Kainate excitotoxicity in organotypic hippocampal slice cultures: Evidence for multiple apoptotic pathways

Brain Research

Volumn 916, Issue 1-2, 2001, Pages 239-248

  Liu, Wei ^c   Liu, Ruolan ^a   Chun, Jong Tai ^b   Bi, Ruifen ^a   Hoe, Warren ^a   Schreiber, Steven S ^b   Baudry, Michel ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bax; Caspase; Cytochrome c; Excitotoxicity; Mithochondrial membrane potential and kainate

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CYCLOSPORIN A; CYTOCHROME C; ENZYME PRECURSOR; EXCITOTOXIN; KAINIC ACID; PROTEIN BAX; RHODAMINE 123;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN LEVEL; BRAIN MITOCHONDRION; BRAIN SLICE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; HIPPOCAMPUS; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN DISEASES; CASPASES; CELLS, CULTURED; CYCLOSPORINE; CYTOCHROME C GROUP; CYTOSOL; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MEMBRANE POTENTIALS; MITOCHONDRIA; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAMIDAL CELLS; RATS; RNA, MESSENGER;

EID: 0035914173     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03006-2     Document Type: Article

References (51)

1. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
2. Hypoxia-induced apoptosis: Effect of hypoxic severity and role of p53 in neuronal cell death
3. Development of kainic acid and N-methyl-D-aspartic acid toxicity in organotypic hippocampal cultures
4. U-83836E prevents kainic acid-induced neuronal damage
5. Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia
6. Ionic dependence of glutamate neurotoxicity
7. p53 expression in brain after middle cerebral artery occlusion in the rat
8. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
9. Bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions
10. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
11. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
12. Mitochondria and apoptosis
13. Role of BCL-2 in the survival and function of developing and mature sympathetic neurons
14. BCL-2 family members and the mitochondria in apoptosis
15. A role for the tumor supressor gene p53 in regulating neuronal apoptosis
16. Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation
17. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures
18. Excitotoxicity in the enteric nervous system
19. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
20. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
21. Upregulation of bax protein levels in neurons following cerebral ischemia
22. Cytochrome c
23. Mitochondrial control of apoptosis
24. Four deaths and a funeral: From caspases to alternative mechanisms
25. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
26. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2
27. p53-immunoreactive protein and p53 mRna expression after transient middle cerebral artery occlusion in rats
28. Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain
29. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
30. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
31. Excitotoxic cell death
32. The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ
33. Apoptosis associated DNA fragmentation in epileptic brain damage
34. Mitochondrial transmembrane potential and free radical production in excitotoxic neurodegeneration
35. BAX translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, BCL-2, and caspases
36. Cytochrome c: Can't live with it - Can't live without it
37. Bcl-2 family proteins and mitochondria
38. Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment
39. Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons
40. Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain
41. Caspases: Enemies within
42. Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurons triggered by excitatory amino acids
43. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
44. Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia
45. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
46. Bax involvement in p53-mediated neuronal cell death
47. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
48. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
49. Apoptosis of hippocampal neurons after amygdala kindled seizures
50. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
51. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9