메뉴 건너뛰기




Volumn 30, Issue 8, 2003, Pages 1825-1834

Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes

Author keywords

Avocado; Cartilage; Cytokines; Osteoarthritis; Soybean

Indexed keywords

AGGRECAN; ALGINIC ACID; DNA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NITRIC OXIDE; NITRITE; PROSTAGLANDIN E2; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

EID: 0043031287     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (96)

References (44)
  • 1
    • 0025300215 scopus 로고
    • MRI demonstration of hypertrophic articular cartilage repair in osteoarthritis
    • Braunstein EM, Brandt KD, Albrecht M. MRI demonstration of hypertrophic articular cartilage repair in osteoarthritis. Skeletal Radiol 1990;19:335-9.
    • (1990) Skeletal Radiol , vol.19 , pp. 335-339
    • Braunstein, E.M.1    Brandt, K.D.2    Albrecht, M.3
  • 2
    • 0025905636 scopus 로고
    • Anterior (cranial) cruciate ligament transection in the dog: A bona fide model of canine osteoarthritis, not merely of cartilage injury and repair
    • Brandt KD, Braunstein EM, Visco DM, O'Connor B, Heck D, Albrecht M. Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of canine osteoarthritis, not merely of cartilage injury and repair. J Rheumatol 1991;18:436-46.
    • (1991) J Rheumatol , vol.18 , pp. 436-446
    • Brandt, K.D.1    Braunstein, E.M.2    Visco, D.M.3    O'Connor, B.4    Heck, D.5    Albrecht, M.6
  • 3
    • 0020656640 scopus 로고
    • Hypertrophic repair of articular cartilage in experimental osteoarthrosis
    • Vignon E, Arlot M, Hartmann D, Moyen B, Ville G. Hypertrophic repair of articular cartilage in experimental osteoarthrosis. Ann Rheum Dis 1983;42:82-8.
    • (1983) Ann Rheum Dis , vol.42 , pp. 82-88
    • Vignon, E.1    Arlot, M.2    Hartmann, D.3    Moyen, B.4    Ville, G.5
  • 4
    • 0025979486 scopus 로고
    • In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage
    • Martel-Pelletier J, Zafarullah M, Kodama S, Pelletier JP. In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage. J Rheumatol 1991;18 Suppl 27:80-4.
    • (1991) J Rheumatol , vol.18 , Issue.SUPPL. 27 , pp. 80-84
    • Martel-Pelletier, J.1    Zafarullah, M.2    Kodama, S.3    Pelletier, J.P.4
  • 5
    • 0030868574 scopus 로고    scopus 로고
    • Collagenase-3 (matrix metalloproteinase 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: In vitro mimicking effect by transforming growth factor beta
    • Moldovan F, Pelletier JP, Hambor J, Cloutier JM, Martel-Pelletier J. Collagenase-3 (matrix metalloproteinase 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta. Arthritis Rheum 1997;40:1653-61.
    • (1997) Arthritis Rheum , vol.40 , pp. 1653-1661
    • Moldovan, F.1    Pelletier, J.P.2    Hambor, J.3    Cloutier, J.M.4    Martel-Pelletier, J.5
  • 6
    • 0031928795 scopus 로고    scopus 로고
    • Collagenase-1 and collagenase-3 synthesis in early experimental osteoarthritic canine cartilage. An immunohistochemical study
    • Fernandes JC, Martel-Pelletier J, Lascau-Coman V, et al. Collagenase-1 and collagenase-3 synthesis in early experimental osteoarthritic canine cartilage. An immunohistochemical study. J Rheumatol 1998;25:1585-94.
    • (1998) J Rheumatol , vol.25 , pp. 1585-1594
    • Fernandes, J.C.1    Martel-Pelletier, J.2    Lascau-Coman, V.3
  • 7
    • 0026682509 scopus 로고
    • The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the GLU 373-Ala 374 bond of the interglobular domain
    • Sandy JD, Flannery CR, Neame PJ, Lohmander LS. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the GLU 373-Ala 374 bond of the interglobular domain. J Clin Invest 1992;89:1512-16.
    • (1992) J Clin Invest , vol.89 , pp. 1512-1516
    • Sandy, J.D.1    Flannery, C.R.2    Neame, P.J.3    Lohmander, L.S.4
  • 8
    • 0026736030 scopus 로고
    • Localization of matrix metalloproteinase-3 (stromelysin) in osteoarthritic cartilage and synovium
    • Okada Y, Shimnei M, Tanaka O, et al. Localization of matrix metalloproteinase-3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest 1992;66:680-90.
    • (1992) Lab Invest , vol.66 , pp. 680-690
    • Okada, Y.1    Shimnei, M.2    Tanaka, O.3
  • 9
    • 0026708439 scopus 로고
    • Preferential mRNA expression of prostromelysin relative to procollagenases and in situ localization in human articular cartilage
    • Nguyen Q, Mort JS, Roughley PJ. Preferential mRNA expression of prostromelysin relative to procollagenases and in situ localization in human articular cartilage. J Clin Invest 1992;89:1189-97.
    • (1992) J Clin Invest , vol.89 , pp. 1189-1197
    • Nguyen, Q.1    Mort, J.S.2    Roughley, P.J.3
  • 10
    • 0027316964 scopus 로고
    • Expression of 92-KD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin-1
    • Mohtai M, Smith RL, Schurman DJ, et al. Expression of 92-KD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin-1. J Clin Invest 1993;92:179-85.
    • (1993) J Clin Invest , vol.92 , pp. 179-185
    • Mohtai, M.1    Smith, R.L.2    Schurman, D.J.3
  • 11
    • 0031977579 scopus 로고    scopus 로고
    • Immunohistochemical analysis of several proteolytic enzymes as parameters of cartilage degradation
    • Walter H, Kawashim A, Nebelung W, Neumann W, Roessner A. Immunohistochemical analysis of several proteolytic enzymes as parameters of cartilage degradation. Pathol Res Pract 1998;194:73-81.
    • (1998) Pathol Res Pract , vol.194 , pp. 73-81
    • Walter, H.1    Kawashim, A.2    Nebelung, W.3    Neumann, W.4    Roessner, A.5
  • 12
    • 0030763495 scopus 로고    scopus 로고
    • Detection of interleukin-1 in cartilage of patients with osteoarthritis: Possible autocrine/paracrine role in pathogenesis
    • Towle C, Hung H, Bonassar L, Treadwell B, Mangham D. Detection of interleukin-1 in cartilage of patients with osteoarthritis: possible autocrine/paracrine role in pathogenesis. Osteoarthritis Cartilage 1997;5:293-300.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 293-300
    • Towle, C.1    Hung, H.2    Bonassar, L.3    Treadwell, B.4    Mangham, D.5
  • 13
    • 0027389684 scopus 로고
    • Co-ordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study
    • Pelletier JP, Faure MP, Di Battista JA, Wilhelm S, Visco D, Martel-Pelletier J. Co-ordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study. Am J Pathol 1993;142:95-105.
    • (1993) Am J Pathol , vol.142 , pp. 95-105
    • Pelletier, J.P.1    Faure, M.P.2    Di Battista, J.A.3    Wilhelm, S.4    Visco, D.5    Martel-Pelletier, J.6
  • 14
    • 0035076487 scopus 로고    scopus 로고
    • Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage
    • Tetlow LC, Adam DJ, Wooley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage. Arthritis Rheum 2001;44:585-94.
    • (2001) Arthritis Rheum , vol.44 , pp. 585-594
    • Tetlow, L.C.1    Adam, D.J.2    Wooley, D.E.3
  • 15
    • 0022558390 scopus 로고
    • Effect of interleukin-1-like factor (mononuclear cell factor) on proteoglycan synthesis in cultured human articular chondrocytes
    • Bocquet J, Daireaux M, Langris M, et al. Effect of interleukin-1-like factor (mononuclear cell factor) on proteoglycan synthesis in cultured human articular chondrocytes. Biochem Biophys Res Commun 1986;134:539-49.
    • (1986) Biochem Biophys Res Commun , vol.134 , pp. 539-549
    • Bocquet, J.1    Daireaux, M.2    Langris, M.3
  • 17
    • 0029779371 scopus 로고    scopus 로고
    • Effects of exogenous IL-1β, TNFα, IL-6, IL-8 and LIF on cytokine production by human chondrocytes
    • Henrotin Y, De Groote D, Labasse A, et al. Effects of exogenous IL-1β, TNFα, IL-6, IL-8 and LIF on cytokine production by human chondrocytes. Osteoarthritis Cartilage 1996;4:163-73.
    • (1996) Osteoarthritis Cartilage , vol.4 , pp. 163-173
    • Henrotin, Y.1    De Groote, D.2    Labasse, A.3
  • 18
    • 0033884311 scopus 로고    scopus 로고
    • Human chondrocytes express functional chemokine receptors and release matrix-degradating enzymes in response to C-X-C and C-C chemokines
    • Borzi RM, Mazzetti I, Cattini L, Uguccioni M, Bagglioni M, Facchini A. Human chondrocytes express functional chemokine receptors and release matrix-degradating enzymes in response to C-X-C and C-C chemokines. Arthritis Rheum 2000;43:1743-51.
    • (2000) Arthritis Rheum , vol.43 , pp. 1743-1751
    • Borzi, R.M.1    Mazzetti, I.2    Cattini, L.3    Uguccioni, M.4    Bagglioni, M.5    Facchini, A.6
  • 19
    • 0024996225 scopus 로고
    • Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines
    • Tiku K, Liesch JB, Robertson FM. Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines. J Immunol 1990;145:690-6.
    • (1990) J Immunol , vol.145 , pp. 690-696
    • Tiku, K.1    Liesch, J.B.2    Robertson, F.M.3
  • 20
    • 0031417266 scopus 로고    scopus 로고
    • Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip: A prospective, multicenter, three months, randomized, double blind, placebo controlled trial
    • Blotman F, Maheu E, Wulwik A, Gaspard H. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip: a prospective, multicenter, three months, randomized, double blind, placebo controlled trial. Rev Rhum Engl Ed 1997;64:825-34.
    • (1997) Rev Rhum Engl Ed , vol.64 , pp. 825-834
    • Blotman, F.1    Maheu, E.2    Wulwik, A.3    Gaspard, H.4
  • 21
    • 0031972565 scopus 로고    scopus 로고
    • Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: A prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six months treatment period and a two months follow-up demonstrating a persistent effect
    • Maheu E, Mazière B, Valat J-P, al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six months treatment period and a two months follow-up demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91.
    • (1998) Arthritis Rheum , vol.41 , pp. 81-91
    • Maheu, E.1    Mazière, B.2    Valat, J.-P.3
  • 23
    • 0036167377 scopus 로고    scopus 로고
    • Structural effects of avocado/soya unsaponifiables (ASU) on joint space loss in osteoarthritis of the hip
    • Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effects of avocado/soya unsaponifiables (ASU) on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.
    • (2002) Arthritis Rheum , vol.47 , pp. 50-58
    • Lequesne, M.1    Maheu, E.2    Cadet, C.3    Dreiser, R.L.4
  • 24
    • 0034533184 scopus 로고    scopus 로고
    • Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables
    • Cake MA, Read RA, Guillou B, Ghosh P. Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables. Osteoarthritis Cartilage 2000;8:404-11.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 404-411
    • Cake, M.A.1    Read, R.A.2    Guillou, B.3    Ghosh, P.4
  • 25
    • 0032928144 scopus 로고    scopus 로고
    • Avocado/soya unsaponifiables enhance the expression of transforming growth factor β1 and β2 in cultured articular chondrocytes
    • Boumediene K, Felisaz N, Bogdanowicz P, Galera P, Guillou B, Pujol J-P. Avocado/soya unsaponifiables enhance the expression of transforming growth factor β1 and β2 in cultured articular chondrocytes. Arthritis Rheum 1999;42:148-56.
    • (1999) Arthritis Rheum , vol.42 , pp. 148-156
    • Boumediene, K.1    Felisaz, N.2    Bogdanowicz, P.3    Galera, P.4    Guillou, B.5    Pujol, J.-P.6
  • 27
    • 0036228958 scopus 로고    scopus 로고
    • Metabolism of human chondrocytes cultured in alginate beads. Longterm effects of interleukin 1β and nonsteroidal antiinflammatory drugs
    • Sanchez C, Mateus M, Defresne M-P, Crielaard J-M, Reginster J-Y, Henrotin Y. Metabolism of human chondrocytes cultured in alginate beads. Longterm effects of interleukin 1β and nonsteroidal antiinflammatory drugs. J Rheumatol 2002;29:772-82.
    • (2002) J Rheumatol , vol.29 , pp. 772-782
    • Sanchez, C.1    Mateus, M.2    Defresne, M.-P.3    Crielaard, J.-M.4    Reginster, J.-Y.5    Henrotin, Y.6
  • 28
    • 0034531762 scopus 로고    scopus 로고
    • In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: Effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes
    • Zheng SX, Mouithys-Mickalad A, Deby-Dupont GP, al. In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes. Osteoarthritis Cartilage 2000;8:419-25.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 419-425
    • Zheng, S.X.1    Mouithys-Mickalad, A.2    Deby-Dupont, G.P.3
  • 29
    • 0018850985 scopus 로고
    • A simple, rapid and sensitive DNA assay procedure
    • Labarca C, Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal Biochem 1980;102:344-52.
    • (1980) Anal Biochem , vol.102 , pp. 344-352
    • Labarca, C.1    Paigen, K.2
  • 32
    • 0025847582 scopus 로고
    • Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    • Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5:2145-54.
    • (1991) FASEB J , vol.5 , pp. 2145-2154
    • Woessner J.F., Jr.1
  • 33
    • 0002944019 scopus 로고    scopus 로고
    • Osteoarthritis and related disorders: Cartilage integrity and homeostasis
    • Klippel JH, Dieppe PA, editors. London: Mosby International
    • Kuettner KE, Thonar EJM. Osteoarthritis and related disorders: cartilage integrity and homeostasis. In: Klippel JH, Dieppe PA, editors. Rheumatology. 2nd ed. London: Mosby International; 1998:861-16.
    • (1998) Rheumatology. 2nd Ed. , pp. 861-816
    • Kuettner, K.E.1    Thonar, E.J.M.2
  • 34
    • 0023627301 scopus 로고
    • Stromelysin is an activator of procollagenase: A study with natural and recombinant enzymes
    • Murphy G, Cocket MI, Stephens PE, Smith BJ, Doherty AJ. Stromelysin is an activator of procollagenase: a study with natural and recombinant enzymes. Biochem J 1987;248:265-8.
    • (1987) Biochem J , vol.248 , pp. 265-268
    • Murphy, G.1    Cocket, M.I.2    Stephens, P.E.3    Smith, B.J.4    Doherty, A.J.5
  • 35
    • 0032076751 scopus 로고    scopus 로고
    • Differential effects of IGF-1 and TGF-β2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes
    • Van Osch GJVM, van den Berg WB, Hunziker EB, Hauselmann HJ. Differential effects of IGF-1 and TGF-β2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes. Osteoarthritis Cartilage 1998;6:187-95.
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 187-195
    • Van Osch, G.J.V.M.1    Van den Berg, W.B.2    Hunziker, E.B.3    Hauselmann, H.J.4
  • 36
    • 0023576229 scopus 로고
    • Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis
    • Lindlad S, Hedfors E. Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis. Arthritis Rheum 1987;30:1081-8.
    • (1987) Arthritis Rheum , vol.30 , pp. 1081-1088
    • Lindlad, S.1    Hedfors, E.2
  • 37
    • 0028784024 scopus 로고
    • Macrophage inflammatory protein-1β: A C-C chemokine in osteoarthritis
    • Koch AE, Kunkel SL, Shah MR, et al. Macrophage inflammatory protein-1β: A C-C chemokine in osteoarthritis. Clin Rheumatol 1995;77:307-14.
    • (1995) Clin Rheumatol , vol.77 , pp. 307-314
    • Koch, A.E.1    Kunkel, S.L.2    Shah, M.R.3
  • 38
    • 0032792867 scopus 로고    scopus 로고
    • Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: Constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis
    • Borzi RM, Mazzetti I, Macor S, et al. Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis. FEBS Lett 1999;455:238-42.
    • (1999) FEBS Lett , vol.455 , pp. 238-242
    • Borzi, R.M.1    Mazzetti, I.2    Macor, S.3
  • 39
    • 0016610513 scopus 로고
    • A scanning electron microscope study of experimental periodontal disease. Its induction and inhibition
    • Kerbel B, Clergeau-Guerithault S, Brion M. A scanning electron microscope study of experimental periodontal disease. Its induction and inhibition. J Periodontol 1975;46:27-35.
    • (1975) J Periodontol , vol.46 , pp. 27-35
    • Kerbel, B.1    Clergeau-Guerithault, S.2    Brion, M.3
  • 40
    • 0032781968 scopus 로고    scopus 로고
    • Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: Comparison with IL-1. Modulation by dexamethasone
    • Guerne PA, Desgeorges A, Jaspar JM, Relic B, Hoffmeyer P, Dayer JM. Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone. Matrix Biol 1999;18:253-60.
    • (1999) Matrix Biol , vol.18 , pp. 253-260
    • Guerne, P.A.1    Desgeorges, A.2    Jaspar, J.M.3    Relic, B.4    Hoffmeyer, P.5    Dayer, J.M.6
  • 41
    • 0032156912 scopus 로고    scopus 로고
    • Effects of interleukin-6 on proliferation and proteoglycan metabolism in articular chondrocyte cultures
    • Jikko A, Wakisaka T, Iwamoto M, al. Effects of interleukin-6 on proliferation and proteoglycan metabolism in articular chondrocyte cultures. Cell Biol Int 1998;22:615-22.
    • (1998) Cell Biol Int , vol.22 , pp. 615-622
    • Jikko, A.1    Wakisaka, T.2    Iwamoto, M.3
  • 42
    • 0033783333 scopus 로고    scopus 로고
    • IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage
    • Flannery CR, Little CB, Hughes CE, Curtis CL, Caterson B, Jones SA. IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix Biol 2000;19:549-53.
    • (2000) Matrix Biol , vol.19 , pp. 549-553
    • Flannery, C.R.1    Little, C.B.2    Hughes, C.E.3    Curtis, C.L.4    Caterson, B.5    Jones, S.A.6
  • 43
    • 0034944224 scopus 로고    scopus 로고
    • Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown
    • Rowan AD, Koshi PJ, Shingleton WD, et al. Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown. Arthritis Rheum 2001;44:1620-32.
    • (2001) Arthritis Rheum , vol.44 , pp. 1620-1632
    • Rowan, A.D.1    Koshi, P.J.2    Shingleton, W.D.3
  • 44
    • 0028872942 scopus 로고
    • Nitric oxide activates metalloprotease enzymes in articular cartilage explants
    • Murrell GAC, Jang D, Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage explants. Biochem Biophys Res Commun 1995;206:121-8.
    • (1995) Biochem Biophys Res Commun , vol.206 , pp. 121-128
    • Murrell, G.A.C.1    Jang, D.2    Williams, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.