Diacerhein and rhein reduce the interleukin 1β stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes

Journal of Rheumatology

Volumn 25, Issue 12, 1998, Pages 2417-2424

  Pelletier, Jean Pierre ^a,b   Mineau, François ^c   Fernandes, Julio C ^a   Duval, Nicholas ^a   Martel Pelletier, Johanne ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c NONE

Author keywords

Chondrocytes; Diacerhein; Nitric oxide; Prostanoids

Indexed keywords

DIACETYLRHEIN; NITRIC OXIDE; PROSTAGLANDIN SYNTHASE; RHEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION;

AGED; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHONDROCYTES; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-1; ISOENZYMES; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NAPROXEN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0031743216     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Pelletier JP, Martel-Pelletier J, Howell DS. Etiopathogenesis of osteoarthritis. In: Koopman WJ, editor. Arthritis and Allied Conditions. A Textbook of Rheumatology. 13th ed. Baltimore: Williams & Wilkins, 1997:1969-84.
2. Pelletier JP, Di Battista JA, Roughley PJ, McCollum R, Martel-Pelletier J. Cytokines and inflammation in cartilage degradation. In: Moskowitz RW, editor. Osteoarthritis. Rheum Dis Clin North Am. Philadelphia: W.B. Saunders, 1993:545-68.
3. Pelletier JP, McCollum R, Cloutier JM, Martel-Pelletier J. Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol 1995;22:109-14.
4. Pelletier JP, Caron JP, Evans CH, et al. In vivo suppression of early experimental osteoarthritis by IL-Ra using gene therapy. Arthritis Rheum 1997;40:1012-9.
5. Caron JP, Fernandas JC, Martel-Pelletier J, et al. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis: suppression of collagenase-1 expression. Arthritis Rheum 1996;39:1535-44.
6. Taskiran D, Stefanovic-Racic M, Georgescu HI, Evans CH. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1994;200:142-8.
7. Järvinen TAH, Moilanen T, Järvinen TLN, Moilanen E. Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage. Mediators of Inflammation 1995;4:107-11.
8. Goldring MB, Birkhead J, Sandell LJ, Kimura T, Krane SM. Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest 1988;82:2026-37.
9. Maier R, Bilbe G, Rediske J, Lotz M. Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. Biochim Biophys Acta 1994;1208:145-50.
10. Palmer RMJ, Hickery MS, Charles IG, Moncada S, Bayliss MT. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun 1993;193:398-405.
11. Stadler J, Stefanovic-Racic M, Billiar TR, et al. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991;147:3915-20.
12. Evans CH, Stefanovic-Racic M, Lancaster J. Nitric oxide and its role in orthopaedic disease. Clin Orthop 1995;312:275-94.
13. Farahat MN, Yanni G, Poston R, Panayi GS. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 1993;52:870-5.
14. Westacott CI, Whicker JT, Barnes IC, Thompson D, Swan AJ, Dieppe PA. Synovial fluid concentration of five different cytokines in rheumatic diseases. Ann Rheum Dis 1993;49:679-81.
15. Attur MG, Patel RN, Abramson SB, Amin AR. Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage. Arthritis Rheum 1997;40:1050-3.
16. Farrell AJ, Blake DR, Palmer RM, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992;51:1219-22.
17. McInnes IB, Leung BP, Field M, et al. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med 1996;184:1519-24.
18. Amin AR, Di Cesare PE, Vyas P, et al. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for an inducible "neuronal-like" nitric oxide synthase. J Exp Med 1995;182:2097-102.
19. Murrell GAC, Jang D, Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun 1995;206:15-21.
20. Pelletier JP, Mineau F, Ranger P, Tardif G, Martel-Pelletier J. The increased synthesis of inducible nitric oxide inhibits IL-1Ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation. Osteoarthritis Cartilage 1996;4:77-84.
21. Stefanovic-Racic M, Morales TI, Taskiran D, McIntyre LA, Evans CH. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol 1996;156:1213-20.
22. Amin AR, Attur MG, Patel RN, et al. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J Clin Invest 1997;99:1231-7.
23. Connor JR, Manning PT, Settle SL, et al. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 1995;273:15-24.
24. Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH. N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum 1994;37:1062-9.
25. Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH. Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. J Rheumatol 1995;22:1922-8.
26. McCartney-Francis N, Allen JB, Mizel DE, et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993;178:749-54.
27. Pelletier JP, Jovanovic D, Fernandes JC, et al. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum 1998;41:1275-86.
28. Nguyen M, Dougados M, Berdah L, Amor B. Diacerhein in the treatment of osteoarthritis of the hip. Arthritis Rheum 1994; 37:529-36.
29. Brandt KD, Smith G, Kang SY, Myers S, O'Connor B, Albrecht M. Effects of diacerhein in an accelerated canine model of osteoarthritis. Osteoarthritis Cartilage 1997;5:438-49.
30. Carney SL. Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation. Osteoarthritis Cartilage 1996;4:251-61.
31. Martel-Pelletier J, Mineau F, Jolicoeur FC, Cloutier JM, Pelletier JP. In vitro effects of diacerhein and rhein on IL-1 and TNF-a systems in human osteoarthritic synovium and chondrocytes. J Rheumatol 1998;25:753-62.
32. Altman RD, Asch E, Bloch DA, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum 1986;29:1039-49.
33. Martel-Pelletier J, McCollum R, Fujimoto N, Obata K, Cloutier JM, Pelletier JP. Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. Lab Invest 1994;70:807-15.
34. 15N]nitrate in biological fluids. Anal Biochem 1982;126:131-8.
35. Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: a role in osteoarthritis. J Clin Invest 1996;97:2011-9.
36. Ialenti A, Moncada S, Di Rosa M. Modulation of adjuvant arthritis by endogenous nitric oxide. Br J Pharmacol 1993;110:701-6.
37. 2 in human synovial cells. Arthritis Rheum 1988;31:126-30.
38. 2. J Rheumatol 1996; 23:420-7.
39. 2. Arthritis Rheum 1994;37:653-61.
40. Franchi-Micheli S, Lavacchi L, Friedmann CA, Zilletti L. The influence of rhein on the biosynthesis of prostaglandin-like substances in-vitro. J Pharm Pharmacol 1983;35:262-4.
41. Salvemini D, Manning PT, Zweifel BS, et al. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J Clin Invest 1995;96:301-8.
42. Geng Y, Maier R, Lotz M. Tyrosine kinases are involved with the expression of inducible nitric oxide synthase in human articular chondrocytes. J Cell Physiol 1995;163:545-54.
43. Cruz TF. Effect of diacerhein on matrix metalloproteinases [abstract]. Abstracts of the 3rd International Congress Research and Therapeutics in Osteoarthritis Interleukin-1 Inhibitors Cannes 3-4 Feb 1996;8.