Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 2167-2176

  Xing, Chengguo ^a   Wang, Liangyou ^a   Tang, XiaoHu ^a   Sham, Yuk Y ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Bcl 2; Inhibitor; Selectivity

Indexed keywords

2 [5 (1 PHENYLBUTYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (1 PHENYLBUTYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 4 METHYLPENTANOIC ACID; 2 [5 (1 PHENYLETHYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 4 METHYLPENTANOIC ACID; 2 [5 (4 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 (3 INDOLYL)PROPANOIC ACID; 2 [5 (4 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 METHYLBUTANOIC ACID; 2 [5 (4 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (4 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 4 METHYLPENTANOIC ACID; 2 [5 (DIPHENYLMETHYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 4 METHYLPENTANOIC ACID; 2 [5 [PHENYL(4 BIPHENYL)METHYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 4 METHYLPENTANOIC ACID; 2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 PROPENYL 2 [5 (4 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOATE; 2 PROPENYL 2 [5 BIPHENYLMETHYLIDENE 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOATE; ANTIMYCIN A3; BHI 1; BHI 2; CHELERYTHRINE; GOSSYPOL; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING ENERGY; BINDING SITE; CALCULATION; CORRELATION ANALYSIS; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENERGY; EVALUATION; MOLECULAR INTERACTION; MOLECULAR MODEL; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

AMINO ACID SEQUENCE; APOPTOSIS; FLUORESCENCE POLARIZATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33846619683     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.020     Document Type: Article

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