Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil

Neuroscience Letters

Volumn 293, Issue 1, 2000, Pages 1-4

  Rao, A Muralikrishna ^a,b,c   Hatcher, J F ^a   Dempsey, R J ^a,c  

^a University of Wisconsin Health   (United States)

^b University of Wisconsin Cardiovascular Research Center   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

1,2 diacylglycerol; 2 Methyl 6 (phenylethynyl) pyridine; Apoptosis; Arachidonic acid; CA1 neuronal death; Hippocampus; Lipid metabolism; Phospholipases

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ARACHIDONIC ACID; DIACYLGLYCEROL; GLUTAMATE RECEPTOR; GLUTAMIC ACID ANTAGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; PHOSPHOLIPASE C; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; FOREBRAIN; GERBIL; HIPPOCAMPUS; LIPID METABOLISM; MALE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ARACHIDONIC ACID; BENZOATES; BRAIN; BRAIN ISCHEMIA; CELL SURVIVAL; EXCITATORY AMINO ACID ANTAGONISTS; GERBILLINAE; GLYCINE; INDANS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PROSENCEPHALON; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; SUPPORT, NON-U.S. GOV'T;

EID: 0034693412     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01483-X     Document Type: Article

References (27)

1. Bezzi P., Carmignoto G., Pasti L., Vesce S., Rossi D., Rizzini B.L., Pozzan T., Volterra A. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. 391:1998;281-285.
2. Blanc E.M., Kelly J.F., Mark R.J., Waeg G., Mattson M.P. 4-hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors - possible action on g-α(q/11). J. Neurochem. 69:1997;570-580.
3. Casabona G., Knopfel T., Kuhn R., Gasparini F., Baumann P., Sortino M.A., Copan A., Nicoletti F. Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain. Eur. J. Neurosci. 9:1997;12-17.
4. Ferraguti F., Pietra C., Valerio E., Corti C., Chiamulera C., Conquet F. Evidence against permissive role of the metabotropic glutamate receptor 1 in acute excitotoxicity. Neuroscience. 79:1997;1-5.
5. Gasparini F., Lingenhohl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., Biollaz M., Allgeier H., Heckendorn R., Urwyler S., Varney M.A., Johnson E.C., Hess S.D., Rao S.P., Sacaan A.I., Santori E.M., Velicelebi G., Kuhn R. 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist, Neuropharmacology. 38:1999;1493-1503.
6. Gilad G.M., Gilad V.H. Novel polyamine derivatives as neuroprotective agents. J. Pharmacol. Exp. Therap. 291:1999;39-43.
7. 3H]phorbol 12, 13-dibutyrate. Neurosci. Lett. 120:1990;120-123.
8. Hodgkin M.N., Pettit T.R., Martin A., Wakelam M.J.O. Regulation of 'signalling diacylglycerol' in cells: the importance of diacylglycerol kinase. Biochem. Soc. Trans. 24:1996;991-994.
9. Jayadev S., Linardic C.M., Hannun Y.A. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor α J. Biol. Chem. 269:1994;5757-5763.
10. Katsuki H., Okuda S. Arachidonic acid as a neurotoxic and neurotrophic substance. Prog. Neurobiol. 46:1995;607-636.
11. Kolesnick R., Fuks Z. Ceramide: a signal for apoptosis or mitogenesis? J. Exp. Med. 181:1995;1949-1952.
12. Lombardi G., Leonardi P., Moroni F. Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices. Br. J. Pharmacol. 117:1996;189-195.
13. 1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17:1997;5196-5205.
14. Mukhin A., Fan L., Faden A.I. Activation of metabotropic glutamate receptor subtype mGLUR1 contributes to post-traumatic neuronal injury. J. Neurosci. 16:1996;6012-6020.
15. Nicoletti F., Bruno V., Copani A., Casabona G., Knopfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. 19:1996;267-271.
16. Pellegrini-Giampietro D.E., Cozzi A., Peruginelli F., Leonardi P., Meli E., Pellicciari R., Moroni F. 1-aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. Eur. J. Neurosci. 11:1999;3637-3647.
17. Pellegrini-Giampietro D.E., Peruginelli F., Meli E., Cozzi A., Albani-Torregrossa S., Pellicciari R., Moroni F. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms. Neuropharmacology. 38:1999;1607-1619.
18. Pellicciari R., Raimondo M., Marinozzi M., Natalini B., Costantino G., Thomsen C. (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I mGluR antagonist. J. Med. Chem. 39:1996;2874-2876.
19. Rao A.M., Baskaya M.K., Maley M.E., Kindy M.S., Dempsey R.J. Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils. Mol. Brain Res. 44:1997;134-138.
20. Rao A.M., Hatcher J.F., Dempsey R.J. CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. J. Neurosci. Res. 58:1999;697-705.
21. Rao A.M., Hatcher J.F., Dempsey R.J. Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection. J. Neurochem. 75:2000;2528-2535.
22. Rao A.M., Hatcher J.F., Dempsey R.J. Lipid metabolism in ischemic neuronal death. Rec. Res. Develop. Neurochem. 2:1999;533-549.
23. 4: role in transient cerebral ischemia of gerbils. Neurochem. Res. 24:1999;1225-1232.
24. Rao V.L.R., Rao A.M., Dogan A., Bowen K.K., Hatcher J.F., Rothstein J.D., Dempsey R.J. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia. Neurochem. Int. 36:2000;531-537.
25. Riedel G., Opitz T., Reymann K.G. Blockade of metabotropic glutamate receptors protects hippocampal neurons from hypoxia-induced cell death in rat in vivo. Prog. Neuro-Psychopharm. Biol. Psych. 20:1996;1253-1263.
26. Schoepp D.D., Jane D.E., Monn J.A. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 38:1999;1431-1476.
27. Sieber F.E., Traystman R.J., Brown P.R., Martin L.J. Protein kinase C expression and activity after global incomplete cerebral ischemia in dogs. Stroke. 29:1998;1445-1452.