Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 1, 2002, Pages 39-49

  Koedel, U ^a   Winkler, F ^a   Angele, B ^a   Fontana, A ^a   Pfister, H W ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

3 Aminobenzamide; Blood brain barrier; Interleukin 1; Occludin; PECAM 1; Streptococcus pneumoniae

Indexed keywords

3 AMINOBENZAMIDE; CD31 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OCCLUDIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID ANALYSIS; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; IMMUNOCYTOCHEMISTRY; INTRACRANIAL PRESSURE; LEUKOCYTE COUNT; MACROPHAGE; MALE; MENINGITIS; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE; WESTERN BLOTTING;

EID: 0036139308     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200201000-00005     Document Type: Article

References (57)

1. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
2. Cell death and control of cell survival in the oligodendrocyte lineage
3. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
4. An improved cycling assay for nicotinamide adenine dinucleotide
5. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo
6. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
7. Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats
8. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo
9. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion
10. Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat
11. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
12. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase
13. Differential expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) in murine tissues
14. Poly(ADP-ribose) polymerase-1 in the nervous system
15. Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: Measurement, mechanism and the effects of nutrition
16. A role of poly(ADP-ribose) polymerase in NF-κB transcriptional activation
17. Inactivation of the poly(ADP ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
18. A fast signal-induced activation of poly(ADP-ribose) polymerase: A novel downstream target of phospholipase c
19. The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA
20. Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis
21. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis
22. Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures
23. Oxidative stress in bacterial meningitis
24. Superoxide production by primary rat cerebral endothelial cells in response to pneumococci
25. Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide
26. Human immunodeficiency virus type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system
27. Pharmacological interference with NF-κB activation attenuates central nervous system complications in experimental pneumococcal meningitis
28. Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice
29. Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry
30. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
31. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose) polymerase
32. Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: Roles in cancer, aging, and the immune system
33. The control of microvascular permeability and blood pressure by neutral endopeptidase
34. Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain
35. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice
36. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
37. Spectrum of complications during bacterial meningitis in adults
38. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
39. Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
40. Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption
41. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation
42. Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis
43. Detection of apoptosis in tissue sections
44. Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart
45. Role of poly(ADP-ribose)synthetase in inflammation
46. DNA strand breakage, activation of poly(ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
47. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite
48. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
49. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase
50. Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition
51. VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly
52. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
53. Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks
54. Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin
55. Cytochemical methods for the detection of apoptosis
56. Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury
57. Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury