Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

Neuropharmacology

Volumn 39, Issue 12, 2000, Pages 2223-2230

  Bruno, V ^a   Ksiazek, I ^b   Battaglia, G ^a   Lukic, S ^b   Leonhardt, T ^b   Sauer, D ^b   Gasparini, F ^b   Kuhn, R ^b   Nicoletti, F ^a,c   Flor, P J ^b  

^a IRCCS NEUROMED   (Italy)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Amyloid toxicity; Excitotoxicity; mGlu5 receptors; MPEP; Neuroprotection; Non competitive antagonists; SIB 1757; SIB 1893

Indexed keywords

2 METHYL 6 PHENYLETHYNYLPYRIDINE; 2 METHYL 6(2 PHENYLETHYNYL)PYRIDINE; [6 METHYL 2(PHENYLAZO) 3 PYRIDINOL; AMYLOID BETA PROTEIN; EXCITOTOXIN; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DEGENERATIVE DISEASE; FETUS; IN VITRO STUDY; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; N-METHYLASPARTATE; NERVE DEGENERATION; NEUROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PHENAZOPYRIDINE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 17044444317     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00079-4     Document Type: Article

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