Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1β and nonsteroidal antiinflammatory drugs

Journal of Rheumatology

Volumn 29, Issue 4, 2002, Pages 772-782

  Sanchez, Christelle ^a   Mateus, Marguarida M ^a   Defresne, Marie Paule ^a   Crielaard, Jean Michel R ^a   Reginster, Jean Yves L ^a   Henrotin, Yves E ^a  

^a CHU Bat B23   (Belgium)

Author keywords

Cartilage; Chondrocytes; Cytokines; Inflammation; Nonsteroidal antiinflammatory drugs; Osteoarthritis

Indexed keywords

ACECLOFENAC; AGGRECAN; ALGINIC ACID; CELECOXIB; DICLOFENAC; IBUPROFEN; INDOMETACIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; ROFECOXIB; STROMELYSIN; THYMIDINE;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL METABOLISM; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; FLUOROMETRY; HUMAN; HUMAN CELL; IMMUNOASSAY; LONG TERM CARE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; THEORETICAL MODEL;

AGGRECANS; ALGINATES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CADAVER; CARTILAGE, ARTICULAR; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL SEPARATION; CELLS, CULTURED; CHONDROCYTES; DNA; EXTRACELLULAR MATRIX PROTEINS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; LECTINS, C-TYPE; MATRIX METALLOPROTEINASE 3; OSTEOARTHRITIS; PROTEOGLYCANS;

EID: 0036228958     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Structure and biology of cartilage and bone matrix noncollagenous macromolecules
2. Cytokines in osteoarthritis: Mediators or markers of joint destruction?
3. Structure and function of normal human adult articular cartilage
4. Hypertrophic repair of canine articular cartilage in osteoarthritis after cruciate ligament transection
5. Catabolic events in osteoarthritic cartilage
6. Biochemical factors in joint articular tissue degradation in osteoarthritis
7. Role of growth factors and cartilage repair
8. Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines
9. Effects of exogenous IL-1β, TNF-α, IL-6, 1L-8 and LIF on cytokine production by human articular chondrocytes
10. 2 production by human chondrocytes
11. Nitric oxide and energy production in articular chondrocytes
12. Basic principles in osteoarthritis treatment
13. Effects of nonsteroidal anti-inflammatory drugs on chondrocyte metabolism, in vitro and in vivo
14. Non-steroidal, anti-inflammatory drug administration in the treatment of osteoarthritis
15. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritis cartilage
16. Effect of non-steroid anti-inflammatory drugs on course of osteoarthritis
17. Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal investigation of nonsteroidal antiinflammatory drugs in knee osteoarthritis
18. Nonsteroidal anti-inflammatory drugs and chondroprotection. A review of the evidence
19. Antioxidant activity of nimesulide and its main metabolites
20. Nimesulide as a downregulator of the activity of the neutrophil myeloperoxidase pathway
21. In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: Effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes
22. Long-term effects of NSAIDs on the production of cytokines and other inflammatory mediators by blood cells of patients with OA
23. 2 production by human articular chondrocytes in vitro
24. Aceclofenac, a new nonsteroidal antiinflammatory drug, decreases the expression and function of some adhesion molecules on human neutrophils
25. Interference of nonsteroidal antiinflammatory drugs with very late activation antigen 4/vascular cell adhesion molecule 1-mediated lymphocyte-endothelial cell adhesion
26. Can nonsteroidal anti-inflammatory drugs act as metalloproteinase modulators? An in vitro study of inhibition of collagenase activity
27. Effects of indomethacin on the production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by human articular chondrocytes
28. Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis
29. The in vitro effect of six NSAIDs on the glycosaminoglycan metabolism of rabbit chondrocytes
30. Nonsteroidal antiinflammatory drugs: Effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro
31. Effects of meloxicam, compared with others NSAIDs, on cartilage proteoglycan metabolism, synovial prostaglandin E2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture
32. The in vitro effect of select classes of nonsteroidal anti-inflammatory drugs on normal cartilage metabolism
33. Effects of tiaprofenic acid and acetylsalicylic acid on human articular chondrocytes in three-dimensional culture
34. In vitro effects of etodolac and acetylsalicylic acid on human chondrocyte metabolism
35. Effects of sodium naproxen on differentiated human chondrocytes cultivated in clusters
36. In-vitro differences among non-steroidal anti-inflammatory drugs in their activities related to osteoarthritis pathophysiology
37. Changes in the type of collagen synthetized as clones of chick chondrocytes grow and eventually lose division capacity
38. Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture
39. Culture and growth characteristics of chondrocytes encapsulated in alginate beads
40. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads
41. Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. Identification of two distinct metabolic matrix pools
42. Differential effects of IGF-1 and TGFβ-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes
43. Characterization of crosslinked collagens synthesized by mature articular chondrocytes cultured in alginate beads: Comparison of two distinct matrix compartments
44. Experimentally induced degenerative joint lesions following partial meniscectomy in the rabbit
45. Metabolism of aceclofenac in humans
46. Aceclofenac. A review of its pharmacodynamic properties and therapeutic potential in the treatment of rheumatic disorders and in pain management
47. Diclofenac sodium, a reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
48. Pharmacokinetics of indomethacin in the elderly
49. Nimesulide, an update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
50. Clinical pharmacokinetics of nimesulide
51. Pharmacokinetics, COX-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans
52. Celecoxib, a review of its use in osteoarthritis, rheumatoid arthritis and acute pain
53. Total and free plasma and total synovial fluid piroxicam concentrations
54. The effect of age on piroxicam disposition in rheumatoid arthritis
55. Clinical pharmacokinetics of ibuprofen. The first 30 years
56. The relationship between the pharmacokinetics of ibuprofen enantiomers and the dose of racemic ibuprofen in humans
57. A simple, rapid and sensitive DNA assay procedure
58. 2 production
59. A novel neutrophil-activating factor produced by human mononuclear phagocytes
60. Induction of synthesis and release of interleukin-8 from human articular chondrocytes and cartilage explants
61. Cartilage and joint inflammation: Regulation of IL-8 expression by human articular chondrocytes
62. Localisation of interleukin-8 in the synovial membrane, cartilage-pannus junction and chondrocytes in rheumatoid arthritis
63. Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo
64. Induction of neutrophils mediated cartilage degradation by interleukin-8
65. An evaluation of the action of aceclofenac on human articular cartilages
66. Relationship between matrix proteoglycan content and the effects of salicylate and indomethacin on articular cartilage
67. Anti-inflammatory drugs, prostanoid and proteoglycan production by cultured bovine articular chondrocytes
68. Effect of antiinflammatory drugs on sulfated glycosaminoglycan synthesis in aged human articular cartilage
69. Evaluation of classical NSAID and COX-2 selective inhibitors on purified ovine enzymes and human whole blood