Matrix metalloproteinase-9 in pneumococcal meningitis: Activation via an oxidative pathway

Journal of Infectious Diseases

Volumn 187, Issue 9, 2003, Pages 1411-1415

  Meli, Damian N ^a   Christen, Stephan ^a   Leib, Stephen L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AZIDE; CATALASE; GELATINASE B; HYPOCHLOROUS ACID; METHIONINE; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL MENINGITIS; BRAIN INJURY; CEREBROSPINAL FLUID; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME METABOLISM; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE; ZYMOGRAPHY;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HUMANS; MATRIX METALLOPROTEINASE 9; MENINGITIS, PNEUMOCOCCAL; NEUTROPHILS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STREPTOCOCCUS PNEUMONIAE;

EID: 0037738484     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/374644     Document Type: Article

References (15)

1. Leib SL, Clements JM, Lindberg RL, et al. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 2001; 124:1734-42.
2. Leib SL, Kim YS, Chow LL, Sheldon RA, Täuber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest 1996; 98:2632-9.
3. Leppert D, Leib SL, Grygar C, Miller KM, Schaad UB, Hollander GA. Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clin Infect Dis 2000; 31:80-4.
4. Leib SL, Leppert D, Clements J, Täuber MG. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis. Infect Immun 2000; 68:615-20.
5. Schaper M, Gergely S, Lykkesfeldt J, et al. Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis. J Neuropathol Exp Neurol 2002; 61:605-13.
6. Auer M, Pfister LA, Leppert D, Tauber MG, Leib SL. Effects of clinically used antioxidants in experimental pneumococcal meningitis. J Infect Dis 2000; 182:347-50.
7. Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002; 3:207-14.
8. Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7): a mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Biol Chem 2001; 276:41279-87.
9. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro: implications for atherosclerotic plaque stability. J Clin Invest 1996; 98:2572-9.
10. Galis ZS, Asanuma K, Godin D, Meng X. N-acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: new target for antioxidant therapy? Circulation 1998; 97:2445-53.
11. Müller N, Vonlaufen N, Gianinazzi C, Leib SL, Hemphill A. Application of real-time fluorescent PCR for quantitative assessment of Neospora caninum infections in organotypic slice cultures of rat central nervous system tissue. J Clin Microbiol 2002; 40:252-5.
12. Kleiner DE, Stetler-Stevenson WG. Quantitative zymography: detection of picogram quantities of gelatinases. Anal Biochem 1994; 218:325-9.
13. Bergt C, Marsche G, Panzenboeck U, Heinecke JW, Malle E, Sattler W. Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoprotein A-I. Eur J Biochem 2001; 268:3523-31.
14. Rosenberg GA. Matrix metalloproteinases in neuroinflammation. Glia 2002; 39:279-91.
15. Yushchenko M, Weber F, Mader M, et al. Matrix metalloproteinase-9 (MMP-9) in human cerebrospinal fluid (CSF): elevated levels are primarily related to CSF cell count. J Neuroimmunol 2000; 110:244-51.