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Volumn 80, Issue 6, 2006, Pages 269-280

Oxidative stress in pneumococcal meningitis: A future target for adjunctive therapy?

Author keywords

Meningitis; N Acetyl l cysteine (NAC); Oxidative stress; Peroxynitrite; Pneumococcal meningitis; Pneumococcus; Streptococcus pneumoniae

Indexed keywords

7 NITROINDAZOLE; ACETYLCYSTEINE; AMINOGUANIDINE; ASCORBIC ACID; BATIMASTAT; BOSENTAN; DEFEROXAMINE; DEXAMETHASONE; DNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPID; MANGANESE TETRAKISBENZOIC ACID PORPHYRIN; MELATONIN; METHYLISOTHIOUREA; N NITROARGININE; N TERT BUTYL ALPHA PHENYLNITRONE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; PORPHYRIN DERIVATIVE; SUPEROXIDE DISMUTASE; THIOGUANINE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; URIC ACID;

EID: 33846258463     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2006.11.008     Document Type: Review
Times cited : (93)

References (106)
  • 1
    • 0033067174 scopus 로고    scopus 로고
    • Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein
    • Abuja P.M. Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein. FEBS Lett. 446 (1999) 305-308
    • (1999) FEBS Lett. , vol.446 , pp. 305-308
    • Abuja, P.M.1
  • 2
    • 0028990177 scopus 로고
    • G-methyl-l-arginine protects the guinea pig cochlea from the cytotoxic effects of pneumolysin
    • G-methyl-l-arginine protects the guinea pig cochlea from the cytotoxic effects of pneumolysin. Acta Otolaryngol. 115 (1995) 386-391
    • (1995) Acta Otolaryngol. , vol.115 , pp. 386-391
    • Amaee, F.R.1    Comis, S.D.2    Osborne, M.P.3
  • 3
    • 0030914233 scopus 로고    scopus 로고
    • Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis
    • Amaee F.R., Comis S.D., Osborne M.P., Drew S., and Tarlow M.J. Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis. Acta Otolaryngol. 117 (1997) 329-336
    • (1997) Acta Otolaryngol. , vol.117 , pp. 329-336
    • Amaee, F.R.1    Comis, S.D.2    Osborne, M.P.3    Drew, S.4    Tarlow, M.J.5
  • 4
    • 0033567065 scopus 로고    scopus 로고
    • Enzymatic function of nitric oxide synthases
    • Andrew P.J., and Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc. Res. 43 (1999) 521-531
    • (1999) Cardiovasc. Res. , vol.43 , pp. 521-531
    • Andrew, P.J.1    Mayer, B.2
  • 5
    • 33750275276 scopus 로고    scopus 로고
    • Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study
    • Auburtin M., Wolff M., Charpentier J., Varon E., Le T.Y., Girault C., Mohammedi I., Renard B., Mourvillier B., Bruneel F., Ricard J.D., and Timsit J.F. Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. Crit. Care Med. 34 (2006) 2758-2765
    • (2006) Crit. Care Med. , vol.34 , pp. 2758-2765
    • Auburtin, M.1    Wolff, M.2    Charpentier, J.3    Varon, E.4    Le, T.Y.5    Girault, C.6    Mohammedi, I.7    Renard, B.8    Mourvillier, B.9    Bruneel, F.10    Ricard, J.D.11    Timsit, J.F.12
  • 6
    • 0033931132 scopus 로고    scopus 로고
    • Effects of clinically used antioxidants in experimental pneumococcal meningitis
    • Auer M., Pfister L.A., Leppert D., Tauber M.G., and Leib S.L. Effects of clinically used antioxidants in experimental pneumococcal meningitis. J. Infect. Dis. 182 (2000) 347-350
    • (2000) J. Infect. Dis. , vol.182 , pp. 347-350
    • Auer, M.1    Pfister, L.A.2    Leppert, D.3    Tauber, M.G.4    Leib, S.L.5
  • 7
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier-an overview: structure, regulation, and clinical implications
    • Ballabh P., Braun A., and Nedergaard M. The blood-brain barrier-an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 16 (2004) 1-13
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 9
    • 33749997196 scopus 로고    scopus 로고
    • Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury
    • Bellac C.L., Coimbra R.S., Christen S., and Leib S.L. Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. Neurobiol. Dis. 24 (2006) 395-402
    • (2006) Neurobiol. Dis. , vol.24 , pp. 395-402
    • Bellac, C.L.1    Coimbra, R.S.2    Christen, S.3    Leib, S.L.4
  • 10
    • 0037899314 scopus 로고    scopus 로고
    • Bacterial meningitis causes two distinct forms of cellular damage in the hippocampal dentate gyrus in infant rats
    • Bifrare Y.D., Gianinazzi C., Imboden H., Leib S.L., and Tauber M.G. Bacterial meningitis causes two distinct forms of cellular damage in the hippocampal dentate gyrus in infant rats. Hippocampus 13 (2003) 481-488
    • (2003) Hippocampus , vol.13 , pp. 481-488
    • Bifrare, Y.D.1    Gianinazzi, C.2    Imboden, H.3    Leib, S.L.4    Tauber, M.G.5
  • 11
    • 0029098586 scopus 로고
    • Cerebrovascular permeability changes during experimental meningitis in the rat
    • Boje K.M. Cerebrovascular permeability changes during experimental meningitis in the rat. J. Pharmacol. Exp. Ther. 274 (1995) 1199-1203
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1199-1203
    • Boje, K.M.1
  • 12
    • 0028891365 scopus 로고
    • Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat
    • Boje K.M. Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat. Eur. J. Pharmacol. 272 (1995) 297-300
    • (1995) Eur. J. Pharmacol. , vol.272 , pp. 297-300
    • Boje, K.M.1
  • 13
    • 0034015556 scopus 로고    scopus 로고
    • Nitric oxide redox species exert differential permeability effects on the blood-brain barrier
    • Boje K.M., and Lakhman S.S. Nitric oxide redox species exert differential permeability effects on the blood-brain barrier. J. Pharmacol. Exp. Ther. 293 (2000) 545-550
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 545-550
    • Boje, K.M.1    Lakhman, S.S.2
  • 14
    • 0029121001 scopus 로고
    • Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats
    • Buster B.L., Weintrob A.C., Townsend G.C., and Scheld W.M. Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats. Infect. Immun. 63 (1995) 3835-3839
    • (1995) Infect. Immun. , vol.63 , pp. 3835-3839
    • Buster, B.L.1    Weintrob, A.C.2    Townsend, G.C.3    Scheld, W.M.4
  • 15
    • 1542782348 scopus 로고    scopus 로고
    • Brief clinical study: lipid peroxidation and antioxidant status in children with acute purulent meningitis and encephalitis
    • Caksen H., Cemek M., Dede S., Dulger H., and Cemek F. Brief clinical study: lipid peroxidation and antioxidant status in children with acute purulent meningitis and encephalitis. Int. J. Neurosci. 114 (2004) 105-111
    • (2004) Int. J. Neurosci. , vol.114 , pp. 105-111
    • Caksen, H.1    Cemek, M.2    Dede, S.3    Dulger, H.4    Cemek, F.5
  • 16
    • 0035884727 scopus 로고    scopus 로고
    • Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment
    • Christen S., Schaper M., Lykkesfeldt J., Siegenthaler C., Bifrare Y.D., Banic S., Leib S.L., and Tauber M.G. Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment. Free Radic. Biol. Med. 31 (2001) 754-762
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 754-762
    • Christen, S.1    Schaper, M.2    Lykkesfeldt, J.3    Siegenthaler, C.4    Bifrare, Y.D.5    Banic, S.6    Leib, S.L.7    Tauber, M.G.8
  • 17
    • 0037079004 scopus 로고    scopus 로고
    • Dexamethasone in adults with bacterial meningitis
    • de Gans J., and van de Beek D. Dexamethasone in adults with bacterial meningitis. N. Engl. J. Med. 347 (2002) 1549-1556
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1549-1556
    • de Gans, J.1    van de Beek, D.2
  • 19
    • 0033796705 scopus 로고    scopus 로고
    • Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits
    • Dumont R.A., Car B.D., Voitenok N.N., Junker U., Moser B., Zak O., and O'Reilly T. Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. Infect. Immun. 68 (2000) 5756-5763
    • (2000) Infect. Immun. , vol.68 , pp. 5756-5763
    • Dumont, R.A.1    Car, B.D.2    Voitenok, N.N.3    Junker, U.4    Moser, B.5    Zak, O.6    O'Reilly, T.7
  • 20
    • 0035079787 scopus 로고    scopus 로고
    • Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin
    • Eichert K., Hamacher J., Wunder M.A., and Wendel A. Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin. J. Pharmacol. Exp. Ther. 297 (2001) 128-132
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 128-132
    • Eichert, K.1    Hamacher, J.2    Wunder, M.A.3    Wendel, A.4
  • 21
    • 33750700047 scopus 로고    scopus 로고
    • Peroxynitrite is a contractile agonist of cerebral artery smooth muscle cells
    • Elliott S.J., Lacey D.J., Chilian W.M., and Brzezinska A.K. Peroxynitrite is a contractile agonist of cerebral artery smooth muscle cells. Am. J. Physiol. 275 (1998) H1585-H1591
    • (1998) Am. J. Physiol. , vol.275
    • Elliott, S.J.1    Lacey, D.J.2    Chilian, W.M.3    Brzezinska, A.K.4
  • 22
  • 23
    • 13944282512 scopus 로고    scopus 로고
    • Melatonin is neuroprotective in experimental Streptococcus pneumoniae meningitis
    • Gerber J., Lotz M., Ebert S., Kiel S., Huether G., Kuhnt U., and Nau R. Melatonin is neuroprotective in experimental Streptococcus pneumoniae meningitis. J. Infect. Dis. 191 (2005) 783-790
    • (2005) J. Infect. Dis. , vol.191 , pp. 783-790
    • Gerber, J.1    Lotz, M.2    Ebert, S.3    Kiel, S.4    Huether, G.5    Kuhnt, U.6    Nau, R.7
  • 24
    • 0034925593 scopus 로고    scopus 로고
    • Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction
    • Greenacre S.A., and Ischiropoulos H. Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction. Free Radic. Res. 34 (2001) 541-581
    • (2001) Free Radic. Res. , vol.34 , pp. 541-581
    • Greenacre, S.A.1    Ischiropoulos, H.2
  • 25
    • 0033120926 scopus 로고    scopus 로고
    • Peroxynitrite: reactive, invasive and enigmatic
    • Groves J.T. Peroxynitrite: reactive, invasive and enigmatic. Curr. Opin. Chem. Biol. 3 (1999) 226-235
    • (1999) Curr. Opin. Chem. Biol. , vol.3 , pp. 226-235
    • Groves, J.T.1
  • 26
    • 0028354975 scopus 로고
    • Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis?
    • Haberl R.L., Anneser F., Kodel U., and Pfister H.W. Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis?. Neurol. Res. 16 (1994) 108-112
    • (1994) Neurol. Res. , vol.16 , pp. 108-112
    • Haberl, R.L.1    Anneser, F.2    Kodel, U.3    Pfister, H.W.4
  • 27
    • 0031985236 scopus 로고    scopus 로고
    • Cerebral blood flow velocity and perfusion in purulent meningitis: a comparative TCD and 99M-TC-HMPAO-SPECT study
    • Haring H., Kampfl A., Grubwieser G., Donnemiller E., Pfausler B., and Schmutzhard E. Cerebral blood flow velocity and perfusion in purulent meningitis: a comparative TCD and 99M-TC-HMPAO-SPECT study. Eur. J. Neurol. 5 (1998) 75-81
    • (1998) Eur. J. Neurol. , vol.5 , pp. 75-81
    • Haring, H.1    Kampfl, A.2    Grubwieser, G.3    Donnemiller, E.4    Pfausler, B.5    Schmutzhard, E.6
  • 29
  • 31
    • 0034674610 scopus 로고    scopus 로고
    • Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits
    • Irazuzta J.E., Mirkin L.D., and Zingarelli B. Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits. Life Sci. 67 (2000) 365-372
    • (2000) Life Sci. , vol.67 , pp. 365-372
    • Irazuzta, J.E.1    Mirkin, L.D.2    Zingarelli, B.3
  • 32
    • 0035933605 scopus 로고    scopus 로고
    • Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat
    • Kastenbauer S., Klein M., Koedel U., and Pfister H.W. Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat. Brain Res. 904 (2001) 208-217
    • (2001) Brain Res. , vol.904 , pp. 208-217
    • Kastenbauer, S.1    Klein, M.2    Koedel, U.3    Pfister, H.W.4
  • 33
    • 0037008268 scopus 로고    scopus 로고
    • Pneumococcal meningitis in the rat: evaluation of peroxynitrite scavengers for adjunctive therapy
    • Kastenbauer S., Koedel U., Becker B., and Pfister H.W. Pneumococcal meningitis in the rat: evaluation of peroxynitrite scavengers for adjunctive therapy. Eur. J. Pharmacol. 449 (2002) 177-181
    • (2002) Eur. J. Pharmacol. , vol.449 , pp. 177-181
    • Kastenbauer, S.1    Koedel, U.2    Becker, B.3    Pfister, H.W.4
  • 34
    • 0035839173 scopus 로고    scopus 로고
    • Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations
    • Kastenbauer S., Koedel U., Becker B.F., and Pfister H.W. Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations. Eur. J. Pharmacol. 425 (2001) 149-152
    • (2001) Eur. J. Pharmacol. , vol.425 , pp. 149-152
    • Kastenbauer, S.1    Koedel, U.2    Becker, B.F.3    Pfister, H.W.4
  • 36
    • 0033375029 scopus 로고    scopus 로고
    • Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis
    • Kastenbauer S., Koedel U., and Pfister H.W. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. J. Infect. Dis. 180 (1999) 1164-1170
    • (1999) J. Infect. Dis. , vol.180 , pp. 1164-1170
    • Kastenbauer, S.1    Koedel, U.2    Pfister, H.W.3
  • 37
    • 0036280158 scopus 로고    scopus 로고
    • Oxidative brain damage by peroxynitrite in bacterial meningitis: a target for adjunctive therapy?
    • Kastenbauer S., Koedel U., and Pfister H.W. Oxidative brain damage by peroxynitrite in bacterial meningitis: a target for adjunctive therapy?. Curr. Med. Chem. (2002) 109-127
    • (2002) Curr. Med. Chem. , pp. 109-127
    • Kastenbauer, S.1    Koedel, U.2    Pfister, H.W.3
  • 38
    • 0037408190 scopus 로고    scopus 로고
    • Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases
    • Kastenbauer S., and Pfister H.W. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 126 (2003) 1015-1025
    • (2003) Brain , vol.126 , pp. 1015-1025
    • Kastenbauer, S.1    Pfister, H.W.2
  • 39
    • 0032039959 scopus 로고    scopus 로고
    • Clinical applications of N-acetylcysteine
    • Kelly G.S. Clinical applications of N-acetylcysteine. Altern. Med. Rev. 3 (1998) 114-127
    • (1998) Altern. Med. Rev. , vol.3 , pp. 114-127
    • Kelly, G.S.1
  • 40
    • 0030781227 scopus 로고    scopus 로고
    • Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis
    • Kissner R., Nauser T., Bugnon P., Lye P.G., and Koppenol W.H. Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis. Chem. Res. Toxicol. 10 (1997) 1285-1292
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 1285-1292
    • Kissner, R.1    Nauser, T.2    Bugnon, P.3    Lye, P.G.4    Koppenol, W.H.5
  • 41
    • 0141870088 scopus 로고    scopus 로고
    • Meningitis-associated hearing loss: protection by adjunctive antioxidant therapy
    • Klein M., Koedel U., Pfister H.W., and Kastenbauer S. Meningitis-associated hearing loss: protection by adjunctive antioxidant therapy. Ann. Neurol. 54 (2003) 451-458
    • (2003) Ann. Neurol. , vol.54 , pp. 451-458
    • Klein, M.1    Koedel, U.2    Pfister, H.W.3    Kastenbauer, S.4
  • 42
    • 0037393866 scopus 로고    scopus 로고
    • Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis
    • Klein M., Koedel U., Pfister H.W., and Kastenbauer S. Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis. Brain Pathol. 13 (2003) 1-10
    • (2003) Brain Pathol. , vol.13 , pp. 1-10
    • Klein, M.1    Koedel, U.2    Pfister, H.W.3    Kastenbauer, S.4
  • 44
    • 0033790833 scopus 로고    scopus 로고
    • Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis
    • Koedel U., Bayerlein I., Paul R., Sporer B., and Pfister H.W. Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis. J. Infect. Dis. 182 (2000) 1437-1445
    • (2000) J. Infect. Dis. , vol.182 , pp. 1437-1445
    • Koedel, U.1    Bayerlein, I.2    Paul, R.3    Sporer, B.4    Pfister, H.W.5
  • 45
    • 0028929617 scopus 로고
    • Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide
    • Koedel U., Bernatowicz A., Paul R., Frei K., Fontana A., and Pfister H.W. Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide. Ann. Neurol. 37 (1995) 313-323
    • (1995) Ann. Neurol. , vol.37 , pp. 313-323
    • Koedel, U.1    Bernatowicz, A.2    Paul, R.3    Frei, K.4    Fontana, A.5    Pfister, H.W.6
  • 46
    • 16944365627 scopus 로고    scopus 로고
    • Increased endothelin levels in cerebrospinal fluid samples from adults with bacterial meningitis
    • Koedel U., Gorriz C., Lorenzl S., and Pfister H.W. Increased endothelin levels in cerebrospinal fluid samples from adults with bacterial meningitis. Clin. Infect. Dis. 25 (1997) 329-330
    • (1997) Clin. Infect. Dis. , vol.25 , pp. 329-330
    • Koedel, U.1    Gorriz, C.2    Lorenzl, S.3    Pfister, H.W.4
  • 48
    • 0030901966 scopus 로고    scopus 로고
    • Protective effect of the antioxidant N-acetyl-l-cysteine in pneumococcal meningitis in the rat
    • Koedel U., and Pfister H.W. Protective effect of the antioxidant N-acetyl-l-cysteine in pneumococcal meningitis in the rat. Neurosci. Lett. 225 (1997) 33-36
    • (1997) Neurosci. Lett. , vol.225 , pp. 33-36
    • Koedel, U.1    Pfister, H.W.2
  • 49
    • 0033519324 scopus 로고    scopus 로고
    • Superoxide production by primary rat cerebral endothelial cells in response to pneumococci
    • Koedel U., and Pfister H.W. Superoxide production by primary rat cerebral endothelial cells in response to pneumococci. J. Neuroimmunol. 96 (1999) 190-200
    • (1999) J. Neuroimmunol. , vol.96 , pp. 190-200
    • Koedel, U.1    Pfister, H.W.2
  • 50
    • 0036900042 scopus 로고    scopus 로고
    • Pathogenesis and pathophysiology of pneumococcal meningitis
    • Koedel U., Scheld W.M., and Pfister H.W. Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect. Dis. 2 (2002) 721-736
    • (2002) Lancet Infect. Dis. , vol.2 , pp. 721-736
    • Koedel, U.1    Scheld, W.M.2    Pfister, H.W.3
  • 51
    • 0036139308 scopus 로고    scopus 로고
    • Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase
    • Koedel U., Winkler F., Angele B., Fontana A., and Pfister H.W. Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. J. Cereb. Blood Flow Metab. 22 (2002) 39-49
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 39-49
    • Koedel, U.1    Winkler, F.2    Angele, B.3    Fontana, A.4    Pfister, H.W.5
  • 52
    • 0035116154 scopus 로고    scopus 로고
    • Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite
    • Koprowski H., Spitsin S.V., and Hooper D.C. Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite. Ann. Neurol. 49 (2001) 139
    • (2001) Ann. Neurol. , vol.49 , pp. 139
    • Koprowski, H.1    Spitsin, S.V.2    Hooper, D.C.3
  • 53
    • 17344361955 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis
    • Leib S.L., Kim Y.S., Black S.M., Tureen J.H., and Tauber M.G. Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis. J. Infect. Dis. 177 (1998) 692-700
    • (1998) J. Infect. Dis. , vol.177 , pp. 692-700
    • Leib, S.L.1    Kim, Y.S.2    Black, S.M.3    Tureen, J.H.4    Tauber, M.G.5
  • 54
    • 0029852720 scopus 로고    scopus 로고
    • Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
    • Leib S.L., Kim Y.S., Chow L.L., Sheldon R.A., and Tauber M.G. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J. Clin. Invest. 98 (1996) 2632-2639
    • (1996) J. Clin. Invest. , vol.98 , pp. 2632-2639
    • Leib, S.L.1    Kim, Y.S.2    Chow, L.L.3    Sheldon, R.A.4    Tauber, M.G.5
  • 55
    • 0030059740 scopus 로고    scopus 로고
    • Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis
    • Leib S.L., Kim Y.S., Ferriero D.M., and Tauber M.G. Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. J. Infect. Dis. 173 (1996) 166-171
    • (1996) J. Infect. Dis. , vol.173 , pp. 166-171
    • Leib, S.L.1    Kim, Y.S.2    Ferriero, D.M.3    Tauber, M.G.4
  • 56
    • 0034749944 scopus 로고    scopus 로고
    • Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis
    • Leppert D., Lindberg R.L., Kappos L., and Leib S.L. Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain Res. Brain Res. Rev. 36 (2001) 249-257
    • (2001) Brain Res. Brain Res. Rev. , vol.36 , pp. 249-257
    • Leppert, D.1    Lindberg, R.L.2    Kappos, L.3    Leib, S.L.4
  • 57
    • 0035863578 scopus 로고    scopus 로고
    • The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis
    • Loeffler J.M., Ringer R., Hablutzel M., Tauber M.G., and Leib S.L. The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. J. Infect. Dis. 183 (2001) 247-252
    • (2001) J. Infect. Dis. , vol.183 , pp. 247-252
    • Loeffler, J.M.1    Ringer, R.2    Hablutzel, M.3    Tauber, M.G.4    Leib, S.L.5
  • 59
    • 0031875938 scopus 로고    scopus 로고
    • Radical nature of peroxynitrite reactivity
    • Lymar S.V., and Hurst J.K. Radical nature of peroxynitrite reactivity. Chem. Res. Toxicol. 11 (1998) 714-715
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 714-715
    • Lymar, S.V.1    Hurst, J.K.2
  • 60
    • 0031460696 scopus 로고    scopus 로고
    • Peroxynitrite rapidly permeates phospholipid membranes
    • Marla S.S., Lee J., and Groves J.T. Peroxynitrite rapidly permeates phospholipid membranes. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 14243-14248
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 14243-14248
    • Marla, S.S.1    Lee, J.2    Groves, J.T.3
  • 61
    • 0037127223 scopus 로고    scopus 로고
    • Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappaB DNA binding activity
    • Matata B.M., and Galinanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappaB DNA binding activity. J. Biol. Chem. 277 (2002) 2330-2335
    • (2002) J. Biol. Chem. , vol.277 , pp. 2330-2335
    • Matata, B.M.1    Galinanes, M.2
  • 62
    • 0034595544 scopus 로고    scopus 로고
    • Nitric oxide donor-induced increase in permeability of the blood-brain barrier
    • Mayhan W.G. Nitric oxide donor-induced increase in permeability of the blood-brain barrier. Brain Res. 866 (2000) 101-108
    • (2000) Brain Res. , vol.866 , pp. 101-108
    • Mayhan, W.G.1
  • 63
    • 0030774198 scopus 로고    scopus 로고
    • Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988
    • McIntyre P.B., Berkey C.S., King S.M., Schaad U.B., Kilpi T., Kanra G.Y., and Perez C.M. Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA 278 (1997) 925-931
    • (1997) JAMA , vol.278 , pp. 925-931
    • McIntyre, P.B.1    Berkey, C.S.2    King, S.M.3    Schaad, U.B.4    Kilpi, T.5    Kanra, G.Y.6    Perez, C.M.7
  • 64
    • 0026504361 scopus 로고
    • Oxygen free radicals and the cerebral arteriolar response to group B streptococci
    • McKnight A.A., Keyes W.G., Hudak M.L., and Jones Jr. M.D. Oxygen free radicals and the cerebral arteriolar response to group B streptococci. Pediatr. Res. 31 (1992) 640-644
    • (1992) Pediatr. Res. , vol.31 , pp. 640-644
    • McKnight, A.A.1    Keyes, W.G.2    Hudak, M.L.3    Jones Jr., M.D.4
  • 65
    • 0037738484 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway
    • Meli D.N., Christen S., and Leib S.L. Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. J. Infect. Dis. 187 (2003) 1411-1415
    • (2003) J. Infect. Dis. , vol.187 , pp. 1411-1415
    • Meli, D.N.1    Christen, S.2    Leib, S.L.3
  • 66
    • 0029812251 scopus 로고    scopus 로고
    • A human temporal bone study of acute bacterial meningogenic labyrinthitis
    • Merchant S.N., and Gopen Q. A human temporal bone study of acute bacterial meningogenic labyrinthitis. Am. J. Otol. 17 (1996) 375-385
    • (1996) Am. J. Otol. , vol.17 , pp. 375-385
    • Merchant, S.N.1    Gopen, Q.2
  • 67
    • 0033843335 scopus 로고    scopus 로고
    • Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage
    • Mihm M.J., Jing L., and Bauer J.A. Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage. J. Cardiovasc. Pharmacol. 36 (2000) 182-187
    • (2000) J. Cardiovasc. Pharmacol. , vol.36 , pp. 182-187
    • Mihm, M.J.1    Jing, L.2    Bauer, J.A.3
  • 69
    • 2542589528 scopus 로고    scopus 로고
    • Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with bacterial meningitis
    • Moller K., Qvist T., Tofteng F., Sahl C., Sonderkaer S., Dethloff T., Knudsen G.M., and Larsen F.S. Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with bacterial meningitis. Stroke 35 (2004) 1333-1339
    • (2004) Stroke , vol.35 , pp. 1333-1339
    • Moller, K.1    Qvist, T.2    Tofteng, F.3    Sahl, C.4    Sonderkaer, S.5    Dethloff, T.6    Knudsen, G.M.7    Larsen, F.S.8
  • 70
    • 0034508769 scopus 로고    scopus 로고
    • Hepatic basolateral plasma high-affinity Ca2+-ATPase is inhibited by nitric oxide and peroxynitrite anion
    • Muriel P., and Sandoval G. Hepatic basolateral plasma high-affinity Ca2+-ATPase is inhibited by nitric oxide and peroxynitrite anion. J. Appl. Toxicol. 20 (2000) 435-439
    • (2000) J. Appl. Toxicol. , vol.20 , pp. 435-439
    • Muriel, P.1    Sandoval, G.2
  • 71
    • 0033030429 scopus 로고    scopus 로고
    • Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis
    • Nau R., Soto A., and Bruck W. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J. Neuropathol. Exp. Neurol. 58 (1999) 265-274
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 265-274
    • Nau, R.1    Soto, A.2    Bruck, W.3
  • 72
    • 0035800858 scopus 로고    scopus 로고
    • Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation
    • Okamoto T., Akaike T., Sawa T., Miyamoto Y., van d.V., and Maeda H. Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. J. Biol. Chem. 276 (2001) 29596-29602
    • (2001) J. Biol. Chem. , vol.276 , pp. 29596-29602
    • Okamoto, T.1    Akaike, T.2    Sawa, T.3    Miyamoto, Y.4    van, d.V.5    Maeda, H.6
  • 74
    • 0009539301 scopus 로고    scopus 로고
    • Effect of alpha-phenyl-N-tert-butylnitrone on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet
    • Park W.S., Chang Y.S., and Lee M. Effect of alpha-phenyl-N-tert-butylnitrone on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet. J. Neurochem. 74 (2000) 763-769
    • (2000) J. Neurochem. , vol.74 , pp. 763-769
    • Park, W.S.1    Chang, Y.S.2    Lee, M.3
  • 75
    • 0034904767 scopus 로고    scopus 로고
    • 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet
    • Park W.S., Chang Y.S., and Lee M. 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. Biol. Neonate 80 (2001) 53-59
    • (2001) Biol. Neonate , vol.80 , pp. 53-59
    • Park, W.S.1    Chang, Y.S.2    Lee, M.3
  • 76
    • 0030767244 scopus 로고    scopus 로고
    • 7-Nitroindazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis
    • Paul R., Koedel U., and Pfister H.W. 7-Nitroindazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis. J. Cereb. Blood Flow Metab. 17 (1997) 985-991
    • (1997) J. Cereb. Blood Flow Metab. , vol.17 , pp. 985-991
    • Paul, R.1    Koedel, U.2    Pfister, H.W.3
  • 77
    • 0042266296 scopus 로고    scopus 로고
    • Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis
    • Paul R., Koedel U., Winkler F., Kieseier B.C., Fontana A., Kopf M., Hartung H.P., and Pfister H.W. Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Brain 126 (2003) 1873-1882
    • (2003) Brain , vol.126 , pp. 1873-1882
    • Paul, R.1    Koedel, U.2    Winkler, F.3    Kieseier, B.C.4    Fontana, A.5    Kopf, M.6    Hartung, H.P.7    Pfister, H.W.8
  • 78
    • 0031723106 scopus 로고    scopus 로고
    • Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
    • Paul R., Lorenzl S., Koedel U., Sporer B., Vogel U., Frosch M., and Pfister H.W. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann. Neurol. 44 (1998) 592-600
    • (1998) Ann. Neurol. , vol.44 , pp. 592-600
    • Paul, R.1    Lorenzl, S.2    Koedel, U.3    Sporer, B.4    Vogel, U.5    Frosch, M.6    Pfister, H.W.7
  • 80
    • 0026457639 scopus 로고
    • Effect of catalase on regional cerebral blood flow and brain edema during the early phase of experimental pneumococcal meningitis
    • Pfister H.W., Kodel U., Dirnagl U., Haberl R.L., Ruckdeschel G., and Einhaupl K.M. Effect of catalase on regional cerebral blood flow and brain edema during the early phase of experimental pneumococcal meningitis. J. Infect. Dis. 166 (1992) 1442-1445
    • (1992) J. Infect. Dis. , vol.166 , pp. 1442-1445
    • Pfister, H.W.1    Kodel, U.2    Dirnagl, U.3    Haberl, R.L.4    Ruckdeschel, G.5    Einhaupl, K.M.6
  • 82
    • 0026488234 scopus 로고
    • Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats
    • Pfister H.W., Koedel U., Lorenzl S., and Tomasz A. Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats. Stroke 23 (1992) 1798-1804
    • (1992) Stroke , vol.23 , pp. 1798-1804
    • Pfister, H.W.1    Koedel, U.2    Lorenzl, S.3    Tomasz, A.4
  • 83
    • 0034009119 scopus 로고    scopus 로고
    • Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis
    • Pfister L.A., Tureen J.H., Shaw S., Christen S., Ferriero D.M., Tauber M.G., and Leib S.L. Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Ann. Neurol. 47 (2000) 329-335
    • (2000) Ann. Neurol. , vol.47 , pp. 329-335
    • Pfister, L.A.1    Tureen, J.H.2    Shaw, S.3    Christen, S.4    Ferriero, D.M.5    Tauber, M.G.6    Leib, S.L.7
  • 84
    • 0027122363 scopus 로고
    • Bacterial meningitis: pathogenesis, pathophysiology, and progress
    • Quagliarello V., and Scheld W.M. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N. Engl. J. Med. 327 (1992) 864-872
    • (1992) N. Engl. J. Med. , vol.327 , pp. 864-872
    • Quagliarello, V.1    Scheld, W.M.2
  • 85
    • 0031826286 scopus 로고    scopus 로고
    • Peroxynitrite reactions and diffusion in biology
    • Radi R. Peroxynitrite reactions and diffusion in biology. Chem. Res. Toxicol. 11 (1998) 720-721
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 720-721
    • Radi, R.1
  • 86
    • 1642570319 scopus 로고    scopus 로고
    • Nitric oxide, oxidants, and protein tyrosine nitration
    • Radi R. Nitric oxide, oxidants, and protein tyrosine nitration. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 4003-4008
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 4003-4008
    • Radi, R.1
  • 87
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff R.M., Kivisakk P., and Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3 (2003) 569-581
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 88
    • 0011929288 scopus 로고
    • Purulent meningitis: the pathologic basis of clinical manifestations
    • Rorke L., and Pitts F. Purulent meningitis: the pathologic basis of clinical manifestations. Clin. Pediatr. (Phila) 2 (1963) 64-71
    • (1963) Clin. Pediatr. (Phila) , vol.2 , pp. 64-71
    • Rorke, L.1    Pitts, F.2
  • 89
    • 0029788750 scopus 로고    scopus 로고
    • Blood chemistry changes in the rat induced by high doses of nitronyl free radical spin traps
    • Schaefer C.F., Janzen E.G., West M.S., Poyer J.L., and Kosanke S.D. Blood chemistry changes in the rat induced by high doses of nitronyl free radical spin traps. Free Radic. Biol. Med. 21 (1996) 427-436
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 427-436
    • Schaefer, C.F.1    Janzen, E.G.2    West, M.S.3    Poyer, J.L.4    Kosanke, S.D.5
  • 90
    • 0036890739 scopus 로고    scopus 로고
    • Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury
    • Scheld W.M., Koedel U., Nathan B., and Pfister H.W. Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury. J. Infect. Dis. 186 Suppl. 2 (2002) S225-S233
    • (2002) J. Infect. Dis. , vol.186 , Issue.SUPPL. 2
    • Scheld, W.M.1    Koedel, U.2    Nathan, B.3    Pfister, H.W.4
  • 92
    • 33244490286 scopus 로고    scopus 로고
    • In bacterial meningitis cortical brain damage is associated with changes in parenchymal MMP-9/TIMP-1 ratio and increased collagen type IV degradation
    • Sellner J., and Leib S.L. In bacterial meningitis cortical brain damage is associated with changes in parenchymal MMP-9/TIMP-1 ratio and increased collagen type IV degradation. Neurobiol. Dis. 21 (2006) 647-656
    • (2006) Neurobiol. Dis. , vol.21 , pp. 647-656
    • Sellner, J.1    Leib, S.L.2
  • 93
    • 0031568386 scopus 로고    scopus 로고
    • C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro
    • Spanaus K.S., Nadal D., Pfister H.W., Seebach J., Widmer U., Frei K., Gloor S., and Fontana A. C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro. J. Immunol. 158 (1997) 1956-1964
    • (1997) J. Immunol. , vol.158 , pp. 1956-1964
    • Spanaus, K.S.1    Nadal, D.2    Pfister, H.W.3    Seebach, J.4    Widmer, U.5    Frei, K.6    Gloor, S.7    Fontana, A.8
  • 94
    • 0030604552 scopus 로고    scopus 로고
    • Complement C3 and factor B cerebrospinal fluid concentrations in bacterial and aseptic meningitis
    • Stahel P.F., Nadal D., Pfister H.W., Paradisis P.M., and Barnum S.R. Complement C3 and factor B cerebrospinal fluid concentrations in bacterial and aseptic meningitis. Lancet 349 (1997) 1886-1887
    • (1997) Lancet , vol.349 , pp. 1886-1887
    • Stahel, P.F.1    Nadal, D.2    Pfister, H.W.3    Paradisis, P.M.4    Barnum, S.R.5
  • 95
    • 0029959717 scopus 로고    scopus 로고
    • DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite
    • Szabo C. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radic. Biol. Med. 21 (1996) 855-869
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 855-869
    • Szabo, C.1
  • 96
    • 0032577469 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose)synthetase in inflammation
    • Szabo C. Role of poly(ADP-ribose)synthetase in inflammation. Eur. J. Pharmacol. 350 (1998) 1-19
    • (1998) Eur. J. Pharmacol. , vol.350 , pp. 1-19
    • Szabo, C.1
  • 97
    • 0037432615 scopus 로고    scopus 로고
    • Multiple pathways of peroxynitrite cytotoxicity
    • Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol. Lett. 140-141 (2003) 105-112
    • (2003) Toxicol. Lett. , vol.140-141 , pp. 105-112
    • Szabo, C.1
  • 98
    • 0030854951 scopus 로고    scopus 로고
    • Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite
    • Szabo C., Cuzzocrea S., Zingarelli B., O'Connor M., and Salzman A.L. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J. Clin. Invest. 100 (1997) 723-735
    • (1997) J. Clin. Invest. , vol.100 , pp. 723-735
    • Szabo, C.1    Cuzzocrea, S.2    Zingarelli, B.3    O'Connor, M.4    Salzman, A.L.5
  • 99
    • 4043062119 scopus 로고    scopus 로고
    • Dexamethasone and pneumococcal meningitis
    • van de Beek D., and de Gans J. Dexamethasone and pneumococcal meningitis. Ann. Intern. Med. 141 (2004) 327
    • (2004) Ann. Intern. Med. , vol.141 , pp. 327
    • van de Beek, D.1    de Gans, J.2
  • 101
    • 0344643456 scopus 로고    scopus 로고
    • Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention
    • Virag L., Szabo E., Gergely P., and Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol. Lett. 140-141 (2003) 113-124
    • (2003) Toxicol. Lett. , vol.140-141 , pp. 113-124
    • Virag, L.1    Szabo, E.2    Gergely, P.3    Szabo, C.4
  • 102
    • 30844443240 scopus 로고    scopus 로고
    • Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series
    • Weisfelt M., van de Beek D., Spanjaard L., Reitsma J.B., and de Gans J. Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol. 5 (2006) 123-129
    • (2006) Lancet Neurol. , vol.5 , pp. 123-129
    • Weisfelt, M.1    van de Beek, D.2    Spanjaard, L.3    Reitsma, J.B.4    de Gans, J.5
  • 103
    • 0036268393 scopus 로고    scopus 로고
    • A reassessment of the peroxynitrite scavenging activity of uric acid
    • Whiteman M., Ketsawatsakul U., and Halliwell B. A reassessment of the peroxynitrite scavenging activity of uric acid. Ann. NY Acad. Sci. 962 (2002) 242-259
    • (2002) Ann. NY Acad. Sci. , vol.962 , pp. 242-259
    • Whiteman, M.1    Ketsawatsakul, U.2    Halliwell, B.3
  • 104
    • 0035877050 scopus 로고    scopus 로고
    • Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown
    • Winkler F., Koedel U., Kastenbauer S., and Pfister H.W. Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown. J. Infect. Dis. 183 (2001) 1749-1759
    • (2001) J. Infect. Dis. , vol.183 , pp. 1749-1759
    • Winkler, F.1    Koedel, U.2    Kastenbauer, S.3    Pfister, H.W.4
  • 105
    • 0343831476 scopus 로고    scopus 로고
    • Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes
    • Zouki C., Jozsef L., Ouellet S., Paquette Y., and Filep J.G. Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes. J. Leukoc. Biol. 69 (2001) 815-824
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 815-824
    • Zouki, C.1    Jozsef, L.2    Ouellet, S.3    Paquette, Y.4    Filep, J.G.5
  • 106
    • 0029992465 scopus 로고    scopus 로고
    • Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis
    • Zysk G., Bruck W., Gerber J., Bruck Y., Prange H.W., and Nau R. Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis. J. Neuropathol. Exp. Neurol. 55 (1996) 722-728
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 722-728
    • Zysk, G.1    Bruck, W.2    Gerber, J.3    Bruck, Y.4    Prange, H.W.5    Nau, R.6


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