Dexamethasone as adjunctive therapy in bacterial meningitis: A meta- analysis of randomized clinical trials since 1988

JAMA

Volumn 278, Issue 11, 1997, Pages 925-931

  McIntyre, Peter B ^a   Berkey, Catherine S ^b   King, Susan M ^c   Schaad, Urs B ^d   Kilpi, Terhi ^e   Kanra, Guler Y ^f   Perez, Carla M Odio ^g  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b CHANNING LABORATORY   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF BASEL   (Switzerland)

^e UNIVERSITY OF HELSINKI   (Finland)

^f HACETTEPE UNIVERSITY   (Turkey)

^g HOSPITAL NACIONAL DE NIÑOS   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CEFTRIAXONE; CEFUROXIME; CHLORAMPHENICOL; DEXAMETHASONE; SULBACTAM;

ANTIBIOTIC THERAPY; BACTERIAL MENINGITIS; CLINICAL TRIAL; DRUG EFFICACY; FEVER; GASTROINTESTINAL HEMORRHAGE; HAEMOPHILUS INFLUENZAE TYPE B; HEARING LOSS; HUMAN; META ANALYSIS; NEUROLOGIC DISEASE; PRIORITY JOURNAL; REACTIVE ARTHRITIS; REVIEW; SEIZURE; STREPTOCOCCUS PNEUMONIAE;

EID: 0030774198     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.278.11.925     Document Type: Review

References (61)

1. Lepper MH, Spies HW. Treatment of pneumoeocci meningitis. Arch Intern Med. 1958;104:252-259.
2. Harbin GL, Hodges GR. Corticosteroids as adjunctive therapy for acute bacterial meningitis. South Med J. 1979;72:977-980.
3. Lebel MH, Freij BJ, Syrogiannopoulos GA, et al. Dexamethasone therapy for bacterial meningitis: results of two double-blind, placebo-controlled trials. N Engl J Med. 1988;319:964-971.
4. American Academy of Pediatrics Committee on Infectious Diseases. Dexamethasone therapy for bacterial meningitis in infants and children. Pediatrics. 1990;86:130-133.
5. Infectious Diseases and Immunisation Committee of Canadian Paediatric Society. Dexamethasone therapy for bacterial meningitis: a time for caution. Can Med Assoc J. 1990;142:307-308.
6. The Meningitis Working Party of the British Paediatric Immunology and Infectious Diseases Group. Should we use dexamethasone in meningitis? Arch Dis Child. 1992;67:324-326.
7. McGowan JE, Chesney PJ, Crossley KB, La-Force FM. Guidelines for the use of systemic glucocorticosteroids in the management of selected infections. J Infect Dis. 1992;165:1-13.
8. American Academy of Pediatrics. Dexamethasone therapy for bacterial meningitis in infants and children. In: Peter G, ed. 1994 Red Book: Report of the Committee on Infectious Diseases. 23rd ed. Elk Grove Village, Ill: American Academy of Pediatrics; 1994:558-559.
9. Peltola H, Kilpi T, Antilla M. Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines. Lancet. 1992;340:592-594.
10. Adams WG, Deaver KA, Cochi SL, et al. Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era. JAMA. 1993;269:221-248.
11. Pomeroy SL, Holmes SJ, Dodge PR, Feigin RD. Seizures and other neurologic sequelae of bacterial meningitis in children. N Engl J Med. 1990;323:1651-1657.
12. Friedland IR, McCracken GH. Management of infections caused by antibiotic-resistant Streptococcus pneumoniae. N Engl J Med. 1994;331:377-382.
13. Havens PL, Wendelberger KJ, Hoffman GM, Lee MB, Chusid MJ. Corticosteroids as adjunctive therapy in bacterial meningitis. AJDC. 1989;143: 1051-1055.
14. Geiman BJ, Smith AL. Dexamethasone and bacterial meningitis: a meta-analysis of randomised controlled trials. West J Med. 1992;157:27-31.
15. Kaplan SL. Dexamethasone for children with bacterial meningitis: should it be routine therapy? AJDC. 1989;143:290-292.
16. Havens PL. Meta-analysis redux: steroids and meningitis revised. West J Med. 1992;157:84-86.
17. Smith AL. Neurologic sequelae of meningitis. N Engl J Med. 1988;319:1012-1014.
18. Kaplan SL, Goddard J, Van Kleek M, et al. Ataxia and deafness in children due to bacterial meningitis. Pediatr Infect Dis J. 1988;7:140-142.
19. Irwig LM, Toteson ANA, Gatsonis C, et al. Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med. 1994;120:667-676.
20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled Clin Trials. 1986;7:177-188.
21. Lau J. Meta-analyst version 0.991. Boston, Mass: New England Medical Center; 1997.
22. Berkey CS, Hoaglin DC, Mosteller F, Colditz G. A random-effects regression model for meta-analysis. Stat Med. 1995;14:395-411.
23. Lebel MH, Hoyt J, Waagner DC, et al. Magnetic resonance imaging and dexamethasone therapy for bacterial meningitis. AJDC. 1989;143:301-306.
24. Odio CM, Faingezicht I, Paris M, et al. The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis. N Engl J Med. 1991;324:1525-1531.
25. Schaad UB, Lips U, Gnehm HE, et al. Dexamethasone therapy for bacterial meningitis in children. Lancet. 1993;342:457-461.
26. King SM, Law B, Langley JM, Heurter H. Dexamethasone therapy for bacterial meningitis: better never than late? Can J Infect Dis. 1994;5:1-7.
27. Wald ER, Kaplan S, Mason E, et al. Dexamethasone therapy for bacterial meningitis in children. Pediatrics. 1995;95:21-28.
28. Kilpi T, Peltola H, Jauhiainen T, Kallio MJT. Oral glycerol and intravenous dexamethasone in preventing hearing impairment due to childhood bacterial meningitis. Pediatr Infect Dis J. 1995;14: 270-278.
29. Girgis NI, Farid Z, Mikhail IA, et al. Dexamethasone treatment for bacterial meningitis in children and adults. Pediatr Infect Dis J. 1989;8:848-851.
30. Kanra GY, Ozen H, Secmeer G, Ceyhan M, Ecevit Z, Belgin E. The beneficial effects of dexamethasone in children with pneumococcal meningitis. Pediatr Infect Dis J. 1995;14:490-194.
31. Ciana G, Parmar N, Antonio C, Pivetta S, Tamburlini G, Cuttini M. Effectiveness of adjunctive treatment with steroids in reducing short-term mortality in a high-risk population of children with bacterial meningitis. J Trop Paediatr. 1995;41:164-168.
32. Gabor K, Zsolt F, Hirschberg J, Gyorgy H. A purulens meningitist noveto hallaskarosodas az adjuvans dexamethasone kezeles turreben. Orvosi Hetilap. 1993;134:247-249.
33. Marguet C, Mallet E. Interet de la dexamethasone au cours des meningites purulentes de l'enfant. Arch Fr Pediatr. 1993;50:111-117.
34. Kennedy WA, Hoyt MJ, McCracken GH. The role of corticosteroid therapy in children with pneumococcal meningitis. AJDC. 1991;145:1374-1378.
35. Macaluso A, Pivetta S, Maggi RS, Tamburlini G, Cattaneo A. Dexamethasone adjunctive therapy for bacterial meningitis in children: a retrospective study in Brazil. Ann Trop Paediatr. 1996;16:193-198.
36. Syrogiannopoulos G, Lourida AN, Theodoridou MC, et al. Dexamethasone therapy for bacterial meningitis in children: 2 versus 4 day regimen. J Infect Dis. 1994;169:853-858.
37. McCracken GH, Lebel MH. Dexamethasone therapy for bacterial meningitis. N Engl J Med. 1989;320:465.
38. Ioannidis JPA, Samarel MD, Lau J, Drapkin MS. Risk of gastrointestinal bleeding from dexamethasone in children with bacterial meningitis. Lancet. 1994;343:792.
39. Fortnum HM. Hearing impairment after bacterial meningitis: a review. Arch Dis Child. 1992;67: 1128-1133.
40. Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children: a meta-analysis. Pediatr Infect Dis J. 1993;12:389-394.
41. Vienny H, Despland PA, Lutchg J, Deonne T, Dutoit-Marco ML, Gander C. Early diagnosis and evolution of deafness in childhood bacterial meningitis: a study using brainstem auditory evoked potentials. Pediatrics. 1984;73:579-586.
42. Bhatt SM, Cabellos C, Nadol JB, et al. The impact of dexamethasone on hearing loss in experimental pneumococcal meningitis. Pediatr Infect Dis J. 1995;14:93-96.
43. Sehaad UB, Kaplan SL, McCracken GH. Steroid therapy for bacterial meningitis. Clin Infect Dis. 1995;20:685-690.
44. Sehaad UB, Ster S, Gianella-Borradori A, et al. A comparison of ceftriaxone and cefuroxine for the treatment of bacterial meningitis in children. N Engl J Med. 1990;322:141-147.
45. Glaziou PP, Irwig LM. An evidence-based approach to individualising treatment. BMJ. 1995;311: 1356-1358.
46. McIntyre P, Jepson R, Leeder S, Irwig L. The outcome of childhood Haemaphilus influenzae meningitis. Med J Aust 1993;159:766-772.
47. Brady MT, Kaplan SL, Taber LH. Association between persistence of pneumococcal meningitis and dexamethasone administration. J Pediatr. 1981; 99:924-926.
48. Nielsen PE, Thelle T, Tvede M. Recrudesence and relapse of meningococcal meningitis and septicaemia. Acta Paediatr. 1995;84:342-345.
49. Friedland IR, Paris M, Ehret S, Hickey S, Olsen K, McCracken GH. Evolution of antimicrobial regimens for treatment of experimental penicillin and cephalosporin-resistant pneumococcal meningitis. Antimicrob Agents Chemother. 1993;37:1630-1636.
50. Klugman KP, Friedland IR, Bradley JS. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob Agents Chemother. 1995;39:1988-1992.
51. Messer J, Reitman D, Sacks HS, Smith H, Chalmers T. Association of adrenocorticosteroid therapy and peptic-ulcer disease. N Engl J Med. 1983;309:21-24.
52. Cook DJ, Fuller HD, Guyatt GH, et al. Risk factors for gastrointestinal bleeding in critically ill patients. N Engl J Med. 1994;330:377-381.
53. Lacroix J, Nadeau D, Laberge S, et al. Frequency of upper gastrointestinal bleeding in a paediatric intensive care unit. Crit Care Med. 1992;20:35-42.
54. Odio CM, Zaglul C, Faingezicht I, et al. A double-blind controlled study of 1 vs 4 days of dexamethasone for patients with purulent meningitis. In: Program and abstracts of the American Society for Microbiology 34th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 4-7, 1994; Orlando, FIa. Abstract M30.
55. Waagner DC, Kennedy WA, Hoyt MS, McCracken GH. Lack of adverse effects of dexamethasone therapy in aseptic meningitis. Pediatr Infect Dis J. 1990;9:922-923.
56. Bergman I, Painter MJ, Wald DR, Chaponis D, Holland AL, Taylor HG. Outcome in children with enteroviral meningitis during the first year of life. J Pediatr. 1987;110:705-709.
57. Bradley JS. Dexamethasone therapy in meningitis: potentially misleading anti-inflammatory effects in central nervous system infections. Pediatr Infect Dis J. 1994;13:823-826.
58. Prasad K, Haines T. Dexamethasone treatment for acute bacterial meningitis: how strong is the evidence for routine use? J Neurol Neurosurg Psychiatry. 1995;59:31-37.
59. Egger M, Smith GD. Misleading meta-analysis. BMJ. 1995;310:752-754.
60. Prober CG. The role of steroids in the management of children with bacterial meningitis. Pediatrics. 1995;95:29-31.
61. Qazi SA, Khan MA, Mughal N, et al. Dexamethasone and bacterial meningitis in Pakistan. Arch Dis Child. 1996;75:482-488.