; Helmick, C.G.; Hochberg, M.C. and Arab, L. (2004) Am. J. Epidemiol., 159(10), 968-77.
82. Machtey, I. and Ouaknine, L. (1978) J. Am. Geriatr. Soc., 26(7), 328-30.
83. Blankenhorn, G. (1986) Z. Orthop. Ihre. Grenzgeb., 124(3), 340-3.
84. Scherak, O.; Kolarz, G.; Schodl, C. and Blankenhorn, G. (1990) Z. Rheumatol., 49(6), 369-73.
85. Brand, C.; Snaddon, J.; Bailey, M. and Cicuttini, F. (2001) Ann. Rheum. Dis., 60(10), 946-9.
86. Wluka, A.E.; Stuckey, S.; Brand, C. and Cicuttini, F.M. (2002) J. Rheumatol., 29(12), 2585-91.
87. McAlindon, T.E.; Jacques, P.; Zhang, Y.; Hannan, M.T.; Aliabadi, P.; Weissman, B.; Rush, D.; Levy, D. and Felson, D.T. (1996) Arthritis Rheum., 39(4), 648-56.
88. Schwartz, E.R.; Oh, W.H. and Leveille, C.R. (1981) Arthritis Rheum., 24(11), 1345-55.
89. Meacock, S.C.; Bodmer, J.L. and Billingham, M.E. (1990) J. Exp. Pathol. (Oxford), 71(2), 279-93.
90. Jensen, N.C. (2003) Ugeskr Laeger, 165(48), 4666-7; 4667-8.
91. De Roos, A.J.; Arab, L.; Renner, J.B.; Craft, N.; Luta, G.; Helmick, C.G.; Hochberg, M.C. and Jordan, J.M. (2001) Public Health Nutr., 4(5), 935-42.
92. Rotruck, J.T.; Pope, A.L.; Ganther, H.E.; Swanson, A.B.; Hafeman, D.G. and Hoekstra, W.G. (1973) Science, 179(73), 588-90.
93. Hill, J. and Bird, H.A. (1990) Br. J. Rheumatol., 29(3), 211-3.
94. Harris, E.D. (1992) J. Nutr., 122(3 Suppl), 636-40.
95. White-O'Connor, B. and Sobal, J. (1986) Clin. Ther., 9(Suppl B), 30-42.
96. Walker, W.R. and Keats, D.M. (1976) Agents Actions, 6(4), 454-9.
97. Reginster, J.Y.; Bruyere, O. and Henrotin, Y. (2003) J. Rheumatol. Suppl., 67, 14-20.
98. Henrotin, Y. (2002) International Clinical Practice Series, 19, 3-17.
99. Sanchez, C.; Mateus, M.M.; Defresne, M.P.; Crielaard, J.M.; Reginster, J.Y. and Henrotin, Y.E. (2002) J. Rheumatol., 29(4), 772-82.
100. Mouithys-Mickalad, A.M.; Zheng, S.X.; Deby-Dupont, G.P.; Deby, C.M.; Lamy, M.M.; Reginster, J.Y. and Henrotin, Y.E. (2000) Free Radic. Res., 33(5), 607-21.
101. Bevilacqua, M.; Vago, T.; Baldi, G.; Renesto, E.; Dallegri, F. and Norbiato, G. (1994) Eur. J. Pharmacol., 268(3), 415-23.
102. Maffei Facino, R.; Carini, M.; Aldini, G.; Saibene, L. and Macciocchi, A. (1993) Int. J. Tissue React., 15(6), 225-34.
103. Maffei, F.C.; Carini, M.; Aldini, G.; Saibene, L. and Morelli, M. (1995) Arzneimittel-Forschung, 45(1102-1109.
104. Guillen, C.; McInnes, I.B. and Brock, J.H. (1998) Adv. Exp. Med. Biol., 443, 161-5.
105. Spencer, C.M. and Wilde, M.I. (1997) Drugs, 53(1), 98-106; discussion 107-8.
106. Nicolas, P.; Tod, M.; Padoin, C. and Petitjean, O. (1998) Clin. Pharmacokinet., 35(5), 347-59.
107. Nguyen, M.; Dougados, M.; Berdah, L. and Amor, B. (1994) Arthritis Rheum., 37(4), 529-36.
108. Pelletier, J.P.; Yaron, M.; Haraoui, B.; Cohen, P.; Nahir, M.A.; Choquette, D.; Wigler, I.; Rosner, I.A. and Beaulieu, A.D. (2000) Arthritis Rheum., 43(10), 2339-48.
109. Kay, A.G.; Griffiths, L.G.; Volans, G.N. and Grahame, R. (1980) Curr. Med. Res. Opin., 6(8), 548-51.
110. Mazière, B.; Berdah, L. and Thièchart, M. (1993) Rev. Rhum., 60(6), S77-81.
111. Bendele, A.M. and Bendele, R.A. (1996) Rev. Prat. Ed. Fr., 46(S3-9).
112. Sanchez, C.; Mathy-Hartert, M.; Deberg, M.A.; Ficheux, H.; Reginster, J.Y. and Henrotin, Y.E. (2003) Biochem. Pharmacol., 65(3), 377-88.
113. Tamura, T. and Ohmori, K. (2001) Eur. J. Pharmacol., 419(2-3), 269-74.
114. Felisaz, N.; Boumediene, K.; Ghayor, C.; Herrouin, J.F.; Bogdanowicz, P.; Galerra, P. and Pujol, J.P. (1999) Osteoarthr. Cartil., 7(3), 255-64.
115. Yaron, M.; Shirazi, I. and Yaron, I. (1999) Osteoarthr. Cartil., 7(3), 272-80.
116. Moldovan, F.; Pelletier, J.P.; Jolicoeur, F.C.; Cloutier, J.M. and Martel-Pelletier, J. (2000) Osteoarthr. Cartil., 8(3), 186-96.
117. Borderie, D.; Hernvann, A.; Lemarechal, H.; Menkes, C.J. and Ekindjian, O. (2001) Osteoarthr. Cartil., 9(1), 1-6.
118. Pelletier, J.P.; Mineau, F.; Fernandes, J.C.; Duval, N. and Martel-Pelletier, J. (1998) J. Rheumatol., 25(12), 2417-24.
119. Bironaite, D. and Ollinger, K. (1997) Chem. Biol. Interact., 103(1), 35-50.
120. Malterud, K.E.; Farbrot, T.L.; Huse, A.E. and Sund, R.B. (1993) Pharmacology, 47(Suppl 1), 77-85.
121. Blotman, F.; Maheu, E.; Wulwik, A.; Caspard, H. and Lopez, A. (1997) Rev. Rhum. Engl. Ed., 64(12), 825-34.
122. Maheu, E.; Mazieres, B.; Valat, J.P.; Loyau, G.; Le Loet, X.; Bourgeois, P.; Grouin, J.M. and Rozenberg, S. (1998) Arthritis Rheum., 41(1), 81-91.
123. Appelboom, T.; Schuermans, J.; Verbruggen, G.; Henrotin, Y. and Reginster, J.Y. (2001) Scand. J. Rheumatol., 30(4), 242-7.
124. Boumediene, K.; Felisaz, N.; Bogdanowicz, P.; Galera, P.; Guillou, G.B. and Pujol, J.P. (1999) Arthritis Rheum., 42(1), 148-56.
125. Henrotin, Y.E.; Sanchez, C.; Deberg, M.A.; Piccardi, N.; Guillou, G.B.; Msika, P. and Reginster, J.Y. (2003) J. Rheumatol., 30(8), 1825-34.
126. Henrotin, Y.E.; Labasse, A.H.; Jaspar, J.M.; De Groote, D.D.; Zheng, S.X.; Guillou, G.B. and Reginster, J.Y. (1998) Clin. Rheumatol., 17(1), 31-9.
127. Pelletier, J.P. and Martel-Pelletier, J. (1993) J. Rheumatol. Suppl., 39(19-24.
128. Schenck, P.; Schneider, S.; Miehlke, R. and Prehm, P. (1995) J. Rheumatol., 22(3), 400-5.
129. Balazs, E.A. and Denlinger, J.L. (1993) J. Rheumatol. Suppl., 39(3-9.
130. Brandt, K.D.; Block, J.A.; Michalski, J.P.; Moreland, L.W.; Caldwell, J.R. and Lavin, P.T. (2001) Clin. Orthop. Relat. Res., 385), 130-43.
131. Petrella, R.J.; DiSilvestro, M.D. and Hildebrand, C. (2002) Arch. Intern. Med., 162(3), 292-8.
132. Raynauld, J.P.; Torrance, G.W.; Band, P.A.; Goldsmith, C.H.; Tugwell, P.; Walker, V.; Schultz, M. and Bellamy, N. (2002) Osteoarthr. Cartil., 10(7), 506-17.
133. Karlsson, J.; Sjogren, L.S. and Lohmander, L.S. (2002) Rheumatology (Oxford), 41(11), 1240-8.
134. Puhl, W.; Bernau, A.; Greiling, H.; Kopcke, W.; Pforringer, W.; Steck, K.J.; Zacher, J. and Scharf, H.P. (1993) Osteoarthr. Cartil., 1(4), 233-41.
135. Day, R.; Brooks, P.; Conaghan, P.G. and Petersen, M. (2004) J. Rheumatol., 31(4), 775-82.
136. Ozturk, C.; Atamaz, F.; Hepguler, S.; Argin, M. and Arkun, R. (2006) Rheumatol. Int. 26(4), 314-19.
137. Felson, D.T. and Anderson, J.J. (2002) Arch. Intern. Med., 162(3), 245-7.
138. Listrat, V.; Ayral, X.; Patarnello, F.; Bonvarlet, J.P.; Simonnet, J.; Amor, B. and Dougados, M. (1997) Osteoarthr. Cartil., 5(3), 153-60.
139. Frizziero, L.; Govoni, E. and Bacchini, P. (1998) Clin. Exp. Rheumatol., 16(4), 441-9.
140. Wenz, W.; Breusch, S.J.; Graf, J. and Stratmann, U. (2000) J. Orthop. Res., 18(4), 604-12.
141. Marshall, K.W. (2000) Curr. Opin. Rheumatol., 12(5), 468-74.
142. Kikuchi, T.; Sakuta, T. and Yamaguchi, T. (1996) Int. J. Tissue React., 18(4-6), 87-95.
143. Kobayashi, K.; Matsuzaka, S.; Yoshida, Y.; Miyauchi, S.; Wada, Y. and Moriya, H. (2004) Osteoarthr. Cartil., 12(7), 536-42.
144. Takahashi, K.; Hashimoto, S.; Kubo, T.; Hirasawa, Y.; Lotz, M. and Amiel, D. (2001) J. Orthop. Res., 19(3), 500-3.
145. Olsen, E.B.; Trier, K.; Jorgensen, B.; Brok, K.E. and Ammitzboll, T. (1991) Acta Orthop. Scand., 62(4), 323-6.
146. Ghosh, P.; Read, R.; Numata, Y.; Smith, S.; Armstrong, S. and Wilson, D. (1993) Semin Arthritis Rheum., 22(6 Suppl 1), 31-42.
147. Morris, E.A.; Wilcon, S. and Treadwell, B.V. (1992) Am. J. Vet. Res., 53(11), 1977-82.
148. Homandberg, G.A.; Ummadi, V.; and Kang, H. (2003) Osteoarthr. Cartil., 11(3), 177-86.
149. Williams, J.M.; Zhang, J.; Kang, H.; Ummadi, V. and Homandberg, G.A. (2003) Osteoarthr. Cartil., 11(1), 44-9.
150. Yasui, T.; Akatsuka, M.; Tobetto, K.; Hayaishi, M. and Ando, T. (1992) Agents Actions, 37(1-2), 155-6.
151. Lisignoli, G.; Grassi, F.; Zini, N.; Toneguzzi, S.; Piacentini, A.; Guidolin, D.; Bevilacqua, C. and Facchini, A. (2001) Arthritis Rheum., 44(8), 1800-7.
152. Fukuda, K.; Asada, S.; Kumano, F.; Saitoh, M.; Otani, K. and Tanaka, S. (1997) J. Lab Clin. Med., 130(2), 209-15.
153. Cortivo, R.; Brun, P.; Cardarelli, L.; O'Regan, M.; Radice, M. and Abatangelo, G. (1996) Semin. Arthritis Rheum., 26(1), 492-501.
154. Takahashi, K.; Hashimoto, S.; Kubo, T.; Hirasawa, Y.; Lotz, M. and Amiel, D. (2000) J. Rheumatol., 27(7), 1713-20.
155. Li, M.; Rosenfeld, L.; Vilar, R.E. and Cowman, M.K. (1997) Arch. Biochem. Biophys., 341(2), 245-50.
156. Green, S.P.; Baker, M.S. and Lowther, D.A. (1990) J. Rheumatol., 17(12), 1670-5.
157. Hawkins, C.L. and Davies, M.J. (1998) Free Radic. Biol. Med., 24(9), 1396-410.
158. Horton, M.R.; McKee, C.M.; Bao, C.; Liao, F.; Farber, J.M.; Hodge-DuFour, J.; Pure, E.; Oliver, B.L.; Wright, T.M. and Noble, P.W. (1998) J. Biol. Chem., 273(52), 35088-94.
159. McKee, C.M.; Lowenstein, C.J.; Horton, M.R.; Wu, J.; Bao, C.; Chin, B.Y.; Choi, A.M. and Noble, P.W. (1997) J. Biol. Chem., 272(12), 8013-8.
160. Dieppe, P.A.; Sathapatayavongs, B.; Jones, H.E.; Bacon, P.A. and Ring, E.F. (1980) Rheumatol. Rehabil., 19(4), 212-7.
161. Friedman, D.M. and Moore, M.E. (1980) J. Rheumatol., 7(6), 850-6.
162. Gaffney, K.; Ledingham, J. and Perry, J.D. (1995) Ann. Rheum. Dis., 54(5), 379-81.
163. Pelletier, J.P.; Mineau, F.; Raynauld, J.P.; Woessner, J.F.; Jr.; Gunja-Smith, Z. and Martel-Pelletier, J. (1994) Arthritis Rheum., 37(3), 414-23.
164. Arroll, B. and Goodyear-Smith, F. (2004) BMJ, 328(7444), 869.
165. Pelletier, J.P. and Martel-Pelletier, J. (1991) J. Rheumatol. Suppl., 27, 127-30.
166. Pelletier, J.P. and Martel-Pelletier, J. (1989) Arthritis Rheum., 32(2), 181-93.
167. Williams, J.M. and Brandt, K.D. (1985) Arthritis Rheum., 28(11), 1267-74.
168. Richardson, D.W. and Dodge, G.R. (2003) Inflamm. Res., 52(1), 39-49.
169. Dechant, J.E.; Baxter, G.M.; Frisbie, D.D.; Trotter, G.W. and McIlwraith, C.W. (2003) Equine Vet. J., 35(5), 444-50.
170. Nakazawa, F.; Matsuno, H.; Yudoh, K.; Watanabe, Y.; Katayama, R. and Kimura, T. (2002) Clin. Exp. Rheumatol., 20(6), 773-81.
171. Chrysis, D.; Zaman, F.; Chagin, A.S.; Takigawa, M. and Savendahl, L. (2005) Endocrinology, 146(3), 1391-7.
172. Palmer, G.; Guerne, P.A.; Mezin, F.; Maret, M.; Guicheux, J.; Goldring, M.B. and Gabay, C. (2002) Arthritis Res., 4(3), 226-31.
173. Miyazaki, Y.; Tsukazaki, T.; Hirota, Y.; Yonekura, A.; Osaki, M.; Shindo, H. and Yamashita, S. (2000) Osteoarthr. Cartil., 8(5), 378-85.
174. Karakurum, G.; Karakok, M.; Tarakcioglu, M.; Kocer, N.E.; Kocabas, R. and Bagci, C. (2003) Tohoku J. Exp. Med., 199(3), 127-34.
175. Mathy-Hartert, M.; Devel, P.; Sanchez, C.; Deberg, M.; Deby-Dupont, G. and Henrotin, Y. (2004) Osteoarthr. Cartil., 12(SupplB), S51.
176. Reginster, J.Y.; Deroisy, R.; Rovati, L.C.; Lee, R.L.; Lejeune, E.; Bruyere, O.; Giacovelli, G.; Henrotin, Y.; Dacre, J.E. and Gossett, C. (2001) Lancet, 357(9252), 251-6.
177. Pavelka, K.; Gatterova, J.; Olejarova, M.; Machacek, S.; Giacovelli, G. and Rovati, L.C. (2002) Arch. Intern. Med., 162(18), 2113-23.
178. Leffler, C.T.; Philippi, A.F.; Leffler, S.G.; Mosure, J.C. and Kim, P.D. (1999) Mil. Med., 164(2), 85-91.
179. Altman, R.D.; Abadie, E.; Avouac, B.; Bouvenot, G.; Branco, J.; Bruyere, O.; Calvo, G.; Devogelaer, J.P.; Dreiser, R.L.; Herrero-Beaumont, G.; Kahan, A.; Kreutz, G.; Laslop, A.; Lemmel, E.M.; Menkes, C.J.; Pavelka, K.; Van De Putte, L.; Vanhaelst, L. and Reginster, J.Y. (2005) Osteoarthr. Cartil., 13(1), 13-9.
180. Dodge, G.R. and Jimenez, S.A. (2003) Osteoarthr. Cartil., 11(6), 424-32.
181. Bassleer, C.; Rovati, L. and Franchimont, P. (1998) Osteoarthr. Cartil., 6(6), 427-34.
182. Albelda, S.M. and Buck, C.A. (1990) FASEB J., 4(11), 2868-80.
183. Piperno, M.; Reboul, P.; Hellio Le Graverand, M.P.; Peschard, M.J.; Annefeld, M.; Richard, M. and Vignon, E. (2000) Osteoarthr. Cartil., 8(3), 207-12.
184. Sandy, J.D.; Gamett, D.; Thompson, V. and Verscharen, C. (1998) Biochem. J., 335(Pt 1), 59-66.
185. Adams, M.E. (1999) Lancet, 354(9176), 353-4.
186. Gouze, J.N.; Bordji, K.; Gulberti, S.; Terlain, B.; Netter, P.; Magdalou, J.; Fournel-Gigleux, S. and Ouzzine, M. (2001) Arthritis Rheum., 44(2), 351-60.
187. Gouze, J.N.; Bianchi, A.; Becuwe, P.; Dauca, M.; Netter, P.; Magdalou, J.; Terlain, B. and Bordji, K. (2002) FEBS Lett., 510(3), 166-70.
188. Cherukuri, D.P.; Goulet, A.C.; Inoue, H. and Nelson, M.A. (2005) Cancer Biol. Ther., 4(2).
189. Singh, R.; Ahmed, S.; Islam, N.; Goldberg, V.M. and Haqqi, T.M. (2002) Arthritis Rheum., 46(8), 2079-86.
190. Ahmed, S.; Wang, N.; Lalonde, M.; Goldberg, V.M. and Haqqi, T.M. (2004) J. Pharmacol. Exp. Ther., 308(2), 767-73.
191. Salvemini, D.; Mazzon, E.; Dugo, L.; Serraino, I.; De Sarro, A.; Caputi, A.P. and Cuzzocrea, S. (2001) Arthritis Rheum., 44(12), 2909-21.
192. Cake, M.A.; Read, R.A.; Guillou, B. and Ghosh, P. (2000) Osteoarthr. Cartil., 8(6):404-411.