Effects of clinically used antioxidants in experimental pneumococcal meningitis

Journal of Infectious Diseases

Volumn 182, Issue 1, 2000, Pages 347-350

  Auer, Marc ^a   Pfister, Luz Andrea ^a   Leppert, David ^b   Täuber, Martin G ^a   Leib, Stephen L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; DEFEROXAMINE; MESYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL MENINGITIS; BRAIN INJURY; BRAIN PROTECTION; DRUG EFFECT; HISTOPATHOLOGY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; DEFEROXAMINE; DISEASE MODELS, ANIMAL; MENINGITIS, PNEUMOCOCCAL; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033931132     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315658     Document Type: Article

References (15)

1. 1. Leib SL, Kim YS, Chow LL, Sheldon RA, Täuber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest 1996;98:2632-9.
2. 2. Koedel U, Pfister HW. Oxidative stress in bacterial meningitis. Brain Pathol 1999;9:57-67.
3. 3. Koedel U, Pfister HW. Superoxide production by primary rat cerebral endothelial cells in response to pneumococci. J Neuroimmunol 1999;96: 190-200.
4. 4. Koedel U, Pfister HW. Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat. Neurosci Lett 1997;225:33-6.
5. 5. Lorenzl S, Koedel U, Frei K, Bernatowicz A, Fontana A, Pfister HW. Protective effect of a 21-aminosteroid during experimental pneumococcal meningitis. J Infect Dis 1995;172:113-8.
6. 6. Pfister HW, Koedel U, Lorenzl S, Tomasz A. Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats. Stroke 1992;23:1798-804.
7. 7. Leib SL, Leppert D, Clements J, Täuber MG. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis. Infect Immun 2000;68:615-20.
8. 8. Pfister LA, Tureen JH, Shaw S, et al. Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Ann Neurol 2000;47:329-35.
9. 9. Allameh A, Vansoun EY, Zarghi A. Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity. Mech Aging Dev 1997;95:71-9.
10. 10. Merali S, Chin K, Del Angel L, Grady RW, Armstrong M, Clarkson AB Jr. Clinically achievable plasma deferoxamine concentrations are therapeutic in a rat model of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother 1995;39:2023-6.
11. 11. Smith SL, Hall ED. Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome. J Neurotrauma 1998;15:707-19.
12. 12. Hall ED, Andrus PK, Smith SL, et al. Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants. Acta Neurochir Suppl (Wien) 1996;66:107-13.
13. 13. Smith SL, Scherch HM, Hall ED. Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury. J Neurosurg 1996;84:229-33.
14. 14. Spapen H, Zhang H, Vincent JL. Potential therapeutic value of lazaroids in endotoxemia and other forms of sepsis. Shock 1997;8:321-7.
15. 15. Bogdan I, Leib SL, Bergeron M, Chow L, Täuber MG. Tumor necrosis factor-alpha contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis. J Infect Dis 1997;176:693-7.