Neuropeptide Y expression in mouse hippocampus and its role in neuronal excitotoxicity

Acta Pharmacologica Sinica

Volumn 26, Issue 1, 2005, Pages 63-68

  Wu, Yong Fei ^a   Li, Sheng Bin ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Epilepsy; Excitotoxicity; Hippocampus; Kainic acid; Neuropeptide Y

Indexed keywords

KAINIC ACID; NEUROPEPTIDE Y; NEUROPEPTIDE Y [13-36]; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; EXCITOTOXICITY; GRANULE CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NERVE CELL; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION;

ANIMALS; ANTICONVULSANTS; APOPTOSIS; DENTATE GYRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; KAINIC ACID; MICE; NEUROPEPTIDE Y; RECEPTORS, NEUROPEPTIDE Y; TIME FACTORS;

EID: 11844304323     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00011.x     Document Type: Article

References (28)

1. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988; 1: 623-34.
2. Choi DW. Excitotoxic cell death. J Neurobiol 1992; 23: 1261-76.
3. Lee JM, Zipfel GJ, Choi DW. The changing landscape of ischaemic brain injury mechanisms. Nature 1999; 399: A7-14.
4. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993; 262: 689-95.
5. McNamara JO. Emerging insights into the genesis of epilepsy. Nature 1999; 399: A14-22.
6. Campocdhiaro P, Coyle J. Ontogenetic development of kainite neurotoxicity: correlates with glutamatergic innervation. Proc Natl Acad Sci USA 1978; 75: 2025-9.
7. Cook T, Crutcher K. Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats. Neuroscience 1986; 18: 79-92.
8. Nadler J, Perry B, Cotman C. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 1978; 271: 676-7.
9. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 1985; 14: 375-403.
10. Dudek F, Obenaus A, Schweitzer J, Wuarin J. Functional significance of hippocampal plasticity in epileptic brain: electrophysiological changes of the dentate granule cells associated with mossy fiber sprouting. Hippocampus 1994; 4: 259-65.
11. Nadler J. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 1981; 29: 2031-42.
12. Baraban SC, Hollopeter G, Erickson JC, Schwartzkroin PA, Palmiter RD. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci 1997; 17: 8927-36.
13. Zhao WJ, Ma YH, Fei J, Mei ZT, Guo LH. Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1. Acta Pharmacol Sin 2003; 24: 991-5.
14. Dong H, Csernansky CA, Goico B, Csernansky JG. Hippocampal neruogenesis follows kainic acid-induced apoptosis in neonatal rats. J Neurosci 2003; 23: 1742-9.
15. Colmers WF, Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. Trend Neurosci 1994; 17: 373-9.
16. Marsh DJ, Baraban SC, Hollopeter G, Palmiter RD. Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc Natl Acad Sci USA 1999; 96: 13518-23.
17. Vezzani A, Sperk G, Colmers W. Neuropeptide Y. Emerging evidence for a functional role in seizure modulation. Trends Neurosci 1999; 22: 25-33.
18. Woldbye D, Madsen TM, Larsen PJ, Mikkelsen JD, Bolwig TG. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res 1996; 737: 162-8.
19. Wu Y, Zhang D, Lou D, Fan Y, Aronow D, Xu M, et al. c-fos regulates neuropeptide Y expression in mouse dentate gyrus. Neurosci Lett 2004; 363: 6-10.
20. Braissant O, Wahli W. A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections. Biochemica 1998; 1: 10-6.
21. Marksteiner J, Sperk G, Maas D. Differential increases in brain levels of neuropeptide Y and vasoactive intestinal polypeptide after kainic acid-induced seizures in the rat. Naunyn Schmiedebergs Arch Pharmacol 1989; 339: 173-7.
22. Pitkänen A, Beal MF, Sirviö J, Swartz KJ, Männistö PT, Riekkinen PJ. Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. Neuropeptides 1989; 14: 197-207.
23. Tønder N, Kragh J, Finsen BR, Bolwig TG, Zimmer J. Kindling induces transient changes in neuronal expression of somatostatin, neuropeptide Y, and calbindin in adult rat hippocampus and fascia dentata. Epilepsia 1994; 35: 1299-308.
24. Gruber B, Greber S, Rupp E, Sperk G. Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection. Hippocampus 1994; 4: 474-82.
25. Kragh J, Tønder N, Finsen BR, Zimmer J, Bolwig TG. Repeated electroconvulsive shocks cause transient changes in rat hippocampal somatostatin and neuropeptide Y immunoreactivity and mRNA in situ hybridization signals. Exp Brain Res 1994; 98: 305-13.
26. Silva AP, Pinheiro PS, Carvalho AP, Carvalho CM, Jakobsen B, Zimmer J, et al. Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. FASEB J 2003; 10: 122-31.
27. Guo H, Castro PA, Palmiter RD, Baraban SC. Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus. J Neurophysiol 2002; 87: 558-66.
28. Wahlestedt C, Reis DJ. Neuropeptide Y-related peptides and their receptors-are the receptors potential therapeutic drug targets? Annu Rev Pharmacol Toxicol 1993; 32: 309-52.