Neuroprotective activity of the potent and selective mGlula metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): Comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlula and mGlu5 receptors

Neuropharmacology

Volumn 38, Issue 2, 1999, Pages 199-207

  Bruno, V ^a   Battaglia, G ^a   Kingston, A ^b   O'Neill, M J ^b   Catania, M V ^c   Di Grezia, R ^a   Nicoletti, F ^a,d  

^a IRCCS NEUROMED   (Italy)

^b ELI LILLY AND COMPANY   (United States)

^c CNR   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

Global ischemia; Group I metabotropic glutamate receptors; LY367366; LY367385; N methyl D aspartate toxicity; Neuroprotection

Indexed keywords

3 [1 AMINO 1 CARBOXY 2 (9H XANTHEN 9 YL)ETHYL]CYCLOBUTANECARBOXYLIC ACID; 4 CARBOXY 2 METHYLPHENYLGLYCINE; ALPHA THIOXANTHYLMETHYL 4 CARBOXYPHENYLGLYCINE; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG EFFICACY; FETUS; GERBIL; INTRACEREBRAL DRUG ADMINISTRATION; MALE; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; ASTROCYTES; BENZOATES; CAUDATE NUCLEUS; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID ANTAGONISTS; FETUS; GERBILLINAE; GLYCINE; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; N-METHYLASPARTATE; NECROSIS; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; THIOPHENES;

EID: 0033046392     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00159-2     Document Type: Article

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