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Volumn 58, Issue 6, 2006, Pages 846-858

Neuroprotective effects of MTEP, a selective mGluR5 antagonist and neuropeptide Y on the kainate-induced toxicity in primary neuronal cultures

Author keywords

Excitotoxicity; Kainic acid; MGluRs; MTEP; Neuroprotection; NPY; Primary neuronal cultures

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; CASPASE 3; KAINIC ACID; LACTATE DEHYDROGENASE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; NEUROPEPTIDE Y;

EID: 33846306749     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (27)

References (100)
  • 1
    • 0036362716 scopus 로고    scopus 로고
    • Glutamate AMPA receptor antagonist treatment for ischaemic stroke
    • Akins PT, Atkinson RP: Glutamate AMPA receptor antagonist treatment for ischaemic stroke. Curr Med Res Opin, 2002, 18, 9-13.
    • (2002) Curr Med Res Opin , vol.18 , pp. 9-13
    • Akins, P.T.1    Atkinson, R.P.2
  • 2
    • 33747151426 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy
    • Alexander GM, Godwin DW: Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy. Epilepsy Res, 2006, 71, 1-22.
    • (2006) Epilepsy Res , vol.71 , pp. 1-22
    • Alexander, G.M.1    Godwin, D.W.2
  • 3
    • 0034064587 scopus 로고    scopus 로고
    • Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro
    • Allen JW, Knoblach SM, Faden AI: Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro. Cell Death Differ, 2000, 7, 470-476.
    • (2000) Cell Death Differ , vol.7 , pp. 470-476
    • Allen, J.W.1    Knoblach, S.M.2    Faden, A.I.3
  • 4
    • 0034989229 scopus 로고    scopus 로고
    • Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: Role of NMDA receptors and arachidonic acid release
    • Allen JW, Vicini S, Faden AI: Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: role of NMDA receptors and arachidonic acid release. Exp Neurol, 2001, 169, 449-460.
    • (2001) Exp Neurol , vol.169 , pp. 449-460
    • Allen, J.W.1    Vicini, S.2    Faden, A.I.3
  • 5
    • 0038825269 scopus 로고    scopus 로고
    • In vivo receptor occupancy of mGluR5 receptor antagonists using the novel radioligand [3H] 3-methoxy-5-(pyridin-2-ytethynyl) pyridine)
    • Anderson JJ, Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Roppe J, King C et al.: In vivo receptor occupancy of mGluR5 receptor antagonists using the novel radioligand [3H] 3-methoxy-5-(pyridin-2-ytethynyl) pyridine). Eur J Pharmacol, 2003, 473, 35-40.
    • (2003) Eur J Pharmacol , vol.473 , pp. 35-40
    • Anderson, J.J.1    Bradbury, M.J.2    Giracello, D.R.3    Chapman, D.F.4    Holtz, G.5    Roppe, J.6    King, C.7
  • 6
    • 0036882079 scopus 로고    scopus 로고
    • 3H]Methoxymethyl-3-[(2-methyl-1, 3-thiazol-4-yl) ethynyl] pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: In vitro and in vivo characterization
    • Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L et al.: [3H]Methoxymethyl-3-[(2-methyl-1, 3-thiazol-4-yl) ethynyl] pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. J Pharmacol Exp Ther, 2002, 303, 1044-1051.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1044-1051
    • Anderson, J.J.1    Rao, S.P.2    Rowe, B.3    Giracello, D.R.4    Holtz, G.5    Chapman, D.F.6    Tehrani, L.7
  • 7
    • 0035924328 scopus 로고    scopus 로고
    • Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia
    • Bao WL, Williams AJ, Faden AI, Tortella FC: Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. Brain Res, 2001, 922, 173-179.
    • (2001) Brain Res , vol.922 , pp. 173-179
    • Bao, W.L.1    Williams, A.J.2    Faden, A.I.3    Tortella, F.C.4
  • 8
    • 0028802238 scopus 로고
    • Effects of neuropeptide Y evoked potentials in the CA1 region and the dentate gyrus of the rat hippocampal slice
    • Bijak M, Śmiałowska M: Effects of neuropeptide Y evoked potentials in the CA1 region and the dentate gyrus of the rat hippocampal slice. Pol J Pharmacol, 1995, 47, 333-338.
    • (1995) Pol J Pharmacol , vol.47 , pp. 333-338
    • Bijak, M.1    Śmiałowska, M.2
  • 9
    • 0028868824 scopus 로고
    • Serum-free B27/neurobasal medium supports differentiated growth of neurones from the striatum, substantia nigra, septum, cerebral cortex, cerebellum and dentate gyrus
    • Brewer GJ: Serum-free B27/neurobasal medium supports differentiated growth of neurones from the striatum, substantia nigra, septum, cerebral cortex, cerebellum and dentate gyrus. J Neurosci Res, 1995, 42, 674-683.
    • (1995) J Neurosci Res , vol.42 , pp. 674-683
    • Brewer, G.J.1
  • 10
    • 0028351384 scopus 로고
    • Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death 10
    • Bruno V, Copani A, Battaglia G, Rafaele R, Shinozaki H, Nicoletti F: Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death. Eur J Pharmacol, 1994, 256, 109-112.
    • (1994) Eur J Pharmacol , vol.256 , pp. 109-112
    • Bruno, V.1    Copani, A.2    Battaglia, G.3    Rafaele, R.4    Shinozaki, H.5    Nicoletti, F.6
  • 11
    • 0029131714 scopus 로고
    • Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells
    • Bruno V, Copani A, Knopfel T, Kuhn R, Casabona G, Dell'Albani P, Condorello DF, Nicoletti F: Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells. Neuropharmacology, 1995, 34, 1089-1098.
    • (1995) Neuropharmacology , vol.34 , pp. 1089-1098
    • Bruno, V.1    Copani, A.2    Knopfel, T.3    Kuhn, R.4    Casabona, G.5    Dell'Albani, P.6    Condorello, D.F.7    Nicoletti, F.8
  • 13
    • 0031032470 scopus 로고    scopus 로고
    • The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling
    • Bruno V, Sureda FX, Storto M, Casabona G, Caruso A, Knopfel T, Kuhn R, Nicoletti F: The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling. J Neurosci, 1997, 17, 1891-1897.
    • (1997) J Neurosci , vol.17 , pp. 1891-1897
    • Bruno, V.1    Sureda, F.X.2    Storto, M.3    Casabona, G.4    Caruso, A.5    Knopfel, T.6    Kuhn, R.7    Nicoletti, F.8
  • 14
    • 0033046392 scopus 로고    scopus 로고
    • Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): Comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors
    • Bruno V, Battaglia G, Kingston A, O'Neill MJ, Catania MV, Di Grezia R, Nicoletti F: Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology, 1999, 38, 199-207.
    • (1999) Neuropharmacology , vol.38 , pp. 199-207
    • Bruno, V.1    Battaglia, G.2    Kingston, A.3    O'Neill, M.J.4    Catania, M.V.5    Di Grezia, R.6    Nicoletti, F.7
  • 16
    • 1842419435 scopus 로고    scopus 로고
    • Raising intracellular calcium attenuates neuronal apoptosis triggered by staurosporine or oxygen-glucose deprivation in the presence of glutamate receptor blockade
    • Canzoniero LMT, Babcock DJ, Gottron FJ, Grabb MC, Manzerra P, Snider BJ, Choi DW: Raising intracellular calcium attenuates neuronal apoptosis triggered by staurosporine or oxygen-glucose deprivation in the presence of glutamate receptor blockade. Neurobiol Dis, 2004, 15, 520-528.
    • (2004) Neurobiol Dis , vol.15 , pp. 520-528
    • Canzoniero, L.M.T.1    Babcock, D.J.2    Gottron, F.J.3    Grabb, M.C.4    Manzerra, P.5    Snider, B.J.6    Choi, D.W.7
  • 17
    • 0026497926 scopus 로고
    • Excitotoxic cell death
    • Choi DW: Excitotoxic cell death. J Neurobiol, 1992, 23, 1267-1276.
    • (1992) J Neurobiol , vol.23 , pp. 1267-1276
    • Choi, D.W.1
  • 18
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi DW: Glutamate neurotoxicity and diseases of the nervous system. Neuron, 1988, 1, 623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 19
    • 0021961417 scopus 로고
    • Glutamate neurotoxicity in cortical cell culture is calcium dependent
    • Choi DW: Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett, 1985, 58, 293-297.
    • (1985) Neurosci Lett , vol.58 , pp. 293-297
    • Choi, D.W.1
  • 20
    • 0028016077 scopus 로고
    • Glutamate receptors and the induction of excitotoxic neuronal death
    • Choi DW: Glutamate receptors and the induction of excitotoxic neuronal death. Prog Brain Res, 1994, 100, 47-51.
    • (1994) Prog Brain Res , vol.100 , pp. 47-51
    • Choi, D.W.1
  • 21
    • 0025543228 scopus 로고
    • Modulation of synaptic transmission in hippocampus by neuropeptide Y: Presynaptic actions
    • Colmers WF: Modulation of synaptic transmission in hippocampus by neuropeptide Y: presynaptic actions. Ann NY Acad Sci, 1990, 611, 206-218.
    • (1990) Ann NY Acad Sci , vol.611 , pp. 206-218
    • Colmers, W.F.1
  • 23
    • 0023162181 scopus 로고
    • Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice
    • Colmers WF, Lukowiak K, Pittman QJ: Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice. J Physiol, 1987, 383, 285-299.
    • (1987) J Physiol , vol.383 , pp. 285-299
    • Colmers, W.F.1    Lukowiak, K.2    Pittman, Q.J.3
  • 24
    • 0037330358 scopus 로고    scopus 로고
    • [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: Potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor
    • Cosford ND, Roppe J, Tehrani L, Schweiger EJ, Seiders TJ, Chaudary A, Rao S, Varney MA: [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett, 2003, 13, 351-354.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 351-354
    • Cosford, N.D.1    Roppe, J.2    Tehrani, L.3    Schweiger, E.J.4    Seiders, T.J.5    Chaudary, A.6    Rao, S.7    Varney, M.A.8
  • 25
    • 0037448394 scopus 로고    scopus 로고
    • 3-[(2-Methyl-1, 3-thiazol-4-yl)-pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
    • Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L et al.: 3-[(2-Methyl-1, 3-thiazol-4-yl)-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem, 2003, 46, 204-206.
    • (2003) J Med Chem , vol.46 , pp. 204-206
    • Cosford, N.D.1    Tehrani, L.2    Roppe, J.3    Schweiger, E.4    Smith, N.D.5    Anderson, J.6    Bristow, L.7
  • 26
    • 0020640626 scopus 로고
    • Neurotoxic action of kainic acid
    • Coyle JT: Neurotoxic action of kainic acid. J Neurochem, 1993, 41, 1-11.
    • (1993) J Neurochem , vol.41 , pp. 1-11
    • Coyle, J.T.1
  • 27
    • 0032429754 scopus 로고    scopus 로고
    • Glycine and N-methyl-D-asparate receptors: Physiological significance and possible therapeutic applications
    • Danysz W, Parsons CG: Glycine and N-methyl-D-asparate receptors: physiological significance and possible therapeutic applications. Pharmacol Rev, 1998, 50, 597-664.
    • (1998) Pharmacol Rev , vol.50 , pp. 597-664
    • Danysz, W.1    Parsons, C.G.2
  • 28
    • 0029149775 scopus 로고
    • Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones
    • Davies CH, Clarke VRJ, Jane DE, Collingridge GL: Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones. Br J Pharmacol, 1995, 116, 1859-1869.
    • (1995) Br J Pharmacol , vol.116 , pp. 1859-1869
    • Davies, C.H.1    Clarke, V.R.J.2    Jane, D.E.3    Collingridge, G.L.4
  • 29
    • 0037067518 scopus 로고    scopus 로고
    • Implication of p53 and caspase-3 in kainic acid but not in N-methyl-D-aspartic acid-induced apoptosis in organotypic hippocampal mouse cultures
    • Djebaili M, De Bock F, Baille V, Bockaert J, Rondouin G: Implication of p53 and caspase-3 in kainic acid but not in N-methyl-D-aspartic acid-induced apoptosis in organotypic hippocampal mouse cultures. Neurosci Lett, 2002, 327, 1-4.
    • (2002) Neurosci Lett , vol.327 , pp. 1-4
    • Djebaili, M.1    De Bock, F.2    Baille, V.3    Bockaert, J.4    Rondouin, G.5
  • 30
    • 0026792438 scopus 로고
    • Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues
    • Dumont Y, Martel JC, Fournier A, St Pierre S, Quirion R: Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog Neurobiol, 1992, 38, 125-167.
    • (1992) Prog Neurobiol , vol.38 , pp. 125-167
    • Dumont, Y.1    Martel, J.C.2    Fournier, A.3    St Pierre, S.4    Quirion, R.5
  • 31
    • 0035134134 scopus 로고    scopus 로고
    • Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma
    • Faden AI, O'Leary DM, Fan L, Bao W, Mullins PGM, Movsesyan VA: Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma. Exp Neurol, 2001, 167, 435-444.
    • (2001) Exp Neurol , vol.167 , pp. 435-444
    • Faden, A.I.1    O'Leary, D.M.2    Fan, L.3    Bao, W.4    Mullins, P.G.M.5    Movsesyan, V.A.6
  • 32
    • 0038555125 scopus 로고    scopus 로고
    • Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices
    • Fazal A, Parker F, Palmer AM, Croucher MJ: Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices. J Neurochem, 2003, 86, 1346-1358.
    • (2003) J Neurochem , vol.86 , pp. 1346-1358
    • Fazal, A.1    Parker, F.2    Palmer, A.M.3    Croucher, M.J.4
  • 33
    • 0020577545 scopus 로고
    • Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids
    • Ferkany JW, Coyle JT: Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids. J Pharmacol Exp Ther, 1983, 225, 399-406.
    • (1983) J Pharmacol Exp Ther , vol.225 , pp. 399-406
    • Ferkany, J.W.1    Coyle, J.T.2
  • 34
    • 0027931560 scopus 로고
    • DNA fragmentation in rat brain after intraperitoneal administration of kainate
    • Filipkowski R, Hetman M, Kamińska B, Kaczmarek L: DNA fragmentation in rat brain after intraperitoneal administration of kainate. Neuroreport, 1994, 5, 1538-1540.
    • (1994) Neuroreport , vol.5 , pp. 1538-1540
    • Filipkowski, R.1    Hetman, M.2    Kamińska, B.3    Kaczmarek, L.4
  • 36
    • 0022544178 scopus 로고
    • Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: Dependence on calcium concentration
    • Garthwaite G, Garthwaite J: Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration. Neurosci Lett, 1986, 66, 193-198.
    • (1986) Neurosci Lett , vol.66 , pp. 193-198
    • Garthwaite, G.1    Garthwaite, J.2
  • 37
    • 0033034991 scopus 로고    scopus 로고
    • (R, S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo
    • Gasparini F, Bruno V, Battaglia G, Lukic S, Leonhardt T, Inderbitzin W, Laurie D et al.: (R, S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther, 1999, 289, 1678-1687.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1678-1687
    • Gasparini, F.1    Bruno, V.2    Battaglia, G.3    Lukic, S.4    Leonhardt, T.5    Inderbitzin, W.6    Laurie, D.7
  • 38
    • 0029145935 scopus 로고
    • Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability
    • Gereau RW and Conn PJ: Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability. J Neurophysiol, 1995, 74, 122-129.
    • (1995) J Neurophysiol , vol.74 , pp. 122-129
    • Gereau, R.W.1    Conn, P.J.2
  • 39
    • 0022617388 scopus 로고
    • Neuropeptide Y: Anatomical distribution and possible function in mammalian nervous system
    • Gray TS, Morley JE: Neuropeptide Y: anatomical distribution and possible function in mammalian nervous system. Life Sci, 1986, 38, 389-401.
    • (1986) Life Sci , vol.38 , pp. 389-401
    • Gray, T.S.1    Morley, J.E.2
  • 40
    • 0028104939 scopus 로고
    • Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro
    • Greber S, Schwarzer C, Sperk G: Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro. Br J Pharmacol, 1994, 113, 737-740.
    • (1994) Br J Pharmacol , vol.113 , pp. 737-740
    • Greber, S.1    Schwarzer, C.2    Sperk, G.3
  • 41
    • 0029044195 scopus 로고
    • Animal models of acute ischaemic stroke: Can they predict clinically successful neuroprotective drugs?
    • Hunter AJ, Green AR, Cross AJ: Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs? TiPS, 1995, 16, 123-128.
    • (1995) TiPS , vol.16 , pp. 123-128
    • Hunter, A.J.1    Green, A.R.2    Cross, A.J.3
  • 42
    • 0141676771 scopus 로고    scopus 로고
    • Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    • Ikonomidou C, Turski L: Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol, 2002, 1, 383-386.
    • (2002) Lancet Neurol , vol.1 , pp. 383-386
    • Ikonomidou, C.1    Turski, L.2
  • 43
    • 0033400042 scopus 로고    scopus 로고
    • Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells
    • Kajta M, Budziszewska B, Lasoń W: Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells. Pol J Pharmacol, 1999, 51, 531-534.
    • (1999) Pol J Pharmacol , vol.51 , pp. 531-534
    • Kajta, M.1    Budziszewska, B.2    Lasoń, W.3
  • 44
    • 14244261959 scopus 로고    scopus 로고
    • Apoptosis in the central nervous system: Mechanisms and protective strategies
    • Kajta M: Apoptosis in the central nervous system: mechanisms and protective strategies. Pol J Pharmacol, 2004, 6, 659-700.
    • (2004) Pol J Pharmacol , vol.6 , pp. 659-700
    • Kajta, M.1
  • 45
    • 0033842706 scopus 로고    scopus 로고
    • Oestrogen effects on kainate-induced toxicity in primary cultures of rat cortical neurons
    • Kajta M, Lasoń W: Oestrogen effects on kainate-induced toxicity in primary cultures of rat cortical neurons. Acta Neurobiol Exp, 2000, 60, 365-369.
    • (2000) Acta Neurobiol Exp , vol.60 , pp. 365-369
    • Kajta, M.1    Lasoń, W.2
  • 46
    • 0346157306 scopus 로고    scopus 로고
    • Effects of estrone on N-methyl-D-aspartic acid- and staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenase-release: Time and tissue-dependent effects in neuronal cultures
    • Kajta M, Lasoń W, Kupiec T: Effects of estrone on N-methyl-D-aspartic acid- and staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenase-release: time and tissue-dependent effects in neuronal cultures. Neuroscience, 2004, 123, 515-526.
    • (2004) Neuroscience , vol.123 , pp. 515-526
    • Kajta, M.1    Lasoń, W.2    Kupiec, T.3
  • 47
    • 27244438915 scopus 로고    scopus 로고
    • Effect of NMDA on staurosporine-induced activation of caspase-3 and LDH release in mouse neocortical and hippocampal cells
    • Kajta, M, Trotter A, Lasoń W, Beyer C: Effect of NMDA on staurosporine-induced activation of caspase-3 and LDH release in mouse neocortical and hippocampal cells. Brain Res Dev Brain Res, 2005, 160, 40-52.
    • (2005) Brain Res Dev Brain Res , vol.160 , pp. 40-52
    • Kajta, M.1    Trotter, A.2    Lasoń, W.3    Beyer, C.4
  • 49
    • 0027336244 scopus 로고
    • On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro
    • Klapstein GJ, Colmers WF: On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro. Hippocampus, 1993, 3, 103-112.
    • (1993) Hippocampus , vol.3 , pp. 103-112
    • Klapstein, G.J.1    Colmers, W.F.2
  • 50
    • 0030796367 scopus 로고    scopus 로고
    • Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro
    • Klapstein GJ, Colmers WF: Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J Neurophysiol, 1997, 78, 1651-1661.
    • (1997) J Neurophysiol , vol.78 , pp. 1651-1661
    • Klapstein, G.J.1    Colmers, W.F.2
  • 51
    • 0023221068 scopus 로고
    • Quantitative determination of glutamate-mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
    • Koh JY, Choi DW: Quantitative determination of glutamate-mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods, 1987, 83-90.
    • (1987) J Neurosci Methods , pp. 83-90
    • Koh, J.Y.1    Choi, D.W.2
  • 52
    • 0022633404 scopus 로고
    • Neuropeptide Y innervation of the hippocampal region in the rat and monkey brain
    • Kohler Ch, Eriksson L, Davies S, Chan-Palay V: Neuropeptide Y innervation of the hippocampal region in the rat and monkey brain. J Comp Neurol, 1986, 244, 384-400.
    • (1986) J Comp Neurol , vol.244 , pp. 384-400
    • Kohler, Ch.1    Eriksson, L.2    Davies, S.3    Chan-Palay, V.4
  • 53
    • 0033965979 scopus 로고    scopus 로고
    • Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus
    • Kondratyev A, Gale K: Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus. Mol Brain Res, 2000, 75, 216-224.
    • (2000) Mol Brain Res , vol.75 , pp. 216-224
    • Kondratyev, A.1    Gale, K.2
  • 54
    • 22044444318 scopus 로고    scopus 로고
    • Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors
    • Lea IV PM, Movsesyan VA, Faden Al: Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Br J Pharmacol, 2005, 145, 527-534.
    • (2005) Br J Pharmacol , vol.145 , pp. 527-534
    • Lea IV, P.M.1    Movsesyan, V.A.2    Faden, Al.3
  • 55
    • 33748062344 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP
    • Lea IV PM, Faden AI: Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev, 2006, 12, 149-166.
    • (2006) CNS Drug Rev , vol.12 , pp. 149-166
    • Lea IV, P.M.1    Faden, A.I.2
  • 56
    • 0033600277 scopus 로고    scopus 로고
    • The changing landscape of ischemic brain injury mechanisms
    • Lee JM, Zipfel GJ, Choi DW: The changing landscape of ischemic brain injury mechanisms. Nature, 1999, 399, A7-A14.
    • (1999) Nature , vol.399
    • Lee, J.M.1    Zipfel, G.J.2    Choi, D.W.3
  • 57
    • 0035914173 scopus 로고    scopus 로고
    • Kainate excitotoxicity in organotypic hippocampal slice cultures: Evidence for multiple apoptotic pathways
    • Liu W, Liu R, Chun JT, Bi R, Hoe W, Schreiber SS, Baudry M: Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways. Brain Res, 2001, 916, 239-248.
    • (2001) Brain Res , vol.916 , pp. 239-248
    • Liu, W.1    Liu, R.2    Chun, J.T.3    Bi, R.4    Hoe, W.5    Schreiber, S.S.6    Baudry, M.7
  • 58
    • 33645846952 scopus 로고    scopus 로고
    • Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models
    • Makarewicz D, Duszczyk M, Gadamski R, Danysz W, Lazarewicz JW: Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models. Neurochem Int, 2006, 48, 485-490.
    • (2006) Neurochem Int , vol.48 , pp. 485-490
    • Makarewicz, D.1    Duszczyk, M.2    Gadamski, R.3    Danysz, W.4    Lazarewicz, J.W.5
  • 59
    • 0031606083 scopus 로고    scopus 로고
    • Kainate receptors in hippocampal CA3 subregion: Evidence for a role in regulating neurotransmitter release
    • Malva JO, Carvalho AP, Carvalho CM: Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release. Neurochem Int, 1998, 32, 1-6.
    • (1998) Neurochem Int , vol.32 , pp. 1-6
    • Malva, J.O.1    Carvalho, A.P.2    Carvalho, C.M.3
  • 60
    • 0025390880 scopus 로고
    • Protection against ischemic neuronal damage by drugs acting on excitatory neurotransmission
    • Meldrum BS: Protection against ischemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc Brain Metab Rev, 1990, 2, 27-57.
    • (1990) Cerebrovasc Brain Metab Rev , vol.2 , pp. 27-57
    • Meldrum, B.S.1
  • 61
    • 0035197286 scopus 로고    scopus 로고
    • mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors
    • Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PGM, Knoblach SM, Faden AI: mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. J Pharmacol Exp Ther, 2001, 296, 41-47.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 41-47
    • Movsesyan, V.A.1    O'Leary, D.M.2    Fan, L.3    Bao, W.4    Mullins, P.G.M.5    Knoblach, S.M.6    Faden, A.I.7
  • 62
    • 3042662255 scopus 로고    scopus 로고
    • MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor
    • Movsesyan VA, Stoica BA, Faden AI: MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem, 2004, 89, 1528-1536.
    • (2004) J Neurochem , vol.89 , pp. 1528-1536
    • Movsesyan, V.A.1    Stoica, B.A.2    Faden, A.I.3
  • 63
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • Muir KW, Lees KR: Clinical experience with excitatory amino acid antagonist drugs. Stroke, 1995, 26, 503-513.
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 65
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
    • Nicoletti F, Bruno V, Copani A, Casabona G, Knopfel T: Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci, 1996, 19, 267-71.
    • (1996) Trends Neurosci , vol.19 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3    Casabona, G.4    Knopfel, T.5
  • 66
    • 0032836680 scopus 로고    scopus 로고
    • Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection
    • Nicoletti F, Bruno V, Catania MV, Battaglia G, Copani A, Barbagallo G, Cena V et al.: Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection. Neuropharmacology, 1999, 38, 1477-1484.
    • (1999) Neuropharmacology , vol.38 , pp. 1477-1484
    • Nicoletti, F.1    Bruno, V.2    Catania, M.V.3    Battaglia, G.4    Copani, A.5    Barbagallo, G.6    Cena, V.7
  • 67
    • 0037458721 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats
    • Novellis V, Marabese I, Palazzo E, Rossi F, Berrino L, Rodella L, Bianchi R, Rossi F, Maione S: Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats. Eur J Pharmacol, 2003, 462, 73-81.
    • (2003) Eur J Pharmacol , vol.462 , pp. 73-81
    • Novellis, V.1    Marabese, I.2    Palazzo, E.3    Rossi, F.4    Berrino, L.5    Rodella, L.6    Bianchi, R.7    Rossi, F.8    Maione, S.9
  • 68
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • O'Leary DM, Movsesyan VA, Vicini S, Faden AI: Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol, 2000, 131, 1429-1437.
    • (2000) Br J Pharmacol , vol.131 , pp. 1429-1437
    • O'Leary, D.M.1    Movsesyan, V.A.2    Vicini, S.3    Faden, A.I.4
  • 69
    • 0001933595 scopus 로고
    • Neurotoxicity of excitatory amino acids
    • In: Ed. McGeer EG, Olney JW, McGeer PL, Raven Press, New York
    • Olney JW: Neurotoxicity of excitatory amino acids. In: Kainic Acid as a Tool in Neurobiology. Ed. McGeer EG, Olney JW, McGeer PL, Raven Press, New York, 1978, pp. 95-121.
    • (1978) Kainic Acid As a Tool in Neurobiology , pp. 95-121
    • Olney, J.W.1
  • 71
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin JP, Duvoisin R: The metabotropic glutamate receptors: structure and functions. Neuropharmacology, 1995, 34, 1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 72
    • 0030898586 scopus 로고    scopus 로고
    • Enhancement of NMDA responses by group-I metabotropic glutamate receptor activation in striatal neurones
    • Pisani A, Calabresi P, Centonie D, Bernardi G: Enhancement of NMDA responses by group-I metabotropic glutamate receptor activation in striatal neurones. Br J Pharmacol, 1997, 120, 1007-1014.
    • (1997) Br J Pharmacol , vol.120 , pp. 1007-1014
    • Pisani, A.1    Calabresi, P.2    Centonie, D.3    Bernardi, G.4
  • 74
    • 3042522901 scopus 로고    scopus 로고
    • Neuroprotective effects of the mGluR5 antagonist MPEP towards quinolinic acid-induced striatal toxicity: Involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity
    • Popoli P, Pintor A, Tebano MT, Frank C, Pepponi R, Nazzicone V, Grieco R et al.: Neuroprotective effects of the mGluR5 antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity. J Neurochem, 2004, 89, 1479-1489.
    • (2004) J Neurochem , vol.89 , pp. 1479-1489
    • Popoli, P.1    Pintor, A.2    Tebano, M.T.3    Frank, C.4    Pepponi, R.5    Nazzicone, V.6    Grieco, R.7
  • 76
    • 0034693412 scopus 로고    scopus 로고
    • Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil
    • Rao AM, Hatcher JF, Dempsey RJ: Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil. Neurosci Lett, 2000, 293, 1-4.
    • (2000) Neurosci Lett , vol.293 , pp. 1-4
    • Rao, A.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 77
    • 29744445316 scopus 로고    scopus 로고
    • + channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions
    • + channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions. Neuroscience, 2006, 137, 211-220.
    • (2006) Neuroscience , vol.137 , pp. 211-220
    • Risterucci, C.1    Coccurello, R.2    Banasr, M.3    Stutzmann, J.M.4    Amalric, M.5    Nieoullon, A.6
  • 78
    • 0028872674 scopus 로고
    • Excitotoxicity and the NMDA receptor-still lethal after eight years
    • Rothman SM, Olney JW: Excitotoxicity and the NMDA receptor-still lethal after eight years. Trends Neurosci, 1995, 18, 57-58.
    • (1995) Trends Neurosci , vol.18 , pp. 57-58
    • Rothman, S.M.1    Olney, J.W.2
  • 79
    • 0031889132 scopus 로고    scopus 로고
    • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
    • Sakahira H, Enari M, Nagata S: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature, 1998, 391, 96-99.
    • (1998) Nature , vol.391 , pp. 96-99
    • Sakahira, H.1    Enari, M.2    Nagata, S.3
  • 80
    • 0030821474 scopus 로고    scopus 로고
    • Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus
    • Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ et al.: Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci, 1997, 17, 7503-7522.
    • (1997) J Neurosci , vol.17 , pp. 7503-7522
    • Shigemoto, R.1    Kinoshita, A.2    Wada, E.3    Nomura, S.4    Ohishi, H.5    Takada, M.6    Flor, P.J.7
  • 81
    • 2942559154 scopus 로고    scopus 로고
    • Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats
    • Shih YH, Chein YC, Wang JY, Fu YS: Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. Neurosci Lett, 2004, 362, 136-140.
    • (2004) Neurosci Lett , vol.362 , pp. 136-140
    • Shih, Y.H.1    Chein, Y.C.2    Wang, J.Y.3    Fu, Y.S.4
  • 82
    • 0037171085 scopus 로고    scopus 로고
    • Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture
    • Shih YH, Wu SL, Chiou WF, Ku HH, Ko TL, Fu YS: Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture. Neuroreport, 2002, 13, 515-519.
    • (2002) Neuroreport , vol.13 , pp. 515-519
    • Shih, Y.H.1    Wu, S.L.2    Chiou, W.F.3    Ku, H.H.4    Ko, T.L.5    Fu, Y.S.6
  • 83
    • 0034770180 scopus 로고    scopus 로고
    • Modulation of intacellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: Differential effects in CA1, CA3 and dentate gyrus
    • Silva AP, Carvalho AP, Carvalho CM, Malva JO: Modulation of intacellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus. J Neurochem, 2001, 79, 286-296.
    • (2001) J Neurochem , vol.79 , pp. 286-296
    • Silva, A.P.1    Carvalho, A.P.2    Carvalho, C.M.3    Malva, J.O.4
  • 84
    • 0037292262 scopus 로고    scopus 로고
    • Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus
    • Silva AP, Carvalho AP, Carvalho CM, Malva JO: Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus. Neuropharmacology, 2003, 42, 282-292.
    • (2003) Neuropharmacology , vol.42 , pp. 282-292
    • Silva, A.P.1    Carvalho, A.P.2    Carvalho, C.M.3    Malva, J.O.4
  • 85
    • 0037704392 scopus 로고    scopus 로고
    • Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures
    • Silva AP, Pinheiro PS, Carvalho AP, Carvalho CM, Jakobsen B, Zimmer J, Malva JO: Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. FASEB J, 2003, 17, 1118-1120.
    • (2003) FASEB J , vol.17 , pp. 1118-1120
    • Silva, A.P.1    Pinheiro, P.S.2    Carvalho, A.P.3    Carvalho, C.M.4    Jakobsen, B.5    Zimmer, J.6    Malva, J.O.7
  • 86
    • 20144388681 scopus 로고    scopus 로고
    • Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats
    • Silva AP, Xapelli S, Pinheiro PS, Ferreira R, Lourenco J, Cristovao A, Grouzmann E: Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats. J Neurochem, 2005, 93, 163-170.
    • (2005) J Neurochem , vol.93 , pp. 163-170
    • Silva, A.P.1    Xapelli, S.2    Pinheiro, P.S.3    Ferreira, R.4    Lourenco, J.5    Cristovao, A.6    Grouzmann, E.7
  • 89
    • 24644454231 scopus 로고    scopus 로고
    • Recent advances in noncompetitive mGluR5 receptor antagonists and their potential therapeutic applications
    • Slassi A, Isaac M, Edwards L, Minidis A, Wensbo D, Mattsson J, Nilsson K et al.: Recent advances in noncompetitive mGluR5 receptor antagonists and their potential therapeutic applications. Curr Top Med Chem, 2005, 5, 897-911.
    • (2005) Curr Top Med Chem , vol.5 , pp. 897-911
    • Slassi, A.1    Isaac, M.2    Edwards, L.3    Minidis, A.4    Wensbo, D.5    Mattsson, J.6    Nilsson, K.7
  • 90
    • 1442274950 scopus 로고    scopus 로고
    • In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands
    • Smolders I, Lindekens H, Clinckers R, Meurs A, O'Neill MJ, Lodge D, Ebinger G, Michotte Y: In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. J Neurochem, 2004, 88, 1068-1077.
    • (2004) J Neurochem , vol.88 , pp. 1068-1077
    • Smolders, I.1    Lindekens, H.2    Clinckers, R.3    Meurs, A.4    O'Neill, M.J.5    Lodge, D.6    Ebinger, G.7    Michotte, Y.8
  • 91
    • 0029983403 scopus 로고    scopus 로고
    • Inhibitory effect of NPY on the picrotoxin-induced activity in the hippocampus: A behavioural and electrophysiological study
    • Śmiałowska M, Bijak M, Sopala M, Tokarski K: Inhibitory effect of NPY on the picrotoxin-induced activity in the hippocampus: a behavioural and electrophysiological study. Neuropeptides, 1996, 30, 7-12.
    • (1996) Neuropeptides , vol.30 , pp. 7-12
    • Śmiałowska, M.1    Bijak, M.2    Sopala, M.3    Tokarski, K.4
  • 92
    • 18544401319 scopus 로고    scopus 로고
    • Neuroprotective effect of NPY on kainate neurotoxicity in the hippocampus
    • Śmiałowska M, Wierońska JM, Szewczyk B: Neuroprotective effect of NPY on kainate neurotoxicity in the hippocampus. Pol J Pharmacol, 2003, 55, 979-986.
    • (2003) Pol J Pharmacol , vol.55 , pp. 979-986
    • Śmiołowska, M.1    Wierońska, J.M.2    Szewczyk, B.3
  • 93
    • 0002862571 scopus 로고    scopus 로고
    • The role of glutamate receptors in the pathophysiology of traumatic central nervous system injury
    • In: Ed. Miller LA, Hayes RL, Newcomb JK, John Wiley & Sons Inc., New York
    • Temple MD, O'Leary DM, Faden AI: The role of glutamate receptors in the pathophysiology of traumatic central nervous system injury. In: Head Trauma: Basic, Preclinical, and Clinical Directions. Ed. Miller LA, Hayes RL, Newcomb JK, John Wiley & Sons Inc., New York, 2001, 87-113.
    • (2001) Head Trauma: Basic, Preclinical, and Clinical Directions , pp. 87-113
    • Temple, M.D.1    O'Leary, D.M.2    Faden, A.I.3
  • 94
    • 0034067960 scopus 로고    scopus 로고
    • Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro
    • Thomas LS, Jane DE, Harris JR, Croucher MJ: Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro. Neuropharmacology, 2000, 39, 1554-1566.
    • (2000) Neuropharmacology , vol.39 , pp. 1554-1566
    • Thomas, L.S.1    Jane, D.E.2    Harris, J.R.3    Croucher, M.J.4
  • 96
    • 20344388665 scopus 로고    scopus 로고
    • Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    • Wang Q, Yu S, Simonyi A, Sun GY, Sun AY: Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol, 2005, 31, 3-16.
    • (2005) Mol Neurobiol , vol.31 , pp. 3-16
    • Wang, Q.1    Yu, S.2    Simonyi, A.3    Sun, G.Y.4    Sun, A.Y.5
  • 97
    • 0346787871 scopus 로고    scopus 로고
    • Neuroprotection in cerebral ischemia: Facts and fancies - The need for new approaches
    • Wahlgren NG, Ahmed N: Neuroprotection in cerebral ischemia: facts and fancies - the need for new approaches. Cerebrovasc Dis, 2004, 17, 153-166.
    • (2004) Cerebrovasc Dis , vol.17 , pp. 153-166
    • Wahlgren, N.G.1    Ahmed, N.2
  • 100
    • 11844304323 scopus 로고    scopus 로고
    • Neuropeptide Y expression in mouse hippocampus and its role in neuronal excitotoxicity
    • Wu Y, Li S: Neuropeptide Y expression in mouse hippocampus and its role in neuronal excitotoxicity. Acta Pharmacol Sin, 2005, 26, 63-68.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 63-68
    • Wu, Y.1    Li, S.2


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