Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT

Immunity

Volumn 14, Issue 3, 2001, Pages 315-329

  Bunnell, Stephen C ^a   Kapoor, Veena ^a   Trible, Ronald P ^a   Zhang, Weiguo ^b   Samelson, Lawrence E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ANTIBODY; LAT PROTEIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL SPREADING; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOSKELETON; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LAMELLIPODIUM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0035075507     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00112-1     Document Type: Article

References (52)

1. Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner
2. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
3. Lymphocyte signalling: A coordinating role for Vav?
4. Regulation of antigen receptor signal transduction by protein tyrosine kinases
5. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
6. The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways
7. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
8. Imaging antigen recognition by naive CD4+ T cells: Compulsory cytoskeletal alterations for the triggering of an intracellular calcium response
9. Isolation of a novel gene mutated in Wiskott-Aldrich Syndrome
10. A synthetic inhibitor of the mitogen-activated protein kinase cascade
11. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling
12. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
13. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
14. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
15. Vav is a regulator of cytoskeletal reorganization mediated by the T- cell receptor
16. The immunological synapse: A molecular machine controlling T cell activation
17. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
18. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
19. Reorientation of the microtubule-organizing center and the golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells
20. The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells
21. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: Immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions
22. TCR-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
23. The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
24. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism
25. Translocation and clustering of endosomes and lysosomes depends on microtubules
26. Three-dimensional segregation of supramolecular activation clusters in T cells
27. Polarity of T cell shape, motility, and sensitivity to antigen
28. Rho GTPases control polarity, protrusion, and adhesion during cell movement
29. Actin polymerization and pseudopod reorganization accompany anti-CD3 induced growth arrest in Jurkat T cells
30. Ptdlns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
31. TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization
32. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
33. LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain
34. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
35. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
36. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
37. Complex complexes: Signaling at the TCR
38. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
39. Actin dynamics in vivo
40. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-γ1 and Ras activation
41. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
42. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
43. Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
44. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell
45. The role of membrane-associated adaptors in T cell receptor signalling
46. Lat: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
47. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
48. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
49. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
50. Essential role of LAT in T cell development
51. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
52. How WASP regulates actin polymerization